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It has been also shown that increased CSF sPDGFR\u03b2 levels can predict cognitive dysfunction in\n                    <jats:italic>APOE4<\/jats:italic>\n                    carriers bearing the main susceptibility gene for AD. Whether plasma sPDGFR\u03b2 levels are also elevated in\n                    <jats:italic>APOE4<\/jats:italic>\n                    carriers has not been explored. Here, we analyzed plasma samples for sPDGFR\u03b2 levels, Ab\n                    <jats:sub>42\/40<\/jats:sub>\n                    ratio, and pTau217 in 115\n                    <jats:italic>APOE3<\/jats:italic>\n                    homozygotes and\n                    <jats:italic>APOE4<\/jats:italic>\n                    carriers with Clinical Dementia Rating (CDR) score of 0 and 0.5. Our data show that plasma sPDGFR\u03b2 levels are increased in\n                    <jats:italic>APOE4<\/jats:italic>\n                    carriers with cognitive impairment compared to\n                    <jats:italic>APOE4<\/jats:italic>\n                    carriers that are cognitively unimpaired as well as relative to cognitively impaired\n                    <jats:italic>APOE3<\/jats:italic>\n                    carriers even after controlling for plasma A\u03b2\n                    <jats:sub>42\/40<\/jats:sub>\n                    ratio and pTau217. Thus, our data suggest that plasma sPDGFR\u03b2 is a useful biomarker of brain pericytes\/BBB damage in\n                    <jats:italic>APOE4<\/jats:italic>\n                    carriers.\n                  <\/jats:p>","DOI":"10.1007\/s11357-026-02291-y","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T06:17:28Z","timestamp":1778566648000},"page":"3649-3657","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Elevated levels of circulating plasma sPDGFR\u03b2 in cognitively impaired APOE4 carriers"],"prefix":"10.1007","volume":"48","author":[{"given":"Abhay P.","family":"Sagare","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor","family":"Lohman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Ramirez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth B.","family":"Joe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Harrington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena C.","family":"Chui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lon S.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein N.","family":"Yassine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Ringman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur W.","family":"Toga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Nation","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berislav V.","family":"Zlokovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"2291_CR1","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1152\/physrev.00050.2017","volume":"99","author":"MD Sweeney","year":"2019","unstructured":"Sweeney MD, Zhao Z, Montagne A, et al. 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