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This meta-analysis evaluated BAG in Alzheimer\u2019s disease (AD), mild cognitive impairment (MCI), multiple sclerosis (MS), Parkinson\u2019s disease (PD), schizophrenia (SCZ), stroke, and bipolar disorder (BD) to determine shared and disorder-specific patterns of accelerated brain aging. Sixty-five MRI-based studies were included. For each cohort, BAG was extracted or calculated, and standardized mean differences (Hedges\u2019\n                    <jats:italic>g<\/jats:italic>\n                    ) were computed between patient and healthy control groups using random-effects models. Subgroup analyses and meta-regressions were conducted to assess the influence of age and disorder characteristics. Publication bias and heterogeneity were evaluated using Egger\u2019s test,\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    statistics, and trim-and-fill procedures. BAG was significantly elevated across all disorders. The largest effects were observed in MS (mean adjusted BAG\u2009=\u20097.81 years;\n                    <jats:italic>g<\/jats:italic>\n                    \u2009=\u20090.89) and AD (5.57 years;\n                    <jats:italic>g<\/jats:italic>\n                    \u2009=\u20090.66). Meta-analyses of adequately powered disorders showed moderate elevations in SCZ (4.40 years;\n                    <jats:italic>g<\/jats:italic>\n                    \u2009=\u20090.42) and MCI (3.77 years;\n                    <jats:italic>g<\/jats:italic>\n                    \u2009=\u20090.43), while PD showed smaller but significant acceleration (3.52 years;\n                    <jats:italic>g<\/jats:italic>\n                    \u2009=\u20090.37). Descriptively, stroke (2 cohorts; mean adjusted BAG\u2009=\u20094.63 years) and BD (1 cohort; mean adjusted BAG\u2009=\u20094.84 years) also showed elevated BAG, though insufficient study numbers precluded formal meta-analysis for these disorders. BAG was largely independent of chronological age in neurodegenerative disorders but increased with age in SCZ. These findings support BAG as a transdiagnostic indicator of apparent accelerated brain aging in conditions where the meta-analytic evidence base is robust (AD, MCI, MS, PD, SCZ), while stroke and BD remain preliminary owing to limited cohort numbers. The magnitude of BAG varies substantially across conditions, and very high between-study heterogeneity (\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009&gt;\u200990% in most disorders) means pooled effect sizes should be interpreted alongside prediction intervals.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphical abstract<\/jats:bold>\n                  <\/jats:p>\n                  <jats:p>\n                    The graphical abstract was created using BioRender. Abu Mhanna, H. (2026)\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/BioRender.com\/2b8823g\" ext-link-type=\"uri\">https:\/\/BioRender.com\/2b8823g<\/jats:ext-link>\n                    .\n                  <\/jats:p>","DOI":"10.1007\/s11357-026-02315-7","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T06:13:26Z","timestamp":1778912006000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Aging beyond diagnosis: the MRI brain age gap across disorders"],"prefix":"10.1007","author":[{"given":"Hamad Yahia Abu","family":"Mhanna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena K. 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