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This study was designed as a preliminary safety and feasibility assessment to inform the design of a subsequent randomized controlled trial. It was conducted in accordance with the Declaration of Helsinki. All data were processed according to EU\/GDPR regulations. All patients provided written informed consent (Online Resource\n                      \n                      ) prior to enrollment, co-signed by their closest relative. All blood plasma donors provided written informed consent (Online Resource\n                      \n                      ) prior to blood plasma donation.","order":1,"name":"Ethics","label":"Ethics approval and consent","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Arne S\u00f8raas is a founder and employee of the company Age Labs AS that develops molecular biomarkers for age-related diseases and aging. Andreas Engvig and Mette Stausland Istre are employees of Age Labs AS. John Arne Dahl acts as a scientific advisor to Age Labs AS. No resources or algorithms from Age Labs were used in this work. All other authors declare no conflicts of interest.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"ClinicalTrials.gov NCT06234436 (registered 22 December 2023).","order":3,"name":"Ethics","label":"Trial registration","group":{"name":"EthicsHeading","label":"Declarations"}}]}}