{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:32:11Z","timestamp":1787754731909,"version":"build-2784847793"},"reference-count":167,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"NIH","award":["AG079336"],"award-info":[{"award-number":["AG079336"]}]},{"name":"NIH","award":["AG057842"],"award-info":[{"award-number":["AG057842"]}]},{"name":"NIH","award":["AG094068"],"award-info":[{"award-number":["AG094068"]}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["25PRE1365157"],"award-info":[{"award-number":["25PRE1365157"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016200","name":"Medical College of Georgia, Augusta University","doi-asserted-by":"publisher","award":["TRIBA\/ Physiology Faculty Startup Fund"],"award-info":[{"award-number":["TRIBA\/ Physiology Faculty Startup Fund"]}],"id":[{"id":"10.13039\/100016200","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["GeroScience"],"DOI":"10.1007\/s11357-026-02492-5","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:31:38Z","timestamp":1787751098000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Calcium dysregulation in neurovascular function in Alzheimer\u2019s disease:\u00a0mechanisms, therapeutic targets"],"prefix":"10.1007","author":[{"given":"Yvan","family":"Hanscom-Trofy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Gregory","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert C.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"2492_CR1","doi-asserted-by":"publisher","unstructured":"2026 Alzheimer's disease facts and figures. Alzheimers Dement. 202621;22:e71345. https:\/\/doi.org\/10.1002\/alz.71345.","DOI":"10.1002\/alz.71345"},{"key":"2492_CR2","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1007\/s11357-022-00591-7","volume":"44","author":"X Fang","year":"2022","unstructured":"Fang X, Zhang J, Roman RJ, Fan F. From 1901 to 2022, how far are we from truly understanding the pathogenesis of age-related dementia? GeroScience. 2022;44:1879\u201383. https:\/\/doi.org\/10.1007\/s11357-022-00591-7.","journal-title":"GeroScience"},{"key":"2492_CR3","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-026-10210-x","author":"M Anwer","year":"2025","unstructured":"Anwer M, Poliakova T, Albanus RD, Bhuiyan MIH, Brickman AM, Chaudhuri S, et al. Vascular contribution to cognitive impairment and dementia (VCID): proceedings of 2025 workshop of the Jackson Laboratory. Mamm Genome. 2025. https:\/\/doi.org\/10.1007\/s00335-026-10210-x.","journal-title":"Mamm Genome"},{"key":"2492_CR4","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1056\/NEJMoa2212948","volume":"388","author":"CH van Dyck","year":"2023","unstructured":"van Dyck CH, Swanson CJ, Aisen P, Bateman RJ, Chen C, Gee M, et al. Lecanemab in Early Alzheimer\u2019s Disease. N Engl J Med. 2023;388:9\u201321. https:\/\/doi.org\/10.1056\/NEJMoa2212948.","journal-title":"N Engl J Med"},{"key":"2492_CR5","doi-asserted-by":"publisher","first-page":"E19","DOI":"10.3174\/ajnr.A7586","volume":"43","author":"PM Cogswell","year":"2022","unstructured":"Cogswell PM, Barakos JA, Barkhof F, Benzinger TS, Jack CR Jr, Poussaint TY, et al. Amyloid-Related Imaging Abnormalities with Emerging Alzheimer Disease Therapeutics: Detection and Reporting Recommendations for Clinical Practice. AJNR Am J Neuroradiol. 2022;43:E19-e35. https:\/\/doi.org\/10.3174\/ajnr.A7586.","journal-title":"AJNR Am J Neuroradiol"},{"key":"2492_CR6","doi-asserted-by":"publisher","first-page":"1412006","DOI":"10.3389\/fnagi.2024.1412006","volume":"16","author":"KE Foley","year":"2024","unstructured":"Foley KE, Wilcock DM. Three major effects of APOE(\u03b54) on A\u03b2 immunotherapy induced ARIA. Front Aging Neurosci. 2024;16:1412006. https:\/\/doi.org\/10.3389\/fnagi.2024.1412006.","journal-title":"Front Aging Neurosci"},{"key":"2492_CR7","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/nrneurol.2015.119","volume":"11","author":"JM Tarasoff-Conway","year":"2015","unstructured":"Tarasoff-Conway JM, Carare RO, Osorio RS, Glodzik L, Butler T, Fieremans E, et al. Clearance systems in the brain-implications for Alzheimer disease. Nat Rev Neurol. 2015;11:457\u201370. https:\/\/doi.org\/10.1038\/nrneurol.2015.119.","journal-title":"Nat Rev Neurol"},{"key":"2492_CR8","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1177\/0271678x20982383","volume":"41","author":"O Bracko","year":"2021","unstructured":"Bracko O, Cruz Hern\u00e1ndez JC, Park L, Nishimura N, Schaffer CB. Causes and consequences of baseline cerebral blood flow reductions in Alzheimer\u2019s disease. J Cereb Blood Flow Metab. 2021;41:1501\u201316. https:\/\/doi.org\/10.1177\/0271678x20982383.","journal-title":"J Cereb Blood Flow Metab"},{"key":"2492_CR9","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1007\/s11357-021-00357-7","volume":"43","author":"F Fan","year":"2021","unstructured":"Fan F, Roman RJ. Reversal of cerebral hypoperfusion: a novel therapeutic target for the treatment of AD\/ADRD? Geroscience. 2021;43:1065\u20137. https:\/\/doi.org\/10.1007\/s11357-021-00357-7.","journal-title":"Geroscience"},{"key":"2492_CR10","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1007\/s00401-020-02215-w","volume":"140","author":"N Korte","year":"2020","unstructured":"Korte N, Nortley R, Attwell D. Cerebral blood flow decrease as an early pathological mechanism in Alzheimer\u2019s disease. Acta Neuropathol. 2020;140:793\u2013810. https:\/\/doi.org\/10.1007\/s00401-020-02215-w.","journal-title":"Acta Neuropathol"},{"key":"2492_CR11","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/nature09613","volume":"468","author":"D Attwell","year":"2010","unstructured":"Attwell D, Buchan AM, Charpak S, Lauritzen M, Macvicar BA, Newman EA. Glial and neuronal control of brain blood flow. Nature. 2010;468:232\u201343. https:\/\/doi.org\/10.1038\/nature09613.","journal-title":"Nature"},{"key":"2492_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2021.106548","volume":"154","author":"Y Liu","year":"2021","unstructured":"Liu Y, Zhang H, Wu CY, Yu T, Fang X, Ryu JJ, et al. 20-HETE-promoted cerebral blood flow autoregulation is associated with enhanced pericyte contractility. Prostaglandins Other Lipid Mediat. 2021;154:106548. https:\/\/doi.org\/10.1016\/j.prostaglandins.2021.106548.","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"2492_CR13","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1177\/0271678X17732229","volume":"39","author":"RI Grant","year":"2019","unstructured":"Grant RI, Hartmann DA, Underly RG, Berthiaume AA, Bhat NR, Shih AY. Organizational hierarchy and structural diversity of microvascular pericytes in adult mouse cortex. J Cereb Blood Flow Metab. 2019;39:411\u201325. https:\/\/doi.org\/10.1177\/0271678X17732229.","journal-title":"J Cereb Blood Flow Metab"},{"key":"2492_CR14","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202100822RR","volume":"36","author":"BJ DeOre","year":"2022","unstructured":"DeOre BJ, Partyka PP, Fan F, Galie PA. CD44 mediates shear stress mechanotransduction in an in vitro blood-brain barrier model through small GTPases RhoA and Rac1. Faseb j. 2022;36:e22278. https:\/\/doi.org\/10.1096\/fj.202100822RR.","journal-title":"Faseb j"},{"key":"2492_CR15","doi-asserted-by":"publisher","first-page":"1077302","DOI":"10.3389\/fragi.2022.1077302","volume":"3","author":"S Wang","year":"2022","unstructured":"Wang S, Tang C, Liu Y, Border JJ, Roman RJ, Fan F. Impact of impaired cerebral blood flow autoregulation on cognitive impairment. Front Aging. 2022;3:1077302. https:\/\/doi.org\/10.3389\/fragi.2022.1077302.","journal-title":"Front Aging"},{"key":"2492_CR16","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1007\/s11357-020-00233-w","volume":"42","author":"S Wang","year":"2020","unstructured":"Wang S, Lv W, Zhang H, Liu Y, Li L, Jefferson JR, et al. Aging exacerbates impairments of cerebral blood flow autoregulation and cognition in diabetic rats. Geroscience. 2020;42:1387\u2013410. https:\/\/doi.org\/10.1007\/s11357-020-00233-w.","journal-title":"Geroscience"},{"key":"2492_CR17","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1161\/HYPERTENSIONAHA.118.10269","volume":"72","author":"RJ Roman","year":"2018","unstructured":"Roman RJ, Fan F. 20-HETE: Hypertension and Beyond. Hypertension. 2018;72:12\u20138. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.118.10269.","journal-title":"Hypertension"},{"key":"2492_CR18","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1152\/physrev.00022.2020","volume":"101","author":"J Claassen","year":"2021","unstructured":"Claassen J, Thijssen DHJ, Panerai RB, Faraci FM. Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation. Physiol Rev. 2021;101:1487\u2013559. https:\/\/doi.org\/10.1152\/physrev.00022.2020.","journal-title":"Physiol Rev"},{"key":"2492_CR19","doi-asserted-by":"publisher","unstructured":"Fang X, Border JJ, Rivers P, Zhang H, Williams JM, Fan F et al. Amyloid beta accumulation in TgF344-AD rats is associated with reduced cerebral capillary endothelial Kir2.1 expression and neurovascular uncoupling. Geroscience. 2023;45:2909\u20132926. https:\/\/doi.org\/10.1007\/s11357-023-00841-2.","DOI":"10.1007\/s11357-023-00841-2"},{"key":"2492_CR20","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1007\/s11357-023-00773-x","volume":"45","author":"X Fang","year":"2023","unstructured":"Fang X, Tang C, Zhang H, Border JJ, Liu Y, Shin SM, et al. Longitudinal characterization of cerebral hemodynamics in the TgF344-AD rat model of Alzheimer\u2019s disease. Geroscience. 2023;45:1471\u201390. https:\/\/doi.org\/10.1007\/s11357-023-00773-x.","journal-title":"Geroscience"},{"key":"2492_CR21","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1111\/bpa.12401","volume":"26","author":"S Love","year":"2016","unstructured":"Love S, Miners JS. Cerebral hypoperfusion and the energy deficit in Alzheimer\u2019s disease. Brain Pathol. 2016;26:607\u201317. https:\/\/doi.org\/10.1111\/bpa.12401.","journal-title":"Brain Pathol"},{"key":"2492_CR22","doi-asserted-by":"publisher","first-page":"5361","DOI":"10.1113\/jp280950","volume":"599","author":"OF Harraz","year":"2021","unstructured":"Harraz OF, Jensen LJ. Vascular calcium signalling and ageing. J Physiol. 2021;599:5361\u201377. https:\/\/doi.org\/10.1113\/jp280950.","journal-title":"J Physiol"},{"key":"2492_CR23","doi-asserted-by":"publisher","DOI":"10.3390\/biom15060892","author":"C Dai","year":"2025","unstructured":"Dai C, Khalil RA. Calcium signaling dynamics in vascular cells and their dysregulation in vascular disease. Biomolecules. 2025. https:\/\/doi.org\/10.3390\/biom15060892.","journal-title":"Biomolecules"},{"issue":"Pt 1","key":"2492_CR24","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1111\/j.1469-7793.1998.199br.x","volume":"508","author":"HJ Knot","year":"1998","unstructured":"Knot HJ, Nelson MT. Regulation of arterial diameter and wall [Ca2+] in cerebral arteries of rat by membrane potential and intravascular pressure. J Physiol. 1998;508(Pt 1):199\u2013209. https:\/\/doi.org\/10.1111\/j.1469-7793.1998.199br.x.","journal-title":"J Physiol"},{"key":"2492_CR25","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2216421120","volume":"120","author":"NR Klug","year":"2023","unstructured":"Klug NR, Sancho M, Gonzales AL, Heppner TJ, O\u2019Brien RIC, Hill-Eubanks D, et al. Intraluminal pressure elevates intracellular calcium and contracts CNS pericytes: Role of voltage-dependent calcium channels. Proc Natl Acad Sci U S A. 2023;120:e2216421120. https:\/\/doi.org\/10.1073\/pnas.2216421120.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2492_CR26","doi-asserted-by":"publisher","unstructured":"Morgan GC, Gregory A, Hanscom-Trofy Y, Dong R, Fan F. Anatomical Identification and Pressure Myography of the Rat Middle Cerebral Artery: A Comprehensive Protocol for Diverse Genetic Models. bioRxiv. 2026:2026.2006.2012.718520. https:\/\/doi.org\/10.64898\/2026.06.12.718520","DOI":"10.64898\/2026.06.12.718520"},{"key":"2492_CR27","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/nn.4533","volume":"20","author":"TA Longden","year":"2017","unstructured":"Longden TA, Dabertrand F, Koide M, Gonzales AL, Tykocki NR, Brayden JE, et al. Capillary K(+)-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow. Nat Neurosci. 2017;20:717\u201326. https:\/\/doi.org\/10.1038\/nn.4533.","journal-title":"Nat Neurosci"},{"key":"2492_CR28","doi-asserted-by":"publisher","first-page":"2909","DOI":"10.1007\/s11357-023-00841-2","volume":"45","author":"X Fang","year":"2023","unstructured":"Fang X, Border JJ, Rivers PL, Zhang H, Williams JM, Fan F, et al. Amyloid beta accumulation in TgF344-AD rats is associated with reduced cerebral capillary endothelial Kir2.1 expression and neurovascular uncoupling. Geroscience. 2023;45:2909\u201326. https:\/\/doi.org\/10.1007\/s11357-023-00841-2.","journal-title":"Geroscience"},{"key":"2492_CR29","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1038\/nn.4428","volume":"19","author":"A Mishra","year":"2016","unstructured":"Mishra A, Reynolds JP, Chen Y, Gourine AV, Rusakov DA, Attwell D. Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles. Nat Neurosci. 2016;19:1619\u201327. https:\/\/doi.org\/10.1038\/nn.4428.","journal-title":"Nat Neurosci"},{"key":"2492_CR30","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nature13165","volume":"508","author":"CN Hall","year":"2014","unstructured":"Hall CN, Reynell C, Gesslein B, Hamilton NB, Mishra A, Sutherland BA, et al. Capillary pericytes regulate cerebral blood flow in health and disease. Nature. 2014;508:55\u201360. https:\/\/doi.org\/10.1038\/nature13165.","journal-title":"Nature"},{"key":"2492_CR31","doi-asserted-by":"publisher","first-page":"8686","DOI":"10.1523\/jneurosci.0435-21.2021","volume":"41","author":"S Ramakrishna","year":"2021","unstructured":"Ramakrishna S, Jhaveri V, Konings SC, Nawalpuri B, Chakraborty S, Holst B, et al. APOE4 affects basal and NMDAR-mediated protein synthesis in neurons by perturbing calcium homeostasis. J Neurosci. 2021;41:8686\u2013709. https:\/\/doi.org\/10.1523\/jneurosci.0435-21.2021.","journal-title":"J Neurosci"},{"key":"2492_CR32","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1016\/j.cell.2006.06.059","volume":"126","author":"H Tu","year":"2006","unstructured":"Tu H, Nelson O, Bezprozvanny A, Wang Z, Lee SF, Hao YH, et al. Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer\u2019s disease-linked mutations. Cell. 2006;126:981\u201393. https:\/\/doi.org\/10.1016\/j.cell.2006.06.059.","journal-title":"Cell"},{"key":"2492_CR33","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1002\/cphy.c200030","volume":"11","author":"M Ottolini","year":"2021","unstructured":"Ottolini M, Sonkusare SK. The Calcium Signaling Mechanisms in Arterial Smooth Muscle and Endothelial Cells. Compr Physiol. 2021;11:1831\u201369. https:\/\/doi.org\/10.1002\/cphy.c200030.","journal-title":"Compr Physiol"},{"key":"2492_CR34","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a041758","author":"I Bezprozvanny","year":"2026","unstructured":"Bezprozvanny I. Calcium signaling and pathogenesis of neurodegenerative disorders: potential therapeutic opportunities. Cold Spring Harb Perspect Biol. 2026. https:\/\/doi.org\/10.1101\/cshperspect.a041758.","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2492_CR35","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-022-02856-0","volume":"24","author":"B Itson-Zoske","year":"2022","unstructured":"Itson-Zoske B, Shin SM, Xu H, Qiu C, Fan F, Hogan QH, et al. Selective block of sensory neuronal T-type\/Cav3.2 activity mitigates neuropathic pain behavior in a rat model of osteoarthritis pain. Arthritis Res Ther. 2022;24:168. https:\/\/doi.org\/10.1186\/s13075-022-02856-0.","journal-title":"Arthritis Res Ther"},{"key":"2492_CR36","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/978-94-007-2888-2_6","volume":"740","author":"J Karlstad","year":"2012","unstructured":"Karlstad J, Sun Y, Singh BB. Ca2+ signaling: an outlook on the characterization of Ca2+ channels and their importance in cellular functions. Adv Exp Med Biol. 2012;740:143\u201357. https:\/\/doi.org\/10.1007\/978-94-007-2888-2_6.","journal-title":"Adv Exp Med Biol"},{"key":"2492_CR37","doi-asserted-by":"publisher","first-page":"2750","DOI":"10.1097\/j.pain.0000000000002356","volume":"162","author":"SM Shin","year":"2021","unstructured":"Shin SM, Moehring F, Itson-Zoske B, Fan F, Stucky CL, Hogan QH, et al. Piezo2 mechanosensitive ion channel is located to sensory neurons and nonneuronal cells in rat peripheral sensory pathway: implications in pain. Pain. 2021;162:2750\u201368. https:\/\/doi.org\/10.1097\/j.pain.0000000000002356.","journal-title":"Pain"},{"key":"2492_CR38","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22042074","volume":"22","author":"S Shekhar","year":"2021","unstructured":"Shekhar S, Liu Y, Wang S, Zhang H, Fang X, Zhang J, et al. Novel mechanistic insights and potential therapeutic impact of TRPC6 in neurovascular coupling and ischemic stroke. Int J Mol Sci. 2021;22:2074.","journal-title":"Int J Mol Sci"},{"key":"2492_CR39","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1042\/CS20090641","volume":"119","author":"S Earley","year":"2010","unstructured":"Earley S, Brayden JE. Transient receptor potential channels and vascular function. Clin Sci (Lond). 2010;119:19\u201336. https:\/\/doi.org\/10.1042\/CS20090641.","journal-title":"Clin Sci (Lond)"},{"key":"2492_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2025.101433","volume":"33","author":"B Itson-Zoske","year":"2025","unstructured":"Itson-Zoske B, Gani U, Mikesell A, Qiu C, Fan F, Stucky CL, et al. Selective RNAi silencing of Schwann cell Piezo1 alleviates mechanical hypersensitization following peripheral nerve injury. Mol Ther Methods Clin Dev. 2025;33:101433. https:\/\/doi.org\/10.1016\/j.omtm.2025.101433.","journal-title":"Mol Ther Methods Clin Dev"},{"key":"2492_CR41","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a004168","author":"M Brini","year":"2011","unstructured":"Brini M, Carafoli E. The plasma membrane Ca2+ ATPase and the plasma membrane sodium calcium exchanger cooperate in the regulation of cell calcium. Cold Spring Harb Perspect Biol. 2011. https:\/\/doi.org\/10.1101\/cshperspect.a004168.","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2492_CR42","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24108803","author":"G Bkaily","year":"2023","unstructured":"Bkaily G, Jacques D. Calcium homeostasis, transporters, and blockers in health and diseases of the cardiovascular system. Int J Mol Sci. 2023. https:\/\/doi.org\/10.3390\/ijms24108803.","journal-title":"Int J Mol Sci"},{"key":"2492_CR43","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.bpj.2016.11.3206","volume":"112","author":"JP Johny","year":"2017","unstructured":"Johny JP, Plank MJ, David T. Importance of altered levels of SERCA, IP(3)R, and RyR in vascular smooth muscle cell. Biophys J. 2017;112:265\u201387. https:\/\/doi.org\/10.1016\/j.bpj.2016.11.3206.","journal-title":"Biophys J"},{"key":"2492_CR44","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-9-21","volume":"9","author":"D Del Prete","year":"2014","unstructured":"Del Prete D, Checler F, Chami M. Ryanodine receptors: physiological function and deregulation in Alzheimer disease. Mol Neurodegener. 2014;9:21. https:\/\/doi.org\/10.1186\/1750-1326-9-21.","journal-title":"Mol Neurodegener"},{"key":"2492_CR45","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1038\/s41586-025-09491-0","volume":"646","author":"M Fan","year":"2025","unstructured":"Fan M, Tsai CW, Zhang J, Zhang J, Krishnan AR, Liu TY, et al. Structure and mechanism of the mitochondrial calcium transporter NCLX. Nature. 2025;646:1272\u201380. https:\/\/doi.org\/10.1038\/s41586-025-09491-0.","journal-title":"Nature"},{"key":"2492_CR46","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1038\/s41580-024-00820-1","volume":"26","author":"B Cartes-Saavedra","year":"2025","unstructured":"Cartes-Saavedra B, Ghosh A, Hajn\u00f3czky G. The roles of mitochondria in global and local intracellular calcium signalling. Nat Rev Mol Cell Biol. 2025;26:456\u201375. https:\/\/doi.org\/10.1038\/s41580-024-00820-1.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2492_CR47","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1007\/s11357-020-00179-z","volume":"42","author":"Y Guo","year":"2020","unstructured":"Guo Y, Wang S, Liu Y, Fan L, Booz GW, Roman RJ, et al. Accelerated cerebral vascular injury in diabetes is associated with vascular smooth muscle cell dysfunction. Geroscience. 2020;42:547\u201361. https:\/\/doi.org\/10.1007\/s11357-020-00179-z.","journal-title":"Geroscience"},{"key":"2492_CR48","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1152\/physrev.00020.2014","volume":"95","author":"M Prakriya","year":"2015","unstructured":"Prakriya M, Lewis RS. Store-Operated Calcium Channels. Physiol Rev. 2015;95:1383\u2013436. https:\/\/doi.org\/10.1152\/physrev.00020.2014.","journal-title":"Physiol Rev"},{"key":"2492_CR49","doi-asserted-by":"publisher","first-page":"H2613","DOI":"10.1152\/ajpheart.01286.2006","volume":"292","author":"S Earley","year":"2007","unstructured":"Earley S, Straub SV, Brayden JE. Protein kinase C regulates vascular myogenic tone through activation of TRPM4. Am J Physiol Heart Circ Physiol. 2007;292:H2613-2622. https:\/\/doi.org\/10.1152\/ajpheart.01286.2006.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2492_CR50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082482","volume":"8","author":"F Fan","year":"2013","unstructured":"Fan F, Sun CW, Maier KG, Williams JM, Pabbidi MR, Didion SP, et al. 20-Hydroxyeicosatetraenoic acid contributes to the inhibition of K+ channel activity and vasoconstrictor response to angiotensin II in rat renal microvessels. PLoS ONE. 2013;8:e82482. https:\/\/doi.org\/10.1371\/journal.pone.0082482.","journal-title":"PLoS ONE"},{"key":"2492_CR51","doi-asserted-by":"publisher","first-page":"49","DOI":"10.26502\/fjppr.070","volume":"7","author":"H Zhang","year":"2023","unstructured":"Zhang H, Border JJ, Fang X, Liu Y, Tang C, Gao W, et al. Enhanced Cerebral Hemodynamics and Cognitive Function Via Knockout of Dual-Specificity Protein Phosphatase 5. J Pharm Pharmacol Res. 2023;7:49\u201361. https:\/\/doi.org\/10.26502\/fjppr.070.","journal-title":"J Pharm Pharmacol Res"},{"key":"2492_CR52","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1161\/01.Res.0000225860.41648.63","volume":"98","author":"VV Koledova","year":"2006","unstructured":"Koledova VV, Khalil RA. Ca2+, calmodulin, and cyclins in vascular smooth muscle cell cycle. Circ Res. 2006;98:1240\u20133. https:\/\/doi.org\/10.1161\/01.Res.0000225860.41648.63.","journal-title":"Circ Res"},{"key":"2492_CR53","doi-asserted-by":"publisher","first-page":"402","DOI":"10.4161\/19336950.2014.950537","volume":"8","author":"A Martinsen","year":"2014","unstructured":"Martinsen A, Dessy C, Morel N. Regulation of calcium channels in smooth muscle: new insights into the role of myosin light chain kinase. Channels (Austin). 2014;8:402\u201313. https:\/\/doi.org\/10.4161\/19336950.2014.950537.","journal-title":"Channels (Austin)"},{"key":"2492_CR54","doi-asserted-by":"publisher","first-page":"6246","DOI":"10.3390\/cimb45080393","volume":"45","author":"DH O'Day","year":"2023","unstructured":"O\u2019Day DH. Alzheimer\u2019s Disease beyond Calcium Dysregulation: The Complex Interplay between Calmodulin, Calmodulin-Binding Proteins and Amyloid Beta from Disease Onset through Progression. Curr Issues Mol Biol. 2023;45:6246\u201361. https:\/\/doi.org\/10.3390\/cimb45080393.","journal-title":"Curr Issues Mol Biol"},{"key":"2492_CR55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ydbio.2003.10.008","volume":"266","author":"RA Schulz","year":"2004","unstructured":"Schulz RA, Yutzey KE. Calcineurin signaling and NFAT activation in cardiovascular and skeletal muscle development. Dev Biol. 2004;266:1\u201316. https:\/\/doi.org\/10.1016\/j.ydbio.2003.10.008.","journal-title":"Dev Biol"},{"key":"2492_CR56","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1159\/000111332","volume":"15","author":"JG McCormack","year":"1993","unstructured":"McCormack JG, Denton RM. Mitochondrial Ca2+ transport and the role of intramitochondrial Ca2+ in the regulation of energy metabolism. Dev Neurosci. 1993;15:165\u201373. https:\/\/doi.org\/10.1159\/000111332.","journal-title":"Dev Neurosci"},{"key":"2492_CR57","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1152\/physrev.2000.80.2.853","volume":"80","author":"AM Gordon","year":"2000","unstructured":"Gordon AM, Homsher E, Regnier M. Regulation of contraction in striated muscle. Physiol Rev. 2000;80:853\u2013924. https:\/\/doi.org\/10.1152\/physrev.2000.80.2.853.","journal-title":"Physiol Rev"},{"key":"2492_CR58","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a011353","volume":"4","author":"TC S\u00fcdhof","year":"2012","unstructured":"S\u00fcdhof TC. Calcium control of neurotransmitter release. Cold Spring Harb Perspect Biol. 2012;4:a011353. https:\/\/doi.org\/10.1101\/cshperspect.a011353.","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2492_CR59","unstructured":"Khachaturian ZS. Towards theories of brain aging. In: Kay DS, Burrows GW, editors. Handbook of studies on psychiatry and old age. Elsevier; 1984. pp. 7\u201330."},{"key":"2492_CR60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1749-6632.1994.tb44398.x","volume":"747","author":"ZS Khachaturian","year":"1994","unstructured":"Khachaturian ZS. Calcium hypothesis of Alzheimer\u2019s disease and brain aging. Ann N Y Acad Sci. 1994;747:1\u201311. https:\/\/doi.org\/10.1111\/j.1749-6632.1994.tb44398.x.","journal-title":"Ann N Y Acad Sci"},{"key":"2492_CR61","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a035212","author":"S Schrank","year":"2020","unstructured":"Schrank S, Barrington N, Stutzmann GE. Calcium-handling defects and neurodegenerative disease. Cold Spring Harb Perspect Biol. 2020. https:\/\/doi.org\/10.1101\/cshperspect.a035212.","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2492_CR62","doi-asserted-by":"publisher","first-page":"10573","DOI":"10.1073\/pnas.90.22.10573","volume":"90","author":"N Arispe","year":"1993","unstructured":"Arispe N, Pollard HB, Rojas E. Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1\u201340)] in bilayer membranes. Proc Natl Acad Sci U S A. 1993;90:10573\u20137. https:\/\/doi.org\/10.1073\/pnas.90.22.10573.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2492_CR63","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1038\/nn1503","volume":"8","author":"EM Snyder","year":"2005","unstructured":"Snyder EM, Nong Y, Almeida CG, Paul S, Moran T, Choi EY, et al. Regulation of NMDA receptor trafficking by amyloid-beta. Nat Neurosci. 2005;8:1051\u20138. https:\/\/doi.org\/10.1038\/nn1503.","journal-title":"Nat Neurosci"},{"key":"2492_CR64","doi-asserted-by":"publisher","first-page":"8566","DOI":"10.1523\/jneurosci.1554-10.2010","volume":"30","author":"H Zhang","year":"2010","unstructured":"Zhang H, Sun S, Herreman A, De Strooper B, Bezprozvanny I. Role of presenilins in neuronal calcium homeostasis. J Neurosci. 2010;30:8566\u201380. https:\/\/doi.org\/10.1523\/jneurosci.1554-10.2010.","journal-title":"J Neurosci"},{"key":"2492_CR65","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s13024-020-00376-6","volume":"15","author":"W Wang","year":"2020","unstructured":"Wang W, Zhao F, Ma X, Perry G, Zhu X. Mitochondria dysfunction in the pathogenesis of Alzheimer\u2019s disease: recent advances. Mol Neurodegener. 2020;15:30. https:\/\/doi.org\/10.1186\/s13024-020-00376-6.","journal-title":"Mol Neurodegener"},{"key":"2492_CR66","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1126\/science.1105681","volume":"307","author":"GB Stokin","year":"2005","unstructured":"Stokin GB, Lillo C, Falzone TL, Brusch RG, Rockenstein E, Mount SL, et al. Axonopathy and transport deficits early in the pathogenesis of Alzheimer\u2019s disease. Science. 2005;307:1282\u20138. https:\/\/doi.org\/10.1126\/science.1105681.","journal-title":"Science"},{"key":"2492_CR67","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/j.bbabio.2008.04.017","volume":"1777","author":"AY Abramov","year":"2008","unstructured":"Abramov AY, Duchen MR. Mechanisms underlying the loss of mitochondrial membrane potential in glutamate excitotoxicity. Biochim Biophys Acta. 2008;1777:953\u201364. https:\/\/doi.org\/10.1016\/j.bbabio.2008.04.017.","journal-title":"Biochim Biophys Acta"},{"key":"2492_CR68","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s13024-017-0169-9","volume":"12","author":"M Arbel-Ornath","year":"2017","unstructured":"Arbel-Ornath M, Hudry E, Boivin JR, Hashimoto T, Takeda S, Kuchibhotla KV, et al. Soluble oligomeric amyloid-\u03b2 induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain. Mol Neurodegener. 2017;12:27. https:\/\/doi.org\/10.1186\/s13024-017-0169-9.","journal-title":"Mol Neurodegener"},{"key":"2492_CR69","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s11357-019-00140-9","volume":"42","author":"T Csipo","year":"2020","unstructured":"Csipo T, Lipecz A, Ashpole NM, Balasubramanian P, Tarantini S. Astrocyte senescence contributes to cognitive decline. Geroscience. 2020;42:51\u20135. https:\/\/doi.org\/10.1007\/s11357-019-00140-9.","journal-title":"Geroscience"},{"key":"2492_CR70","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s42466-021-00102-7","volume":"3","author":"I Silva","year":"2021","unstructured":"Silva I, Silva J, Ferreira R, Trigo D. Glymphatic system, AQP4, and their implications in Alzheimer\u2019s disease. Neurol Res Pract. 2021;3:5. https:\/\/doi.org\/10.1186\/s42466-021-00102-7.","journal-title":"Neurol Res Pract"},{"key":"2492_CR71","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1038\/s42003-024-05996-y","volume":"7","author":"RB Renden","year":"2024","unstructured":"Renden RB, Institoris A, Sharma K, Tran CHT. Modulatory effects of noradrenergic and serotonergic signaling pathway on neurovascular coupling. Commun Biol. 2024;7:287. https:\/\/doi.org\/10.1038\/s42003-024-05996-y.","journal-title":"Commun Biol"},{"key":"2492_CR72","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.202402594","author":"S Ramakrishna","year":"2024","unstructured":"Ramakrishna S, Radhakrishna BK, Kaladiyil AP, Shah NM, Basavaraju N, Freude KK, et al. Distinct calcium sources regulate temporal profiles of NMDAR and mGluR-mediated protein synthesis. Life Sci Alliance. 2024. https:\/\/doi.org\/10.26508\/lsa.202402594.","journal-title":"Life Sci Alliance"},{"key":"2492_CR73","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s13195-022-00999-5","volume":"14","author":"M Simon","year":"2022","unstructured":"Simon M, Wang MX, Ismail O, Braun M, Schindler AG, Reemmer J, et al. Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid \u03b2 plaque formation in mice. Alzheimers Res Ther. 2022;14:59. https:\/\/doi.org\/10.1186\/s13195-022-00999-5.","journal-title":"Alzheimers Res Ther"},{"key":"2492_CR74","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1001\/jamaneurol.2016.4370","volume":"74","author":"DM Zeppenfeld","year":"2017","unstructured":"Zeppenfeld DM, Simon M, Haswell JD, D\u2019Abreo D, Murchison C, Quinn JF, et al. Association of Perivascular Localization of Aquaporin-4 With Cognition and Alzheimer Disease in Aging Brains. JAMA Neurol. 2017;74:91\u20139. https:\/\/doi.org\/10.1001\/jamaneurol.2016.4370.","journal-title":"JAMA Neurol"},{"key":"2492_CR75","doi-asserted-by":"publisher","DOI":"10.1002\/alz70858_100207","author":"M Guo","year":"2025","unstructured":"Guo M, Zhao N, Yang Q, Fan F. Treatment of Alzheimer\u2019s disease with deep cervical lymph\u2010venous anastomosis. Alzheimers Dement. 2025. https:\/\/doi.org\/10.1002\/alz70858_100207.","journal-title":"Alzheimers Dement"},{"key":"2492_CR76","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1038\/s41467-023-37240-2","volume":"14","author":"A Lia","year":"2023","unstructured":"Lia A, Sansevero G, Chiavegato A, Sbrissa M, Pendin D, Mariotti L, et al. Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling Alzheimer\u2019s disease. Nat Commun. 2023;14:1590. https:\/\/doi.org\/10.1038\/s41467-023-37240-2.","journal-title":"Nat Commun"},{"key":"2492_CR77","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a020388","author":"BA MacVicar","year":"2015","unstructured":"MacVicar BA, Newman EA. Astrocyte regulation of blood flow in the brain. Cold Spring Harb Perspect Biol. 2015. https:\/\/doi.org\/10.1101\/cshperspect.a020388.","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2492_CR78","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22157887","author":"C Nanclares","year":"2021","unstructured":"Nanclares C, Baraibar AM, Araque A, Kofuji P. Dysregulation of astrocyte-neuronal communication in Alzheimer\u2019s disease. Int J Mol Sci. 2021. https:\/\/doi.org\/10.3390\/ijms22157887.","journal-title":"Int J Mol Sci"},{"key":"2492_CR79","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1126\/science.1169096","volume":"323","author":"KV Kuchibhotla","year":"2009","unstructured":"Kuchibhotla KV, Lattarulo CR, Hyman BT, Bacskai BJ. Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice. Science. 2009;323:1211\u20135. https:\/\/doi.org\/10.1126\/science.1169096.","journal-title":"Science"},{"key":"2492_CR80","doi-asserted-by":"publisher","first-page":"6132","DOI":"10.1523\/jneurosci.0877-17.2017","volume":"37","author":"P Sompol","year":"2017","unstructured":"Sompol P, Furman JL, Pleiss MM, Kraner SD, Artiushin IA, Batten SR, et al. Calcineurin\/NFAT signaling in activated astrocytes drives network hyperexcitability in A\u03b2-bearing mice. J Neurosci. 2017;37:6132\u201348. https:\/\/doi.org\/10.1523\/jneurosci.0877-17.2017.","journal-title":"J Neurosci"},{"key":"2492_CR81","doi-asserted-by":"publisher","first-page":"983","DOI":"10.3389\/fneur.2020.00983","volume":"11","author":"E Gonzalez-Fernandez","year":"2020","unstructured":"Gonzalez-Fernandez E, Staursky D, Lucas K, Nguyen BV, Li M, Liu Y, et al. 20-HETE Enzymes and Receptors in the Neurovascular Unit: Implications in Cerebrovascular Disease. Front Neurol. 2020;11:983. https:\/\/doi.org\/10.3389\/fneur.2020.00983.","journal-title":"Front Neurol"},{"key":"2492_CR82","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.2741\/4465","volume":"21","author":"F Fan","year":"2016","unstructured":"Fan F, Ge Y, Lv W, Elliott MR, Muroya Y, Hirata T, et al. Molecular mechanisms and cell signaling of 20-hydroxyeicosatetraenoic acid in vascular pathophysiology. Front Biosci (Landmark Ed). 2016;21:1427\u201363.","journal-title":"Front Biosci (Landmark Ed)"},{"key":"2492_CR83","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1111\/bph.12315","volume":"170","author":"L Zhang","year":"2013","unstructured":"Zhang L, Papadopoulos P, Hamel E. Endothelial TRPV4 channels mediate dilation of cerebral arteries: impairment and recovery in cerebrovascular pathologies related to Alzheimer\u2019s disease. Br J Pharmacol. 2013;170:661\u201370. https:\/\/doi.org\/10.1111\/bph.12315.","journal-title":"Br J Pharmacol"},{"key":"2492_CR84","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1126\/science.1216283","volume":"336","author":"SK Sonkusare","year":"2012","unstructured":"Sonkusare SK, Bonev AD, Ledoux J, Liedtke W, Kotlikoff MI, Heppner TJ, et al. Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function. Science. 2012;336:597\u2013601. https:\/\/doi.org\/10.1126\/science.1216283.","journal-title":"Science"},{"key":"2492_CR85","doi-asserted-by":"publisher","first-page":"H549","DOI":"10.1152\/ajpheart.00726.2020","volume":"320","author":"Y Liu","year":"2021","unstructured":"Liu Y, Zhang H, Wang S, Guo Y, Fang X, Zheng B, et al. Reduced pericyte and tight junction coverage in old diabetic rats are associated with hyperglycemia-induced cerebrovascular pericyte dysfunction. Am J Physiol Heart Circ Physiol. 2021;320:H549\u201362. https:\/\/doi.org\/10.1152\/ajpheart.00726.2020.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2492_CR86","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1097\/FJC.0b013e3181f580d9","volume":"57","author":"S Earley","year":"2011","unstructured":"Earley S. Endothelium-dependent cerebral artery dilation mediated by transient receptor potential and Ca2+-activated K+ channels. J Cardiovasc Pharmacol. 2011;57:148\u201353. https:\/\/doi.org\/10.1097\/FJC.0b013e3181f580d9.","journal-title":"J Cardiovasc Pharmacol"},{"key":"2492_CR87","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1177\/0271678x241235790","volume":"44","author":"A Mughal","year":"2024","unstructured":"Mughal A, Sackheim AM, Koide M, Bonson G, Ebner G, Hennig G, et al. Pathogenic soluble tau peptide disrupts endothelial calcium signaling and vasodilation in the brain microvasculature. J Cereb Blood Flow Metab. 2024;44:680\u20138. https:\/\/doi.org\/10.1177\/0271678x241235790.","journal-title":"J Cereb Blood Flow Metab"},{"key":"2492_CR88","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12535","volume":"26","author":"JM Diaz-Otero","year":"2019","unstructured":"Diaz-Otero JM, Yen TC, Ahmad A, Laimon-Thomson E, Abolibdeh B, Kelly K, et al. Transient receptor potential vanilloid 4 channels are important regulators of parenchymal arteriole dilation and cognitive function. Microcirculation. 2019;26:e12535. https:\/\/doi.org\/10.1111\/micc.12535.","journal-title":"Microcirculation"},{"key":"2492_CR89","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1161\/01.RES.0000194321.60300.d6","volume":"97","author":"S Earley","year":"2005","unstructured":"Earley S, Heppner TJ, Nelson MT, Brayden JE. TRPV4 forms a novel Ca2+ signaling complex with ryanodine receptors and BKCa channels. Circ Res. 2005;97:1270\u20139. https:\/\/doi.org\/10.1161\/01.RES.0000194321.60300.d6.","journal-title":"Circ Res"},{"key":"2492_CR90","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.1038\/s41467-023-37840-y","volume":"14","author":"SA Hussong","year":"2023","unstructured":"Hussong SA, Banh AQ, Van Skike CE, Dorigatti AO, Hernandez SF, Hart MJ, et al. Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy. Nat Commun. 2023;14:2367. https:\/\/doi.org\/10.1038\/s41467-023-37840-y.","journal-title":"Nat Commun"},{"key":"2492_CR91","doi-asserted-by":"publisher","first-page":"12463","DOI":"10.1074\/jbc.R109.080895","volume":"285","author":"A Demuro","year":"2010","unstructured":"Demuro A, Parker I, Stutzmann GE. Calcium signaling and amyloid toxicity in Alzheimer disease. J Biol Chem. 2010;285:12463\u20138. https:\/\/doi.org\/10.1074\/jbc.R109.080895.","journal-title":"J Biol Chem"},{"key":"2492_CR92","doi-asserted-by":"publisher","first-page":"1693456","DOI":"10.3389\/fmolb.2025.1693456","volume":"12","author":"Y Liu","year":"2025","unstructured":"Liu Y, Xu YQ, Long YY, Xiao H, Ma YY, Li YW. Mechanosensitive channel Piezo1 in calcium dynamics: structure, function, and emerging therapeutic strategies. Front Mol Biosci. 2025;12:1693456. https:\/\/doi.org\/10.3389\/fmolb.2025.1693456.","journal-title":"Front Mol Biosci"},{"key":"2492_CR93","doi-asserted-by":"publisher","first-page":"2355","DOI":"10.4103\/1673-5374.335829","volume":"17","author":"YL Zhang","year":"2022","unstructured":"Zhang YL, Wang J, Zhang ZN, Su Q, Guo JH. The relationship between amyloid-beta and brain capillary endothelial cells in Alzheimer\u2019s disease. Neural Regen Res. 2022;17:2355\u201363. https:\/\/doi.org\/10.4103\/1673-5374.335829.","journal-title":"Neural Regen Res"},{"key":"2492_CR94","doi-asserted-by":"publisher","unstructured":"Fang X, Border JJ, Zhang H, Morgan GC, Gregory A, Hanscom-Trofy Y, Dong R, Yang J, Hwang SH, Morisseau C, et al. Inhibition of Soluble Epoxide Hydrolase Rescues Cognitive Deficits by Preserving Neurovascular Integrity and Attenuating Glial- and Neuropathology in Diabetic-Related Dementia. bioRxiv. 2026:2026.2006.2001.729327. https:\/\/doi.org\/10.64898\/2026.06.01.729327","DOI":"10.64898\/2026.06.01.729327"},{"key":"2492_CR95","doi-asserted-by":"publisher","first-page":"4429","DOI":"10.1007\/s11357-025-01550-8","volume":"47","author":"C Tang","year":"2025","unstructured":"Tang C, Border JJ, Zhang H, Gregory A, Bai S, Fang X, et al. Inhibition of soluble epoxide hydrolase ameliorates cerebral blood flow autoregulation and cognition in alzheimer\u2019s disease and diabetes-related dementia rat models. Geroscience. 2025;47:4429\u201349. https:\/\/doi.org\/10.1007\/s11357-025-01550-8.","journal-title":"Geroscience"},{"key":"2492_CR96","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-026-02140-y","author":"GC Morgan","year":"2026","unstructured":"Morgan GC, Gregory A, Tang C, Hwang SH, Border JJ, Xu J, et al. PTUPB improves cognitive function in Alzheimer\u2019s disease associated with enhancing cerebral vascular myogenic response and attenuating vascular remodeling. Geroscience. 2026. https:\/\/doi.org\/10.1007\/s11357-026-02140-y.","journal-title":"Geroscience"},{"key":"2492_CR97","doi-asserted-by":"publisher","first-page":"1432002","DOI":"10.3389\/fncel.2024.1432002","volume":"18","author":"SSK Durairajan","year":"2024","unstructured":"Durairajan SSK, Selvarasu K, Singh AK, Patnaik S, Iyaswamy A, Jaiswal Y, et al. Unraveling the interplay of kinesin-1, tau, and microtubules in neurodegeneration associated with Alzheimer\u2019s disease. Front Cell Neurosci. 2024;18:1432002. https:\/\/doi.org\/10.3389\/fncel.2024.1432002.","journal-title":"Front Cell Neurosci"},{"key":"2492_CR98","doi-asserted-by":"publisher","first-page":"3307","DOI":"10.1007\/s11357-023-00927-x","volume":"45","author":"KK Ting","year":"2023","unstructured":"Ting KK, Coleman P, Kim HJ, Zhao Y, Mulangala J, Cheng NC, et al. Vascular senescence and leak are features of the early breakdown of the blood-brain barrier in Alzheimer\u2019s disease models. Geroscience. 2023;45:3307\u201331. https:\/\/doi.org\/10.1007\/s11357-023-00927-x.","journal-title":"Geroscience"},{"key":"2492_CR99","doi-asserted-by":"publisher","first-page":"149","DOI":"10.33696\/neurol.2.048","volume":"2","author":"R Crumpler","year":"2021","unstructured":"Crumpler R, Roman RJ, Fan F. Capillary Stalling: A Mechanism of Decreased Cerebral Blood Flow in AD\/ADRD. J Exp Neurol. 2021;2:149\u201353. https:\/\/doi.org\/10.33696\/neurol.2.048.","journal-title":"J Exp Neurol"},{"key":"2492_CR100","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.900761","volume":"16","author":"CD Nielson","year":"2022","unstructured":"Nielson CD, Shih AY. In vivo Single Cell Optical Ablation of Brain Pericytes. Front Neurosci. 2022;16:900761. https:\/\/doi.org\/10.3389\/fnins.2022.900761.","journal-title":"Front Neurosci"},{"key":"2492_CR101","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.1038\/s41593-024-01753-w","volume":"27","author":"N Korte","year":"2024","unstructured":"Korte N, Barkaway A, Wells J, Freitas F, Sethi H, Andrews SP, et al. Inhibiting Ca(2+) channels in Alzheimer\u2019s disease model mice relaxes pericytes, improves cerebral blood flow and reduces immune cell stalling and hypoxia. Nat Neurosci. 2024;27:2086\u2013100. https:\/\/doi.org\/10.1038\/s41593-024-01753-w.","journal-title":"Nat Neurosci"},{"key":"2492_CR102","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1177\/0271678x221111598","volume":"42","author":"C Hirunpattarasilp","year":"2022","unstructured":"Hirunpattarasilp C, Barkaway A, Davis H, Pfeiffer T, Sethi H, Attwell D. Hyperoxia evokes pericyte-mediated capillary constriction. J Cereb Blood Flow Metab. 2022;42:2032\u201347. https:\/\/doi.org\/10.1177\/0271678x221111598.","journal-title":"J Cereb Blood Flow Metab"},{"key":"2492_CR103","doi-asserted-by":"publisher","first-page":"eaav9518","DOI":"10.1126\/science.aav9518","volume":"365","author":"R Nortley","year":"2019","unstructured":"Nortley R, Korte N, Izquierdo P, Hirunpattarasilp C, Mishra A, Jaunmuktane Z, Kyrargyri V, Pfeiffer T, Khennouf L, Madry C, et al. Amyloid beta oligomers constrict human capillaries in Alzheimer\u2019s disease via signaling to pericytes. Science. 2019;365:eaav9518. https:\/\/doi.org\/10.1126\/science.aav9518.","journal-title":"Science."},{"key":"2492_CR104","doi-asserted-by":"publisher","first-page":"5912","DOI":"10.1038\/s41467-022-33464-w","volume":"13","author":"AA Berthiaume","year":"2022","unstructured":"Berthiaume AA, Schmid F, Stamenkovic S, Coelho-Santos V, Nielson CD, Weber B, et al. Pericyte remodeling is deficient in the aged brain and contributes to impaired capillary flow and structure. Nat Commun. 2022;13:5912. https:\/\/doi.org\/10.1038\/s41467-022-33464-w.","journal-title":"Nat Commun"},{"issue":"1661","key":"2492_CR105","doi-asserted-by":"publisher","first-page":"00103","DOI":"10.1556\/1661.2025.00103","volume":"2026","author":"A Gregory","year":"2025","unstructured":"Gregory A, Wang S, Morgan GC, Hanscom-Trofy Y, Liu Y, Swardfager W, et al. Sex differences in cerebral blood flow regulation and Alzheimer\u2019s disease: Mechanistic insights and opportunities for precision pharmacology. Advances in Translational Research. 2025;2026(1661):00103. https:\/\/doi.org\/10.1556\/1661.2025.00103.","journal-title":"Advances in Translational Research"},{"key":"2492_CR106","doi-asserted-by":"publisher","first-page":"H1219","DOI":"10.1152\/ajpheart.00722.2019","volume":"318","author":"S Wang","year":"2020","unstructured":"Wang S, Zhang H, Liu Y, Li L, Guo Y, Jiao F, et al. Sex differences in the structure and function of rat middle cerebral arteries. Am J Physiol Heart Circ Physiol. 2020;318:H1219\u201332. https:\/\/doi.org\/10.1152\/ajpheart.00722.2019.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2492_CR107","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13503","volume":"21","author":"W Deng","year":"2022","unstructured":"Deng W, Guo S, van Veluw SJ, Yu Z, Chan SJ, Takase H, et al. Effects of cerebral amyloid angiopathy on the brain vasculome. Aging Cell. 2022;21:e13503. https:\/\/doi.org\/10.1111\/acel.13503.","journal-title":"Aging Cell"},{"key":"2492_CR108","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/bs.apha.2016.07.001","volume":"78","author":"WF Jackson","year":"2017","unstructured":"Jackson WF. Potassium Channels in Regulation of Vascular Smooth Muscle Contraction and Growth. Adv Pharmacol. 2017;78:89\u2013144. https:\/\/doi.org\/10.1016\/bs.apha.2016.07.001.","journal-title":"Adv Pharmacol"},{"key":"2492_CR109","doi-asserted-by":"publisher","first-page":"F565","DOI":"10.1152\/ajprenal.00404.2012","volume":"304","author":"M Burke","year":"2013","unstructured":"Burke M, Pabbidi M, Fan F, Ge Y, Liu R, Williams JM, et al. Genetic basis of the impaired renal myogenic response in FHH rats. Am J Physiol Renal Physiol. 2013;304:F565-577. https:\/\/doi.org\/10.1152\/ajprenal.00404.2012.","journal-title":"Am J Physiol Renal Physiol"},{"issue":"7","key":"2492_CR110","doi-asserted-by":"publisher","first-page":"H989-H1000","DOI":"10.1152\/ajpheart.00636.2013","volume":"306","author":"MR Pabbidi","year":"2014","unstructured":"Pabbidi MR, Mazur O, Fan F, Farley JM, Gebremedhinm D, Harder DR, Roman RJ. Enhanced large conductance K+ channel (BK) activity contributes to the impaired myogenic response in the cerebral vasculature of Fawn Hooded Hypertensive rats. Am J Physiol Heart Circ Physiol. 2014;306(7):H989\u20131000.","journal-title":"Am J Physiol Heart Circ Physiol."},{"key":"2492_CR111","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.2022.36.S1.R2710","author":"X Fang","year":"2022","unstructured":"Fang X, Zhang H, Border JJ, Rivers PL, Strong LB, Cooper J, et al. Contribution of beta\u2010amyloid accumulation to cerebral hypoperfusion in Alzheimer\u2019s disease. FASEB J. 2022. https:\/\/doi.org\/10.1096\/fasebj.2022.36.S1.R2710.","journal-title":"FASEB J"},{"key":"2492_CR112","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.105466","volume":"110","author":"H van den Brink","year":"2024","unstructured":"van den Brink H, Voigt S, Kozberg M, van Etten ES. The role of neuroinflammation in cerebral amyloid angiopathy. EBioMedicine. 2024;110:105466. https:\/\/doi.org\/10.1016\/j.ebiom.2024.105466.","journal-title":"EBioMedicine"},{"key":"2492_CR113","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1161\/atvbaha.121.315836","volume":"41","author":"KI Bostr\u00f6m","year":"2021","unstructured":"Bostr\u00f6m KI. DNA damage response, Runx2 (runt-related transcription factor 2), and vascular calcification. Arterioscler Thromb Vasc Biol. 2021;41:1358\u20139. https:\/\/doi.org\/10.1161\/atvbaha.121.315836.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2492_CR114","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155726","volume":"11","author":"L Chen","year":"2016","unstructured":"Chen L, DeWispelaere A, Dastvan F, Osborne WR, Blechner C, Windhorst S, et al. Smooth muscle-alpha actin inhibits vascular smooth muscle cell proliferation and migration by inhibiting Rac1 activity. PLoS ONE. 2016;11:e0155726. https:\/\/doi.org\/10.1371\/journal.pone.0155726.","journal-title":"PLoS ONE"},{"key":"2492_CR115","doi-asserted-by":"publisher","DOI":"10.3390\/cells12182269","author":"A Nolze","year":"2023","unstructured":"Nolze A, Matern S, Grossmann C. Calcineurin is a universal regulator of vessel function-focus on vascular smooth muscle cells. Cells. 2023. https:\/\/doi.org\/10.3390\/cells12182269.","journal-title":"Cells"},{"key":"2492_CR116","doi-asserted-by":"publisher","first-page":"9158","DOI":"10.18632\/aging.202963","volume":"13","author":"F Fan","year":"2021","unstructured":"Fan F, Booz GW, Roman RJ. Aging diabetes, deconstructing the cerebrovascular wall. Aging (Albany NY). 2021;13:9158\u20139. https:\/\/doi.org\/10.18632\/aging.202963.","journal-title":"Aging (Albany NY)"},{"key":"2492_CR117","doi-asserted-by":"publisher","first-page":"842.6-842.6","DOI":"10.1096\/fasebj.31.1_supplement.842.6","volume":"31","author":"F Fan","year":"2017","unstructured":"Fan F, Wang SX, Mims PN, Maeda KJ, Li LY, Geurts AM, Roman RJ. Knockout of matrix metalloproteinase-9 rescues the development of cognitive impairments in hypertensive Dahl salt sensitive rats. FASEB J. 2017;31:842.6-842.6. https:\/\/doi.org\/10.1096\/fasebj.31.1_supplement.842.6.","journal-title":"FASEB J."},{"key":"2492_CR118","doi-asserted-by":"publisher","first-page":"17","DOI":"10.5853\/jos.2015.17.1.17","volume":"17","author":"M Yamada","year":"2015","unstructured":"Yamada M. Cerebral amyloid angiopathy: emerging concepts. J Stroke. 2015;17:17\u201330. https:\/\/doi.org\/10.5853\/jos.2015.17.1.17.","journal-title":"J Stroke"},{"key":"2492_CR119","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1002\/jnr.20180","volume":"77","author":"S Pawate","year":"2004","unstructured":"Pawate S, Shen Q, Fan F, Bhat NR. Redox regulation of glial inflammatory response to lipopolysaccharide and interferongamma. J Neurosci Res. 2004;77:540\u201351. https:\/\/doi.org\/10.1002\/jnr.20180.","journal-title":"J Neurosci Res"},{"key":"2492_CR120","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/s41419-025-07592-2","volume":"16","author":"X Zhan","year":"2025","unstructured":"Zhan X, Wang S, B\u00e8chet N, Gouras G, Wen G. Perivascular macrophages in the central nervous system: insights into their roles in health and disease. Cell Death Dis. 2025;16:350. https:\/\/doi.org\/10.1038\/s41419-025-07592-2.","journal-title":"Cell Death Dis"},{"key":"2492_CR121","doi-asserted-by":"publisher","DOI":"10.1111\/acel.70372","volume":"25","author":"M Milan","year":"2026","unstructured":"Milan M, Troyano-Rodriguez E, Ihuoma J, Negri S, Rudraboina R, Kosmider A, et al. Fasting as Medicine: Mitochondrial and Endothelial Rejuvenation in Vascular Aging. Aging Cell. 2026;25:e70372. https:\/\/doi.org\/10.1111\/acel.70372.","journal-title":"Aging Cell"},{"key":"2492_CR122","doi-asserted-by":"publisher","DOI":"10.1177\/0271678x261444196","author":"S Negri","year":"2026","unstructured":"Negri S, Milan M, Rudraboina R, Tavakol SA, Reyff Z, Ihuoma J, et al. Targeting senescence mitigates the deleterious effects of midlife obesity on neurovascular function by partially restoring blood-brain barrier integrity and neurovascular coupling. J Cereb Blood Flow Metab. 2026. https:\/\/doi.org\/10.1177\/0271678x261444196.","journal-title":"J Cereb Blood Flow Metab"},{"key":"2492_CR123","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2026.104118","volume":"92","author":"J Ihuoma","year":"2026","unstructured":"Ihuoma J, Milan M, Negri S, Troyano-Rodriguez E, Rudraboina R, Kosmider A, et al. LDL oxidation and cerebrovascular aging: mechanisms of endothelial dysfunction, inflammation, and vascular cognitive impairment and dementia. Redox Biol. 2026;92:104118. https:\/\/doi.org\/10.1016\/j.redox.2026.104118.","journal-title":"Redox Biol"},{"key":"2492_CR124","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.3233\/jad-170672","volume":"62","author":"J Folch","year":"2018","unstructured":"Folch J, Busquets O, Ettcheto M, S\u00e1nchez-L\u00f3pez E, Castro-Torres RD, Verdaguer E, et al. Memantine for the Treatment of Dementia: A Review on its Current and Future Applications. J Alzheimers Dis. 2018;62:1223\u201340. https:\/\/doi.org\/10.3233\/jad-170672.","journal-title":"J Alzheimers Dis"},{"key":"2492_CR125","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2024.115173","volume":"472","author":"MR Rafe","year":"2024","unstructured":"Rafe MR, Saha P, Bello ST. Targeting NMDA receptors with an antagonist is a promising therapeutic strategy for treating neurological disorders. Behav Brain Res. 2024;472:115173. https:\/\/doi.org\/10.1016\/j.bbr.2024.115173.","journal-title":"Behav Brain Res"},{"key":"2492_CR126","doi-asserted-by":"publisher","DOI":"10.1101\/2024.07.02.601784","author":"E Carrillo","year":"2024","unstructured":"Carrillo E, Monta\u00f1o Romero A, Gonzalez CU, Turcu AL, Chen SR, Chen H, et al. Memantine Inhibits Calcium-Permeable AMPA Receptors bioRxiv. 2024. https:\/\/doi.org\/10.1101\/2024.07.02.601784.","journal-title":"Memantine Inhibits Calcium-Permeable AMPA Receptors bioRxiv"},{"key":"2492_CR127","doi-asserted-by":"publisher","first-page":"841","DOI":"10.3233\/jad-2012-121447","volume":"33","author":"R Ni","year":"2013","unstructured":"Ni R, Marutle A, Nordberg A. Modulation of \u03b17 nicotinic acetylcholine receptor and fibrillar amyloid-\u03b2 interactions in Alzheimer\u2019s disease brain. J Alzheimers Dis. 2013;33:841\u201351. https:\/\/doi.org\/10.3233\/jad-2012-121447.","journal-title":"J Alzheimers Dis"},{"key":"2492_CR128","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1021\/acsptsci.0c00013","volume":"3","author":"KS Abd-Elrahman","year":"2020","unstructured":"Abd-Elrahman KS, Hamilton A, Albaker A, Ferguson SSG. mGluR5 Contribution to Neuropathology in Alzheimer Mice Is Disease Stage-Dependent. ACS Pharmacol Transl Sci. 2020;3:334\u201344. https:\/\/doi.org\/10.1021\/acsptsci.0c00013.","journal-title":"ACS Pharmacol Transl Sci"},{"key":"2492_CR129","doi-asserted-by":"publisher","first-page":"eabi8593","DOI":"10.1126\/scitranslmed.abi8593","volume":"14","author":"J Spurrier","year":"2022","unstructured":"Spurrier J, Nicholson L, Fang XT, Stoner AJ, Toyonaga T, Holden D, Siegert TR, Laird W, Allnutt MA, Chiasseu M, et al. Reversal of synapse loss in Alzheimer mouse models by targeting mGluR5 to prevent synaptic tagging by C1Q. Sci Transl Med. 2022;14:eabi8593. https:\/\/doi.org\/10.1126\/scitranslmed.abi8593.","journal-title":"Sci Transl Med."},{"key":"2492_CR130","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.4103\/NRR.NRR-D-4125-00540","volume":"21","author":"F Fan","year":"2025","unstructured":"Fan F, Zhao N, Guo M. Lymphatic-venous anastomosis: Cracking the code of Alzheimer\u2019s disease treatment? Neural Regen Res. 2025;21:2367. https:\/\/doi.org\/10.4103\/NRR.NRR-D-4125-00540.","journal-title":"Neural Regen Res."},{"key":"2492_CR131","doi-asserted-by":"publisher","first-page":"668","DOI":"10.2174\/1871527317666180619162649","volume":"18","author":"Y Shi","year":"2019","unstructured":"Shi Y, Wang Y, Wei H. Dantrolene\u202f: From Malignant Hyperthermia to Alzheimer\u2019s Disease. CNS Neurol Disord Drug Targets. 2019;18:668\u201376. https:\/\/doi.org\/10.2174\/1871527317666180619162649.","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"2492_CR132","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1016\/j.celrep.2016.04.077","volume":"15","author":"A Hamilton","year":"2016","unstructured":"Hamilton A, Vasefi M, Vander Tuin C, McQuaid Robyn J, Anisman H, Ferguson Stephen SG. Chronic Pharmacological mGluR5 Inhibition Prevents Cognitive Impairment and Reduces Pathogenesis in an Alzheimer Disease Mouse Model. Cell Rep. 2016;15:1859\u201365. https:\/\/doi.org\/10.1016\/j.celrep.2016.04.077.","journal-title":"Cell Rep"},{"key":"2492_CR133","doi-asserted-by":"publisher","first-page":"7259018","DOI":"10.1155\/np\/7259018","volume":"2025","author":"J Kim","year":"2025","unstructured":"Kim J, Lee J, Song H, Koo JW, Kang S. mGluR5 as a Potential Orchestrator of Astrocyte Interactions in Neurological Disorders. Neural Plast. 2025;2025:7259018. https:\/\/doi.org\/10.1155\/np\/7259018.","journal-title":"Neural Plast"},{"key":"2492_CR134","doi-asserted-by":"publisher","first-page":"1283331","DOI":"10.3389\/fimmu.2023.1283331","volume":"14","author":"IBQ de Lima","year":"2023","unstructured":"de Lima IBQ, Cardozo PL, Fahel JS, Lacerda JPS, Miranda AS, Teixeira AL, et al. Blockade of mGluR5 in astrocytes derived from human iPSCs modulates astrocytic function and increases phagocytosis. Front Immunol. 2023;14:1283331. https:\/\/doi.org\/10.3389\/fimmu.2023.1283331.","journal-title":"Front Immunol"},{"key":"2492_CR135","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci15101101","author":"B Zhang","year":"2025","unstructured":"Zhang B, Li Y, Li H, Shen X, Zhu Z. Therapeutic advances in targeting the amyloid-\u03b2 pathway for Alzheimer\u2019s disease. Brain Sci. 2025. https:\/\/doi.org\/10.3390\/brainsci15101101.","journal-title":"Brain Sci"},{"issue":"40","key":"2492_CR136","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.0349-25.2025","volume":"45","author":"BE Weiss","year":"2025","unstructured":"Weiss BE, Gant JC, Lin RL, Gollihue JL, Rogers CB, Kraner SD, Rucker EB, Katsumata Y, Jiang Y, Nelson PT, et al. Disrupted Calcium Dynamics in Reactive Astrocytes Occur with End Feet-Arteriole Decoupling in an Amyloid Mouse Model of Alzheimer\u2019s Disease. J Neurosci. 2025;45(40): e0349252025. https:\/\/doi.org\/10.1523\/jneurosci.0349-25.2025.","journal-title":"J Neurosci."},{"key":"2492_CR137","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19040938","author":"G Guerra","year":"2018","unstructured":"Guerra G, Lucariello A, Perna A, Botta L, De Luca A, Moccia F. The role of endothelial Ca(2+) signaling in neurovascular coupling: a view from the lumen. Int J Mol Sci. 2018. https:\/\/doi.org\/10.3390\/ijms19040938.","journal-title":"Int J Mol Sci"},{"key":"2492_CR138","doi-asserted-by":"publisher","first-page":"48","DOI":"10.3390\/neuroglia2010006","volume":"2","author":"J Haidey","year":"2021","unstructured":"Haidey J, Gordon G. Direct Deviations in Astrocyte Free Ca Concentration Control Multiple Arteriole Tone States. Neuroglia. 2021;2:48\u201356. https:\/\/doi.org\/10.3390\/neuroglia2010006.","journal-title":"Neuroglia"},{"key":"2492_CR139","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3389\/fphar.2019.00006","volume":"10","author":"S Baratchi","year":"2019","unstructured":"Baratchi S, Keov P, Darby WG, Lai A, Khoshmanesh K, Thurgood P, et al. The TRPV4 Agonist GSK1016790A Regulates the Membrane Expression of TRPV4 Channels. Front Pharmacol. 2019;10:6. https:\/\/doi.org\/10.3389\/fphar.2019.00006.","journal-title":"Front Pharmacol"},{"key":"2492_CR140","doi-asserted-by":"publisher","unstructured":"Kwon HC, Eiden A, Li J, MacKinnon M, Garfinkel JB, Hooper SM, Liu Y, Nelson MT, Koretsky A, Mughal A. Electro-Calcium uncoupling precedes neurodegeneration in Alzheimer\u2019s disease. bioRxiv. 2026:2026.2001.2026.701803. https:\/\/doi.org\/10.64898\/2026.01.26.701803","DOI":"10.64898\/2026.01.26.701803"},{"key":"2492_CR141","doi-asserted-by":"publisher","first-page":"15843","DOI":"10.1074\/jbc.M112.427187","volume":"288","author":"D Bi","year":"2013","unstructured":"Bi D, Toyama K, Lemaitre V, Takai J, Fan F, Jenkins DP, et al. The intermediate conductance calcium-activated potassium channel KCa3.1 regulates vascular smooth muscle cell proliferation via controlling calcium-dependent signaling. J Biol Chem. 2013;288:15843\u201353. https:\/\/doi.org\/10.1074\/jbc.M112.427187.","journal-title":"J Biol Chem"},{"key":"2492_CR142","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1007\/s11357-020-00231-y","volume":"42","author":"J Royea","year":"2020","unstructured":"Royea J, Hamel E. Brain angiotensin II and angiotensin IV receptors as potential Alzheimer\u2019s disease therapeutic targets. Geroscience. 2020;42:1237\u201356. https:\/\/doi.org\/10.1007\/s11357-020-00231-y.","journal-title":"Geroscience"},{"key":"2492_CR143","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/s1474-4422(21)00263-5","volume":"20","author":"PG Kehoe","year":"2021","unstructured":"Kehoe PG, Turner N, Howden B, Jarutyte L, Clegg SL, Malone IB, et al. Safety and efficacy of losartan for the reduction of brain atrophy in clinically diagnosed Alzheimer\u2019s disease (the RADAR trial): a double-blind, randomised, placebo-controlled, phase 2 trial. Lancet Neurol. 2021;20:895\u2013906. https:\/\/doi.org\/10.1016\/s1474-4422(21)00263-5.","journal-title":"Lancet Neurol"},{"key":"2492_CR144","volume-title":"Efficacy and mechanism evaluation","author":"PG Kehoe","year":"2021","unstructured":"Kehoe PG, Turner N, Howden B, Jarutyt L, Clegg SL, Malone IB, et al. Losartan to slow the progression of mild-to-moderate Alzheimer\u2019s disease through angiotensin targeting: the RADAR RCT. In: Efficacy and mechanism evaluation. Southampton (UK): NIHR Journals Library; 2021."},{"issue":"3","key":"2492_CR145","doi-asserted-by":"publisher","first-page":"593","DOI":"10.3390\/cells10030593","volume":"10","author":"A Lin","year":"2021","unstructured":"Lin A, Peiris NJ, Dhaliwal H, Hakim M, Li W, Ganesh S, Ramaswamy Y, Patel S, Misra A. Mural Cells: Potential Therapeutic Targets to Bridge Cardiovascular Disease and Neurodegeneration. Cells. 2021;10(3):593. https:\/\/doi.org\/10.3390\/cells10030593.","journal-title":"Cells."},{"key":"2492_CR146","doi-asserted-by":"publisher","DOI":"10.1113\/jp289276","author":"JL Taylor","year":"2025","unstructured":"Taylor JL, Baudel MM, Pereira da Silva E, Hell JW, Nieves-Cintron M, Navedo MF. Amyloid \u03b2 alters vascular Ca(V)1.2 channel spatiotemporal properties. J Physiol. 2025. https:\/\/doi.org\/10.1113\/jp289276.","journal-title":"J Physiol"},{"key":"2492_CR147","doi-asserted-by":"publisher","first-page":"1451032","DOI":"10.3389\/fphar.2024.1451032","volume":"15","author":"C Dang","year":"2024","unstructured":"Dang C, Wang Q, Zhuang Y, Li Q, Feng L, Xiong Y, et al. Pharmacological treatments for vascular dementia: a systematic review and Bayesian network meta-analysis. Front Pharmacol. 2024;15:1451032. https:\/\/doi.org\/10.3389\/fphar.2024.1451032.","journal-title":"Front Pharmacol"},{"key":"2492_CR148","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70704","volume":"21","author":"JM Erichsen","year":"2025","unstructured":"Erichsen JM, Register TC, Sutphen C, Ma D, Gaussoin SA, Rudolph M, et al. A phase 2A\/B randomized trial of metabolic modulators intranasal insulin and empagliflozin for MCI and early AD. Alzheimers Dement. 2025;21:e70704. https:\/\/doi.org\/10.1002\/alz.70704.","journal-title":"Alzheimers Dement"},{"key":"2492_CR149","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/s10787-024-01608-7","volume":"33","author":"SA Joodi","year":"2025","unstructured":"Joodi SA, Ibrahim WW, Khattab MM. Drugs repurposing in the experimental models of Alzheimer\u2019s disease. Inflammopharmacology. 2025;33:195\u2013214. https:\/\/doi.org\/10.1007\/s10787-024-01608-7.","journal-title":"Inflammopharmacology"},{"key":"2492_CR150","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1007\/s00125-017-4509-7","volume":"61","author":"L Uthman","year":"2018","unstructured":"Uthman L, Baartscheer A, Bleijlevens B, Schumacher CA, Fiolet JWT, Koeman A, et al. Class effects of SGLT2 inhibitors in mouse cardiomyocytes and hearts: inhibition of Na(+)\/H(+) exchanger, lowering of cytosolic Na(+) and vasodilation. Diabetologia. 2018;61:722\u20136. https:\/\/doi.org\/10.1007\/s00125-017-4509-7.","journal-title":"Diabetologia"},{"key":"2492_CR151","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1146\/annurev-physiol-031620-095920","volume":"83","author":"V Vallon","year":"2021","unstructured":"Vallon V, Verma S. Effects of SGLT2 Inhibitors on Kidney and Cardiovascular Function. Annu Rev Physiol. 2021;83:503\u201328. https:\/\/doi.org\/10.1146\/annurev-physiol-031620-095920.","journal-title":"Annu Rev Physiol"},{"key":"2492_CR152","doi-asserted-by":"publisher","first-page":"C1150","DOI":"10.1152\/ajpcell.00569.2025","volume":"329","author":"BR G\u00f3es-Santos","year":"2025","unstructured":"G\u00f3es-Santos BR, Castro PC, Girardi ACC, Antunes-Correa LM, Davel AP. Vascular effects of SGLT2 inhibitors: evidence and mechanisms. Am J Physiol Cell Physiol. 2025;329:C1150-c1160. https:\/\/doi.org\/10.1152\/ajpcell.00569.2025.","journal-title":"Am J Physiol Cell Physiol"},{"key":"2492_CR153","doi-asserted-by":"publisher","DOI":"10.3390\/ijms27062573","volume":"27","author":"DG Buriman","year":"2026","unstructured":"Buriman DG, Noveanu L, Furdui-Lin\u021ba AV, Feier HB, Lazou A, Kiss A, et al. Vasculoprotective effects of sodium-glucose co-transporter inhibitors in non-diabetic experimental settings: a narrative review. Int J Mol Sci. 2026;27:2573.","journal-title":"Int J Mol Sci"},{"key":"2492_CR154","doi-asserted-by":"publisher","first-page":"H246","DOI":"10.1152\/ajpheart.00438.2021","volume":"322","author":"S Wang","year":"2022","unstructured":"Wang S, Jiao F, Border JJ, Fang X, Crumpler RF, Liu Y, et al. Luseogliflozin, a sodium-glucose cotransporter-2 inhibitor, reverses cerebrovascular dysfunction and cognitive impairments in 18-mo-old diabetic animals. Am J Physiol Heart Circ Physiol. 2022;322:H246\u201359. https:\/\/doi.org\/10.1152\/ajpheart.00438.2021.","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"Suppl 1","key":"2492_CR155","doi-asserted-by":"publisher","DOI":"10.1002\/alz70855_096815","volume":"21","author":"AP Gregory","year":"2025","unstructured":"Gregory AP, Morgan GC, Tang C, Zhang H, Border JJ, Fang X, et al. SGLT2 inhibition protects cognitive function in Alzheimer\u2019s disease by enhancing brain perfusion, independent of glucose control. Alzheimers Dement. 2025;21(Suppl 1):e096815. https:\/\/doi.org\/10.1002\/alz70855_096815.","journal-title":"Alzheimers Dement"},{"key":"2492_CR156","doi-asserted-by":"publisher","first-page":"113","DOI":"10.3390\/ph7020113","volume":"7","author":"H Zheng","year":"2014","unstructured":"Zheng H, Fridkin M, Youdim M. From single target to multitarget\/network therapeutics in Alzheimer\u2019s therapy. Pharmaceuticals (Basel). 2014;7:113\u201335. https:\/\/doi.org\/10.3390\/ph7020113.","journal-title":"Pharmaceuticals (Basel)"},{"key":"2492_CR157","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1006\/phrs.2001.0903","volume":"45","author":"IT Mak","year":"2002","unstructured":"Mak IT, Zhang J, Weglicki WB. Protective effects of dihydropyridine Ca-blockers against endothelial cell oxidative injury due to combined nitric oxide and superoxide. Pharmacol Res. 2002;45:27\u201333. https:\/\/doi.org\/10.1006\/phrs.2001.0903.","journal-title":"Pharmacol Res"},{"key":"2492_CR158","doi-asserted-by":"publisher","first-page":"1830","DOI":"10.1002\/glia.24370","volume":"71","author":"A Krogsgaard","year":"2023","unstructured":"Krogsgaard A, Sperling L, Dahlqvist M, Thomsen K, Vydmantaite G, Li F, et al. PV interneurons evoke astrocytic Ca(2+) responses in awake mice, which contributes to neurovascular coupling. Glia. 2023;71:1830\u201346. https:\/\/doi.org\/10.1002\/glia.24370.","journal-title":"Glia"},{"key":"2492_CR159","doi-asserted-by":"publisher","first-page":"7872","DOI":"10.1038\/s41467-022-35383-2","volume":"13","author":"A Institoris","year":"2022","unstructured":"Institoris A, Vandal M, Peringod G, Catalano C, Tran CH, Yu X, et al. Astrocytes amplify neurovascular coupling to sustained activation of neocortex in awake mice. Nat Commun. 2022;13:7872. https:\/\/doi.org\/10.1038\/s41467-022-35383-2.","journal-title":"Nat Commun"},{"key":"2492_CR160","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1161\/CIRCRESAHA.118.311378","volume":"123","author":"Z Ungvari","year":"2018","unstructured":"Ungvari Z, Tarantini S, Donato AJ, Galvan V, Csiszar A. Mechanisms of Vascular Aging. Circ Res. 2018;123:849\u201367. https:\/\/doi.org\/10.1161\/CIRCRESAHA.118.311378.","journal-title":"Circ Res"},{"key":"2492_CR161","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/s41569-018-0030-z","volume":"15","author":"Z Ungvari","year":"2018","unstructured":"Ungvari Z, Tarantini S, Kiss T, Wren JD, Giles CB, Griffin CT, et al. Endothelial dysfunction and angiogenesis impairment in the ageing vasculature. Nat Rev Cardiol. 2018;15:555\u201365. https:\/\/doi.org\/10.1038\/s41569-018-0030-z.","journal-title":"Nat Rev Cardiol"},{"key":"2492_CR162","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.neuron.2017.07.030","volume":"96","author":"C Iadecola","year":"2017","unstructured":"Iadecola C. The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease. Neuron. 2017;96:17\u201342. https:\/\/doi.org\/10.1016\/j.neuron.2017.07.030.","journal-title":"Neuron"},{"key":"2492_CR163","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2025-105271","volume":"16","author":"SJ Park","year":"2026","unstructured":"Park SJ, Kim HJ, Seo M, Byun DW, Suh K, Yoo MH, et al. Comparative risk of the neurodegenerative outcomes between sodium-glucose co-transporter 2 (SGLT2) inhibitors and thiazolidinediones in type 2 diabetes: a multicentre cohort study using the Korean healthcare database (2014\u20132025). BMJ Open. 2026;16:e105271. https:\/\/doi.org\/10.1136\/bmjopen-2025-105271.","journal-title":"BMJ Open"},{"key":"2492_CR164","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70416","volume":"21","author":"JM Burns","year":"2025","unstructured":"Burns JM, Morris JK, Vidoni ED, Wilkins HM, Choi IY, Lee P, et al. Effects of the SGLT2 inhibitor dapagliflozin in early Alzheimer\u2019s disease: A randomized controlled trial. Alzheimers Dement. 2025;21:e70416. https:\/\/doi.org\/10.1002\/alz.70416.","journal-title":"Alzheimers Dement"},{"key":"2492_CR165","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1016\/j.bbadis.2011.08.013","volume":"1812","author":"TS Anekonda","year":"2011","unstructured":"Anekonda TS, Quinn JF. Calcium channel blocking as a therapeutic strategy for Alzheimer\u2019s disease: the case for isradipine. Biochim Biophys Acta. 2011;1812:1584\u201390. https:\/\/doi.org\/10.1016\/j.bbadis.2011.08.013.","journal-title":"Biochim Biophys Acta"},{"key":"2492_CR166","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.csbj.2022.11.049","volume":"21","author":"CA Crossley","year":"2023","unstructured":"Crossley CA, Rajani V, Yuan Q. Modulation of L-type calcium channels in Alzheimer\u2019s disease: A potential therapeutic target. Comput Struct Biotechnol J. 2023;21:11\u201320. https:\/\/doi.org\/10.1016\/j.csbj.2022.11.049.","journal-title":"Comput Struct Biotechnol J"},{"key":"2492_CR167","doi-asserted-by":"publisher","first-page":"R379","DOI":"10.1152\/ajpregu.00256.2014","volume":"308","author":"F Fan","year":"2015","unstructured":"Fan F, Geurts AM, Murphy SR, Pabbidi MR, Jacob HJ, Roman RJ. Impaired myogenic response and autoregulation of cerebral blood flow is rescued in CYP4A1 transgenic Dahl salt-sensitive rat. Am J Physiol Regul Integr Comp Physiol. 2015;308:R379-390. https:\/\/doi.org\/10.1152\/ajpregu.00256.2014.","journal-title":"Am J Physiol Regul Integr Comp Physiol"}],"container-title":["GeroScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-026-02492-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11357-026-02492-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-026-02492-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:31:41Z","timestamp":1787751101000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11357-026-02492-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,26]]},"references-count":167,"alternative-id":["2492"],"URL":"https:\/\/doi.org\/10.1007\/s11357-026-02492-5","relation":{},"ISSN":["2509-2723"],"issn-type":[{"value":"2509-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,26]]},"assertion":[{"value":"12 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}