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Low HGS is strongly associated with morbidity, disability, and mortality. However, the neural mechanisms underlying age-related declines in HGS have not been fully elucidated. The multi-finger force deficit (MFFD), which reflects the central nervous system\u2019s capacity to coordinate finger activation during a power grip, provides an innovative approach to assess these neural contributions. Prior MFFD studies have inferred neural contributions to grip force, but this assumes that multi-finger dynamometry captures coordination processes relevant to conventional HGS. Because prior paradigms used non-standard hand\/forearm postures and generally studied younger-old, high-functioning adults, the clinical relevance of MFFD to age-related weakness remains uncertain. Therefore, we tested younger (\n                    <jats:italic>n\u2009=\u2009<\/jats:italic>\n                    12; 23.7\u2009\u00b1\u20091.7\u00a0years) and markedly older (\n                    <jats:italic>n\u2009=\u2009<\/jats:italic>\n                    10; 80.3\u2009\u00b1\u20098.8\u00a0years) adults\u00a0using a biomimetic setup that replicated traditional HGS assessment and examined whether HGS is altered under cognitively demanding dual-task conditions. Older adults exhibited 48.8% lower HGS, greater MFFD (25.8\u2009\u00b1\u200911.4% vs. 16.5\u2009\u00b1\u20097.1%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), and lower performance on HGS during continuous reading aloud than younger adults (17.7\u2009\u00b1\u20096.7\u00a0kg vs. 29.8\u2009\u00b1\u20099.2\u00a0kg;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Further, sarcopenic older adults exhibited a higher MFFD compared to their non-sarcopenic counterparts (33.4\u2009\u00b1\u20098.6% vs. 18.0\u2009\u00b1\u20098.3%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.021), when data are pooled across hands. These findings suggest that age-related reductions in HGS are partly attributable to neural mechanisms. The MFFD may represent a candidate behavioral marker of multi-digit reserve, but its predictive and clinical utility require validation.\n                  <\/jats:p>","DOI":"10.1007\/s11357-026-02517-z","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T18:08:47Z","timestamp":1788890927000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neural contributions to age-related handgrip weakness revealed by multi-finger force deficit and dual-task testing"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7796-8371","authenticated-orcid":false,"given":"Gregory M.","family":"Shaw","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leatha A.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dustin R.","family":"Grooms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard G.","family":"Carson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian C.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"2517_CR1","doi-asserted-by":"publisher","first-page":"e0219041","DOI":"10.1371\/journal.pone.0219041","volume":"14","author":"JJ Aarden","year":"2019","unstructured":"Aarden JJ, van der Schaaf M, van der Esch M, Reichardt LA, van Seben R, Bosch JA, et al. 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He has also served as a consultant to Schrodinger on research related to aging and muscle weakness. The other authors do not declare any relevant disclosures.","order":1,"name":"Ethics","label":"Disclosures","group":{"name":"EthicsHeading","label":"Declarations"}}]}}