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As effective treatments remain limited once neurodegeneration has occurred, prevention and delay of decline onset are crucial. While physical exercise is associated with improved cognition, exercise-specific mechanisms remain unclear. We therefore examined the effects of 12\u00a0weeks explosive lower-body resistance training (RT) in community-dwelling older adults on proposed markers associated with brain metabolism and sleep. Thirty-six participants (64\u201381\u00a0years) completed pre and post assessments consisting of sensorimotor lactate and N-acetylaspartate (NAA) levels via 7\u00a0T magnetic resonance spectroscopy (analyzable lactate data:\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200924; NAA:\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200932), objective sleep architecture with wearable polysomnography (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200934), and subjective sleep quality of the recorded nights with the revised sleep questionnaire A (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200925) as well as of the preceding 4 weeks with the Pittsburgh Sleep Quality Index (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200936). Participants were assigned to RT (3 sessions per week) or a control group (CON; maintaining lifestyle). After significant Group\u2009\u00d7\u2009Time interactions via repeated-measures ANCOVA with sex as covariate, paired\n                    <jats:italic>t<\/jats:italic>\n                    -tests revealed that RT significantly (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) reduced resting lactate concentration (\n                    <jats:italic>d<\/jats:italic>\n                    \u2009=\u20090.78), improved objective sleep efficiency (\n                    <jats:italic>d<\/jats:italic>\n                    \u2009=\u20090.75), and prolonged total sleep time (\n                    <jats:italic>d<\/jats:italic>\n                    \u2009=\u20090.61). Our findings suggest that resistance training may be particularly beneficial for older adults experiencing fragmented sleep and impaired neural oxidative metabolism.\n                  <\/jats:p>","DOI":"10.1007\/s11357-026-02519-x","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T21:31:14Z","timestamp":1788989474000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reduced sensorimotor lactate concentration and improved sleep efficiency following resistance training in older adults"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4476-6633","authenticated-orcid":false,"given":"Selin","family":"Scherrer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4623-7201","authenticated-orcid":false,"given":"Sven","family":"Egger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0567-5264","authenticated-orcid":false,"given":"Xinyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7364-7243","authenticated-orcid":false,"given":"Anna Zo\u00e9","family":"Wick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7607-3415","authenticated-orcid":false,"given":"Bj\u00f6rn","family":"Rasch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5450-6109","authenticated-orcid":false,"given":"Lijing","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9684-3675","authenticated-orcid":false,"given":"Benedikt","family":"Lauber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8802-2065","authenticated-orcid":false,"given":"Wolfgang","family":"Taube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"2519_CR1","doi-asserted-by":"publisher","first-page":"2937","DOI":"10.14336\/AD.2024.1071","volume":"16","author":"S Wang","year":"2024","unstructured":"Wang S, Jiang Y, Yang A, Meng F, Zhang J. 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