{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T17:06:55Z","timestamp":1789492015113,"version":"build-2803163510"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["136859"],"award-info":[{"award-number":["136859"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["GeroScience"],"DOI":"10.1007\/s11357-026-02522-2","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T16:42:37Z","timestamp":1789490557000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Common and distinct plasma proteomic signature of aerobic and motor physical activity interventions and their link to episodic memory"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5202-7078","authenticated-orcid":false,"given":"Pauline","family":"Mury","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Jaulgey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tudor","family":"Vrinceanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristell","family":"Pothier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Berryman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany","family":"Intzandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Lussier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thien-Tuong Minh","family":"Vu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Nigam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Bosquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antony D.","family":"Karelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Z. H.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2258-8194","authenticated-orcid":false,"given":"Louis","family":"Bherer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"2522_CR1","unstructured":"World Health Organization (2025) La d\u00e9mence. https:\/\/www.who.int\/fr\/news-room\/fact-sheets\/detail\/dementia. Accessed 6 Feb 2026"},{"key":"2522_CR2","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/j.cger.2013.07.002","volume":"29","author":"CN Harada","year":"2013","unstructured":"Harada CN, Natelson Love MC, Triebel KL. Normal cognitive aging. Clin Geriatr Med. 2013;29:737\u201352. https:\/\/doi.org\/10.1016\/j.cger.2013.07.002.","journal-title":"Clin Geriatr Med"},{"key":"2522_CR3","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.030780","volume":"12","author":"A Saeed","year":"2023","unstructured":"Saeed A, Lopez O, Cohen A, Reis SE. Cardiovascular disease and Alzheimer\u2019s disease: the heart-brain axis. J Am Heart Assoc. 2023;12:e030780. https:\/\/doi.org\/10.1161\/JAHA.123.030780.","journal-title":"J Am Heart Assoc"},{"key":"2522_CR4","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1007\/s11886-023-01990-8","volume":"25","author":"J-R Hu","year":"2023","unstructured":"Hu J-R, Abdullah A, Nanna MG, Soufer R. The brain-heart axis: neuroinflammatory interactions in cardiovascular disease. Curr Cardiol Rep. 2023;25:1745\u201358. https:\/\/doi.org\/10.1007\/s11886-023-01990-8.","journal-title":"Curr Cardiol Rep"},{"key":"2522_CR5","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1093\/cvr\/cvae185","volume":"120","author":"A Simats","year":"2025","unstructured":"Simats A, Sager HB, Liesz A. Heart-brain axis in health and disease: role of innate and adaptive immunity. Cardiovasc Res. 2025;120:2325\u201335. https:\/\/doi.org\/10.1093\/cvr\/cvae185.","journal-title":"Cardiovasc Res"},{"issue":"Suppl 1","key":"2522_CR6","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1093\/gerona\/glu057","volume":"69","author":"C Franceschi","year":"2014","unstructured":"Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 2014;69(Suppl 1):S4-9. https:\/\/doi.org\/10.1093\/gerona\/glu057.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2522_CR7","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.jacc.2021.12.017","volume":"79","author":"L Liberale","year":"2022","unstructured":"Liberale L, Badimon L, Montecucco F, et al. Inflammation, aging, and cardiovascular disease: JACC review topic of the week. J Am Coll Cardiol. 2022;79:837\u201347. https:\/\/doi.org\/10.1016\/j.jacc.2021.12.017.","journal-title":"J Am Coll Cardiol"},{"key":"2522_CR8","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","volume":"5","author":"J-P Copp\u00e9","year":"2010","unstructured":"Copp\u00e9 J-P, Desprez P-Y, Krtolica A, Campisi J. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol. 2010;5:99\u2013118. https:\/\/doi.org\/10.1146\/annurev-pathol-121808-102144.","journal-title":"Annu Rev Pathol"},{"key":"2522_CR9","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13188","volume":"19","author":"E Fielder","year":"2020","unstructured":"Fielder E, Tweedy C, Wilson C, et al. Anti-inflammatory treatment rescues memory deficits during aging in nfkb1-\/- mice. Aging Cell. 2020;19:e13188. https:\/\/doi.org\/10.1111\/acel.13188.","journal-title":"Aging Cell"},{"key":"2522_CR10","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s00401-010-0722-x","volume":"120","author":"VH Perry","year":"2010","unstructured":"Perry VH. Contribution of systemic inflammation to chronic neurodegeneration. Acta Neuropathol (Berl). 2010;120:277\u201386. https:\/\/doi.org\/10.1007\/s00401-010-0722-x.","journal-title":"Acta Neuropathol (Berl)"},{"key":"2522_CR11","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.54285","volume":"7","author":"P Iso-Markku","year":"2024","unstructured":"Iso-Markku P, Aaltonen S, Kujala UM, et al. Physical activity and cognitive decline among older adults: a systematic review and meta-analysis. JAMA Netw Open. 2024;7:e2354285. https:\/\/doi.org\/10.1001\/jamanetworkopen.2023.54285.","journal-title":"JAMA Netw Open"},{"key":"2522_CR12","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jphys.2019.11.014","volume":"66","author":"C-K Law","year":"2020","unstructured":"Law C-K, Lam FM, Chung RC, Pang MY. Physical exercise attenuates cognitive decline and reduces behavioural problems in people with mild cognitive impairment and dementia: a systematic review. J Physiother. 2020;66:9\u201318. https:\/\/doi.org\/10.1016\/j.jphys.2019.11.014.","journal-title":"J Physiother"},{"key":"2522_CR13","doi-asserted-by":"publisher","first-page":"6950","DOI":"10.1007\/s12035-023-03492-8","volume":"60","author":"M Augusto-Oliveira","year":"2023","unstructured":"Augusto-Oliveira M, Arrifano GP, Leal-Nazar\u00e9 CG, et al. Exercise reshapes the brain: molecular, cellular, and structural changes associated with cognitive improvements. Mol Neurobiol. 2023;60:6950\u201374. https:\/\/doi.org\/10.1007\/s12035-023-03492-8.","journal-title":"Mol Neurobiol"},{"key":"2522_CR14","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-023-00341-5","volume":"12","author":"Y Lu","year":"2023","unstructured":"Lu Y, Bu F-Q, Wang F, et al. Recent advances on the molecular mechanisms of exercise-induced improvements of cognitive dysfunction. Transl Neurodegener. 2023;12:9. https:\/\/doi.org\/10.1186\/s40035-023-00341-5.","journal-title":"Transl Neurodegener"},{"key":"2522_CR15","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1186\/s40001-025-03165-3","volume":"30","author":"Y Su","year":"2025","unstructured":"Su Y, Su Z. Effects of exercise on neuroinflammation in age-related neurodegenerative disorders. Eur J Med Res. 2025;30:909. https:\/\/doi.org\/10.1186\/s40001-025-03165-3.","journal-title":"Eur J Med Res"},{"key":"2522_CR16","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-02753-6","volume":"20","author":"M Wang","year":"2023","unstructured":"Wang M, Zhang H, Liang J, et al. Exercise suppresses neuroinflammation for alleviating Alzheimer\u2019s disease. J Neuroinflammation. 2023;20:76. https:\/\/doi.org\/10.1186\/s12974-023-02753-6.","journal-title":"J Neuroinflammation"},{"key":"2522_CR17","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.brainresbull.2016.03.012","volume":"125","author":"LJ Spielman","year":"2016","unstructured":"Spielman LJ, Little JP, Klegeris A. Physical activity and exercise attenuate neuroinflammation in neurological diseases. Brain Res Bull. 2016;125:19\u201329. https:\/\/doi.org\/10.1016\/j.brainresbull.2016.03.012.","journal-title":"Brain Res Bull"},{"key":"2522_CR18","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7239639","author":"N Sallam","year":"2016","unstructured":"Sallam N, Laher I. Exercise modulates oxidative stress and inflammation in aging and cardiovascular diseases. Oxid Med Cell Longev. 2016. https:\/\/doi.org\/10.1155\/2016\/7239639.","journal-title":"Oxid Med Cell Longev"},{"key":"2522_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbih.2026.101291","volume":"55","author":"P Solis-Urra","year":"2026","unstructured":"Solis-Urra P, Sewell KR, Collins AM, et al. Inflammatory, metabolic, and vascular pathways linking cardiorespiratory fitness to cognition: results from the IGNITE study. Brain Behav Immun-Health. 2026;55:101291. https:\/\/doi.org\/10.1016\/j.bbih.2026.101291.","journal-title":"Brain Behav Immun-Health"},{"key":"2522_CR20","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2019.00098","author":"G Zheng","year":"2019","unstructured":"Zheng G, Qiu P, Xia R, et al. Effect of aerobic exercise on inflammatory markers in healthy middle-aged and older adults: a systematic review and meta-analysis of randomized controlled trials. Front Aging Neurosci. 2019. https:\/\/doi.org\/10.3389\/fnagi.2019.00098.","journal-title":"Front Aging Neurosci"},{"key":"2522_CR21","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2023.1253329","author":"Y-H Wang","year":"2023","unstructured":"Wang Y-H, Tan J, Zhou H-H, et al. Long-term exercise training and inflammatory biomarkers in healthy subjects: a meta-analysis of randomized controlled trials. Front Psychol. 2023. https:\/\/doi.org\/10.3389\/fpsyg.2023.1253329.","journal-title":"Front Psychol"},{"key":"2522_CR22","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1249\/MSS.0000000000001936","volume":"51","author":"KI Erickson","year":"2019","unstructured":"Erickson KI, Hillman C, Stillman CM, et al. Physical activity, cognition, and brain outcomes: a review of the 2018 physical activity guidelines. Med Sci Sports Exerc. 2019;51:1242\u201351. https:\/\/doi.org\/10.1249\/MSS.0000000000001936.","journal-title":"Med Sci Sports Exerc"},{"key":"2522_CR23","doi-asserted-by":"publisher","first-page":"5333","DOI":"10.1002\/jcb.27810","volume":"120","author":"BM Antunes","year":"2019","unstructured":"Antunes BM, Campos EZ, Dos Santos RVT, et al. Anti-inflammatory response to acute exercise is related with intensity and physical fitness. J Cell Biochem. 2019;120:5333\u201342. https:\/\/doi.org\/10.1002\/jcb.27810.","journal-title":"J Cell Biochem"},{"key":"2522_CR24","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2024.1432909","volume":"16","author":"S Gujral","year":"2024","unstructured":"Gujral S, Cameron JL, Conaty K, et al. Intermittent low-intensity and moderate-intensity exercise effects on cognition in community-dwelling older adults: a pilot study exploring biological mechanisms. Front Aging Neurosci. 2024;16:1432909. https:\/\/doi.org\/10.3389\/fnagi.2024.1432909.","journal-title":"Front Aging Neurosci"},{"key":"2522_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2021.111331","volume":"149","author":"K Pothier","year":"2021","unstructured":"Pothier K, Vrinceanu T, Intzandt B, et al. A comparison of physical exercise and cognitive training interventions to improve determinants of functional mobility in healthy older adults. Exp Gerontol. 2021;149:111331. https:\/\/doi.org\/10.1016\/j.exger.2021.111331.","journal-title":"Exp Gerontol"},{"key":"2522_CR26","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1093\/geronb\/gbab216","volume":"77","author":"T Vrinceanu","year":"2022","unstructured":"Vrinceanu T, Blanchette C-A, Intzandt B, et al. A comparison of the effect of physical activity and cognitive training on dual-task performance in older adults. J Gerontol B Psychol Sci Soc Sci. 2022;77:1069\u201379. https:\/\/doi.org\/10.1093\/geronb\/gbab216.","journal-title":"J Gerontol B Psychol Sci Soc Sci"},{"key":"2522_CR27","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","volume":"12","author":"MF Folstein","year":"1975","unstructured":"Folstein MF, Folstein SE, McHugh PR. \u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189\u201398. https:\/\/doi.org\/10.1016\/0022-3956(75)90026-6.","journal-title":"J Psychiatr Res"},{"key":"2522_CR28","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1016\/j.exger.2013.08.017","volume":"48","author":"N Berryman","year":"2013","unstructured":"Berryman N, Bherer L, Nadeau S, et al. Executive functions, physical fitness and mobility in well-functioning older adults. Exp Gerontol. 2013;48:1402\u20139. https:\/\/doi.org\/10.1016\/j.exger.2013.08.017.","journal-title":"Exp Gerontol"},{"key":"2522_CR29","doi-asserted-by":"publisher","DOI":"10.1037\/1040-3590.8.2.145","author":"RHB Benedict","year":"1996","unstructured":"Benedict RHB, Schretlen D, Groninger L, et al. Revision of the brief visuospatial memory test: studies of normal performance, reliability, and validity. Psychol Assess. 1996. https:\/\/doi.org\/10.1037\/1040-3590.8.2.145.","journal-title":"Psychol Assess"},{"key":"2522_CR30","unstructured":"Singh B, Goyal A, Patel BC. C-reactive protein: clinical relevance and interpretation. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2026 [cited 2026 Sep 8]. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK441843\/."},{"key":"2522_CR31","doi-asserted-by":"publisher","first-page":"6961","DOI":"10.4049\/jimmunol.0904176","volume":"184","author":"M Al-Alwan","year":"2010","unstructured":"Al-Alwan M, Hou S, Zhang T, et al. Bam32\/DAPP1 promotes B cell adhesion and formation of polarized conjugates with T cells. J Immunol. 2010;184:6961\u20139. https:\/\/doi.org\/10.4049\/jimmunol.0904176.","journal-title":"J Immunol"},{"key":"2522_CR32","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1016\/s0960-9822(00)00794-6","volume":"10","author":"KE Anderson","year":"2000","unstructured":"Anderson KE, Lipp P, Bootman M, et al. DAPP1 undergoes a PI 3-kinase-dependent cycle of plasma-membrane recruitment and endocytosis upon cell stimulation. Curr Biol. 2000;10:1403\u201312. https:\/\/doi.org\/10.1016\/s0960-9822(00)00794-6.","journal-title":"Curr Biol"},{"key":"2522_CR33","doi-asserted-by":"publisher","first-page":"5413","DOI":"10.1523\/JNEUROSCI.2730-19.2020","volume":"40","author":"V Danelon","year":"2020","unstructured":"Danelon V, Goldner R, Martinez E, et al. Modular and distinct Plexin-A4\/FARP2\/Rac1 signaling controls dendrite morphogenesis. J Neurosci. 2020;40:5413\u201330. https:\/\/doi.org\/10.1523\/JNEUROSCI.2730-19.2020.","journal-title":"J Neurosci"},{"key":"2522_CR34","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.bbi.2022.09.011","volume":"107","author":"CP Walsh","year":"2023","unstructured":"Walsh CP, Lindsay EK, Grosse P, et al. A systematic review and meta-analysis of the stability of peripheral immune markers in healthy adults. Brain Behav Immun. 2023;107:32\u201346. https:\/\/doi.org\/10.1016\/j.bbi.2022.09.011.","journal-title":"Brain Behav Immun"},{"key":"2522_CR35","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20123024","volume":"20","author":"S Di Meo","year":"2019","unstructured":"Di Meo S, Napolitano G, Venditti P. Mediators of physical activity protection against ROS-linked skeletal muscle damage. Int J Mol Sci. 2019;20:3024. https:\/\/doi.org\/10.3390\/ijms20123024.","journal-title":"Int J Mol Sci"},{"issue":"Suppl 4","key":"2522_CR36","doi-asserted-by":"publisher","first-page":"S7","DOI":"10.1038\/ijo.2008.116","volume":"32","author":"DG Hardie","year":"2008","unstructured":"Hardie DG. AMPK: a key regulator of energy balance in the single cell and the whole organism. Int J Obes. 2008;32(Suppl 4):S7-12. https:\/\/doi.org\/10.1038\/ijo.2008.116.","journal-title":"Int J Obes"},{"key":"2522_CR37","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/s41586-023-06877-w","volume":"629","author":"MoTrPAC Study Group","year":"2024","unstructured":"MoTrPAC Study Group, Lead Analysts, MoTrPAC Study Group. Temporal dynamics of the multi-omic response to endurance exercise training. Nature. 2024;629:174\u201383. https:\/\/doi.org\/10.1038\/s41586-023-06877-w.","journal-title":"Nature"},{"key":"2522_CR38","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26073069","volume":"26","author":"X Wen","year":"2025","unstructured":"Wen X, Fan J, Duan X, et al. Mitochondrial DNA in exercise-mediated innate immune responses. Int J Mol Sci. 2025;26:3069. https:\/\/doi.org\/10.3390\/ijms26073069.","journal-title":"Int J Mol Sci"},{"key":"2522_CR39","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1002\/jcp.21168","volume":"214","author":"C Grondard","year":"2008","unstructured":"Grondard C, Biondi O, Pariset C, et al. Exercise-induced modulation of calcineurin activity parallels the time course of myofibre transitions. J Cell Physiol. 2008;214:126\u201335. https:\/\/doi.org\/10.1002\/jcp.21168.","journal-title":"J Cell Physiol"},{"issue":"10","key":"2522_CR40","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1055\/s-0032-1331758","volume":"34","author":"IJ Vechetti-J\u00fanior","year":"2013","unstructured":"Vechetti-J\u00fanior IJ, Aguiar AF, de Souza RW, et al. NFAT isoforms regulate muscle fiber type transition without altering CaN during aerobic training. Int J Sports Med. 2013;34(10):861\u20137. https:\/\/doi.org\/10.1055\/s-0032-1331758.","journal-title":"Int J Sports Med"},{"key":"2522_CR41","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/s0092-8674(01)00396-8","volume":"105","author":"IA Graef","year":"2001","unstructured":"Graef IA, Chen F, Chen L, et al. Signals transduced by Ca(2+)\/calcineurin and NFATc3\/c4 pattern the developing vasculature. Cell. 2001;105:863\u201375. https:\/\/doi.org\/10.1016\/s0092-8674(01)00396-8.","journal-title":"Cell"},{"key":"2522_CR42","first-page":"934","volume":"13","author":"W Liu","year":"2014","unstructured":"Liu W, Chen G, Li F, et al. Calcineurin-NFAT signaling and neurotrophins control transformation of myosin heavy chain isoforms in rat soleus muscle in response to aerobic treadmill training. J Sports Sci Med. 2014;13:934\u201344.","journal-title":"J Sports Sci Med"},{"key":"2522_CR43","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1084\/jem.193.5.607","volume":"193","author":"GL Hern\u00e1ndez","year":"2001","unstructured":"Hern\u00e1ndez GL, Volpert OV, I\u00f1iguez MA, et al. Selective inhibition of vascular endothelial growth factor-mediated angiogenesis by cyclosporin A: roles of the nuclear factor of activated T cells and cyclooxygenase 2. J Exp Med. 2001;193:607\u201320. https:\/\/doi.org\/10.1084\/jem.193.5.607.","journal-title":"J Exp Med"},{"key":"2522_CR44","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1080\/15438627.2021.1917408","volume":"30","author":"Y Liu","year":"2022","unstructured":"Liu Y, Sun Z, Chen T, Yang C. Does exercise training improve the function of vascular smooth muscle? A systematic review and meta-analysis. Res Sports Med. 2022;30:577\u201392. https:\/\/doi.org\/10.1080\/15438627.2021.1917408.","journal-title":"Res Sports Med"},{"key":"2522_CR45","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s10456-005-9013-x","volume":"8","author":"CM Bloor","year":"2005","unstructured":"Bloor CM. Angiogenesis during exercise and training. Angiogenesis. 2005;8:263\u201371. https:\/\/doi.org\/10.1007\/s10456-005-9013-x.","journal-title":"Angiogenesis"},{"key":"2522_CR46","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1177\/1533317514524812","volume":"29","author":"KD Kane","year":"2014","unstructured":"Kane KD, Yochim BP. Construct validity and extended normative data for older adults for the Brief Visuospatial Memory Test, Revised. Am J Alzheimers Dis Other Demen. 2014;29:601\u20136. https:\/\/doi.org\/10.1177\/1533317514524812.","journal-title":"Am J Alzheimers Dis Other Demen"},{"key":"2522_CR47","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7027949","author":"C Engelmann","year":"2016","unstructured":"Engelmann C, Haenold R. Transcriptional control of synaptic plasticity by transcription factor NF-\u03baB. Neural Plast. 2016. https:\/\/doi.org\/10.1155\/2016\/7027949.","journal-title":"Neural Plast"},{"key":"2522_CR48","doi-asserted-by":"publisher","first-page":"3375","DOI":"10.1111\/j.1460-9568.2006.04859.x","volume":"23","author":"JM Horwood","year":"2006","unstructured":"Horwood JM, Dufour F, Laroche S, Davis S. Signalling mechanisms mediated by the phosphoinositide 3-kinase\/Akt cascade in synaptic plasticity and memory in the rat. Eur J Neurosci. 2006;23:3375\u201384. https:\/\/doi.org\/10.1111\/j.1460-9568.2006.04859.x.","journal-title":"Eur J Neurosci"},{"key":"2522_CR49","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-014-9710-8","volume":"36","author":"N Berryman","year":"2014","unstructured":"Berryman N, Bherer L, Nadeau S, et al. Multiple roads lead to Rome: combined high-intensity aerobic and strength training vs. gross motor activities leads to equivalent improvement in executive functions in a cohort of healthy older adults. Age. 2014;36:9710. https:\/\/doi.org\/10.1007\/s11357-014-9710-8.","journal-title":"Age"},{"key":"2522_CR50","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1093\/geronb\/gbu167","volume":"71","author":"SM Hayes","year":"2016","unstructured":"Hayes SM, Forman DE, Verfaellie M. Cardiorespiratory fitness is associated with cognitive performance in older but not younger adults. J Gerontol B Psychol Sci Soc Sci. 2016;71:474\u201382. https:\/\/doi.org\/10.1093\/geronb\/gbu167.","journal-title":"J Gerontol B Psychol Sci Soc Sci"}],"container-title":["GeroScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-026-02522-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11357-026-02522-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-026-02522-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T16:42:44Z","timestamp":1789490564000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11357-026-02522-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,15]]},"references-count":50,"alternative-id":["2522"],"URL":"https:\/\/doi.org\/10.1007\/s11357-026-02522-2","relation":{},"ISSN":["2509-2723"],"issn-type":[{"value":"2509-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,15]]},"assertion":[{"value":"5 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}