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All scientific hypotheses, claims, and interpretations are the authors\u2019 own.","order":2,"name":"Ethics","label":"Use of AI-assisted tools","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"W.S. is founder and chief executive of Functional Longevity Labs, Inc. (FLL) D.S., S.M., and D.I. are scientific advisors to FLL. W.S., S.M., and D.S. hold equity positions in FLL, a privately held company developing therapeutics in the class described in Sect. \u2018\u2018\n                      \n                      \u2019\u2019. A lead preclinical candidate from this program has been disclosed publicly as a poster at the Alzheimer\u2019s Association International Conference (Smith, Sajish, & Seiden, FLL-001, a first-in-class YARS1 modulator in preclinical development for Alzheimer\u2019s disease; AAIC 2026, London, UK, July 12\u201315, 2026; Control No. 2026-DTA-13223-AAIC). Compound structure, pharmacokinetic parameters, and safety-pharmacology data are proprietary and are not relied upon in the present manuscript; no proprietary data appear in any figure or table. The cascade model and the chronomodulator design criteria advanced here are intended as a class-level, mechanistic framework testable with any agent meeting the Sect. \u2018\u2018\n                      \n                      \u2019\u2019 specification and are presented independently of any specific clinical-stage asset.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}