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UK Biobank has full ethical approval from the North West Multicenter Research Ethics Committee (Ref: 11\/NW\/0382). All participants provided written informed consent at enrollment. The present analysis involved only de-identified data and required no additional ethical approval.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}