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No primary human or animal research is reported.","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The author is the owner of Cubic Bio, a privately held biotechnology company engaged in the biomanufacturing of cell therapeutics, including natural killer (NK) cell products of the kind discussed in this review. The author therefore has a direct financial and commercial interest in the autologous NK cell therapy approach that the review advocates. Cubic Bio did not fund this work and played no role in its design, drafting, or the decision to submit, and the review draws only on publicly available, independently published literature. This commercial alignment is disclosed in full so that readers and reviewers may weigh the synthesis and recommendations accordingly.","order":4,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This is a narrative (non-systematic) review. Eight thematic literature buckets were curated across NK cell aging biology, senescence and its immune surveillance, and autologous cytokine-induced NK cell manufacturing and clinical translation. AI-based tools (Claude, Anthropic) were used to assist literature search and organization and to produce initial structural and prose drafts. All such drafts were subsequently verified and rewritten by the author, and every citation was checked against PubMed and ClinicalTrials.gov primary records. The author takes full responsibility for the content, all scientific interpretations, and the final version of the text. AI tools are not, and do not satisfy the criteria for, authorship.","order":5,"name":"Ethics","label":"Methodology and use of AI tools","group":{"name":"EthicsHeading","label":"Declarations"}}]}}