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Research has documented age and racial disparities in HIV viral suppression. Men who have sex with men (MSM) are particularly affected by HIV infections, especially in the Southern United States. Studies indicate that substance use among people with HIV in the U.S. presents significant barriers to engaging in HIV care. This study investigated the relationships between age, race, MSM status, and viral suppression among men living with HIV (MLWH), who participated in the Helping HAND program at an academic medical center in a Southern state. The analysis included 746 male participants, primarily Black\/African American. The results showed that increases in age were positively associated with a greater likelihood of viral suppression, even after adjusting for harmful or hazardous drinking, problematic substance use, race, and MSM status. Younger MSM participants were less likely to achieve viral suppression than older MSM participants. In this male only sample, neither race nor MSM status was found to be related to viral suppression. Additionally, harmful or hazardous drinking and problematic substance use did not moderate the associations between age, race, or MSM and viral suppression. These findings highlight disparities in viral suppression across different age groups among men living with HIV. The results emphasize the need for targeted outreach initiatives specifically designed for younger age cohorts living with HIV, including MSM.<\/jats:p>","DOI":"10.1007\/s11414-025-09948-0","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T11:55:15Z","timestamp":1746791715000},"page":"131-141","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Age and Race Disparities in Viral Suppression and the Moderating Effect of Substance Use Among Men Who Have Sex with Men Living with HIV"],"prefix":"10.1007","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1739-0741","authenticated-orcid":false,"given":"Ran","family":"Fang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jake C.","family":"Steggerda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Konkle-Parker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew C.","family":"Voluse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,9]]},"reference":[{"key":"9948_CR1","unstructured":"HIV Treatment as Prevention. 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