{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:01:24Z","timestamp":1790287284272,"version":"4.1.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2010,6,18]],"date-time":"2010-06-18T00:00:00Z","timestamp":1276819200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nat Med"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1007\/s11418-010-0429-2","type":"journal-article","created":{"date-parts":[[2010,6,17]],"date-time":"2010-06-17T10:34:03Z","timestamp":1276770843000},"page":"436-441","source":"Crossref","is-referenced-by-count":27,"title":["Biological effects of Ocimum gratissimum L. are due to synergic action among multiple compounds present in essential oil"],"prefix":"10.1007","volume":"64","author":[{"given":"Luciane Almeida","family":"Galindo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"de Moraes Pultrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirtes","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,6,18]]},"reference":[{"key":"429_CR1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0041-0101(00)00154-9","volume":"39","author":"SMK Rates","year":"2001","unstructured":"Rates SMK (2001) Plants as source of drugs. Toxicon 39:603\u2013613","journal-title":"Toxicon"},{"key":"429_CR2","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.phymed.2006.11.011","volume":"14","author":"G Ulrich-Merzenich","year":"2007","unstructured":"Ulrich-Merzenich G, Zeitler H, Jobst D, Panek D, Vetter H, Wagner H (2007) Application of the \u201c-omic\u201d technologies in phytomedicine. Phytomedicine 14:70\u201382","journal-title":"Phytomedicine"},{"key":"429_CR3","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1021\/np030096l","volume":"66","author":"DJ Newman","year":"2003","unstructured":"Newman DJ, Cragg GM, Snader KM (2003) Natural products as sources of new drugs over the period 1981\u20132002. J Nat Prod 66:1022\u20131037","journal-title":"J Nat Prod"},{"key":"429_CR4","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0031-9422(00)00456-8","volume":"56","author":"JD Phillipson","year":"2001","unstructured":"Phillipson JD (2001) Phytochemistry and medicinal plants. Phytochemistry 56:237\u2013243","journal-title":"Phytochemistry"},{"key":"429_CR5","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0091-3057(03)00112-6","volume":"75","author":"EA Carlini","year":"2003","unstructured":"Carlini EA (2003) Plants and the central nervous system. Pharmacol Biochem Behav 75:501\u2013512","journal-title":"Pharmacol Biochem Behav"},{"key":"429_CR6","doi-asserted-by":"crossref","first-page":"801","DOI":"10.2165\/00003495-199754060-00003","volume":"54","author":"PAGM Smet De","year":"1997","unstructured":"De Smet PAGM (1997) The role of plant-derived drugs and herbal medicines in healthcare. Drugs 54:801\u2013840","journal-title":"Drugs"},{"key":"429_CR7","first-page":"677","volume-title":"CRC handbook of medicinal herbs","author":"JA Duke","year":"1985","unstructured":"Duke JA (1985) CRC handbook of medicinal herbs. Boca Raton, CRC, p 677"},{"key":"429_CR8","first-page":"111","volume":"23","author":"J Tortoriello","year":"1992","unstructured":"Tortoriello J, Romero O (1992) Plants used by Mexican traditional medicine with presumable sedative properties: an ethnobotanical approach. Arch Med Res 23:111\u2013116","journal-title":"Arch Med Res"},{"key":"429_CR9","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0378-8741(93)90049-B","volume":"39","author":"V Feo De","year":"1993","unstructured":"De Feo V, Senatore F (1993) Medicinal plants and phytotherapy in the Amalfitan Coast, Salerno Province, Campania, Southern Italy. J Ethnopharmacol 39:39\u201351","journal-title":"J Ethnopharmacol"},{"key":"429_CR10","first-page":"8","volume":"1","author":"JL P\u00e9rez de Alejo","year":"1996","unstructured":"P\u00e9rez de Alejo JL, Miranda R, Rodriguez G (1996) Actividad antidepresiva y anticonvulsivante del extracto fluido del Ocimum tenuiflorum L. (albahaca morada). Rev Cuba Plantas Med 1:8\u201312","journal-title":"Rev Cuba Plantas Med"},{"key":"429_CR11","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0378-8741(96)01491-2","volume":"55","author":"FM V\u00e1zquez","year":"1997","unstructured":"V\u00e1zquez FM, Suarez MA, P\u00e9rez A (1997) Medicinal plants used in the Barros Area, Badajoz Province (Spain). J Ethnopharmacol 55:81\u201385","journal-title":"J Ethnopharmacol"},{"key":"429_CR12","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0367-326X(01)00362-8","volume":"73","author":"LC Di Stasi","year":"2002","unstructured":"Di Stasi LC, Oliveira GP, Carvalhaes MA, Queiroz M Jr, Tien OS, Kakinami SH, Reis MS (2002) Medicinal plants popularly used in the Brazilian Tropical Atlantic Forest. Fitoterapia 73:69\u201391","journal-title":"Fitoterapia"},{"key":"429_CR13","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jep.2005.10.013","volume":"105","author":"CMM Freire","year":"2006","unstructured":"Freire CMM, Marques MOM, Costa M (2006) Effects of seasonal variation on the central nervous system activity of Ocimum gratissimum L. essential oil. J Ethnopharmacol 105:161\u2013166","journal-title":"J Ethnopharmacol"},{"key":"429_CR14","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0022-3565(25)13017-6","volume":"125","author":"PC Dandiya","year":"1959","unstructured":"Dandiya PC, Cullumbine H (1959) Studies on Acorus calamus: some pharmacological actions of the volatile oil. J Pharmacol Exp Ther 125:353\u2013359","journal-title":"J Pharmacol Exp Ther"},{"key":"429_CR15","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1037\/0033-2909.83.3.482","volume":"83","author":"RN Walsh","year":"1976","unstructured":"Walsh RN, Cummins RA (1976) The open-field test: a critical review. Psychol Bull 83:482\u2013504","journal-title":"Psychol Bull"},{"key":"429_CR16","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/jps.3030460322","volume":"46","author":"NW Dunham","year":"1957","unstructured":"Dunham NW, Miya TS (1957) A note on a simple apparatus for detecting neurological deficits in rats and mice. J Am Pharm Assoc 46:208\u2013209","journal-title":"J Am Pharm Assoc"},{"key":"429_CR17","unstructured":"Dr Duke\u2019s Phytochemical and Ethnobotanical Databases. USDA-ARS-NGRI, Beltsville Agricultural Research Centre, Maryland. http:\/\/www.ars-grin.gov\/duke\/ . Accessed 29 Jan 2009"},{"key":"429_CR18","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1159\/000137479","volume":"22","author":"K Dallmeier","year":"1981","unstructured":"Dallmeier K, Carlini EA (1981) Anesthetic, hypothermic, myorelaxant and anticonvulsant effects of synthetic eugenol derivatives and natural analogues. Pharmacology 22:113\u2013127","journal-title":"Pharmacology"},{"key":"429_CR19","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1365-2885.2006.00740.x","volume":"29","author":"SA Guenette","year":"2006","unstructured":"Guenette SA, Beaudry F, Marier JF, Vachon P (2006) Pharmacokinetics and anesthetic activity of eugenol in male Sprague-Dawley rats. J Vet Pharmacol Ther 29:265\u2013270","journal-title":"J Vet Pharmacol Ther"},{"key":"429_CR20","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1467-2995.2006.00316.x","volume":"34","author":"SA Guenette","year":"2007","unstructured":"Guenette SA, H\u00e9lie P, Beaudry F, Vachon P (2007) Eugenol for anesthesia of African clawed frogs (Xenopus laevis). Vet Anaesth Analg 34:164\u2013170","journal-title":"Vet Anaesth Analg"},{"key":"429_CR21","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.neuroscience.2006.02.036","volume":"140","author":"M M\u00fcller","year":"2006","unstructured":"M\u00fcller M, Pape HC, Speckmann EJ, Gorji A (2006) Effect of eugenol on spreading depression and epileptiform discharges in rat neocortical and hippocampal tissues. Neuroscience 140:743\u2013751","journal-title":"Neuroscience"},{"key":"429_CR22","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/1099-1573(200006)14:4<240::AID-PTR573>3.0.CO;2-X","volume":"14","author":"FA Santos","year":"2000","unstructured":"Santos FA, Rao VS (2000) Antiinflammatory and antinociceptive effects of 1,8-cineole a terpenoid oxide present in many plant essential oils. Phytother Res 14:240\u2013244","journal-title":"Phytother Res"},{"key":"429_CR23","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0091-3057(01)00543-3","volume":"69","author":"T Umezu","year":"2001","unstructured":"Umezu T, Sakata A, Ito H (2001) Ambulation-promoting effect of peppermint oil and identification of its active constituents. Pharmacol Biochem Behav 69:383\u2013390","journal-title":"Pharmacol Biochem Behav"},{"key":"429_CR24","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0091-3057(03)00074-1","volume":"75","author":"KP Devi","year":"2003","unstructured":"Devi KP, Sreepriya M, Devaki T, Balakrishna K (2003) Antinociceptive and hypnotic effects of Premna tomentosa L. (Verbenaceae) in experimental animals. Pharmacol Biochem Behav 75:261\u2013264","journal-title":"Pharmacol Biochem Behav"},{"key":"429_CR25","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0920-1211(88)90054-X","volume":"2","author":"W L\u00f6scher","year":"1988","unstructured":"L\u00f6scher W, Schmidt D (1988) Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations. Epilepsy Res 2:145\u2013181","journal-title":"Epilepsy Res"},{"key":"429_CR26","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1078\/0944-7113-00060","volume":"8","author":"EM Williamson","year":"2001","unstructured":"Williamson EM (2001) Synergy and other interactions in phytomedicines. Phytomedicine 8:401\u2013409","journal-title":"Phytomedicine"},{"key":"429_CR27","first-page":"130","volume":"7","author":"M Spinella","year":"2002","unstructured":"Spinella M (2002) The importance of pharmacological synergy in psychoactive herbal medicines. Altern Med Rev 7:130\u2013137","journal-title":"Altern Med Rev"},{"key":"429_CR28","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.phymed.2004.03.006","volume":"12","author":"A Capasso","year":"2005","unstructured":"Capasso A, Sorrentino L (2005) Pharmacological studies on the sedative and hypnotic effect of Kava kava and Passiflora extracts combination. Phytomedicine 12:39\u201345","journal-title":"Phytomedicine"},{"key":"429_CR29","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jep.2005.05.029","volume":"100","author":"L Pieters","year":"2005","unstructured":"Pieters L, Vlietinck AJ (2005) Bioguided isolation of pharmacologically active plant components, still a valuable strategy for the finding of new lead compounds? J Ethnopharmacol 100:57\u201360","journal-title":"J Ethnopharmacol"},{"key":"429_CR30","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jep.2005.05.033","volume":"100","author":"R Verpoorte","year":"2005","unstructured":"Verpoorte R, Choi YH, Kim HK (2005) Ethnopharmacology and systems biology: a perfect holistic match. J Ethnopharmacol 100:53\u201356","journal-title":"J Ethnopharmacol"},{"key":"429_CR31","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.phymed.2008.12.018","volume":"16","author":"H Wagner","year":"2009","unstructured":"Wagner H, Ulrich-Merzenich G (2009) Synergy research: approaching a new generation of phytopharmaceuticals. Phytomedicine 16:97\u2013110","journal-title":"Phytomedicine"}],"container-title":["Journal of Natural Medicines"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-010-0429-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11418-010-0429-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-010-0429-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T01:39:24Z","timestamp":1740188364000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11418-010-0429-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,18]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["429"],"URL":"https:\/\/doi.org\/10.1007\/s11418-010-0429-2","relation":{},"ISSN":["1340-3443","1861-0293"],"issn-type":[{"value":"1340-3443","type":"print"},{"value":"1861-0293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,18]]}}}