{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T16:30:05Z","timestamp":1780677005239,"version":"3.54.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,7,24]],"date-time":"2010-07-24T00:00:00Z","timestamp":1279929600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nat Med"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1007\/s11418-010-0442-5","type":"journal-article","created":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T07:59:21Z","timestamp":1279871961000},"page":"1-8","source":"Crossref","is-referenced-by-count":23,"title":["Protection of HT22 neuronal cells against glutamate toxicity mediated by the antioxidant activity of Pueraria candollei var. mirifica extracts"],"prefix":"10.1007","volume":"65","author":[{"given":"Apirada","family":"Sucontphunt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanchai","family":"De-Eknamkul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ubonthip","family":"Nimmannit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Dan Dimitrijevich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Gracy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,7,24]]},"reference":[{"key":"442_CR1","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/188774a0","volume":"188","author":"JC Cain","year":"1960","unstructured":"Cain JC (1960) Miroestrol: an oestrogen from the plant Pueraria mirifica. Nature 188:774\u2013777","journal-title":"Nature"},{"key":"442_CR2","first-page":"300","volume":"53","author":"V Muangman","year":"2001","unstructured":"Muangman V, Cherdshewasart W (2001) Clinical trial of the phytoestrogen-rich herb, Pueraria mirifica as a crude drug in the treatment of symptoms in menopausal women. Siriraj Hosp Gaz 53:300\u2013309","journal-title":"Siriraj Hosp Gaz"},{"key":"442_CR3","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.maturitas.2006.09.007","volume":"56","author":"N Urasopon","year":"2007","unstructured":"Urasopon N, Hamada Y, Asaoka K, Cherdshewasart W, Malaivijitnond S (2007) Pueraria mirifica, a phytoestrogen-rich herb, prevents bone loss in orchidectomized rats. Maturitas 56:322\u2013331","journal-title":"Maturitas"},{"key":"442_CR4","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1055\/s-2000-8603","volume":"66","author":"S Chansakaow","year":"2000","unstructured":"Chansakaow S, Ishikawa T, Sekine K, Okada M, Higuchi Y, Kudo M, Chaichantipyuth C (2000) Isoflavonoids from Pueraria mirifica and their estrogenic activity. Planta Med 66:572\u2013575","journal-title":"Planta Med"},{"key":"442_CR5","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1021\/np990547v","volume":"63","author":"S Chansakaow","year":"2000","unstructured":"Chansakaow S, Ishikawa T, Seki H, Sekine (n\u00e9e Yoshizawa) K, Okada M, Chaichantipyuth C (2000) Identification of deoxymiroestrol as the actual rejuvenating principle of \u201cKwao Keur\u201d, Pueraria mirifica. The known miroestrol may be an artifact. J Nat Prod 63:173\u2013175","journal-title":"J Nat Prod"},{"key":"442_CR6","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0921-8777(00)00069-0","volume":"485","author":"J Sierens","year":"2001","unstructured":"Sierens J, Hartley JA, Campbell MJ, Leathem AJC, Woodside JV (2001) Effect of phytoestrogen and antioxidant supplementation on oxidative DNA damage assessed using the comet assay. Mutat Res DNA Repair 485:169\u2013176","journal-title":"Mutat Res DNA Repair"},{"key":"442_CR7","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.neuro.2003.11.001","volume":"25","author":"M Sonee","year":"2004","unstructured":"Sonee M, Sum T, Wang C, Mukherjee SK (2004) The soy isoflavone, genistein, protects human cortical neuronal cells from oxidative stress. Neurotoxicology 25:885\u2013891","journal-title":"Neurotoxicology"},{"key":"442_CR8","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.nutres.2006.09.020","volume":"26","author":"M Lof","year":"2006","unstructured":"Lof M, Weiderpass E (2006) Epidemiologic evidence suggests that dietary phytoestrogen intake is associated with reduced risk of breast, endometrial, and prostate cancers. Nutr Res 26:609\u2013619","journal-title":"Nutr Res"},{"key":"442_CR9","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.tiv.2006.09.002","volume":"21","author":"HJ Wu","year":"2007","unstructured":"Wu HJ, Chan WH (2007) Genistein protects methylglyoxal-induced oxidative DNA damage and cell injury in human mononuclear cells. Toxicol In Vitro 21:335\u2013342","journal-title":"Toxicol In Vitro"},{"key":"442_CR10","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.freeradbiomed.2003.10.018","volume":"36","author":"H Zeng","year":"2004","unstructured":"Zeng H, Chen Q, Zhao B (2004) Genistein ameliorates beta-amyloid peptide (25\u201335)-induced hippocampal neuronal apoptosis. Free Radic Biol Med 36:180\u2013188","journal-title":"Free Radic Biol Med"},{"key":"442_CR11","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1146\/annurev.pa.36.040196.000503","volume":"36","author":"NA Simonian","year":"1996","unstructured":"Simonian NA, Coyle JT (1996) Oxidative stress in neurodegenerative diseases. Annu Rev Pharmacol Toxicol 36:83\u2013106","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"442_CR12","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1126\/science.7901908","volume":"262","author":"JT Coyle","year":"1993","unstructured":"Coyle JT, Puttfarcken P (1993) Oxidative stress, glutamate, and neurodegenerative disorders. Science 262:689\u2013695","journal-title":"Science"},{"key":"442_CR13","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1016\/j.lfs.2004.11.020","volume":"76","author":"M Sokmen","year":"2005","unstructured":"Sokmen M, Angelova M, Krumova E, Pashova S, Ivancheva S, Sokmen A, Serkedjieva J (2005) In vitro antioxidant activity of polyphenol extracts with antiviral properties from Geranium sanguineum L. Life Sci 76:2981\u20132993","journal-title":"Life Sci"},{"key":"442_CR14","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/jnci\/82.13.1107","volume":"82","author":"P Skehan","year":"1990","unstructured":"Skehan P, Storeng R, Scudiero D, Monks A, McMahon J, Vistica D, Warren JT, Bokesch H, Kenney S, Boyd MR (1990) New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst 82:1107\u20131112","journal-title":"J Natl Cancer Inst"},{"key":"442_CR15","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/S0142-9612(96)80001-9","volume":"17","author":"G Ciapetti","year":"1996","unstructured":"Ciapetti G, Granchi D, Verri E, Savarino L, Cavedagna D, Pizzoferrato A (1996) Application of a combination of neutral red and amido black staining for rapid, reliable cytotoxicity testing of biomaterials. Biomaterials 17:1259\u20131264","journal-title":"Biomaterials"},{"key":"442_CR16","doi-asserted-by":"crossref","first-page":"4619","DOI":"10.1021\/jf010586o","volume":"49","author":"B Ou","year":"2001","unstructured":"Ou B, Hampsch-Woodill M, Prior RL (2001) Development and validation of an improved oxygen radical absorbance capacity assay using fluorescein as the fluorescent probe. J Agric Food Chem 49:4619\u20134626","journal-title":"J Agric Food Chem"},{"key":"442_CR17","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0304-4165(02)00217-9","volume":"1571","author":"J Choi","year":"2002","unstructured":"Choi J, Conrad CC, Malakowsky CA, Talent JM, Yuan CS, Gracy RW (2002) Flavones from Scutellaria baicalensis Georgi attenuate apoptosis and protein oxidation in neuronal cell lines. Biochim Biophys Acta 1571:201\u2013210","journal-title":"Biochim Biophys Acta"},{"key":"442_CR18","doi-asserted-by":"crossref","first-page":"4290","DOI":"10.1021\/jf0502698","volume":"53","author":"RL Prior","year":"2005","unstructured":"Prior RL, Wu X, Schaich K (2005) Standardized methods for the determination of antioxidant capacity and phenolics in foods and dietary supplements. J Agric Food Chem 53:4290\u20134302","journal-title":"J Agric Food Chem"},{"key":"442_CR19","doi-asserted-by":"crossref","first-page":"7748","DOI":"10.1073\/pnas.95.13.7748","volume":"95","author":"Y Li","year":"1998","unstructured":"Li Y, Maher P, Schubert D (1998) Phosphatidylcholine-specific phospholipase C regulates glutamate-induced nerve cell death. Proc Natl Acad Sci USA 95:7748\u20137753","journal-title":"Proc Natl Acad Sci USA"},{"key":"442_CR20","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/0896-6273(89)90043-3","volume":"2","author":"TH Murphy","year":"1989","unstructured":"Murphy TH, Miyamoto M, Sastre A, Schnaar RL, Coyle JT (1989) Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress. Neuron 2:1547\u20131558","journal-title":"Neuron"},{"key":"442_CR21","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0891-5849(00)00498-6","volume":"30","author":"K Ishige","year":"2001","unstructured":"Ishige K, Schubert D, Sagara Y (2001) Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms. Free Radic Biol Med 30:433\u2013446","journal-title":"Free Radic Biol Med"},{"key":"442_CR22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0304-4165(97)00125-6","volume":"1380","author":"AJ Nappi","year":"1998","unstructured":"Nappi AJ, Vass E (1998) Hydroxyl radical formation resulting from the interaction of nitric oxide and hydrogen peroxide. Biochim Biophys Acta 1380:55\u201363","journal-title":"Biochim Biophys Acta"},{"key":"442_CR23","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0891-5849(88)90104-9","volume":"5","author":"PLB Cheton","year":"1988","unstructured":"Cheton PLB, Archibald FS (1988) Manganese complexes and the generation and scavenging of hydroxyl free radicals. Free Radic Biol Med 5:325\u2013333","journal-title":"Free Radic Biol Med"},{"key":"442_CR24","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/jlb.47.5.440","volume":"47","author":"G Rothe","year":"1990","unstructured":"Rothe G, Valet G (1990) Flow cytometric analysis of respiratory burst activity in phagocytes with hydroethidine and 2\u2032,7\u2032-dichlorofluorescin. J Leukoc Biol 47:440\u2013448","journal-title":"J Leukoc Biol"}],"container-title":["Journal of Natural Medicines"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-010-0442-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11418-010-0442-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-010-0442-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T14:46:57Z","timestamp":1559400417000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11418-010-0442-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,24]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["442"],"URL":"https:\/\/doi.org\/10.1007\/s11418-010-0442-5","relation":{},"ISSN":["1340-3443","1861-0293"],"issn-type":[{"value":"1340-3443","type":"print"},{"value":"1861-0293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,24]]}}}