{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:26:02Z","timestamp":1788837962561,"version":"build-2803163510"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2011,1,22]],"date-time":"2011-01-22T00:00:00Z","timestamp":1295654400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nat Med"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1007\/s11418-010-0496-4","type":"journal-article","created":{"date-parts":[[2011,1,21]],"date-time":"2011-01-21T04:29:44Z","timestamp":1295584184000},"page":"330-335","source":"Crossref","is-referenced-by-count":27,"title":["Evaluation of anti-inflammatory and antinociceptive effects of D-002 (beeswax alcohols)"],"prefix":"10.1007","volume":"65","author":[{"given":"Yazmin","family":"Ravelo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy","family":"Carbajal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilia","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio C.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda L.","family":"Arruzazabala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"M\u00e1s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,1,22]]},"reference":[{"key":"496_CR1","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1111\/j.1582-4934.2010.01022.x","volume":"30","author":"RJ Wierda","year":"2010","unstructured":"Wierda RJ, Geutskens SB, Jukema JW, Quax PH, van den Elsen PJ (2010) Epigenetics in atherosclerosis and inflammation. J Cell Mol Med 30:1225\u20131240","journal-title":"J Cell Mol Med"},{"key":"496_CR2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cyto.2009.12.015","volume":"50","author":"CF Gokkusu","year":"2010","unstructured":"Gokkusu CF, Tulubas F, Unlucerci Y, Ozkok E, Umman B, Aydin M (2010) Homocysteine and pro-inflammatory cytokine concentrations in acute heart disease. Cytokine 50:15\u201318","journal-title":"Cytokine"},{"key":"496_CR3","first-page":"1563","volume":"30","author":"TA Abdel-Meguid","year":"2009","unstructured":"Abdel-Meguid TA, Mosli HA, Al-Maghrabi JA (2009) Prostate inflammation: association with benign prostatic hyperplasia and prostate cancer. Saudi Med J 30:1563\u20131567","journal-title":"Saudi Med J"},{"issue":"1","key":"496_CR4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.berh.2009.08.005","volume":"24","author":"AM Vald\u00e9s","year":"2010","unstructured":"Vald\u00e9s AM, Spector TD (2010) The clinical relevance of genetic susceptibility to osteoarthritis. Best Pract Res Clin Rheumatol 24(1):3\u201314","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"496_CR5","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00776-007-1139-9","volume":"12","author":"H Yajima","year":"2007","unstructured":"Yajima H, Yamao J, Fukui H, Takakura Y (2007) Up-to-date information on gastric mucosal lesions from long-term NSAID therapy in orthopaedic outpatients: a study using logistic regression analysis. J Orthop Sci 12:341\u2013346","journal-title":"J Orthop Sci"},{"key":"496_CR6","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/00045391-200007020-00008","volume":"7","author":"G Singh","year":"2000","unstructured":"Singh G (2000) Gastrointestinal complications of prescription and over-the-counter non-steroidal anti-inflammatory drugs: a view from the ARAMIS database. Am J Ther 7:115\u2013121","journal-title":"Am J Ther"},{"key":"496_CR7","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1358\/dof.2001.026.08.630956","volume":"26","author":"R M\u00e1s","year":"2001","unstructured":"M\u00e1s R (2001) D-002: a product obtained from beeswax. Drugs Future 26:731\u2013744","journal-title":"Drugs Future"},{"key":"496_CR8","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0952-3278(98)90135-1","volume":"59","author":"D Carbajal","year":"1998","unstructured":"Carbajal D, Molina V, Vald\u00e9s S, Arruzazabala ML, M\u00e1s R, Magraner J (1998) Anti-inflammatory activity of D-002: an active product isolated from beeswax. Prostagl Leukotr Essent Fatty Acids 59:235\u2013238","journal-title":"Prostagl Leukotr Essent Fatty Acids"},{"key":"496_CR9","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/j.2042-7158.1995.tb06732.x","volume":"47","author":"D Carbajal","year":"1995","unstructured":"Carbajal D, Molina V, Vald\u00e9s S, Arruzazabala ML, M\u00e1s R (1995) Anti-ulcer activity of higher primary alcohols of beeswax. J Pharm Phamacol 47:731\u2013733","journal-title":"J Pharm Phamacol"},{"key":"496_CR10","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1111\/j.2042-7158.1996.tb03987.x","volume":"48","author":"D Carbajal","year":"1996","unstructured":"Carbajal D, Molina V, Vald\u00e9s S, Arruzazabala ML, Rodeiro I, M\u00e1s R, Magraner J (1996) Possible cytoprotective mechanism in rats of D-002 an anti-ulcerogenic product isolated from beeswax. J Pharm Pharmacol 48:858\u2013860","journal-title":"J Pharm Pharmacol"},{"key":"496_CR11","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1006\/phrs.2000.0693","volume":"42","author":"D Carbajal","year":"2000","unstructured":"Carbajal D, Molina V, Noa M, Vald\u00e9s S, Arruzazabala ML, Aguiar A, M\u00e1s R (2000) Effects of D-002 on gastric mucus composition in ethanol-induced ulcer. Pharmacol Res 42:329\u2013332","journal-title":"Pharmacol Res"},{"key":"496_CR12","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1089\/109662001300341734","volume":"4","author":"V Molina","year":"2001","unstructured":"Molina V, Vald\u00e9s S, Carbajal D, Arruzazabala ML, Men\u00e9ndez R, M\u00e1s R (2001) Antioxidant effects of D-002 on gastric mucosa of rats with experimentally-induced injury. J Med Food 4:79\u201383","journal-title":"J Med Food"},{"key":"496_CR13","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1089\/jmf.2005.8.59","volume":"18","author":"V Molina","year":"2005","unstructured":"Molina V, Carbajal D, Arruzazabala ML, M\u00e1s R (2005) Therapeutic effect of D-002 (Abexol) on gastric ulcer induced experimentally in rats. J Med Food 18:59\u201362","journal-title":"J Med Food"},{"key":"496_CR14","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/S0011-393X(01)89004-4","volume":"62","author":"O Hano","year":"2001","unstructured":"Hano O, Illnait J, M\u00e1s R, Fern\u00e1ndez L, Pi\u00f1ol F, Fern\u00e1ndez J (2001) Effects of D-002, a product isolated from beeswax, on duodenal ulcer: a double-blind, placebo-controlled study. Curr Ther Res 62:394\u2013407","journal-title":"Curr Ther Res"},{"key":"496_CR15","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1089\/jmf.2005.8.63","volume":"8","author":"J Illnait","year":"2005","unstructured":"Illnait J, Terry H, M\u00e1s R, Fern\u00e1ndez L, Carbajal D (2005) Effects of D-002, a product isolated from beeswax, on gastric symptoms of patients with osteoarthritis treated with piroxicam: a pilot study. J Med Food 8:63\u201368","journal-title":"J Med Food"},{"key":"496_CR16","first-page":"147","volume":"40","author":"I Rodr\u00edguez","year":"2009","unstructured":"Rodr\u00edguez I, Illnait J, Terry H, M\u00e1s R, Fernandez L, Fern\u00e1ndez JC, G\u00e1mez R, Mesa M, Mendoza S, Ruiz D, Cruz Y (2009) Effects of Abexol\u00ae (beeswax alcohols) on gastrointestinal symptoms of middle-aged and older subjects. Rev CENIC Cien Biol 40:147\u2013154","journal-title":"Rev CENIC Cien Biol"},{"key":"496_CR17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3736\/jcim20070101","volume":"5","author":"S Lin","year":"2007","unstructured":"Lin S, Zhang H, Han T, Wu J, Rahman K, Qin L (2007) In vivo effect of casticin on acute inflammation. J Chin Integr Med 5:1\u20134","journal-title":"J Chin Integr Med"},{"key":"496_CR18","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1248\/bpb.28.176","volume":"28","author":"K Junping","year":"2005","unstructured":"Junping K, Yun N, Wang N, Liang L, Zhi-Hong H (2005) Analgesic and anti-inflammatory activities of total extract and individual fractions of Chinese medicinal plants Polyrhachis lamellidens. Biol Pharm Bull 28:176\u2013180","journal-title":"Biol Pharm Bull"},{"key":"496_CR19","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1213\/ane.0b013e318172b993","volume":"106","author":"RM Stepanovic-Petrovic","year":"2008","unstructured":"Stepanovic-Petrovic RM, Tomic MA, Vuckovic SM, Paranos S, Ugresic ND, Prostran MS, Milovanovic S, Boskovic B (2008) The antinociceptive effects of anticonvulsants in a mouse visceral pain model. Anesth Analg 106:1897\u20131990","journal-title":"Anesth Analg"},{"key":"496_CR20","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1254\/jphs.08094FP","volume":"109","author":"S Chiba","year":"2009","unstructured":"Chiba S, Nishiyama T, Yoshikawa M, Yamada Y (2009) The antinociceptive effects of midazolam on three different types of nociception in mice. J Pharmacol Sci 109:71\u201377","journal-title":"J Pharmacol Sci"},{"key":"496_CR21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/978-1-60327-323-7_4","volume":"617","author":"JM Boyce-Rustay","year":"2010","unstructured":"Boyce-Rustay JM, Honore P, Jarvis MF (2010) Animal models of acute and chronic inflammatory and nociceptive pain. Methods Mol Biol 617:41\u201355","journal-title":"Methods Mol Biol"},{"key":"496_CR22","first-page":"123","volume":"39","author":"V Gonz\u00e1lez","year":"2008","unstructured":"Gonz\u00e1lez V, Marrero D, Sierra R, Vel\u00e1zquez C, Vicente R (2008) Nuevo m\u00e9todo por cromatograf\u00eda gaseosa capilar para el an\u00e1lisis del ingrediente activo D-002. Rev CENIC Cien Quim 39:123\u2013125","journal-title":"Rev CENIC Cien Quim"},{"key":"496_CR23","unstructured":"Worthington Biochemical Corp (1972) Worthington enzyme manual. Worthington Biochemical Corp, New Jersey, pp 43\u201345"},{"key":"496_CR24","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jep.2007.05.024","volume":"113","author":"TC Lu","year":"2007","unstructured":"Lu TC, Ko YZ, Huang HW, Hung YC, Lin YC, Peng WH (2007) Analgesic and anti-inflammatory activities of aqueous extract from Glycine tomentella root in mice. J Ethnopharmacol 113:142\u2013148","journal-title":"J Ethnopharmacol"},{"key":"496_CR25","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/0014-2999(79)90327-3","volume":"58","author":"P Holzer","year":"1979","unstructured":"Holzer P, Jurna I, Gambe R, Lembeck F (1979) Nociceptive threshold after neonatal capsaicin treatment. Eur J Pharmacol 58:511\u2013514","journal-title":"Eur J Pharmacol"},{"key":"496_CR26","unstructured":"Fern\u00e1ndez L, P\u00e9rez H, M\u00e1s R (1987) Efectos de Justicia pectoralis sobre la conducta exploratoria en ratones. En Estudios Avanzados en Neurociencias. CENIC, Cuba, pp 257\u2013264"},{"key":"496_CR27","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0091-3057(77)90036-3","volume":"6","author":"L Coughenour","year":"1977","unstructured":"Coughenour L, McLean J, Parker R (1977) A new device for the rapid measurement of impaired motor function in mice. Pharmacol Biochem Behavior 6:351\u2013355","journal-title":"Pharmacol Biochem Behavior"},{"key":"496_CR28","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1089\/ars.2009.2538","volume":"11","author":"BS Veen van der","year":"2009","unstructured":"van der Veen BS, de Winther MP, Heeringa P, Augusto O, Chen JW, Davies M, Ma XL, Malle E, Pignatelli P, Rudolph T (2009) Myeloperoxidase: molecular mechanisms of action and their relevance to human health and disease. Antioxid Redox Signal 11:2899\u20132937","journal-title":"Antioxid Redox Signal"},{"key":"496_CR29","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1590\/S0100-879X2000000100012","volume":"33","author":"R Men\u00e9ndez","year":"2000","unstructured":"Men\u00e9ndez R, Amor AM, Gonz\u00e1lez RM, Jim\u00e9nez S, M\u00e1s R (2000) Inhibition of rat microsomal lipid peroxidation by the oral administration of D-002. Braz J Med Biol Res 33:85\u201390","journal-title":"Braz J Med Biol Res"},{"key":"496_CR30","first-page":"3","volume":"33","author":"Y P\u00e9rez","year":"2002","unstructured":"P\u00e9rez Y, Gonzalez RM, Amor AM, Jim\u00e9nez S, Men\u00e9ndez R (2002) D-002 on antioxidant enzymes in liver and brain of rats. Rev CENIC Cien Biol 33:3\u20135","journal-title":"Rev CENIC Cien Biol"},{"key":"496_CR31","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/S0188-4409(01)00315-0","volume":"32","author":"R Men\u00e9ndez","year":"2001","unstructured":"Men\u00e9ndez R, M\u00e1s R, Amor AM, Perez Y, Gonz\u00e1lez RM, Fern\u00e1ndez JC, Jim\u00e9nez S (2001) Antioxidant effects of D-002 on the in vitro susceptibility in healthy volunteers. Arch Med Res 32:436\u2013441","journal-title":"Arch Med Res"},{"key":"496_CR32","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1089\/109662001300341725","volume":"4","author":"R Men\u00e9ndez","year":"2001","unstructured":"Men\u00e9ndez R, M\u00e1s R, Illnait J, P\u00e9rez J, Amor AM, Fern\u00e1ndez JC, Gonz\u00e1lez RM (2001) Effects of D-002 on lipid peroxidation in older subjects. J Med Food 4:71\u201377","journal-title":"J Med Food"},{"key":"496_CR33","first-page":"695","volume":"27","author":"E L\u00f3pez","year":"2008","unstructured":"L\u00f3pez E, Illnait J, Molina V, Oyarz\u00e1bal A, Fern\u00e1ndez L, P\u00e9rez Y, M\u00e1s R, Mesa M, Fern\u00e1ndez JC, Mendoza S, G\u00e1mez R, Jim\u00e9nez S, Ruiz D, Jardines Y (2008) Effects of D-002 (beeswax alcohols) on lipid peroxidation in middle-aged and older subjects. LAJP 27:695\u2013703","journal-title":"LAJP"},{"key":"496_CR34","first-page":"255","volume":"29","author":"I Rodriguez","year":"2009","unstructured":"Rodriguez I, Illnait J, Molina V, Oyarzabal A, Fern\u00e1ndez L, Fern\u00e1ndez JC, Mesa M, M\u00e1s R, Mendoza S, G\u00e1mez R, Jimenez Sy, Ruiz D (2009) Comparison of the antioxidant effects of D-002 (beeswax alcohols) and grape seed extract (GSE) on plasma oxidative variables in healthy subjects. LAJP 29:255\u2013262","journal-title":"LAJP"},{"key":"496_CR35","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.jep.2005.08.011","volume":"103","author":"HJ Koo","year":"2006","unstructured":"Koo HJ, Lim KH, Jung HJ, Park EH (2006) Anti-inflammatory evaluation of gardenia extract, geniposide and genipin. J Ethnopharmacol 103:496\u2013500","journal-title":"J Ethnopharmacol"},{"key":"496_CR36","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1016\/j.lfs.2005.05.031","volume":"77","author":"FA Oliveira","year":"2005","unstructured":"Oliveira FA, Costa CL, Chaves MH, Almeida FR, Cavalcante IJ, Lima AF, Lima RC Jr, Silva RM, Campos AR, Santos FA (2005) Attenuation of capsaicin-induced acute and visceral nociceptive pain by alpha-and beta-amyrin, a triterpene mixture isolated from Protium heptaphyllum resin in mice. Life Sci 77:2942\u20132952","journal-title":"Life Sci"},{"key":"496_CR37","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/0028-3908(87)90065-7","volume":"26","author":"SE File","year":"1987","unstructured":"File SE (1987) The contribution of behavioural studies to the neuropharmacology of anxiety. Neuropharmacology 26:877\u2013886","journal-title":"Neuropharmacology"},{"key":"496_CR38","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jneumeth.2006.06.001","volume":"158","author":"C Monville","year":"2006","unstructured":"Monville C, Torres EM, Dunnett SB (2006) Comparison of incremental and accelerating protocols of the rotarod test for the assessment of motor deficits in the 6-OHDA model. J Neurosci Methods 158:219\u2013223","journal-title":"J Neurosci Methods"}],"container-title":["Journal of Natural Medicines"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-010-0496-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11418-010-0496-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-010-0496-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T10:46:59Z","timestamp":1559386019000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11418-010-0496-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,22]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["496"],"URL":"https:\/\/doi.org\/10.1007\/s11418-010-0496-4","relation":{},"ISSN":["1340-3443","1861-0293"],"issn-type":[{"value":"1340-3443","type":"print"},{"value":"1861-0293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,22]]}}}