{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:06:33Z","timestamp":1789095993944,"version":"build-2803163510"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T00:00:00Z","timestamp":1418774400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nat Med"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1007\/s11418-014-0880-6","type":"journal-article","created":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T09:04:15Z","timestamp":1418720655000},"page":"209-217","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Inhibitory effect of Moutan Cortex aqueous fraction on mast cell-mediated allergic inflammation"],"prefix":"10.1007","volume":"69","author":[{"given":"Ji-Ye","family":"Kee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Inujima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsugunobu","family":"Andoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Kuraishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Sakurai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naotoshi","family":"Shibahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuo","family":"Saiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Koizumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,12,17]]},"reference":[{"key":"880_CR1","unstructured":"Pawankar R, Canonica GW, Holgate, ST, Lockey RF (2012) WAO White book on allergy 2011\u20132012: executive summary. http:\/\/www.worldallergy.org\/publications\/wao_white_book.pdf"},{"key":"880_CR2","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nri2018","volume":"7","author":"SC Bischoff","year":"2007","unstructured":"Bischoff SC (2007) Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data. Nat Rev Immunol 7:93\u2013104","journal-title":"Nat Rev Immunol"},{"key":"880_CR3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1600-065X.2007.00519.x","volume":"217","author":"TC Theoharides","year":"2007","unstructured":"Theoharides TC, Kempuraj D, Tagen M, Conti P, Kalogeromitros D (2007) Differential release of mast cell mediators and the pathogenesis of inflammation. Immunol Rev 217:65\u201378","journal-title":"Immunol Rev"},{"key":"880_CR4","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1159\/000087568","volume":"87","author":"S Yamasaki","year":"2005","unstructured":"Yamasaki S, Saito T (2005) Regulation of mast cell activation through FcepsilonRI. Chem Immunol Allergy 87:22\u201331","journal-title":"Chem Immunol Allergy"},{"key":"880_CR5","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1146\/annurev.immunol.21.120601.141025","volume":"23","author":"SJ Galli","year":"2005","unstructured":"Galli SJ, Kalesnikoff J, Grimbaldeston MA, Piliponsky AM, Williams CM, Tsai M (2005) Mast cells as \u201ctunable\u201d effector and immunoregulatory cells: recent advances. Annu Rev Immunol 23:749\u2013786","journal-title":"Annu Rev Immunol"},{"key":"880_CR6","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1002\/eji.201040559","volume":"40","author":"SJ Galli","year":"2010","unstructured":"Galli SJ, Tsai M (2010) Mast cells in allergy and infection: versatile effector and regulatory cells in innate and adaptive immunity. Eur J Immunol 40:1843\u20131851","journal-title":"Eur J Immunol"},{"key":"880_CR7","first-page":"403","volume-title":"The pharmacology of Chinese herbs","author":"KC Huang","year":"1999","unstructured":"Huang KC (1999) The pharmacology of Chinese herbs. CRC, New York, pp\u00a0403\u2013404"},{"key":"880_CR8","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1093\/ecam\/nel093","volume":"4","author":"SC Chun","year":"2007","unstructured":"Chun SC, Jee SY, Lee SG, Park SJ, Lee JR, Kim SC (2007) Anti-inflammatory activity of the methanol extract of moutan cortex in LPS-activated Raw264.7 cells. Evid Based Complement Alternat Med 4:327\u2013333","journal-title":"Evid Based Complement Alternat Med"},{"key":"880_CR9","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1271\/bbb.90676","volume":"74","author":"MH Hong","year":"2010","unstructured":"Hong MH, Kim JH, Na SH, Bae H, Shin YC, Kim SH, Ko SG (2010) Inhibitory effects of Paeonia suffruticosa on allergic reactions by inhibiting the NF-kappaB\/IkappaB-alpha signaling pathway and phosphorylation of ERK in an animal model and human mast cells. Biosci Biotechnol Biochem 74:1152\u20131156","journal-title":"Biosci Biotechnol Biochem"},{"key":"880_CR10","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1248\/bpb.30.1707","volume":"30","author":"S Jiang","year":"2007","unstructured":"Jiang S, Nakano Y, Yatsuzuka R, Ono R, Kamei C (2007) Inhibitory effects of Moutan cortex on immediate allergic reactions. Biol Pharm Bull 30:1707\u20131710","journal-title":"Biol Pharm Bull"},{"key":"880_CR11","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.intimp.2003.12.013","volume":"4","author":"SH Kim","year":"2004","unstructured":"Kim SH, Kim SA, Park MK, Kim SH, Park YD, Na HJ, Kim HM, Shin MK, Ahn KS (2004) Paeonol inhibits anaphylactic reaction by regulating histamine and TNF-alpha. Int Immunopharmacol 4:279\u2013287","journal-title":"Int Immunopharmacol"},{"key":"880_CR12","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s12272-001-1177-6","volume":"31","author":"B Lee","year":"2008","unstructured":"Lee B, Shin YW, Bae EA, Han SJ, Kim JS, Kang SS, Kim DH (2008) Antiallergic effect of the root of Paeonia lactiflora and its constituents paeoniflorin and paeonol. Arch Pharm Res 31:445\u2013450","journal-title":"Arch Pharm Res"},{"key":"880_CR13","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0898-6568(00)00070-X","volume":"12","author":"A Alfonso","year":"2000","unstructured":"Alfonso A, Cabado AG, Vieytes MR, Botana LM (2000) Functional compartments in rat mast cells for cAMP and calcium on histamine release. Cell Signal 12:343\u2013350","journal-title":"Cell Signal"},{"key":"880_CR14","doi-asserted-by":"crossref","first-page":"664","DOI":"10.4049\/jimmunol.112.2.664","volume":"112","author":"M Kaliner","year":"1974","unstructured":"Kaliner M, Austen KF (1974) Cyclic AMP, ATP, and reversed anaphylactic histamine release from rat mast cells. J Immunol 112:664\u2013674","journal-title":"J Immunol"},{"key":"880_CR15","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1089\/107999004323065057","volume":"24","author":"B Shakoory","year":"2004","unstructured":"Shakoory B, Fitzgerald SM, Lee SA, Chi DS, Krishnaswamy G (2004) The role of human mast cell-derived cytokines in eosinophil biology. J Interferon Cytokine Res 24:271\u2013281","journal-title":"J Interferon Cytokine Res"},{"key":"880_CR16","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1365-2249.2005.02678.x","volume":"139","author":"CK Wong","year":"2005","unstructured":"Wong CK, Wang CB, Ip WK, Tian YP, Lam CW (2005) Role of p38 MAPK and NF-kB for chemokine release in coculture of human eosinophils and bronchial epithelial cells. Clin Exp Immunol 139:90\u2013100","journal-title":"Clin Exp Immunol"},{"key":"880_CR17","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.4049\/jimmunol.139.8.2605","volume":"139","author":"BK Wershil","year":"1987","unstructured":"Wershil BK, Mekori YA, Murakami T, Galli SJ (1987) 125I-fibrin deposition in IgE-dependent immediate hypersensitivity reactions in mouse skin. Demonstration of the role of mast cells using genetically mast cell-deficient mice locally reconstituted with cultured mast cells. J Immunol 139:2605\u20132614","journal-title":"J Immunol"},{"key":"880_CR18","doi-asserted-by":"crossref","first-page":"317","DOI":"10.5115\/acb.2010.43.4.317","volume":"43","author":"YH Choi","year":"2010","unstructured":"Choi YH, Chai OH, Han EH, Choi SY, Kim HT, Song CH (2010) Lipoic acid suppresses compound 48\/80-induced anaphylaxis-like reaction. Anat Cell Biol 43:317\u2013324","journal-title":"Anat Cell Biol"},{"key":"880_CR19","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s00011-009-0074-y","volume":"58","author":"E Passante","year":"2009","unstructured":"Passante E, Frankish N (2009) The RBL-2H3 cell line: its provenance and suitability as a model for the mast cell. Inflamm Res 58:737\u2013745","journal-title":"Inflamm Res"},{"key":"880_CR20","doi-asserted-by":"crossref","first-page":"4220","DOI":"10.1073\/pnas.88.10.4220","volume":"88","author":"LJ Walsh","year":"1991","unstructured":"Walsh LJ, Trinchieri G, Waldorf HA, Whitaker D, Murphy GF (1991) Human dermal mast cells contain and release tumor necrosis factor alpha, which induces endothelial leukocyte adhesion molecule 1. Proc Natl Acad Sci USA 88:4220\u20134224","journal-title":"Proc Natl Acad Sci USA"},{"key":"880_CR21","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1159\/000233825","volume":"77","author":"N Chand","year":"1985","unstructured":"Chand N, Pillar J, Diamantis W, Sofia RD (1985) Inhibition of allergic histamine release by azelastine and selected antiallergic drugs from rabbit leukocytes. Int Arch Allergy Appl Immunol 77:451\u2013455","journal-title":"Int Arch Allergy Appl Immunol"},{"key":"880_CR22","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.4049\/jimmunol.159.6.2932","volume":"159","author":"I Hide","year":"1997","unstructured":"Hide I, Toriu N, Nuibe T, Inoue A, Hide M, Yamamoto S, Nakata Y (1997) Suppression of TNF-alpha secretion by 10% azelastine in a rat mast (RBL-2H3) cell line: evidence for differential regulation of TNF-alpha release, transcription, and degranulation. J Immunol 159:2932\u20132940","journal-title":"J Immunol"},{"key":"880_CR23","first-page":"631","volume":"15","author":"SW Lee","year":"2001","unstructured":"Lee SW, Kim DH, Seol IC, Kim SH (2001) Antiallergic effect of water and EA extract of Moutan radicis cortex. Korean J Orient Physiol Pathol 15:631\u2013635","journal-title":"Korean J Orient Physiol Pathol"},{"key":"880_CR24","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1111\/j.1471-4159.2009.06069.x","volume":"109","author":"H Fujiwara","year":"2009","unstructured":"Fujiwara H, Tabuchi M, Yamaguchi T, Iwasaki K, Furukawa K, Sekiguchi K, Ikarashi Y, Kudo Y, Higuchi M, Saido TC, Maeda S, Takashima A, Hara M, Yaegashi N, Kase Y, Arai H (2009) A traditional medicinal herb Paeonia suffruticosa and its active constituent 1,2,3,4,6-penta-O-galloyl-beta-d-glucopyranose have potent anti-aggregation effects on Alzheimer\u2019s amyloid beta proteins in vitro and in vivo. J Neurochem 109:1648\u20131657","journal-title":"J Neurochem"},{"key":"880_CR25","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.fob.2013.07.008","volume":"5","author":"YH Kim","year":"2013","unstructured":"Kim YH, Yoshimoto M, Nakayama K, Tanino S, Fujimura Y, Yamada K, Tachibana H (2013) Tannic acid, a higher galloylated pentagalloylglucose, suppresses antigen-specific IgE production by inhibiting \u025b germline transcription induced by STAT6 activation. FEBS Open Bio 5:341\u2013345","journal-title":"FEBS Open Bio"},{"key":"880_CR26","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.febslet.2009.11.007","volume":"584","author":"N Kageyama-Yahara","year":"2009","unstructured":"Kageyama-Yahara N, Suehiro Y, Maeda F, Kageyama S, Fukuoka J, Katagiri T, Yamamoto T, Kadowaki M (2009) Pentagalloylglucose down-regulates mast cell surface FcepsilonRI expression in vitro and in vivo. FEBS Lett 584:111\u2013118","journal-title":"FEBS Lett"}],"container-title":["Journal of Natural Medicines"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-014-0880-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11418-014-0880-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-014-0880-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,30]],"date-time":"2023-07-30T18:11:25Z","timestamp":1690740685000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11418-014-0880-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,17]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["880"],"URL":"https:\/\/doi.org\/10.1007\/s11418-014-0880-6","relation":{},"ISSN":["1340-3443","1861-0293"],"issn-type":[{"value":"1340-3443","type":"print"},{"value":"1861-0293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,17]]}}}