{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:12:53Z","timestamp":1777612373012,"version":"3.51.4"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T00:00:00Z","timestamp":1473292800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"a Grant-in-Aid from the Japan Health Sciences Foundation"},{"name":"the Research on Development of New Drugs from the Japan Agency for Medical Research and Development (AMED)"},{"name":"the All Kitasato Project Study Collaborative Research (AKPS)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nat Med"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1007\/s11418-016-1034-9","type":"journal-article","created":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T06:53:17Z","timestamp":1473317597000},"page":"105-113","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Ephedra Herb extract activates\/desensitizes transient receptor potential vanilloid 1 and reduces capsaicin-induced pain"],"prefix":"10.1007","volume":"71","author":[{"given":"Shunsuke","family":"Nakamori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7612-2870","authenticated-orcid":false,"given":"Sumiko","family":"Hyuga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiko","family":"Tanaka-Kagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideto","family":"Jinno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Hyuga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Hakamatsuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Odaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Goda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiko","family":"Hanawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,9,8]]},"reference":[{"key":"1034_CR1","unstructured":"Ministry of Health, Labor and Welfare of Japan (2010) The Japanese pharmacopoeia, 16th edn. Tokyo"},{"key":"1034_CR2","volume-title":"Today\u2019s drug therapy in 2015","author":"A Urabe","year":"2015","unstructured":"Urabe A, Shimada K, Kwai S (2015) Today\u2019s drug therapy in 2015. Nankodo, Tokyo"},{"key":"1034_CR3","volume-title":"Monographs of pharmacological research on traditional herbal medicines (Shoyaku no yakuso yakuri)","author":"K Toriizuka","year":"2003","unstructured":"Toriizuka K (2003) Monographs of pharmacological research on traditional herbal medicines (Shoyaku no yakuso yakuri). Ishiyaku, Tokyo"},{"key":"1034_CR4","volume-title":"Pharmacist\u2019s letter\/Prescriber\u2019s letter natural medicines comprehensive database","author":"F Batz","year":"2012","unstructured":"Batz F, Hitchens K, Jellin JM (2012) Pharmacist\u2019s letter\/Prescriber\u2019s letter natural medicines comprehensive database, 13th edn. Therapeutic Research Faculty, Stockton","edition":"13"},{"key":"1034_CR5","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1254\/jphs.FP0050637","volume":"100","author":"MJ Yeom","year":"2006","unstructured":"Yeom MJ, Lee HC, Kim GH, Lee HJ, Shim I, Oh SK, Kang SK, Hahm DH (2006) Anti-arthritic effects of Ephedra sinica STAPF herb-acupuncture: inhibition of lipopolysaccharide-induced inflammation and adjuvant-induced polyarthritis. J Pharmacol Sci 100:41\u201350","journal-title":"J Pharmacol Sci"},{"key":"1034_CR6","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1055\/s-2007-969503","volume":"4","author":"Y Kasahara","year":"1985","unstructured":"Kasahara Y, Hikino H, Tsurufuji S, Watanabe M, Ohuchi K (1985) Antiinflammatory actions of ephedrines in acute inflammations. Planta Med 4:325\u2013331","journal-title":"Planta Med"},{"key":"1034_CR7","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s11418-016-0979-z","volume":"70","author":"S Hyuga","year":"2016","unstructured":"Hyuga S, Hyuga M, Oshima M, Maruyama M, Kamakura H, Yamashita T, Yoshimura M, Amakura Y, Hakamatsuka T, Odaguchi H, Goda Y, Hanawa T (2016) Ephedrine alkaloids-free Ephedra Herb extract: a safer alternative to ephedra with comparable analgesic, anticancer, and anti-influenza activities. J Nat Med 70:571\u2013583","journal-title":"J Nat Med"},{"key":"1034_CR8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neuroscience.2011.12.041","volume":"211","author":"M Barrot","year":"2012","unstructured":"Barrot M (2012) Tests and models of nociception and pain in rodents. Neuroscience 211:39\u201350","journal-title":"Neuroscience"},{"key":"1034_CR9","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/39807","volume":"389","author":"MJ Caterina","year":"1997","unstructured":"Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D (1997) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389:816\u2013824","journal-title":"Nature"},{"key":"1034_CR10","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0896-6273(00)80564-4","volume":"21","author":"M Tominaga","year":"1998","unstructured":"Tominaga M, Caterina MJ, Malmberg AB, Rosen TA, Gilbert H, Skinner K, Raumann BE, Basbaum AI, Julius D (1998) The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 21:531\u2013543","journal-title":"Neuron"},{"key":"1034_CR11","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/22761","volume":"400","author":"PM Zygmunt","year":"1999","unstructured":"Zygmunt PM, Petersson J, Andersson DA, Chuang H, S\u00f8rg\u00e5rd M, Di Marzo V, Julius D, H\u00f6gest\u00e4tt ED (1999) Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature 400:452\u2013457","journal-title":"Nature"},{"key":"1034_CR12","doi-asserted-by":"crossref","first-page":"6155","DOI":"10.1073\/pnas.97.11.6155","volume":"97","author":"SW Hwang","year":"2000","unstructured":"Hwang SW, Cho H, Kwak J, Lee SY, Kang CJ, Jung J, Cho S, Min KH, Suh YG, Kim D, Oh U (2000) Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances. Proc Natl Acad Sci USA 97:6155\u20136160","journal-title":"Proc Natl Acad Sci USA"},{"key":"1034_CR13","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.tips.2012.09.002","volume":"33","author":"J Szolcs\u00e1nyi","year":"2012","unstructured":"Szolcs\u00e1nyi J, S\u00e1ndor Z (2012) Multisteric TRPV1 nocisensor: a target for analgesics. Trends Pharmacol Sci 33:646\u2013655","journal-title":"Trends Pharmacol Sci"},{"key":"1034_CR14","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00424-005-1423-5","volume":"451","author":"R Planells-Cases","year":"2005","unstructured":"Planells-Cases R, Garc\u00eca-Sanz N, Morenilla-Palao C, Ferrer-Montiel A (2005) Functional aspects and mechanisms of TRPV1 involvement in neurogenic inflammation that leads to thermal hyperalgesia. Pflug Arch 451:151\u2013159","journal-title":"Pflug Arch"},{"key":"1034_CR15","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/ejn.12466","volume":"39","author":"GR Lewin","year":"2014","unstructured":"Lewin GR, Nykjaer A (2014) Pro-neurotrophins, sortilin, and nociception. Eur J Neurosci 39:363\u2013374","journal-title":"Eur J Neurosci"},{"key":"1034_CR16","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1124\/pr.112.006163","volume":"64","author":"J O\u2019Neill","year":"2012","unstructured":"O\u2019Neill J, Brock C, Olesen AE, Andresen T, Nilsson M, Dickenson AH (2012) Unravelling the mystery of capsaicin: a tool to understand and treat pain. Pharmacol Rev 64:939\u2013971","journal-title":"Pharmacol Rev"},{"key":"1034_CR17","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1248\/bpb.33.1434","volume":"33","author":"S Ohkawara","year":"2010","unstructured":"Ohkawara S, Tanaka-Kagawa T, Furukawa Y, Nishimura T, Jinno H (2010) Activation of the human transient receptor potential vanilloid subtype 1 by essential oils. Biol Pharm Bull 33:1434\u20131437","journal-title":"Biol Pharm Bull"},{"key":"1034_CR18","doi-asserted-by":"crossref","first-page":"831","DOI":"10.2131\/jts.37.831","volume":"37","author":"S Ohkawara","year":"2012","unstructured":"Ohkawara S, Tanaka-Kagawa T, Furukawa Y, Jinno H (2012) Methylglyoxal activates the human transient receptor potential ankyrin 1 channel. J Toxicol Sci 37:831\u2013835","journal-title":"J Toxicol Sci"},{"key":"1034_CR19","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1055\/s-2006-931564","volume":"72","author":"CM Melo","year":"2006","unstructured":"Melo CM, Maia JL, Cavalcante IJ, Lima MA, Vieira GA, Silveira ER, Rao VS, Santos FA (2006) 12-Acetoxyhawtriwaic acid lactone, a diterpene from Egletes viscosa, attenuates capsaicin-induced ear edema and hindpaw nociception in mice: possible mechanisms. Planta Med 72:584\u2013589","journal-title":"Planta Med"},{"key":"1034_CR20","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/j.1600-0773.1990.tb00766.x","volume":"66","author":"JH Rosland","year":"1990","unstructured":"Rosland JH, Hunskaar S, Hole K (1990) Diazepam attenuates morphine antinociception test-dependently in mice. Pharmacol Toxicol 66:382\u2013386","journal-title":"Pharmacol Toxicol"},{"key":"1034_CR21","doi-asserted-by":"crossref","first-page":"40601","DOI":"10.1074\/jbc.M111.256669","volume":"286","author":"S Wang","year":"2011","unstructured":"Wang S, Chuang HH (2011) C-terminal dimerization activates the nociceptive transduction channel transient receptor potential vanilloid 1. J Biol Chem 286:40601\u201340607","journal-title":"J Biol Chem"},{"key":"1034_CR22","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1124\/jpet.102.045674","volume":"306","author":"KJ Valenzano","year":"2003","unstructured":"Valenzano KJ, Grant ER, Wu G, Hachicha M, Schmid L, Tafesse L, Sun Q, Rotshteyn Y, Francis J, Limberis J, Malik S, Whittemore ER, Hodges D (2003) N-(4-Tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties. J Pharmacol Exp Ther 306:377\u2013386","journal-title":"J Pharmacol Exp Ther"},{"key":"1034_CR23","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1124\/jpet.102.046268","volume":"306","author":"JD Pomonis","year":"2003","unstructured":"Pomonis JD, Harrison JE, Mark L, Bristol DR, Valenzano KJ, Walker K (2003) N-(4-Tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropathic pain. J Pharmacol Exp Ther 306:387\u2013393","journal-title":"J Pharmacol Exp Ther"},{"key":"1034_CR24","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1055\/s-0032-1315387","volume":"78","author":"H Okumi","year":"2012","unstructured":"Okumi H, Takashima K, Matsumoto K, Namiki T, Terasawa K, Horie S (2012) Dietary agonists of TRPV1 inhibit gastric acid secretion in mice. Planta Med 78:1801\u20131806","journal-title":"Planta Med"},{"key":"1034_CR25","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1124\/mol.105.015727","volume":"68","author":"NR Gavva","year":"2005","unstructured":"Gavva NR, Tamir R, Klionsky L, Norman MH, Louis JC, Wild KD, Treanor JJ (2005) Proton activation does not alter antagonist interaction with the capsaicin-binding pocket of TRPV1. Mol Pharmacol 68:1524\u20131533","journal-title":"Mol Pharmacol"},{"key":"1034_CR26","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1007\/978-3-319-05161-1_19","volume":"223","author":"FC Meotti","year":"2014","unstructured":"Meotti FC, Lemos de Andrade E, Calixto JB (2014) TRP modulation by natural compounds. Handb Exp Pharmacol 223:1177\u20131238","journal-title":"Handb Exp Pharmacol"},{"key":"1034_CR27","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1055\/s-2003-39701","volume":"69","author":"Y Kobayashi","year":"2003","unstructured":"Kobayashi Y (2003) The nociceptive and anti-nociceptive effects of evodiamine from fruits of Evodia rutaecarpa in mice. Planta Med 69:425\u2013428","journal-title":"Planta Med"},{"key":"1034_CR28","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1093\/bja\/aer260","volume":"107","author":"P Anand","year":"2011","unstructured":"Anand P, Bley K (2011) Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch. Br J Anaesth 107:490\u2013502","journal-title":"Br J Anaesth"},{"key":"1034_CR29","doi-asserted-by":"crossref","first-page":"7","DOI":"10.2147\/JPR.S25272","volume":"5","author":"LR Webster","year":"2012","unstructured":"Webster LR, Peppin JF, Murphy FT, Tobias JK, Vanhove GF (2012) Tolerability of NGX-4010, a capsacin 8% patch, in conjunction with three topical anesthetic formulations for the treatment of neuropathic pain. J Pain Res 5:7\u201313","journal-title":"J Pain Res"},{"key":"1034_CR30","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/ejp.703","volume":"20","author":"T Mainka","year":"2016","unstructured":"Mainka T, Malewicz NM, Baron R, Enax-Krumova EK, Treede RD, Maier C (2016) Presence of hyperalgesia predicts analgesic efficacy of topically applied capsaicin 8% in patients with peripheral neuropathic pain. Eur J Pain 20:116\u2013129","journal-title":"Eur J Pain"},{"key":"1034_CR31","doi-asserted-by":"crossref","first-page":"122","DOI":"10.2174\/138920111793937826","volume":"12","author":"F Touska","year":"2011","unstructured":"Touska F, Marsakova L, Teisinger J, Vlachova V (2011) A \u201ccute\u201d desensitization of TRPV1. Curr Pharm Biotechnol 12:122\u2013129","journal-title":"Curr Pharm Biotechnol"},{"key":"1034_CR32","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1523\/JNEUROSCI.17-10-03525.1997","volume":"17","author":"PA Koplas","year":"1997","unstructured":"Koplas PA, Rosenberg RL, Oxford GS (1997) The role of calcium in the desensitization of capsaicin responses in rat dorsal root ganglion neurons. J Neurosci 17:3525\u20133537","journal-title":"J Neurosci"},{"key":"1034_CR33","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.ceca.2003.11.003","volume":"35","author":"S Mandadi","year":"2004","unstructured":"Mandadi S, Numazaki M, Tominaga M, Bhat MB, Armati PJ, Roufogalis BD (2004) Activation of protein kinase C reverses capsaicin-induced calcium-dependent desensitization of TRPV1 ion channels. Cell Calcium 35:471\u2013478","journal-title":"Cell Calcium"},{"key":"1034_CR34","doi-asserted-by":"crossref","first-page":"13424","DOI":"10.1074\/jbc.M410917200","volume":"280","author":"DP Mohapatra","year":"2005","unstructured":"Mohapatra DP, Nau C (2005) Regulation of Ca2+-dependent desensitization in the vanilloid receptor TRPV1 by calcineurin and cAMP-dependent protein kinase. J Biol Chem 280:13424\u201313432","journal-title":"J Biol Chem"},{"key":"1034_CR35","doi-asserted-by":"crossref","first-page":"8002","DOI":"10.1073\/pnas.1337252100","volume":"100","author":"M Numazaki","year":"2003","unstructured":"Numazaki M, Tominaga T, Takeuchi K, Murayama N, Toyooka H, Tominaga M (2003) Structural determinant of TRPV1 desensitization interacts with calmodulin. Proc Natl Acad Sci USA 100:8002\u20138006","journal-title":"Proc Natl Acad Sci USA"},{"key":"1034_CR36","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1085\/jgp.200308906","volume":"123","author":"T Rosenbaum","year":"2004","unstructured":"Rosenbaum T, Gordon-Shaag A, Munari M, Gordon SE (2004) Ca2+\/calmodulin modulates TRPV1 activation by capsaicin. J Gen Physiol 123:53\u201362","journal-title":"J Gen Physiol"},{"key":"1034_CR37","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.neuron.2007.05.027","volume":"54","author":"PV Lishko","year":"2007","unstructured":"Lishko PV, Procko E, Jin X, Phelps CB, Gaudet R (2007) The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity. Neuron 54:905\u2013918","journal-title":"Neuron"},{"key":"1034_CR38","doi-asserted-by":"crossref","first-page":"19462","DOI":"10.1074\/jbc.M111.289751","volume":"287","author":"L Sanz-Salvador","year":"2012","unstructured":"Sanz-Salvador L, Andr\u00e9s-Borderia A, Ferrer-Montiel A, Planells-Cases R (2012) Agonist- and Ca2+-dependent desensitization of TRPV1 channel targets the receptor to lysosomes for degradation. J Biol Chem 287:19462\u201319471","journal-title":"J Biol Chem"},{"key":"1034_CR39","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.jpain.2009.09.019","volume":"11","author":"WR Kennedy","year":"2010","unstructured":"Kennedy WR, Vanhove GF, Lu SP, Tobias J, Bley KR, Walk D, Wendelschafer-Crabb G, Simone DA, Selim MM (2010) A randomized, controlled, open-label study of the long-term effects of NGX-4010, a high-concentration capsaicin patch, on epidermal nerve fiber density and sensory function in healthy volunteers. J Pain 11:579\u2013587","journal-title":"J Pain"},{"key":"1034_CR40","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.jep.2014.05.065","volume":"155","author":"P Wei","year":"2014","unstructured":"Wei P, Huo HL, Ma QH, Li HC, Xing XF, Tan XM, Luo JB (2014) Pharmacokinetic comparisons of five ephedrine alkaloids following oral administration of four different Mahuang-Guizhi herb-pair aqueous extracts ratios in rats. J Ethnopharmacol 155:642\u2013648","journal-title":"J Ethnopharmacol"},{"key":"1034_CR41","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1111\/bph.12414","volume":"171","author":"Y Kaneko","year":"2014","unstructured":"Kaneko Y, Szallasi A (2014) Transient receptor potential (TRP) channels: a clinical perspective. Br J Pharmacol 171:2474\u20132507","journal-title":"Br J Pharmacol"},{"key":"1034_CR42","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.pain.2008.01.024","volume":"136","author":"NR Gavva","year":"2008","unstructured":"Gavva NR, Treanor JJ, Garami A, Fang L, Surapaneni S, Akrami A, Alvarez F, Bak A, Darling M, Gore A, Jang GR, Kesslak JP, Ni L, Norman MH, Palluconi G, Rose MJ, Salfi M, Tan E, Romanovsky AA, Banfield C, Davar G (2008) Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans. Pain 136:202\u2013210","journal-title":"Pain"},{"key":"1034_CR43","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.pain.2011.01.051","volume":"152","author":"MC Rowbotham","year":"2011","unstructured":"Rowbotham MC, Nothaft W, Duan WR, Wang Y, Faltynek C, McGaraughty S, Chu KL, Svensson P (2011) Oral and cutaneous thermosensory profile of selective TRPV1 inhibition by ABT-102 in a randomized healthy volunteer trial. Pain 152:1192\u20131200","journal-title":"Pain"}],"updated-by":[{"DOI":"10.1007\/s11418-018-1196-8","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000}}],"container-title":["Journal of Natural Medicines"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11418-016-1034-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-016-1034-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-016-1034-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T04:13:10Z","timestamp":1568347990000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11418-016-1034-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,8]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["1034"],"URL":"https:\/\/doi.org\/10.1007\/s11418-016-1034-9","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s11418-018-1196-8","asserted-by":"object"}]},"ISSN":["1340-3443","1861-0293"],"issn-type":[{"value":"1340-3443","type":"print"},{"value":"1861-0293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,8]]}}}