{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T14:27:06Z","timestamp":1782311226497,"version":"3.54.5"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T00:00:00Z","timestamp":1536278400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Shanghai Science and Technology Commission, Shanghai Natural Science Foundation","award":["16ZR1433700"],"award-info":[{"award-number":["16ZR1433700"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nat Med"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1007\/s11418-018-1243-5","type":"journal-article","created":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T10:41:47Z","timestamp":1536316907000},"page":"76-84","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Ameliorative effect of Xiaoyao-jieyu-san on post-stroke depression and its potential mechanisms"],"prefix":"10.1007","volume":"73","author":[{"given":"Changde","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenguo","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,9,7]]},"reference":[{"key":"1243_CR1","doi-asserted-by":"publisher","first-page":"446","DOI":"10.3390\/nu9050446","volume":"9","author":"M Daglia","year":"2017","unstructured":"Daglia M, Lorenzo AD, Nabavi SF (2017) Improvement of antioxidant defences and mood status by oral GABA tea administration in a mouse model of post-stroke depression. Nutrients 9:446","journal-title":"Nutrients"},{"key":"1243_CR2","doi-asserted-by":"publisher","first-page":"270","DOI":"10.3389\/fnagi.2017.00270","volume":"9","author":"W Zhao","year":"2017","unstructured":"Zhao W, Jiang F, Zhang Z, Zhang J, Ding Y, Ji X (2017) Remote ischemic conditioning: a novel non-invasive approach to prevent post-stroke depression. Front Aging Neurosci 9:270","journal-title":"Front Aging Neurosci"},{"key":"1243_CR3","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1080\/13548506.2017.1371778","volume":"23","author":"DM Dou","year":"2018","unstructured":"Dou DM, Huang LL, Dou J, Wang XX, Wang PX (2018) Post-stroke depression as a predictor of caregivers burden of acute ischemic stroke patients in China. Psychol Health Med 23:541\u2013547","journal-title":"Psychol Health Med"},{"key":"1243_CR4","doi-asserted-by":"publisher","first-page":"179","DOI":"10.3233\/NRE-171470","volume":"41","author":"S Sternnezer","year":"2017","unstructured":"Sternnezer S, Eyngorn I, Mlynash M, Snider RW, Venkatsubramanian C, Wijman CAC, Buckwalter MS (2017) Depression 1\u00a0year after hemorrhagic stroke is associated with late worsening of\u00a0outcomes. Neurorehabilitation 41:179\u2013187","journal-title":"Neurorehabilitation"},{"key":"1243_CR5","doi-asserted-by":"publisher","first-page":"8674","DOI":"10.1038\/s41598-017-09000-y","volume":"7","author":"Y Zhang","year":"2017","unstructured":"Zhang Y, Jiang H, Yue Y, Yin Y, Zhang Y, Liang J, Li S, Wang J, Lu J, Geng D, Wu A, Yuan Y (2017) The protein and mRNA expression levels of glial cell line-derived neurotrophic factor in post stroke depression and major depressive disorder. Sci Rep 7:8674","journal-title":"Sci Rep"},{"key":"1243_CR6","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3390\/medicines4010016","volume":"4","author":"SP Tseng","year":"2017","unstructured":"Tseng SP, Hsu YC, Chiu CJ, Wu ST (2017) A population-based cohort study on the ability of acupuncture to reduce post-stroke depression. Medicines 4:16","journal-title":"Medicines"},{"key":"1243_CR7","first-page":"CD003437","volume":"40","author":"ML Hackett","year":"2008","unstructured":"Hackett ML, Anderson CS, House A, Halteh C (2008) Interventions for preventing depression after stroke. Cochrane Database Syst Rev 40:CD003437","journal-title":"Cochrane Database Syst Rev"},{"key":"1243_CR8","doi-asserted-by":"publisher","first-page":"e859","DOI":"10.4088\/JCP.12m08259","volume":"74","author":"WH Hou","year":"2013","unstructured":"Hou WH, Liang HW, Li CY (2013) Effects of stroke rehabilitation on incidence of post-stroke depression: a population-based cohort study. J Clin Psychiatry 74:e859\u2013e866","journal-title":"J Clin Psychiatry"},{"key":"1243_CR9","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-018-2215-8","author":"W Peng","year":"2018","unstructured":"Peng W, Shen W, Lin B, Han P, Li CH, Zhang QY, Ye BZ, Rahman K, Xin HL, Qin LP, Han T (2018) Docking study and antiosteoporosis effects of a dibenzylbutane lignan isolated from Litsea cubeba targeting Cathepsin K and MEK1. Med Chem Res. \nhttps:\/\/doi.org\/10.1007\/s00044-018-2215-8","journal-title":"Med Chem Res"},{"key":"1243_CR10","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.jep.2005.06.006","volume":"100","author":"B Patwardhan","year":"2005","unstructured":"Patwardhan B (2005) Ethnopharmacology and drug discovery. J Ethnopharmacol 100:50\u201352","journal-title":"J Ethnopharmacol"},{"key":"1243_CR11","first-page":"2943","volume":"18","author":"LCD Wang","year":"2007","unstructured":"Wang LCD, Shao FY, Hu J, Chen YY (2007) Clinical research of the treatment effects of Xiaoyao-jieyu-san on post-stroke depression and its effects on 5-HT contents in plasma. Lishizhen Med Mater Med Res 18:2943\u20132944","journal-title":"Lishizhen Med Mater Med Res"},{"key":"1243_CR12","first-page":"38","volume":"3","author":"CD Wang","year":"2007","unstructured":"Wang CD (2007) Clinical research regarding effects of Xiaoyao-jieyu-san on post-stroke depression. Capt Med 3:38","journal-title":"Capt Med"},{"key":"1243_CR13","doi-asserted-by":"publisher","first-page":"31843","DOI":"10.1038\/srep31843","volume":"6","author":"SW Kim","year":"2016","unstructured":"Kim SW, Lee HK, Kim ID, Lee H, Luo L, Park JY, Yoon SH, Lee JK (2016) Robust neuroprotective effects of 2-((2-oxopropanoyl) oxy)-4-(trifluoromethyl) benzoic acid (OPTBA), a HTB\/pyruvate ester, in the postischemic rat brain. Sci Rep 6:31843","journal-title":"Sci Rep"},{"key":"1243_CR14","first-page":"1","volume":"2017","author":"S Zhang","year":"2017","unstructured":"Zhang S, Yang P, Li X, Wang X, Song J, Peng W, Wu C (2017) Comparative researches of semen arecae and charred semen arecae on gastrointestinal motility, motilin, substance P, and CCK in chronically stressed rats. Evid Based Complement Alternat Med 2017:1\u20138","journal-title":"Evid Based Complement Alternat Med"},{"key":"1243_CR15","doi-asserted-by":"publisher","first-page":"589","DOI":"10.3109\/13880209.2012.751616","volume":"51","author":"P Han","year":"2013","unstructured":"Han P, Han T, Peng W, Wang XR (2013) Antidepressant-like effects of essential oil and asarone, a major essential oil component from the rhizome of Acorus tatarinowii. Pharm Biol 51:589\u2013594","journal-title":"Pharm Biol"},{"key":"1243_CR16","doi-asserted-by":"publisher","first-page":"14926","DOI":"10.1038\/s41598-017-13929-5","volume":"7","author":"HJ Jin","year":"2017","unstructured":"Jin HJ, Pei L, Li YN, Zheng H, Yang S, Wan Y, Mao L, Xia YP, He QW, Li M, Yue ZY, Hu B (2017) Alleviative effects of fluoxetine on depressive-like behaviors by epigenetic regulation of BDNF gene transcription in mouse model of post-stroke depression. Sci Rep 7:14926","journal-title":"Sci Rep"},{"key":"1243_CR17","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.ejphar.2004.07.038","volume":"500","author":"MJ Millan","year":"2004","unstructured":"Millan MJ (2004) The role of monoamines in the actions of established and \u201cnovel\u201d antidepressant agents: a critical review. Eur J Pharmacol 500:371\u2013384","journal-title":"Eur J Pharmacol"},{"key":"1243_CR18","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/S0006-3223(01)01083-6","volume":"50","author":"B Chen","year":"2001","unstructured":"Chen B, Dowlatshahi D, Macqueen GM, Wang JF, Young LT (2001) Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication. Biol Psychiat 50:260\u2013265","journal-title":"Biol Psychiat"},{"key":"1243_CR19","doi-asserted-by":"publisher","first-page":"S310","DOI":"10.1038\/sj.bjp.0707509","volume":"153","author":"AL Carvalho","year":"2008","unstructured":"Carvalho AL, Caldeira MV, Santos SD, Duarte CB (2008) Role of the brain-derived neurotrophic factor at glutamatergic synapses. Br J Pharmacol 153:S310\u2013S324","journal-title":"Br J Pharmacol"},{"key":"1243_CR20","doi-asserted-by":"publisher","first-page":"433","DOI":"10.2147\/NDT.S5700","volume":"5","author":"Y Dwivedi","year":"2009","unstructured":"Dwivedi Y (2009) Brain-derived neurotrophic factor: role in depression and suicide. Neuropsychiatr Dis Treat 5:433\u2013449","journal-title":"Neuropsychiatr Dis Treat"},{"key":"1243_CR21","doi-asserted-by":"publisher","first-page":"737","DOI":"10.3892\/mmr.2013.1601","volume":"8","author":"K Han","year":"2013","unstructured":"Han K, Jia N, Li J, Yang L, Min LQ (2013) Chronic caffeine treatment reverses memory impairment and the expression of brain BNDF and TrkB in the PS1\/APP double transgenic mouse model of Alzheimer\u2019s disease. Mol Med Rep 8:737\u2013740","journal-title":"Mol Med Rep"},{"key":"1243_CR22","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s11418-014-0878-0","volume":"69","author":"D Duan","year":"2015","unstructured":"Duan D, Chen L, Yang X, Tu Y, Jiao S (2015) Antidepressant-like effect of essential oil isolated from Toona ciliata Roem. var. yunnanensis. J Nat Med 69:191\u2013197","journal-title":"J Nat Med"},{"key":"1243_CR23","doi-asserted-by":"publisher","first-page":"411","DOI":"10.3389\/fnmol.2017.00411","volume":"10","author":"FF Scarante","year":"2017","unstructured":"Scarante FF, Vilaverde C, Detoni VL, Ferreirajunior NC, Guimar\u00e3es FS, Campos AC (2017) Cannabinoid modulation of the stressed hippocampus. Front Mol Neurosci 10:411","journal-title":"Front Mol Neurosci"},{"key":"1243_CR24","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.brainresbull.2016.01.006","volume":"121","author":"S Wang","year":"2016","unstructured":"Wang S, Sun H, Liu S, Wang T, Guan J, Jia J (2016) Role of hypothalamic cannabinoid receptors in post-stroke depression in rats. Brain Res Bull 121:91\u201397","journal-title":"Brain Res Bull"},{"key":"1243_CR25","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.bbr.2018.03.019","volume":"347","author":"K Pekala","year":"2018","unstructured":"Pekala K, Michalak A, Kruk-Slomka M, Budzynska B, Biala G (2018) Impacts of cannabinoid receptor ligands on nicotine- and chronic mild stress-induced cognitive and depression-like effects in mice. Behav Brain Res 347:167\u2013174","journal-title":"Behav Brain Res"},{"key":"1243_CR26","first-page":"1983","volume":"31","author":"JX Yin","year":"2006","unstructured":"Yin JX, Tian JZ, Shi J, Cheng L, Wang YY (2006) Influence of Chinese herbal extract complex on expression of corticotropin-releasing factor and protein kinasec protein in hippocampus of middle cerebral artery occlusion rats. Chin J Chin Mater Med 31:1983\u20131986","journal-title":"Chin J Chin Mater Med"}],"container-title":["Journal of Natural Medicines"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11418-018-1243-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-018-1243-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-018-1243-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T10:10:12Z","timestamp":1588068612000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11418-018-1243-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,7]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["1243"],"URL":"https:\/\/doi.org\/10.1007\/s11418-018-1243-5","relation":{},"ISSN":["1340-3443","1861-0293"],"issn-type":[{"value":"1340-3443","type":"print"},{"value":"1861-0293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,7]]},"assertion":[{"value":"17 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no conflict of interests exists.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}