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Whereas all compounds showed anti-trypanosomal activity, only compounds <jats:bold>1\u20134<\/jats:bold> displayed anti-leishmanial activity. The 50% growth inhibition (GI<jats:sub>50<\/jats:sub>) values for the trypanocidal and leishmanicidal activity of the compounds ranged between 2.5 and 14.9\u00a0\u03bcM. Kotschyienone A (<jats:bold>1<\/jats:bold>) was found to be the most active compound with a minimal inhibition concentration (MIC) value of 10\u00a0\u03bcM and GI<jats:sub>50<\/jats:sub> values between 2.5 and 2.9\u00a0\u03bcM. Only compounds <jats:bold>1<\/jats:bold> and <jats:bold>3<\/jats:bold> showed moderate cytotoxicity against HL-60 cells with MIC and GI<jats:sub>50<\/jats:sub> values of 100\u00a0\u03bcM and 31.5\u201346.2\u00a0\u03bcM, respectively. Compound <jats:bold>1<\/jats:bold> was also found to show activity against intracellular amastigotes of <jats:italic>L. major<\/jats:italic> with a GI<jats:sub>50<\/jats:sub> value of 1.5\u00a0\u03bcM. The results suggest that limonoids have potential as drug candidates for the development of new treatments against trypanosomiasis and leishmaniasis.<\/jats:p>","DOI":"10.1007\/s11418-020-01408-7","type":"journal-article","created":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T12:02:26Z","timestamp":1586520146000},"page":"606-611","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Trypanocidal and leishmanicidal activity of six limonoids"],"prefix":"10.1007","volume":"74","author":[{"given":"Dietmar","family":"Steverding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lazare S.","family":"Sidjui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9den Ramalho","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bathelemy","family":"Ngameni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel N.","family":"Folefoc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Mahiou-Leddet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyne","family":"Ollivier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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