{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:33:35Z","timestamp":1790253215263,"version":"4.1.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T00:00:00Z","timestamp":1668470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T00:00:00Z","timestamp":1668470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nat Med"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1007\/s11418-022-01664-9","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T11:30:37Z","timestamp":1668511837000},"page":"188-201","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Tryptanthrin ameliorates imiquimod-induced psoriasis in mice by suppressing inflammation and oxidative stress via NF-\u03baB\/MAPK\/Nrf2 pathways"],"prefix":"10.1007","volume":"77","author":[{"given":"Yuxia","family":"Xiong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinshu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,15]]},"reference":[{"key":"1664_CR1","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1111\/jdv.13854","volume":"31","author":"IM Michalek","year":"2017","unstructured":"Michalek IM, Loring B, John SM (2017) A systematic review of worldwide epidemiology of psoriasis. J Eur Acad Dermatol Venereol 31:205\u2013212","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"Suppl 2","key":"1664_CR2","first-page":"ii18","volume":"64","author":"RG Langley","year":"2005","unstructured":"Langley RG, Krueger GG, Griffiths CE (2005) Psoriasis: epidemiology, clinical features and quality of life. Ann Rheum Dis 64(Suppl 2):ii18\u2013ii23","journal-title":"Ann Rheum Dis"},{"key":"1664_CR3","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1111\/jdv.14460","volume":"31","author":"J Koo","year":"2017","unstructured":"Koo J, Marangell LB, Nakamura M, Armstrong A, Jeon C, Bhutani T et al (2017) Depression and suicidality in psoriasis: review of the literature including the cytokine theory of depression. J Eur Acad Dermatol Venereol 31:1999\u20132009","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"1664_CR4","doi-asserted-by":"crossref","unstructured":"Menter A, Korman NJ, Elmets CA, Feldman SR, Gelfand JM, Gordon KB, et al. (2009). Guidelines of care for the management of psoriasis and psoriatic arthritis: section 4. Guidelines of care for the management and treatment of psoriasis with traditional systemic agents. J Am Acad Dermatol 61:451-485","DOI":"10.1016\/j.jaad.2009.03.027"},{"key":"1664_CR5","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.jconrel.2016.07.003","volume":"239","author":"M Sala","year":"2016","unstructured":"Sala M, Elaissari A, Fessi H (2016) Advances in psoriasis physiopathology and treatments: up to date of mechanistic insights and perspectives of novel therapies based on innovative skin drug delivery systems (ISDDS). J Control Release 239:182\u2013202","journal-title":"J Control Release"},{"key":"1664_CR6","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1111\/j.1365-2133.2004.05984.x","volume":"150","author":"P Rocha-Pereira","year":"2004","unstructured":"Rocha-Pereira P, Santos-Silva A, Rebelo I, Figueiredo A, Quintanilha A, Teixeira F (2004) The inflammatory response in mild and in severe psoriasis. Br J Dermatol 150:917\u2013928","journal-title":"Br J Dermatol"},{"issue":"17","key":"1664_CR7","doi-asserted-by":"publisher","first-page":"6206","DOI":"10.3390\/ijms21176206","volume":"21","author":"J Ple\u0144kowska","year":"2020","unstructured":"Ple\u0144kowska J, Gabig-Cimi\u0144ska M, Mozolewski P (2020) Oxidative stress as an important contributor to the pathogenesis of psoriasis. Int J Mol Sci 21(17):6206","journal-title":"Int J Mol Sci"},{"key":"1664_CR8","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1146\/annurev-immunol-032713-120225","volume":"32","author":"MA Lowes","year":"2014","unstructured":"Lowes MA, Su\u00e1rez-Fari\u00f1as M, Krueger JG (2014) Immunology of psoriasis. Annu Rev Immunol 32:227\u2013255","journal-title":"Annu Rev Immunol"},{"key":"1664_CR9","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1159\/000330330","volume":"223","author":"P Quaglino","year":"2011","unstructured":"Quaglino P, Bergallo M, Ponti R, Barberio E, Cicchelli S, Buffa E et al (2011) Th1, Th2, Th17 and regulatory T cell pattern in psoriatic patients: modulation of cytokines and gene targets induced by etanercept treatment and correlation with clinical response. Dermatology 223:57\u201367","journal-title":"Dermatology"},{"key":"1664_CR10","doi-asserted-by":"publisher","first-page":"4733","DOI":"10.4049\/jimmunol.181.7.4733","volume":"181","author":"I Kryczek","year":"2008","unstructured":"Kryczek I, Bruce AT, Gudjonsson JE, Johnston A, Aphale A, Vatan L et al (2008) Induction of IL-17+ T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasis. J Immunol 181:4733\u20134741","journal-title":"J Immunol"},{"key":"1664_CR11","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.immuni.2012.04.010","volume":"37","author":"Y Lai","year":"2012","unstructured":"Lai Y, Li D, Li C, Muehleisen B, Radek KA, Park HJ et al (2012) The antimicrobial protein REG3A regulates keratinocyte proliferation and differentiation after skin injury. Immunity 37:74\u201384","journal-title":"Immunity"},{"key":"1664_CR12","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.gene.2017.01.016","volume":"614","author":"K Chen","year":"2017","unstructured":"Chen K, Kolls JK (2017) Interluekin-17A (IL17A). Gene 614:8\u201314","journal-title":"Gene"},{"key":"1664_CR13","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1517\/14740338.2015.977251","volume":"14","author":"W Sheremata","year":"2015","unstructured":"Sheremata W, Brown AD, Rammohan KW (2015) Dimethyl fumarate for treating relapsing multiple sclerosis. Expert Opin Drug Saf 14:161\u2013170","journal-title":"Expert Opin Drug Saf"},{"key":"1664_CR14","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s13020-018-0174-0","volume":"13","author":"S Meng","year":"2018","unstructured":"Meng S, Lin Z, Wang Y, Wang Z, Li P, Zheng Y (2018) Psoriasis therapy by Chinese medicine and modern agents. Chin Med 13:16","journal-title":"Chin Med"},{"key":"1664_CR15","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.bbrc.2007.04.107","volume":"358","author":"ST Yu","year":"2007","unstructured":"Yu ST, Chen TM, Tseng SY, Chen YH (2007) Tryptanthrin inhibits MDR1 and reverses doxorubicin resistance in breast cancer cells. Biochem Biophys Res Commun 358:79\u201384","journal-title":"Biochem Biophys Res Commun"},{"key":"1664_CR16","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1055\/s-2006-931562","volume":"72","author":"MC Recio","year":"2006","unstructured":"Recio MC, Cerd\u00e1-Nicol\u00e1s M, Potterat O, Hamburger M, R\u00edos JL (2006) Anti-inflammatory and antiallergic activity in vivo of lipophilic Isatis tinctoria extracts and tryptanthrin. Planta Med 72:539\u2013546","journal-title":"Planta Med"},{"key":"1664_CR17","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1055\/s-2008-1074877","volume":"38","author":"G Honda","year":"1980","unstructured":"Honda G, Tosirisuk V, Tabata M (1980) Isolation of an antidermatophytic, tryptanthrin, from indigo plants, Polygonum tinctorium and Isatis tinctoria. Planta Med 38:275\u2013276","journal-title":"Planta Med"},{"key":"1664_CR18","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1111\/j.1525-1470.2012.01721.x","volume":"30","author":"CY Liang","year":"2013","unstructured":"Liang CY, Lin TY, Lin YK (2013) Successful treatment of pediatric nail psoriasis with periodic pustular eruption using topical indigo naturalis oil extract. Pediatr Dermatol 30:117\u2013119","journal-title":"Pediatr Dermatol"},{"key":"1664_CR19","doi-asserted-by":"publisher","first-page":"101310","DOI":"10.1016\/j.eujim.2021.101310","volume":"43","author":"MJ Yazdanpanah","year":"2021","unstructured":"Yazdanpanah MJ, Vahabi-Amlashi S, Pishgouy M, Imani M, Banihashemi M, Mohammadpoor AH et al (2021) Comparing the topical preparations of Indigo naturalis from Chinese and Iranian origin in the treatment of plaque-type psoriasis: a preliminary randomized double-blind pilot study. Eur J Integr Med 43:101310","journal-title":"Eur J Integr Med"},{"key":"1664_CR20","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1111\/bjd.15894","volume":"178","author":"YK Lin","year":"2018","unstructured":"Lin YK, See LC, Huang YH, Chi CC, Hui RC (2018) Comparison of indirubin concentrations in indigo naturalis ointment for psoriasis treatment: a randomized, double-blind, dosage-controlled trial. Br J Dermatol 178:124\u2013131","journal-title":"Br J Dermatol"},{"key":"1664_CR21","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.3389\/fphar.2020.01145","volume":"11","author":"LN Kirpotina","year":"2020","unstructured":"Kirpotina LN, Schepetkin IA, Hammaker D, Kuhs A, Khlebnikov AI, Quinn MT (2020) Therapeutic effects of tryptanthrin and tryptanthrin-6-oxime in models of rheumatoid arthritis. Front Pharmacol 11:1145","journal-title":"Front Pharmacol"},{"key":"1664_CR22","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1248\/bpb.b14-00363","volume":"37","author":"SY Moon","year":"2014","unstructured":"Moon SY, Lee JH, Choi HY, Cho IJ, Kim SC, Kim YW (2014) Tryptanthrin protects hepatocytes against oxidative stress via activation of the extracellular signal-regulated kinase\/NF-E2-related factor 2 pathway. Biol Pharm Bull 37:1633\u20131640","journal-title":"Biol Pharm Bull"},{"key":"1664_CR23","doi-asserted-by":"publisher","first-page":"153054","DOI":"10.1016\/j.phymed.2019.153054","volume":"64","author":"L Yue","year":"2019","unstructured":"Yue L, Ailin W, Jinwei Z, Leng L, Jianan W, Li L et al (2019) PSORI-CM02 ameliorates psoriasis in vivo and in vitro by inducing autophagy via inhibition of the PI3K\/Akt\/mTOR pathway. Phytomedicine 64:153054","journal-title":"Phytomedicine"},{"key":"1664_CR24","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1586\/1744666X.2015.1026894","volume":"11","author":"O Y\u00e9lamos","year":"2015","unstructured":"Y\u00e9lamos O, Puig L (2015) Systemic methotrexate for the treatment of psoriasis. Expert Rev Clin Immunol 11:553\u2013563","journal-title":"Expert Rev Clin Immunol"},{"key":"1664_CR25","doi-asserted-by":"publisher","first-page":"635076","DOI":"10.3389\/fimmu.2021.635076","volume":"12","author":"S Zhang","year":"2021","unstructured":"Zhang S, Zhang J, Yu J, Chen X, Zhang F, Wei W et al (2021) Hyperforin ameliorates imiquimod-induced psoriasis-like murine skin inflammation by modulating IL-17A-producing \u03b3\u03b4 T cells. Front Immunol 12:635076","journal-title":"Front Immunol"},{"key":"1664_CR26","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta delta C(T)) method. Methods 25:402\u2013408","journal-title":"Methods"},{"key":"1664_CR27","doi-asserted-by":"publisher","first-page":"5836","DOI":"10.4049\/jimmunol.0802999","volume":"182","author":"L van der Fits","year":"2009","unstructured":"van der Fits L, Mourits S, Voerman JS, Kant M, Boon L, Laman JD et al (2009) Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23\/IL-17 axis. J Immunol 182:5836\u20135845","journal-title":"J Immunol"},{"key":"1664_CR28","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1038\/nature05663","volume":"445","author":"MA Lowes","year":"2007","unstructured":"Lowes MA, Bowcock AM, Krueger JG (2007) Pathogenesis and therapy of psoriasis. Nature 445:866\u2013873","journal-title":"Nature"},{"key":"1664_CR29","doi-asserted-by":"publisher","first-page":"112760","DOI":"10.1016\/j.jep.2020.112760","volume":"255","author":"HM Cheng","year":"2020","unstructured":"Cheng HM, Kuo YZ, Chang CY, Chang CH, Fang WY, Chang CN et al (2020) The anti-TH17 polarization effect of Indigo naturalis and tryptanthrin by differentially inhibiting cytokine expression. J Ethnopharmacol 255:112760","journal-title":"J Ethnopharmacol"},{"key":"1664_CR30","doi-asserted-by":"publisher","first-page":"112772","DOI":"10.1016\/j.jep.2020.112772","volume":"255","author":"CL Lee","year":"2020","unstructured":"Lee CL, Wang CM, Kuo YH, Yen HR, Song YC, Chou YL et al (2020) IL-17A inhibitions of indole alkaloids from traditional Chinese medicine Qing Dai. J Ethnopharmacol 255:112772","journal-title":"J Ethnopharmacol"},{"key":"1664_CR31","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1038\/sj.jid.5700807","volume":"127","author":"JE Gudjonsson","year":"2007","unstructured":"Gudjonsson JE, Johnston A, Dyson M, Valdimarsson H, Elder JT (2007) Mouse models of psoriasis. J Invest Dermatol 127:1292\u20131308","journal-title":"J Invest Dermatol"},{"key":"1664_CR32","first-page":"7","volume":"6","author":"N Ayala-Font\u00e1nez","year":"2016","unstructured":"Ayala-Font\u00e1nez N, Soler DC, McCormick TS (2016) Current knowledge on psoriasis and autoimmune diseases. Psoriasis (Auckl) 6:7\u201332","journal-title":"Psoriasis (Auckl)"},{"key":"1664_CR33","doi-asserted-by":"publisher","first-page":"2405291","DOI":"10.1155\/2017\/2405291","volume":"2017","author":"Y Tan","year":"2017","unstructured":"Tan Y, Qi Q, Lu C, Niu X, Bai Y, Jiang C et al (2017) Cytokine imbalance as a common mechanism in both psoriasis and rheumatoid arthritis. Mediators Inflamm 2017:2405291","journal-title":"Mediators Inflamm"},{"key":"1664_CR34","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.intimp.2017.04.022","volume":"48","author":"H Chen","year":"2017","unstructured":"Chen H, Lu C, Liu H, Wang M, Zhao H, Yan Y et al (2017) Quercetin ameliorates imiquimod-induced psoriasis-like skin inflammation in mice via the NF-\u03baB pathway. Int Immunopharmacol 48:110\u2013117","journal-title":"Int Immunopharmacol"},{"key":"1664_CR35","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.jdermsci.2012.11.002","volume":"69","author":"AM Goldminz","year":"2013","unstructured":"Goldminz AM, Au SC, Kim N, Gottlieb AB, Lizzul PF (2013) NF-\u03baB: an essential transcription factor in psoriasis. J Dermatol Sci 69:89\u201394","journal-title":"J Dermatol Sci"},{"key":"1664_CR36","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1111\/j.0022-202X.2005.23735.x","volume":"124","author":"PF Lizzul","year":"2005","unstructured":"Lizzul PF, Aphale A, Malaviya R, Sun Y, Masud S, Dombrovskiy V et al (2005) Differential expression of phosphorylated NF-kappaB\/RelA in normal and psoriatic epidermis and downregulation of NF-kappaB in response to treatment with etanercept. J Invest Dermatol 124:1275\u20131283","journal-title":"J Invest Dermatol"},{"key":"1664_CR37","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1172\/JCI12153","volume":"108","author":"I Haase","year":"2001","unstructured":"Haase I, Hobbs RM, Romero MR, Broad S, Watt FM (2001) A role for mitogen-activated protein kinase activation by integrins in the pathogenesis of psoriasis. J Clin Invest 108:527\u2013536","journal-title":"J Clin Invest"},{"key":"1664_CR38","doi-asserted-by":"publisher","first-page":"e49701","DOI":"10.1371\/journal.pone.0049701","volume":"7","author":"RB Guo","year":"2012","unstructured":"Guo RB, Wang GF, Zhao AP, Gu J, Sun XL, Hu G (2012) Paeoniflorin protects against ischemia-induced brain damages in rats via inhibiting MAPKs\/NF-\u03baB-mediated inflammatory responses. PLoS ONE 7:e49701","journal-title":"PLoS ONE"},{"key":"1664_CR39","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1111\/j.1365-2133.2004.06304.x","volume":"152","author":"C Johansen","year":"2005","unstructured":"Johansen C, Kragballe K, Westergaard M, Henningsen J, Kristiansen K, Iversen L (2005) The mitogen-activated protein kinases p38 and ERK1\/2 are increased in lesional psoriatic skin. Br J Dermatol 152:37\u201342","journal-title":"Br J Dermatol"},{"key":"1664_CR40","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.yexmp.2007.05.002","volume":"83","author":"XJ Yu","year":"2007","unstructured":"Yu XJ, Li CY, Dai HY, Cai DX, Wang KY, Xu YH et al (2007) Expression and localization of the activated mitogen-activated protein kinase in lesional psoriatic skin. Exp Mol Pathol 83:413\u2013418","journal-title":"Exp Mol Pathol"},{"key":"1664_CR41","doi-asserted-by":"publisher","first-page":"101521","DOI":"10.1016\/j.redox.2020.101521","volume":"34","author":"Z El Ali","year":"2020","unstructured":"El Ali Z, Ollivier A, Manin S, Rivard M, Motterlini R, Foresti R (2020) Therapeutic effects of CO-releaser\/Nrf2 activator hybrids (HYCOs) in the treatment of skin wound, psoriasis and multiple sclerosis. Redox Biol 34:101521","journal-title":"Redox Biol"},{"key":"1664_CR42","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.foodchem.2014.11.090","volume":"174","author":"MS Lee","year":"2015","unstructured":"Lee MS, Lee B, Park KE, Utsuki T, Shin T, Oh CW et al (2015) Dieckol enhances the expression of antioxidant and detoxifying enzymes by the activation of Nrf2-MAPK signalling pathway in HepG2 cells. Food Chem 174:538\u2013546","journal-title":"Food Chem"},{"issue":"7","key":"1664_CR43","doi-asserted-by":"publisher","first-page":"633","DOI":"10.3390\/antiox9070633","volume":"9","author":"E Jasek-Gajda","year":"2020","unstructured":"Jasek-Gajda E, Jurkowska H, Jasi\u0144ska M, Lis GJ (2020) Targeting the MAPK\/ERK and PI3K\/AKT signaling pathways affects NRF2, Trx and GSH antioxidant systems in leukemia cells. Antioxidants (Basel) 9(7):633. https:\/\/doi.org\/10.3390\/antiox9070633","journal-title":"Antioxidants (Basel)"},{"key":"1664_CR44","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1093\/toxsci\/kfg083","volume":"73","author":"LM Zipper","year":"2003","unstructured":"Zipper LM, Mulcahy RT (2003) Erk activation is required for Nrf2 nuclear localization during pyrrolidine dithiocarbamate induction of glutamate cysteine ligase modulatory gene expression in HepG2 cells. Toxicol Sci 73:124\u2013134","journal-title":"Toxicol Sci"},{"issue":"13","key":"1664_CR45","doi-asserted-by":"publisher","first-page":"4777","DOI":"10.3390\/ijms21134777","volume":"21","author":"F He","year":"2020","unstructured":"He F, Ru X, Wen T (2020) NRF2, a transcription factor for stress response and beyond. Int J Mol Sci 21(13):4777","journal-title":"Int J Mol Sci"},{"key":"1664_CR46","doi-asserted-by":"publisher","first-page":"e6588","DOI":"10.1371\/journal.pone.0006588","volume":"4","author":"Z Sun","year":"2009","unstructured":"Sun Z, Huang Z, Zhang DD (2009) Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response. PLoS ONE 4:e6588","journal-title":"PLoS ONE"},{"key":"1664_CR47","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1089\/ars.2005.7.385","volume":"7","author":"M Kobayashi","year":"2005","unstructured":"Kobayashi M, Yamamoto M (2005) Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation. Antioxid Redox Signal 7:385\u2013394","journal-title":"Antioxid Redox Signal"},{"key":"1664_CR48","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1093\/aje\/kwu024","volume":"179","author":"H Qiao","year":"2014","unstructured":"Qiao H, Sai X, Gai L, Huang G, Chen X, Tu X et al (2014) Association between heme oxygenase 1 gene promoter polymorphisms and susceptibility to coronary artery disease: a HuGE review and meta-analysis. Am J Epidemiol 179:1039\u20131048","journal-title":"Am J Epidemiol"},{"key":"1664_CR49","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/j.1365-2613.2006.00505.x","volume":"88","author":"A Wojas-Pelc","year":"2007","unstructured":"Wojas-Pelc A, Marcinkiewicz J (2007) What is a role of haeme oxygenase-1 in psoriasis? Current concepts of pathogenesis. Int J Exp Pathol 88:95\u2013102","journal-title":"Int J Exp Pathol"}],"container-title":["Journal of Natural Medicines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-022-01664-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11418-022-01664-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-022-01664-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,7]],"date-time":"2023-01-07T19:07:49Z","timestamp":1673118469000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11418-022-01664-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,15]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["1664"],"URL":"https:\/\/doi.org\/10.1007\/s11418-022-01664-9","relation":{},"ISSN":["1340-3443","1861-0293"],"issn-type":[{"value":"1340-3443","type":"print"},{"value":"1861-0293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,15]]},"assertion":[{"value":"6 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 November 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}