{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T14:28:33Z","timestamp":1777127313085,"version":"3.51.4"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nat Med"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1007\/s11418-023-01683-0","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T09:03:08Z","timestamp":1675414988000},"page":"352-362","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hochuekkito exerts the anti-allergic effects via activating regulatory T cells in a murine model of contact hypersensitivity"],"prefix":"10.1007","volume":"77","author":[{"given":"Atsushi","family":"Tsuge","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsuke","family":"Chiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yui","family":"Yagura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Muto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsuke","family":"Hisaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2337-9696","authenticated-orcid":false,"given":"Mitsuhiko","family":"Nose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,2,3]]},"reference":[{"key":"1683_CR1","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1111\/1346-8138.15730","volume":"48","author":"K Miyano","year":"2021","unstructured":"Miyano K, Tsunemi Y (2021) Current treatments for atopic dermatitis in Japan. J Dermatol 48:140\u2013151","journal-title":"J Dermatol"},{"key":"1683_CR2","doi-asserted-by":"crossref","first-page":"e315","DOI":"10.1111\/1346-8138.15982","volume":"49","author":"H Saeki","year":"2022","unstructured":"Saeki H, Huya Y, Furuta AH, Ichiyama S, Katsunuma T, Katoh N, Tanaka A, Tsunemi Y, Nakahara T, Nagao M, Narita M, Hide M, Fujisawa T, Futamura M, Masuda K, Matsubara T, Murota H, Yamamoto-Hanada K (2022) English version of clinical practice guidelines for the management of atopic dermatitis 2021. J Dermatol 49:e315\u2013e375","journal-title":"J Dermatol"},{"key":"1683_CR3","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1056\/NEJMra074081","volume":"358","author":"T Bieber","year":"2008","unstructured":"Bieber T (2008) Atopic dermatitis N Eng J Med 358:1483\u20131494","journal-title":"Atopic dermatitis N Eng J Med"},{"key":"1683_CR4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.jdermsci.2013.02.001","volume":"70","author":"K Kabashima","year":"2013","unstructured":"Kabashima K (2013) New concept of the pathogenesis of atopic dermatitis: interplay among the barrier, allergy, and pruritus as a trinity. J Dermatol Sci 70:3\u201311","journal-title":"J Dermatol Sci"},{"key":"1683_CR5","doi-asserted-by":"publisher","first-page":"100042","DOI":"10.1016\/j.xjidi.2021.100042","volume":"1","author":"M Kamata","year":"2021","unstructured":"Kamata M, Tada Y (2021) A literature review of real-world effectiveness and safety of dupilumab for atopic dermatitis. JID Innovations 1:100042. https:\/\/doi.org\/10.1016\/j.xjidi.2021.100042","journal-title":"JID Innovations"},{"key":"1683_CR6","doi-asserted-by":"publisher","first-page":"1555664","DOI":"10.1016\/j.cyto.2021.155664","volume":"148","author":"S Nakajima","year":"2021","unstructured":"Nakajima S, Tie D, Nomura T, Kabashima K (2021) Novel pathogenesis of atopic dermatitis from the view of cytokines in mice and humans. Cytokine 148:1555664. https:\/\/doi.org\/10.1016\/j.cyto.2021.155664","journal-title":"Cytokine"},{"key":"1683_CR7","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.alit.2022.04.003","volume":"71","author":"M Tominaga","year":"2022","unstructured":"Tominaga M, Takamori K (2022) Peripheral itch sensitization in atopic dermatitis. Allergol Int 71:265\u2013277","journal-title":"Allergol Int"},{"key":"1683_CR8","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1007\/s13555-022-00751-9","volume":"12","author":"H Saeki","year":"2022","unstructured":"Saeki H, Imamura T, Yokota D, Tsubouchi H (2022) Difamilast ointment in Japanese adult and pediatric patients with atopic dermatitis: a phase III, long-term, open-label study. Dermatol Ther 12:1589\u20131601","journal-title":"Dermatol Ther"},{"key":"1683_CR9","doi-asserted-by":"publisher","first-page":"9412","DOI":"10.3390\/ijms21249412","volume":"21","author":"YH Vu","year":"2020","unstructured":"Vu YH, Hashimoto-Hachiya A, Takemura M, Yumine A, Mitamura Y, Nakahara T, Furue M, Tsuji G (2020) IL-24 negatively regulates keratinocyte differentiation induced by tapinarof, an aryl hydrocarbon receptor modulator: implication in the treatment of atopic dermatitis. Int J Mol Sci 21:9412. https:\/\/doi.org\/10.3390\/ijms21249412","journal-title":"Int J Mol Sci"},{"key":"1683_CR10","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1007\/s13555-022-00738-6","volume":"12","author":"T Nakahara","year":"2022","unstructured":"Nakahara T, Takemoto S, Houzawa H, Nakayama M (2022) Desire for alternative treatment options in patients with atopic dermatitis in Japan: results of a web-based cross-sectional study (AD-JOIN study). Dermatol Ther 12:1383\u20131396","journal-title":"Dermatol Ther"},{"key":"1683_CR11","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/260235","author":"T Shimizu","year":"2013","unstructured":"Shimizu T (2013) Efficacy of kampo medicine in treating atopic dermatitis: an overview. Evid Based Complement Altern Med. https:\/\/doi.org\/10.1155\/2013\/260235","journal-title":"Evid Based Complement Altern Med"},{"key":"1683_CR12","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1248\/bpb.22.48","volume":"22","author":"M Nose","year":"1999","unstructured":"Nose M, Sakushima J, Harada D, Ogihara Y (1999) Comparison of immunopharmacological actions of 8 kinds of Kampo-hozais clinically used in atopic dermatitis on delayed-type hypersensitivity in mice. Biol Pharm Bull 22:48\u201354","journal-title":"Biol Pharm Bull"},{"key":"1683_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000518448","volume":"183","author":"A Tsuge","year":"2022","unstructured":"Tsuge A, Yonekura S, Watanabe S, Kurosaki Y, Hisaka S, Nose M (2022) Juzentaihoto exerts anti-allergic effects by inhibiting effector T-cell activation and inducing and\/or activating regulatory T cells in a murine model of contact hypersensitivity. Int Arch Allergy Immunol 183:1\u201313","journal-title":"Int Arch Allergy Immunol"},{"key":"1683_CR14","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1007\/s11418-021-01566-2","volume":"76","author":"A Tsuge","year":"2022","unstructured":"Tsuge A, Watanabe A, Kodama Y, Hisaka S, Nose M (2022) Orengedokuto exerts anti-allergic effects via inhibition of effector T cell activation in a murine model of contact hypersensitivity. J Nat Med 76:144\u2013151","journal-title":"J Nat Med"},{"key":"1683_CR15","unstructured":"The Ministry of Health, Labour and Welfare of Japan (2021) The Japanese pharmacopeia 18th ed., Crude drugs and related drugs. The Ministry og Health, Labour and Welfare of Japan, Tokyo. https:\/\/www.mhlw.go.jp\/content\/11120000\/000904450.pdf"},{"key":"1683_CR16","doi-asserted-by":"publisher","first-page":"27","DOI":"10.4103\/0976-0105.177703","volume":"7","author":"AB Nair","year":"2016","unstructured":"Nair AB, Jacob S (2016) A simple practice guide for dose conversion between animals and human. J Basic Clin Pharm 7:27\u201331","journal-title":"J Basic Clin Pharm"},{"key":"1683_CR17","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1016\/S1567-5769(02)00027-9","volume":"2","author":"T Nakada","year":"2002","unstructured":"Nakada T, Watanabe K, Matsumoto T, Santa K, Triizuka K, Hanawa T (2002) Effect of orally administered Hochu-ekki-to, a Japanese herbal medicine, on contact hypersensitivity caused by repeated application of antigen. Int Immunopharmacol 2:910\u2013911","journal-title":"Int Immunopharmacol"},{"key":"1683_CR18","doi-asserted-by":"crossref","unstructured":"Gao XK, Fuseda K, Shibata T, Tanaka H, Inagaki N, Nagai H (2005) Kampo medicines for mite antigen-induced allergic dermatitis in NC\/Nga mice. eCAM 2:191\u2013199","DOI":"10.1093\/ecam\/neh077"},{"key":"1683_CR19","first-page":"114","volume":"30","author":"H Yamashita","year":"2013","unstructured":"Yamashita H, Makino T, Inagaki N, Nose M, Mizukami H (2013) Assessment of relief from pruritus due to Kampo medicines by using murine models of atopic dermatitis. J Trad Med 30:114\u2013123","journal-title":"J Trad Med"},{"key":"1683_CR20","doi-asserted-by":"crossref","unstructured":"Wang XQ, Takahashi T, Zhu SJ, Moriya J, Saegusa S, Yamakawa J, Kusaka K, Itoh T, Kanda T (2004) Effect of hochu-ekki-to (TJ-41), a Japanese herbal medicine, on daily activity in a murine model of chronic fatigue syndrome. eCAM 1:203\u2013206","DOI":"10.1093\/ecam\/neh020"},{"key":"1683_CR21","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1177\/1534735410383170","volume":"9","author":"JS Jeong","year":"2010","unstructured":"Jeong JS, Ryu BH, Kim JS, Park JW, Choi WC, Yoon SW (2010) Bojungikki-Tang for cancer-related fatigue: a pilot randomized clinical trial. Integr Cancer Ther 9:331\u2013338","journal-title":"Integr Cancer Ther"},{"key":"1683_CR22","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1248\/bpb.b19-00616","volume":"43","author":"Q He","year":"2020","unstructured":"He Q, Sawada M, Yamasaki A, Akazawa S, Furuta H, Uenishi H, Meng X, Nakahashi T, Ishigaki Y, Moriya J (2020) Neuroinflammation, oxidative stress, and the treatment with Kampo medicine. Biol Pharm Bull 43:110\u2013115","journal-title":"Biol Pharm Bull"},{"key":"1683_CR23","first-page":"81","volume":"29","author":"H Kobayashi","year":"2003","unstructured":"Kobayashi H, Mizuno N, Kutsuna H, Teramae H, Ueoku S, Onoyama J, Yamanaka K, Fujita N, Ishii M (2003) Hochu-ekki-to suppresses development of dermatitis and elevation of serum IgE level in NC\/Nga mice. Drug Exp Clin Res 29:81\u201384","journal-title":"Drug Exp Clin Res"},{"key":"1683_CR24","doi-asserted-by":"crossref","unstructured":"Kobayashi H, Takahashi K, Mizuno N, Kutsuna H, Ishii M (2004) An alternative approach to atopic dermatitis. Part I\u2014Case-series presentation. eCAM 1:49\u201362","DOI":"10.1093\/ecam\/neh015"},{"key":"1683_CR25","doi-asserted-by":"crossref","unstructured":"Kobayashi H, Takahashi K, Mizuno N, Kutsuna H, Ishii M (2004) An alternative approach to atopic dermatitis: Part II\u2014Summary of cases and discussion. eCAM 1:145\u2013155","DOI":"10.1093\/ecam\/neh026"},{"key":"1683_CR26","doi-asserted-by":"crossref","unstructured":"Kobayashi H, Ishii M, Takeuchi S, Tanaka Y, Shintani T, Yamatodani A, Kusunoki T, Furue M (2010) Efficacy and safety of a traditional herbal medicine, Hochu-ekki-to in the long-term management of kikyo (delicate constitution) patients with atopic dermatitis: a 6 month, multicenter, double-blind, randomized, placebo-controlled study. eCAM 7:367\u2013373","DOI":"10.1093\/ecam\/nen003"},{"key":"1683_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/MD.0000000000013938","volume":"98","author":"MK Jeong","year":"2019","unstructured":"Jeong MK, Kim TE, Kim A, Jung J, Son MJ (2019) The herbal drug, Bu-Zhong-Yi-Qi-Tang, for the treatment of atopic dermatitis. Medicine 98:1\u20134","journal-title":"Medicine"},{"key":"1683_CR28","first-page":"196","volume":"23","author":"X Gao","year":"2006","unstructured":"Gao X, Yanaka H, Inagaki N, Teramachi H, Tsuchiya T, Nagai H (2006) Immunopharmacological studies on the effects of Juzentaihoto and Hochuekkito on experimental autoimmune encephalomyelitis in rats. J Trad Med 23:196\u2013202","journal-title":"J Trad Med"},{"key":"1683_CR29","doi-asserted-by":"publisher","unstructured":"Kiyomi A, Matsuda A, Nara M, Yamazaki K, Imai S, Sugiura M (2021) Immunological differences in human peripheral blood mononuclear cells treated with traditional Japanese herbal medicines Hochuekkito, Juzentaihoto, and Ninjin\u2019yoeito from different pharmaceutical companies. eCAM. Doi: https:\/\/doi.org\/10.1155\/2021\/7605057","DOI":"10.1155\/2021\/7605057"},{"key":"1683_CR30","doi-asserted-by":"publisher","first-page":"239","DOI":"10.2174\/187152806779010981","volume":"5","author":"S Jiang","year":"2006","unstructured":"Jiang S, Lechier RI (2006) CD4+CD25+ regulatory T-cell therapy for allergy, autoimmune disease and transplant rejection. Inflamm Allrgy Drug Targets 5:239\u2013242","journal-title":"Inflamm Allrgy Drug Targets"},{"key":"1683_CR31","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/j.jaci.2009.03.001","volume":"123","author":"M Miyara","year":"2009","unstructured":"Miyara M, Wing K, Sakaguchi S (2009) Therapeutic approaches to allergy and autoimmunity based on FoxP3+ regulatory T-cell activation and expansion. J Allergy Clin Immunol 123:749\u2013755","journal-title":"J Allergy Clin Immunol"},{"key":"1683_CR32","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/j.jep.2010.11.020","volume":"133","author":"JH Lee","year":"2011","unstructured":"Lee JH, Cho SH (2011) Korean red ginseng extract ameliorates skin lesions in NC\/Nga mice: an atopic dermatitis model. J Ethnopharmacol 133:810\u2013817","journal-title":"J Ethnopharmacol"}],"container-title":["Journal of Natural Medicines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-023-01683-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11418-023-01683-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-023-01683-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T00:09:51Z","timestamp":1677110991000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11418-023-01683-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,3]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["1683"],"URL":"https:\/\/doi.org\/10.1007\/s11418-023-01683-0","relation":{},"ISSN":["1340-3443","1861-0293"],"issn-type":[{"value":"1340-3443","type":"print"},{"value":"1861-0293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,3]]},"assertion":[{"value":"15 December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}