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In addition, we describe (5) suppressive effects of the extract and chakasaponins from <jats:italic>Camellia sinensis<\/jats:italic> (flower buds) on obesity based on inhibition of food intake in mice. The active saponins were classified into the following three types: (1) olean-12-en-28-oic acid 3-<jats:italic>O<\/jats:italic>-monodesmoside, (2) olean-12-ene 3,28-<jats:italic>O<\/jats:italic>-acylated bisdesmoside, and (3) acylated polyhydroxyolean-12-ene 3-<jats:italic>O<\/jats:italic>-monodesmoside. Furthermore, common modes of action, such as involvements of capsaicin-sensitive nerves, endogenous NO and PGs, and possibly sympathetic nerves, as well as common structural requirements, were observed. Based on our findings, a common mechanism of action might mediate the pharmacological effects of active saponins. It should be noted that the gastrointestinal tract is an important action site of saponins, and the role of the saponins in the gastrointestinal tract should be carefully considered.<\/jats:p>","DOI":"10.1007\/s11418-023-01730-w","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T09:02:11Z","timestamp":1689152531000},"page":"644-664","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["New biofunctional effects of oleanane-type triterpene saponins"],"prefix":"10.1007","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4217-065X","authenticated-orcid":false,"given":"Hisashi","family":"Matsuda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Morikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seikou","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Muraoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,12]]},"reference":[{"key":"1730_CR1","doi-asserted-by":"publisher","first-page":"3904","DOI":"10.3390\/molecules25173904","volume":"25","author":"F Li","year":"2020","unstructured":"Li F, Liu B, Li T, Wu Q, Xu Z, Gu Y, Li W, Wang P, Ma T, Lei H (2020) Review of constituents and biological activities of triterpene saponins from Glycyrrhizae Radix et Rhizoma and its solubilization characteristics. 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