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Six new limonoids, ceramicines U\u2013Z (<jats:bold>1<\/jats:bold>\u2013<jats:bold>6<\/jats:bold>), with a cyclopentanone[\u03b1]phenanthrene ring system with a \u03b2-furyl ring at C-17 were isolated from the barks of <jats:italic>C. ceramicus<\/jats:italic>. Their structures were determined on the basis of the 1D and 2D NMR analyses, and their absolute configurations were investigated by CD spectroscopy. Ceramicine W (<jats:bold>3<\/jats:bold>) exhibited potent antimalarial activity against <jats:italic>Plasmodium falciparum<\/jats:italic> 3D7 strain with IC<jats:sub>50<\/jats:sub> value of 1.2\u00a0\u00b5M. In addition, the structure\u2013antimalarial activity relationship (SAR) of the ceramicines was investigated to identify substituent patterns that may enhance activity. It appears that ring B and the functional groups in the vicinity of rings B and C are critical for the antimalarial activity of the ceramicines. In particular, bulky ester substituents with equatorial orientation at C-7 and C-12 greatly increase the antimalarial activity.<\/jats:p>\n          <jats:p>\n            <jats:bold>Graphical Abstract<\/jats:bold>\n          <\/jats:p>","DOI":"10.1007\/s11418-023-01746-2","type":"journal-article","created":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T07:01:56Z","timestamp":1694329316000},"page":"68-77","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Ceramicines U\u2013Z from Chisocheton ceramicus and structure\u2013antimalarial activity relationship study"],"prefix":"10.1007","volume":"78","author":[{"given":"Alfarius Eko","family":"Nugroho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Komuro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Shindo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin Piow","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Hirasawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Kaneda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Tougan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Horii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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