{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T17:16:39Z","timestamp":1772817399182,"version":"3.50.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:00:00Z","timestamp":1709164800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:00:00Z","timestamp":1709164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"JSPS KAKENHI","award":["21K06625"],"award-info":[{"award-number":["21K06625"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nat Med"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1007\/s11418-024-01785-3","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T02:02:22Z","timestamp":1709172142000},"page":"774-783","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Screening of growth inhibitors for epithelial\u2013mesenchymal transition-induced cells by TGF-\u03b2 from plant-based sources identified the active compound hydroxychavicol from Piper bitle"],"prefix":"10.1007","volume":"78","author":[{"given":"Hirotaka","family":"Matsuo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitomi","family":"Kawakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Anjiki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriaki","family":"Kawano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Fuchino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Kawahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayo","family":"Yoshimatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,29]]},"reference":[{"key":"1785_CR1","doi-asserted-by":"publisher","first-page":"716","DOI":"10.3390\/cancers30100716","volume":"3","author":"D Kong","year":"2011","unstructured":"Kong D, Li Y, Wang Z, Sarkar FH (2011) Cancer stem cells and epithelial-to-mesenchymal transition (EMT)-phenotypic cells: are they cousins or twins? Cancers 3:716\u2013729","journal-title":"Cancers"},{"key":"1785_CR2","first-page":"311","volume":"15","author":"F Marcucci","year":"2016","unstructured":"Marcucci F, Stassi G, Maria RD (2016) Epithelial-mesenchymal transition: a new target in anticancer drug discovery. Nat Rev 15:311\u2013325","journal-title":"Nat Rev"},{"key":"1785_CR3","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1159\/000337106","volume":"79","author":"M Ksi\u0105\u017ckiewicz","year":"2012","unstructured":"Ksi\u0105\u017ckiewicz M, Markiewicz A, \u017baczek AJ (2012) Epithelial-mesenchymal transition: a hallmark in metastasis formation linking circulating tumor cells and cancer stem cells. Pathobiology 79:195\u2013208","journal-title":"Pathobiology"},{"key":"1785_CR4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162394","volume":"11","author":"K Arai","year":"2016","unstructured":"Arai K, Eguchi T, Rahman MM, Sakamoto R, Masuda N, Nakatsura T, Calderwood SK, Kozakz K, Itoh M (2016) A novel high-throughput 3D screening system for EMT inhibitors: a pilot screening discovered the EMT inhibitory activity of CDK2 inhibitor SU9516. PLoS ONE 11:e0162394","journal-title":"PLoS ONE"},{"key":"1785_CR5","doi-asserted-by":"publisher","first-page":"715","DOI":"10.3389\/fphar.2019.00715","volume":"10","author":"L Avila-Carrasco","year":"2019","unstructured":"Avila-Carrasco L, Majano P, S\u00e1nchez-Tom\u00e9r JA, Selgas R, L\u00f3pez-Cabrera M, Aguilera A, Mateo GG (2019) Natural plants compounds as modulators of epithelial-to-mesenchymal transition. Front Pharmacol 10:715","journal-title":"Front Pharmacol"},{"key":"1785_CR6","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/j.jbiosc.2017.01.011","volume":"123","author":"T Nakashima","year":"2017","unstructured":"Nakashima T, Kimura T, Miyano R, Matsuo H, Hirose T, Kimishima A, Nonaka K, Iwatsuki M, Nakanishi J, Takahashi Y, \u014cmura S (2017) Nanaomycin H: a new nanaomycin analog. J Biosci Bioeng 123:765\u2013770","journal-title":"J Biosci Bioeng"},{"key":"1785_CR7","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.jbiosc.2019.09.007","volume":"129","author":"H Matsuo","year":"2020","unstructured":"Matsuo H, Nakanishi J, Noguchi Y, Kitagawa K, Shigemura K, Sunazuka T, Takahashi Y, \u014cmura S, Nakashima T (2020) Nanaomycin K, a new epithelial-mesenchymal transition inhibitor, produced by actinomycete strain \u201cStreptomyces rosa subsp. notensis OS-3966\u201d. J Biosci Bioeng 129:291\u2013295","journal-title":"J Biosci Bioeng"},{"key":"1785_CR8","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.bcp.2016.09.026","volume":"134","author":"T Nakashima","year":"2017","unstructured":"Nakashima T, Takahashi Y, \u014cmura S (2017) Search for new compounds from Kitasato microbial library by physicochemical screening. Biochem Pharmacol 134:42\u201355","journal-title":"Biochem Pharmacol"},{"key":"1785_CR9","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1038\/ja.2015.142","volume":"69","author":"T Nakashima","year":"2016","unstructured":"Nakashima T, Miyano R, Iwatsuki M, Shirahata T, Kimura T, Asami Y, Kobayashi Y, Shiomi K, Petersson GA, Takahashi Y, \u014cmura S (2016) Iminimycin A, the new iminium metabolite produced by Streptomyces griseus OS-3601. J Antibiot 69:611\u2013615","journal-title":"J Antibiot"},{"key":"1785_CR10","doi-asserted-by":"publisher","first-page":"3284","DOI":"10.1016\/j.tetlet.2016.06.040","volume":"30","author":"T Nakashima","year":"2016","unstructured":"Nakashima T, Miyano R, Matsuo H, Iwatsuki M, Shirahata T, Kobayashi Y, Shiomi K, Peretsson GA, Takahashi Y, \u014cmura S (2016) Absolute configuration of iminimyin B, a new indolizidine alkaloid, from Streptomyces griseus OS-3601. Tetrahedron Lett 30:3284\u20133286","journal-title":"Tetrahedron Lett"},{"key":"1785_CR11","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.jbiosc.2018.05.003","volume":"126","author":"R Miyan","year":"2018","unstructured":"Miyan R, Matsuo H, Nonaka K, Mokudai T, Niwano Y, Shiomi K, Takahashi Y, \u014cmura S, Nakashima T (2018) Pochoniolides A and B, new antioxidants from the fungal strain Pochonia chlamydosporia var. spinulospora FKI-7537. J Biosci Bioeng 126:661\u2013666","journal-title":"J Biosci Bioeng"},{"key":"1785_CR12","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1038\/s41429-018-0038-y","volume":"71","author":"T Kimura","year":"2018","unstructured":"Kimura T, Inahashi Y, Matsuo H, Suga T, Iwatsuki M, Shiomi K, Takahashi Y, \u014cmura S, Nakashima T (2018) Pyrizomicin A and B: Structure and bioactivity of new thiazolyl pyridines from Lechevalieria aerocolonigenes K10\u20130216. J Antibiot 71:606\u2013608","journal-title":"J Antibiot"},{"key":"1785_CR13","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1080\/09168451.2018.1467264","volume":"82","author":"H Matsuo","year":"2018","unstructured":"Matsuo H, Nonaka K, Nagan Y, Yabuki A, Fujikura K, Takahashi Y, \u014cmura S, Nakashima T (2018) New metabolites, sarcopodinols A and B, isolated from deep-sea derived fungal strain Sarcopodium sp. FKJ-0025. Biosci Biotechnol Biochem 82:1323\u20131326","journal-title":"Biosci Biotechnol Biochem"},{"key":"1785_CR14","doi-asserted-by":"publisher","first-page":"236","DOI":"10.3390\/antibiotics9050236","volume":"9","author":"H Matsuo","year":"2020","unstructured":"Matsuo H, Noguchi Y, Miyano R, Higo M, Nonaka K, Sunazuka T, Takahashi Y, \u014cmura S, Nakashima T (2020) Thioporidiols A and B: anti-fungal sulfur compounds discovered by molybdenum-catalyzed oxidation screening from Trichoderma polypori FKI-7382. Antibiotics 9:236","journal-title":"Antibiotics"},{"key":"1785_CR15","doi-asserted-by":"publisher","first-page":"513","DOI":"10.3390\/md18100513","volume":"18","author":"H Matsuo","year":"2020","unstructured":"Matsuo H, Hokari R, Ishiyama A, Higo M, Nonaka K, Iwatsuki M, Nagano Y, Nagahama T, Takahashi Y, \u014cmura S, Nakashima T (2020) Hatsusamide A and B: two new metabolites produced by deep-sea derived fungal strain Penicillium steckii FKJ-0213. Mar Drugs 18:513","journal-title":"Mar Drugs"},{"key":"1785_CR16","unstructured":"\u014cmura S, Takahashi Y, Nakashima T, Matsumoto A, Nakanishi J, Matsuo H (2018) Epithelial\u2013mesenchymal transition induced cell inhibitor containing nanaomycin derivative. PCT Int. Appl. WO 2018056470 A1, 29 Mar"},{"key":"1785_CR17","doi-asserted-by":"publisher","first-page":"65","DOI":"10.2116\/analsci.18SDP07","volume":"35","author":"J Nakanishi","year":"2019","unstructured":"Nakanishi J, Sugiyama K, Matsuo H, Takahashi Y, \u014cmura S, Nakashima T (2019) An application of photoactivatable substrate for the evaluation of epithelial\u2013mesenchymal transition inhibitors. Anal Sci 35:65\u201369","journal-title":"Anal Sci"},{"key":"1785_CR18","doi-asserted-by":"publisher","first-page":"9217","DOI":"10.1038\/s41598-021-88741-3","volume":"11","author":"K Kitagawa","year":"2021","unstructured":"Kitagawa K, Shigemura K, Ishii A, Nakashima T, Matsuo H, Takahashi Y, \u014cmura S, Nakanishi J, Fujisawa M (2021) Nanaomycin K inhibited epithelial-mesenchymal transition and tumor growth in bladder cancer cells in vitro and in vivo. Sci rep 11:9217","journal-title":"Sci rep"},{"key":"1785_CR19","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1080\/14786419.2018.1495634","volume":"24","author":"A Atiya","year":"2020","unstructured":"Atiya A, Sinha BN, Lal UR (2020) The new ether derivative of phenylpropanoid and bioactivity was investigated from the leaves of Piper betle L. Nat Prod Res 24:638\u2013645","journal-title":"Nat Prod Res"},{"key":"1785_CR20","doi-asserted-by":"publisher","first-page":"37867","DOI":"10.1038\/srep37867","volume":"6","author":"I Ali","year":"2016","unstructured":"Ali I, Satti NK, Dutt P, Prasad R, Khan IA (2016) Hydroxychavicol: a phytochemical targeting cutaneous fungal infections. Sci Rep 6:37867","journal-title":"Sci Rep"},{"key":"1785_CR21","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s11418-009-0331-y","volume":"63","author":"K Murata","year":"2009","unstructured":"Murata K, Nakao K, Hirata N, Namba K, Nomi T, Kitamura Y, Moriyama K, Shintani T, Iinuma M, Matsuda H (2009) Hydroxychavicol: a potent xanthine oxidase inhibitor obtained from the leaves of betel, Piper betle. J Nat Med 63:355\u2013359","journal-title":"J Nat Med"}],"container-title":["Journal of Natural Medicines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-024-01785-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11418-024-01785-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-024-01785-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T08:20:47Z","timestamp":1715934047000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11418-024-01785-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,29]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["1785"],"URL":"https:\/\/doi.org\/10.1007\/s11418-024-01785-3","relation":{},"ISSN":["1340-3443","1861-0293"],"issn-type":[{"value":"1340-3443","type":"print"},{"value":"1861-0293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,29]]},"assertion":[{"value":"14 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}