{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:41:13Z","timestamp":1787982073263,"version":"build-2784847793"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"The Joint project of Chongqing Health Commission and Science and Technology Bureau","award":["2023MSXM157"],"award-info":[{"award-number":["2023MSXM157"]}]},{"name":"The Graduate Student Innovation Program of Chongqing University of Technology","award":["gzlcx2023391"],"award-info":[{"award-number":["gzlcx2023391"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nat Med"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1007\/s11418-025-01916-4","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T19:51:55Z","timestamp":1753300315000},"page":"1030-1043","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Diosmetin alleviates osteoarthritis through modulating the polarization of macrophages by inhibiting the PI3K\/Akt signaling pathway"],"prefix":"10.1007","volume":"79","author":[{"given":"Shaoju","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangyu","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7743-3423","authenticated-orcid":false,"given":"Ruidong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"key":"1916_CR1","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1111\/joim.13634","volume":"293","author":"M Englund","year":"2023","unstructured":"Englund M (2023) Osteoarthritis, part of life or a curable disease? A bird\u2019s-eye view. J Intern Med 293:681\u2013693","journal-title":"J Intern Med"},{"key":"1916_CR2","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1007\/s10787-021-00888-7","volume":"29","author":"MA Abdel-Aziz","year":"2021","unstructured":"Abdel-Aziz MA, Ahmed HMS, El-Nekeety AA, Abdel-Wahhab MA (2021) Osteoarthritis complications and the recent therapeutic approaches. Inflammopharmacology 29:1653\u20131667","journal-title":"Inflammopharmacology"},{"key":"1916_CR3","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.molmed.2021.12.007","volume":"28","author":"J Loughlin","year":"2022","unstructured":"Loughlin J (2022) Translating osteoarthritis genetics research: challenging times ahead. Trends Mol Med 28:176\u2013182","journal-title":"Trends Mol Med"},{"key":"1916_CR4","doi-asserted-by":"crossref","unstructured":"Brophy RH, Fillingham YA (2022) AAOS Clinical Practice Guideline Summary: Management of Osteoarthritis of the Knee (Nonarthroplasty), Third Edition. J Am Acad Orthop Surg, 30:e721\u2013e729","DOI":"10.5435\/JAAOS-D-21-01233"},{"key":"1916_CR5","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.matbio.2018.05.008","volume":"71\u201372","author":"F Guilak","year":"2018","unstructured":"Guilak F, Nims RJ, Dicks A, Wu CL, Meulenbelt I (2018) Osteoarthritis as a disease of the cartilage pericellular matrix. Matrix Biol 71\u201372:40\u201350","journal-title":"Matrix Biol"},{"issue":"5","key":"1916_CR6","doi-asserted-by":"publisher","first-page":"2697","DOI":"10.3390\/ijms22052697","volume":"22","author":"E Rezu\u015f","year":"2021","unstructured":"Rezu\u015f E, Burlui A, Cardoneanu A, Macovei LA, Tamba BI, Rezu\u015f C (2021) From pathogenesis to therapy in knee osteoarthritis: bench-to-bedside. Int J Mol Sci 22(5):2697","journal-title":"Int J Mol Sci"},{"key":"1916_CR7","first-page":"204","volume":"9","author":"DL Goldenberg","year":"1982","unstructured":"Goldenberg DL, Egan MS, Cohen AS (1982) Inflammatory synovitis in degenerative joint disease. J Rheumatol 9:204\u2013209","journal-title":"J Rheumatol"},{"issue":"6","key":"1916_CR8","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1093\/procel\/pwad060","volume":"15","author":"F Liu","year":"2023","unstructured":"Liu F, Lu Y, Wang X, Sun S, Pan H, Wang M, Wang Z, Zhang W, Ma S, Sun G, Chu Q, Wang S, Qu J, Liu GH (2023) Identification of FOXO1 as a geroprotector in human synovium through single-nucleus transcriptomic profiling. Protein Cell 15(6):441\u2013459","journal-title":"Protein Cell"},{"key":"1916_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103618","volume":"72","author":"DE Nanus","year":"2021","unstructured":"Nanus DE, Badoume A, Wijesinghe SN, Halsey AM, Hurley P, Ahmed Z, Botchu R, Davis ET, Lindsay MA, Jones SW (2021) Synovial tissue from sites of joint pain in knee osteoarthritis patients exhibits a differential phenotype with distinct fibroblast subsets. EBioMedicine 72:103618","journal-title":"EBioMedicine"},{"key":"1916_CR10","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1136\/annrheumdis-2018-213450","volume":"77","author":"H Zhang","year":"2018","unstructured":"Zhang H, Lin C, Zeng C, Wang Z, Wang H, Lu J, Liu X, Shao Y, Zhao C, Pan J, Xu S, Zhang Y, Xie D, Cai D, Bai X (2018) Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2. Ann Rheum Dis 77:1524\u20131534","journal-title":"Ann Rheum Dis"},{"key":"1916_CR11","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1146\/annurev-pathmechdis-012418-012718","volume":"15","author":"M Locati","year":"2020","unstructured":"Locati M, Curtale G, Mantovani A (2020) Diversity, mechanisms, and significance of macrophage plasticity. Annu Rev Pathol 15:123\u2013147","journal-title":"Annu Rev Pathol"},{"key":"1916_CR12","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.607186","volume":"7","author":"C Lambert","year":"2020","unstructured":"Lambert C, Zappia J, Sanchez C, Florin A, Dubuc JE, Henrotin Y (2020) The damage-associated molecular patterns (DAMPs) as potential targets to treat osteoarthritis: perspectives from a review of the literature. Front Med (Lausanne) 7:607186","journal-title":"Front Med (Lausanne)"},{"issue":"4","key":"1916_CR13","doi-asserted-by":"publisher","first-page":"4120","DOI":"10.3390\/ijms24044120","volume":"24","author":"S Semenistaja","year":"2023","unstructured":"Semenistaja S, Skuja S, Kadisa A, Groma V (2023) Healthy and osteoarthritis-affected joints facing the cellular crosstalk. Int J Mol Sci 24(4):4120","journal-title":"Int J Mol Sci"},{"key":"1916_CR14","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1002\/art.42424","volume":"75","author":"S Yoshida","year":"2023","unstructured":"Yoshida S, Nishitani K, Yoshitomi H, Kuriyama S, Nakamura S, Fujii T, Saito M, Kobori Y, Murakami A, Murata K, Ito H, Ueno H, Matsuda S (2023) Knee alignment correction by high tibial osteotomy reduces symptoms and synovial inflammation in knee osteoarthritis accompanied by macrophage phenotypic change from M1 to M2. Arthritis Rheumatol 75:950\u2013960","journal-title":"Arthritis Rheumatol"},{"key":"1916_CR15","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1016\/j.joca.2021.04.006","volume":"29","author":"JW Xie","year":"2021","unstructured":"Xie JW, Wang Y, Xiao K, Xu H, Luo ZY, Li L, Pei FX, Kraus VB, Huang ZY (2021) Alpha defensin-1 attenuates surgically induced osteoarthritis in association with promoting M1 to M2 macrophage polarization. Osteoarthritis Cartilage 29:1048\u20131059","journal-title":"Osteoarthritis Cartilage"},{"key":"1916_CR16","doi-asserted-by":"publisher","first-page":"3660","DOI":"10.1002\/ptr.8214","volume":"38","author":"Z Sun","year":"2024","unstructured":"Sun Z, Liu K, Liang C, Wen L, Wu J, Liu X, Li X (2024) Diosmetin as a promising natural therapeutic agent: In vivo, in vitro mechanisms, and clinical studies. Phytother Res 38:3660\u20133694","journal-title":"Phytother Res"},{"key":"1916_CR17","doi-asserted-by":"publisher","first-page":"122060","DOI":"10.1016\/j.lfs.2023.122060","volume":"331","author":"L Zhao","year":"2023","unstructured":"Zhao L, Jin L, Yang B (2023) Diosmetin alleviates S. aureus-induced mastitis by inhibiting SIRT1\/GPX4 mediated ferroptosis. Life Sci 331:122060","journal-title":"Life Sci"},{"key":"1916_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109091","volume":"117","author":"J Choi","year":"2019","unstructured":"Choi J, Lee DH, Park SY, Seol JW (2019) Diosmetin inhibits tumor development and block tumor angiogenesis in skin cancer. Biomed Pharmacother 117:109091","journal-title":"Biomed Pharmacother"},{"key":"1916_CR19","doi-asserted-by":"publisher","first-page":"11072","DOI":"10.1080\/21655979.2022.2068755","volume":"13","author":"G Guo","year":"2022","unstructured":"Guo G, Dong J (2022) Diosmetin attenuates oxidative stress-induced damage to lens epithelial cells via the mitogen-activated protein kinase (MAPK) pathway. Bioengineered 13:11072\u201311081","journal-title":"Bioengineered"},{"key":"1916_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2022.110311","volume":"370","author":"H Ding","year":"2023","unstructured":"Ding H, Ding H, Mu P, Lu X, Xu Z (2023) Diosmetin inhibits subchondral bone loss and indirectly protects cartilage in a surgically-induced osteoarthritis mouse model. Chem Biol Interact 370:110311","journal-title":"Chem Biol Interact"},{"key":"1916_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110390","volume":"120","author":"S Zhao","year":"2023","unstructured":"Zhao S, Liu Y, Wang J, Wen Y, Wu B, Yang D, Wang G, Xiu G, Ling B, Du D, Xu J (2023) ADSCs increase the autophagy of chondrocytes through decreasing miR-7-5p in Osteoarthritis rats by targeting ATG4A. Int Immunopharmacol 120:110390","journal-title":"Int Immunopharmacol"},{"key":"1916_CR22","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.1038\/s41467-019-09839-x","volume":"10","author":"Y Shi","year":"2019","unstructured":"Shi Y, Hu X, Cheng J, Zhang X, Zhao F, Shi W, Ren B, Yu H, Yang P, Li Z, Liu Q, Liu Z, Duan X, Fu X, Zhang J, Wang J, Ao Y (2019) A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development. Nat Commun 10:1914","journal-title":"Nat Commun"},{"key":"1916_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122536","volume":"343","author":"M Qiu","year":"2024","unstructured":"Qiu M, Cheng L, Xu J, Jin M, Yuan W, Ge Q, Zou K, Chen J, Huang Y, Li J, Zhu L, Xu B, Zhang C, Jin H, Wang P (2024) Liquiritin reduces chondrocyte apoptosis through P53\/PUMA signaling pathway to alleviate osteoarthritis. Life Sci 343:122536","journal-title":"Life Sci"},{"issue":"Suppl 3","key":"1916_CR24","doi-asserted-by":"publisher","first-page":"S17","DOI":"10.1016\/j.joca.2010.05.025","volume":"18","author":"SS Glasson","year":"2010","unstructured":"Glasson SS, Chambers MG, Van Den Berg WB, Little CB (2010) The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse. Osteoarthritis Cartilage 18(Suppl 3):S17\u2013S23","journal-title":"Osteoarthritis Cartilage"},{"key":"1916_CR25","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.molimm.2023.04.001","volume":"159","author":"W Su","year":"2023","unstructured":"Su W, Zheng X, Zhou H, Yang S, Zhu X (2023) Fibroblast growth factor 10 delays the progression of osteoarthritis by attenuating synovial fibrosis via inhibition of IL-6\/JAK2\/STAT3 signaling in vivo and in vitro. Mol Immunol 159:46\u201357","journal-title":"Mol Immunol"},{"key":"1916_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115990","volume":"170","author":"B Chen","year":"2024","unstructured":"Chen B, Wang L, Xie D, Wang Y (2024) Exploration and breakthrough in the mode of chondrocyte death - a potential new mechanism for osteoarthritis. Biomed Pharmacother 170:115990","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"1916_CR27","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3390\/biomedicines12010009","volume":"12","author":"R Shumnalieva","year":"2023","unstructured":"Shumnalieva R, Kotov G, Ermencheva P, Monov S (2023) Pathogenic mechanisms and therapeutic approaches in obesity-related knee osteoarthritis. Biomedicines 12(1):9","journal-title":"Biomedicines"},{"key":"1916_CR28","doi-asserted-by":"publisher","first-page":"745","DOI":"10.2147\/JIR.S297166","volume":"14","author":"H Wang","year":"2021","unstructured":"Wang H, Jiang Z, Pang Z, Qi G, Hua B, Yan Z, Yuan H (2021) Engeletin protects against TNF-\u03b1-induced apoptosis and reactive oxygen species generation in chondrocytes and alleviates osteoarthritis in vivo. J Inflamm Res 14:745\u2013760","journal-title":"J Inflamm Res"},{"key":"1916_CR29","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1186\/s13075-023-03230-4","volume":"25","author":"C Li","year":"2023","unstructured":"Li C, Ouyang Z, Huang Y, Lin S, Li S, Xu J, Liu T, Wu J, Guo P, Chen Z, Wu H, Ding Y (2023) NOD2 attenuates osteoarthritis via reprogramming the activation of synovial macrophages. Arthritis Res Ther 25:249","journal-title":"Arthritis Res Ther"},{"key":"1916_CR30","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.13261","volume":"44","author":"H Lee","year":"2020","unstructured":"Lee H, Sung J, Kim Y, Jeong HS, Lee J (2020) Inhibitory effect of diosmetin on inflammation and lipolysis in coculture of adipocytes and macrophages. J Food Biochem 44:e13261","journal-title":"J Food Biochem"},{"key":"1916_CR31","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1002\/ptr.6596","volume":"34","author":"Y Chen","year":"2020","unstructured":"Chen Y, Wang Y, Liu M, Zhou B, Yang G (2020) Diosmetin exhibits anti-proliferative and anti-inflammatory effects on TNF-\u03b1-stimulated human rheumatoid arthritis fibroblast-like synoviocytes through regulating the Akt and NF-\u03baB signaling pathways. Phytother Res 34:1310\u20131319","journal-title":"Phytother Res"},{"key":"1916_CR32","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1007\/s00109-023-02360-1","volume":"101","author":"A Salminen","year":"2023","unstructured":"Salminen A (2023) The role of immunosuppressive myofibroblasts in the aging process and age-related diseases. J Mol Med (Berl) 101:1169\u20131189","journal-title":"J Mol Med (Berl)"},{"issue":"1","key":"1916_CR33","first-page":"3","volume":"11","author":"YA Rim","year":"2020","unstructured":"Rim YA, Ju JH (2020) The role of fibrosis in osteoarthritis progression. Life (Basel) 11(1):3","journal-title":"Life (Basel)"},{"key":"1916_CR34","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.bone.2012.02.012","volume":"51","author":"CR Scanzello","year":"2012","unstructured":"Scanzello CR, Goldring SR (2012) The role of synovitis in osteoarthritis pathogenesis. Bone 51:249\u2013257","journal-title":"Bone"},{"key":"1916_CR35","doi-asserted-by":"publisher","first-page":"1269724","DOI":"10.3389\/fcell.2023.1269724","volume":"11","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Ji Q (2023) Macrophage polarization in osteoarthritis progression: a promising therapeutic target. Front Cell Dev Biol 11:1269724","journal-title":"Front Cell Dev Biol"},{"key":"1916_CR36","doi-asserted-by":"crossref","unstructured":"Li H, Yuan Y, Zhang L, Xu C, Xu H, Chen Z (2023) Reprogramming macrophage polarization, depleting ros by astaxanthin and thioketal-containing polymers delivering rapamycin for osteoarthritis treatment. Adv Sci (Weinh), e2305363","DOI":"10.1002\/advs.202305363"},{"key":"1916_CR37","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202300315","volume":"12","author":"L Pang","year":"2023","unstructured":"Pang L, Jin H, Lu Z, Xie F, Shen H, Li X, Zhang X, Jiang X, Wu L, Zhang M, Zhang T, Zhai Y, Zhang Y, Guan H, Su J, Li M, Gao J (2023) Treatment with mesenchymal stem cell-derived nanovesicle-containing gelatin methacryloyl hydrogels alleviates osteoarthritis by modulating chondrogenesis and macrophage polarization. Adv Healthc Mater 12:e2300315","journal-title":"Adv Healthc Mater"},{"issue":"7","key":"1916_CR38","doi-asserted-by":"publisher","first-page":"2915","DOI":"10.3390\/molecules28072915","volume":"28","author":"X Ji","year":"2023","unstructured":"Ji X, Du W, Che W, Wang L, Zhao L (2023) Apigenin inhibits the progression of osteoarthritis by mediating macrophage polarization. Molecules 28(7):2915","journal-title":"Molecules"},{"key":"1916_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115488","volume":"167","author":"X Shen","year":"2023","unstructured":"Shen X, Qin J, Wei Z, Liu F (2023) Bone marrow mesenchymal stem cell exosome-derived lncRNA TUC339 influences the progression of osteoarthritis by regulating synovial macrophage polarization and chondrocyte apoptosis. Biomed Pharmacother 167:115488","journal-title":"Biomed Pharmacother"},{"issue":"5","key":"1916_CR40","doi-asserted-by":"publisher","first-page":"2336","DOI":"10.3390\/ijms22052336","volume":"22","author":"R Uchiyama","year":"2021","unstructured":"Uchiyama R, Toyoda E, Maehara M, Wasai S, Omura H, Watanabe M, Sato M (2021) Effect of platelet-rich plasma on M1\/M2 macrophage polarization. Int J Mol Sci 22(5):2336","journal-title":"Int J Mol Sci"},{"key":"1916_CR41","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.chom.2013.12.010","volume":"15","author":"YG Kim","year":"2014","unstructured":"Kim YG, Udayanga KG, Totsuka N, Weinberg JB, N\u00fa\u00f1ez G, Shibuya A (2014) Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE\u2082. Cell Host Microbe 15:95\u2013102","journal-title":"Cell Host Microbe"},{"key":"1916_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153582","volume":"87","author":"X Gong","year":"2021","unstructured":"Gong X, Xiong L, Bi C, Zhang B (2021) Diosmetin ameliorate type 2 diabetic mellitus by up-regulating Corynebacterium glutamicum to regulate IRS\/PI3K\/AKT-mediated glucose metabolism disorder in KK-Ay mice. Phytomedicine 87:153582","journal-title":"Phytomedicine"},{"key":"1916_CR43","doi-asserted-by":"publisher","first-page":"2238","DOI":"10.12659\/MSM.911860","volume":"25","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Jiang Y, Lu D (2019) Diosmetin suppresses neuronal apoptosis and inflammation by modulating the phosphoinositide 3-kinase (PI3K)\/AKT\/nuclear factor-\u03baB (NF-\u03baB) signaling pathway in a rat model of pneumococcal meningitis. Med Sci Monit 25:2238\u20132245","journal-title":"Med Sci Monit"},{"key":"1916_CR44","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.4049\/jimmunol.1601515","volume":"198","author":"E Vergadi","year":"2017","unstructured":"Vergadi E, Ieronymaki E, Lyroni K, Vaporidi K, Tsatsanis C (2017) Akt signaling pathway in macrophage activation and M1\/M2 polarization. J Immunol 198:1006\u20131014","journal-title":"J Immunol"}],"container-title":["Journal of Natural Medicines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-025-01916-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11418-025-01916-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-025-01916-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T15:07:05Z","timestamp":1756912025000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11418-025-01916-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,23]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["1916"],"URL":"https:\/\/doi.org\/10.1007\/s11418-025-01916-4","relation":{},"ISSN":["1340-3443","1861-0293"],"issn-type":[{"value":"1340-3443","type":"print"},{"value":"1861-0293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,23]]},"assertion":[{"value":"14 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declared no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All the animal experiments were approved by the Animal Ethical and Welfare Committee of Chongqing University of Technology (Approval No: 2023 Postgraduate-32).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}