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(Convolvulaceae), along with six known calyhedins: calyhedins II (<jats:bold>9<\/jats:bold>), III (<jats:bold>10<\/jats:bold>), IV (<jats:bold>11<\/jats:bold>), V (<jats:bold>12<\/jats:bold>), VIII (<jats:bold>13<\/jats:bold>), and XII (<jats:bold>14<\/jats:bold>). Their structures were determined from the spectroscopic data. Compounds <jats:bold>1<\/jats:bold>\u2013<jats:bold>7<\/jats:bold> were hexa- or hepta-glycosides with macrolactone structures (jalapins), and their sugar moieties were partially acylated by five organic acids, including 2<jats:italic>S<\/jats:italic>-methylbutyric, (<jats:italic>E<\/jats:italic>)-2-methylbut-2-enoic, and 2<jats:italic>R<\/jats:italic>-methyl-3<jats:italic>R<\/jats:italic>-hydroxybutyric acids. Compounds <jats:bold>1<\/jats:bold>\u2013<jats:bold>7<\/jats:bold> were macrolactones with 22- (<jats:bold>1<\/jats:bold>, <jats:bold>7<\/jats:bold>), 23- (<jats:bold>2<\/jats:bold>), 27- (<jats:bold>3<\/jats:bold>\u2013<jats:bold>5<\/jats:bold>), or 28- (<jats:bold>6<\/jats:bold>) membered rings. Compound <jats:bold>8<\/jats:bold> was identified as an acylated glycosidic acid methyl ester, corresponding to the compound in which the lactone ring of <jats:bold>1<\/jats:bold> was cleaved and subsequently methylated. In addition, the cytotoxic activities of <jats:bold>1<\/jats:bold>\u2013<jats:bold>8<\/jats:bold>, <jats:bold>11<\/jats:bold>, <jats:bold>12<\/jats:bold>, and <jats:bold>14<\/jats:bold> against HL-60 human promyelocytic leukemia cells and the antiviral activities of <jats:bold>1<\/jats:bold>\u2013<jats:bold>14<\/jats:bold> and 11 previously isolated calyhedins against herpes simplex virus type 1 (HSV-1) were evaluated. Except for <jats:bold>1<\/jats:bold>, the other ten tested compounds exhibited cytotoxicity against HL-60 cells, with the IC<jats:sub>50<\/jats:sub> values of <jats:bold>3<\/jats:bold>, <jats:bold>4<\/jats:bold>, <jats:bold>6<\/jats:bold>, <jats:bold>7<\/jats:bold>, <jats:bold>11<\/jats:bold>, and <jats:bold>12<\/jats:bold> being closer to or rather lower than that of the positive control cisplatin. Additionally, all tested compounds demonstrated anti-HSV-1 activity, with seven compounds, i.e., <jats:bold>3<\/jats:bold>, <jats:bold>6<\/jats:bold>, <jats:bold>9<\/jats:bold>, <jats:bold>10<\/jats:bold>, <jats:bold>22<\/jats:bold>, <jats:bold>23<\/jats:bold>, and <jats:bold>24<\/jats:bold>, having EC<jats:sub>50<\/jats:sub> values lower than or comparable to that of the positive control acyclovir.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Graphical abstract<\/jats:title>\n          <\/jats:sec>","DOI":"10.1007\/s11418-025-01919-1","type":"journal-article","created":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T10:26:39Z","timestamp":1748773599000},"page":"845-862","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Eight new resin glycosides, calyhedins XXIV\u2013XXXI, from the rhizomes of Calystegia hederacea"],"prefix":"10.1007","volume":"79","author":[{"given":"Masateru","family":"Ono","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryota","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Shimadzu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takumi","family":"Nagasawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotaka","family":"Nishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Miyashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumi","family":"Yokomizo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Yoshimitsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryota","family":"Tsuchihasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Okawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junei","family":"Kinjo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,1]]},"reference":[{"key":"1919_CR1","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1007\/s11418-017-1114-5","volume":"71","author":"M Ono","year":"2017","unstructured":"Ono M (2017) Resin glycosides from Convolvulaceae plants. 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