{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:03:26Z","timestamp":1783037006359,"version":"3.54.6"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460819"],"award-info":[{"award-number":["82460819"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81960759"],"award-info":[{"award-number":["81960759"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004763","name":"Natural Science Foundation of Inner Mongolia Autonomous Region","doi-asserted-by":"publisher","award":["2024LHMS08029"],"award-info":[{"award-number":["2024LHMS08029"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004763","name":"Natural Science Foundation of Inner Mongolia Autonomous Region","doi-asserted-by":"publisher","award":["2019MS08010"],"award-info":[{"award-number":["2019MS08010"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Inner Mongolia Autonomous Region grassland talent training program"},{"name":"Zhiyuan Talent Project of Inner Mongolia Medical University-Zhixue"},{"name":"Inner Mongolia Talent Development Fund","award":["22056"],"award-info":[{"award-number":["22056"]}]},{"name":"Key Project of Inner Mongolia Medical University","award":["YKD2022ZD019"],"award-info":[{"award-number":["YKD2022ZD019"]}]},{"name":"Scientific and Technological Innovation Team of Inner Mongolia Medical University on the Anti-Liver Fibrosis Effect of Mongolian Medicine","award":["YKD2022TD039"],"award-info":[{"award-number":["YKD2022TD039"]}]},{"name":"Natural Science Foundation of Inner Mongolia Autonomous Region of China","award":["2023MS08043"],"award-info":[{"award-number":["2023MS08043"]}]},{"DOI":"10.13039\/100019027","name":"Inner Mongolia University of Science and Technology","doi-asserted-by":"publisher","award":["YKD2023MS072"],"award-info":[{"award-number":["YKD2023MS072"]}],"id":[{"id":"10.13039\/100019027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nat Med"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s11418-025-01958-8","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T19:00:27Z","timestamp":1770404427000},"page":"288-300","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Total flavonoids from Carthamus tinctorius L. inhibit the liver fibrosis progression via Hippo\/YAP pathway"],"prefix":"10.1007","volume":"80","author":[{"given":"Xiaomei","family":"Bao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haisheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghe","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1414-0066","authenticated-orcid":false,"given":"Yuehong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"issue":"9","key":"1958_CR1","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/S1875-5364(23)60443-1","volume":"21","author":"Y Li","year":"2023","unstructured":"Li Y, Lu Y, Nian M, Sheng Q, Zhang C, Han C, Dou X, Ding Y (2023) Therapeutic potential and mechanism of Chinese herbal medicines in treating fibrotic liver disease. Chin J Nat Med 21(9):643\u2013657. https:\/\/doi.org\/10.1016\/S1875-5364(23)60443-1","journal-title":"Chin J Nat Med"},{"issue":"08","key":"1958_CR2","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1604\/j.cnki.cn15-1175.2018.08.033","volume":"24","author":"M Silimu","year":"2018","unstructured":"Silimu M, Liang J, Jin R, Su XL, Ma YH (2018) Research progress on mongolian medicine in the treatment of liver diseases. J Med Pharm Chin Minor 24(08):60\u201363. https:\/\/doi.org\/10.1604\/j.cnki.cn15-1175.2018.08.033","journal-title":"J Med Pharm Chin Minor"},{"issue":"9","key":"1958_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13091098","volume":"13","author":"NS Alshareef","year":"2024","unstructured":"Alshareef NS, AlSedairy SA, Al-Harbi LN, Alshammari GM, Yahya MA (2024) Carthamus tinctorius L. (safflower) flower extract attenuates hepatic injury and steatosis in a rat model of type 2 diabetes mellitus via Nrf2-dependent hypoglycemic, antioxidant, and hypolipidemic effects. Antioxidants 13(9):1098. https:\/\/doi.org\/10.3390\/antiox13091098","journal-title":"Antioxidants"},{"issue":"11","key":"1958_CR4","doi-asserted-by":"publisher","first-page":"104","DOI":"10.13412\/j.cnki.zyyl.2023.11.003","volume":"39","author":"YB Liu","year":"2023","unstructured":"Liu YB, Zhou BC, Ding X, Wu YJ, Fu HQ, Li MH (2023) Informatics study on the treatment of liver diseases with Gurigumu prescriptions. Pharmacol Clin Chin Mater Med 39(11):104\u2013110. https:\/\/doi.org\/10.13412\/j.cnki.zyyl.2023.11.003","journal-title":"Pharmacol Clin Chin Mater Med"},{"issue":"01","key":"1958_CR5","doi-asserted-by":"publisher","first-page":"200","DOI":"10.13193\/j.issn.1673-7717.2024.01.036","volume":"42","author":"MQ Li","year":"2024","unstructured":"Li MQ, Zhao XL, Gao XY, Ma YH (2024) Pharmacological mechanism and application progress of total flavonoids in botanicals. Chin J Tradit Chin Med 42(01):200\u2013204. https:\/\/doi.org\/10.13193\/j.issn.1673-7717.2024.01.036","journal-title":"Chin J Tradit Chin Med"},{"issue":"3","key":"1958_CR6","doi-asserted-by":"publisher","first-page":"215","DOI":"10.2174\/0113816128288527240108110844","volume":"30","author":"K He","year":"2024","unstructured":"He K, Wang Z, Liu M, Du W, Yin T, Bai R, Duan Q, Wang Y, Lei H, Zheng Y (2024) Exploring the effect of Xiao-Chai-Hu decoction on treating psoriasis based on network pharmacology and experiment validation. Curr Pharm Des 30(3):215\u2013229. https:\/\/doi.org\/10.2174\/0113816128288527240108110844","journal-title":"Curr Pharm Des"},{"issue":"7","key":"1958_CR7","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1007\/s11011-021-00750-3","volume":"36","author":"MM Gravandi","year":"2021","unstructured":"Gravandi MM, Fakhri S, Zarneshan SN, Yarmohammadi A, Khan H (2021) Flavonoids modulate AMPK\/PGC-1\u03b1 and interconnected pathways toward potential neuroprotective activities. Metab Brain Dis 36(7):1501\u20131521. https:\/\/doi.org\/10.1007\/s11011-021-00750-3","journal-title":"Metab Brain Dis"},{"issue":"4","key":"1958_CR8","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1111\/bcpt.13944","volume":"133","author":"P Tveden-Nyborg","year":"2023","unstructured":"Tveden-Nyborg P, Bergmann TK, Jessen N, Simonsen U, Lykkesfeldt J (2023) BCPT 2023 policy for experimental and clinical studies. Basic Clin Pharmacol Toxicol 133(4):391\u2013396. https:\/\/doi.org\/10.1111\/bcpt.13944","journal-title":"Basic Clin Pharmacol Toxicol"},{"issue":"6","key":"1958_CR9","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1111\/bcpt.14109","volume":"135","author":"P Tveden-Nyborg","year":"2024","unstructured":"Tveden-Nyborg P, Yang BX, Simonsen U, Lykkesfeldt J (2024) BCPT perspectives on studies involving natural products, traditional Chinese medicine and systems pharmacology. Basic Clin Pharmacol Toxicol 135(6):782\u2013785. https:\/\/doi.org\/10.1111\/bcpt.14109","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"1958_CR10","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-030420-105050","author":"JH Driskill","year":"2020","unstructured":"Driskill JH, Pan DJ (2020) The hippo pathway in liver homeostasis and pathophysiology. Annu Rev Pathol. https:\/\/doi.org\/10.1146\/annurev-pathol-030420-105050","journal-title":"Annu Rev Pathol"},{"key":"1958_CR11","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2017.3207","author":"J Peng","year":"2017","unstructured":"Peng J, Wang HL, Wang X, Sun MH, Deng SP, Wang Y (2017) YAP and TAZ mediate steroid-induced alterations in the trabecular meshwork cytoskeleton in human trabecular meshwork cells. Int J Mol Med. https:\/\/doi.org\/10.3892\/ijmm.2017.3207","journal-title":"Int J Mol Med"},{"issue":"1","key":"1958_CR12","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.jcmgh.2023.09.008","volume":"17","author":"HY Kim","year":"2020","unstructured":"Kim HY, Sakane S, Eguileor A, Carvalho Gontijo Weber R, Lee W, Liu X, Lam K, Ishizuka K, Rosenthal SB, Diggle K, Brenner DA, Kisseleva T (2020) The origin and fate of liver myofibroblasts. Cell Mol Gastroenterol Hepatol 17(1):93\u2013106. https:\/\/doi.org\/10.1016\/j.jcmgh.2023.09.008","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"1958_CR13","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.730176","volume":"9","author":"Z Tan","year":"2021","unstructured":"Tan Z, Sun H, Xue T, Gan C, Liu H, Xie Y, Yao Y, Ye T (2021) Liver fibrosis: therapeutic targets and advances in drug therapy. Front Cell Dev Biol 9:730176. https:\/\/doi.org\/10.3389\/fcell.2021.730176","journal-title":"Front Cell Dev Biol"},{"key":"1958_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2020.108445","volume":"689","author":"E Novo","year":"2020","unstructured":"Novo E, Bocca C, Foglia B, Protopapa F, Maggiora M, Parola M, Cannito S (2020) Liver fibrogenesis: un update on established and emerging basic concepts. Arch Biochem Biophys 689:108445. https:\/\/doi.org\/10.1016\/j.abb.2020.108445","journal-title":"Arch Biochem Biophys"},{"key":"1958_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.112714","volume":"254","author":"B Zhang","year":"2020","unstructured":"Zhang B, Lai L, Tan Y, Liang Q, Bai F, Mai W, Huang Q, Ye Y (2020) Hepatoprotective effect of total flavonoids of Mallotus apelta (Lour.) Muell. Arg. leaf against carbon tetrachloride-induced liver fibrosis in rats via modulation of TGF-\u03b21\/Smad and NF-\u03baB signaling pathways. J Ethnopharmacol 254:112714. https:\/\/doi.org\/10.1016\/j.jep.2020.112714","journal-title":"J Ethnopharmacol"},{"key":"1958_CR16","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.actbio.2022.08.065","volume":"152","author":"L Zhou","year":"2022","unstructured":"Zhou L, Liang Q, Li Y, Cao Y, Li J, Yang J, Liu J, Bi J, Liu Y (2022) Collagenase-I decorated co-delivery micelles potentiate extracellular matrix degradation and hepatic stellate cell targeting for liver fibrosis therapy. Acta Biomater 152:235\u2013254. https:\/\/doi.org\/10.1016\/j.actbio.2022.08.065","journal-title":"Acta Biomater"},{"issue":"14","key":"1958_CR17","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14508","volume":"8","author":"M Fenlon","year":"2020","unstructured":"Fenlon M, Short C, Xu J, Malkoff N, Mahdi E, Hough M, Glazier A, Lee C, Asahina K, Wang KS (2020) Prominin-1-expressing hepatic progenitor cells induce fibrogenesis in murine cholestatic liver injury. Physiol Rep 8(14):e14508. https:\/\/doi.org\/10.14814\/phy2.14508","journal-title":"Physiol Rep"},{"issue":"4","key":"1958_CR18","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1002\/hep.30965","volume":"71","author":"Y Nakano","year":"2020","unstructured":"Nakano Y, Kamiya A, Sumiyoshi H, Tsuruya K, Kagawa T, Inagaki Y (2020) A deactivation factor of fibrogenic hepatic stellate cells induces regression of liver fibrosis in mice. Hepatology 71(4):1437\u20131452. https:\/\/doi.org\/10.1002\/hep.30965","journal-title":"Hepatology"},{"key":"1958_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103029","volume":"69","author":"Y Fu","year":"2024","unstructured":"Fu Y, Zhou X, Wang L, Fan W, Gao S, Zhang D, Ling Z, Zhang Y, Ma L, Bai F, Chen J, Sun B, Liu P (2024) Salvianolic acid B attenuates liver fibrosis by targeting Ecm1 and inhibiting hepatocyte ferroptosis. Redox Biol 69:103029. https:\/\/doi.org\/10.1016\/j.redox.2024.103029","journal-title":"Redox Biol"},{"issue":"10","key":"1958_CR20","doi-asserted-by":"publisher","first-page":"119","DOI":"10.13193\/j.issn.1673-7717.2023.10.024","volume":"41","author":"Yu Yang","year":"2023","unstructured":"Yang Yu, Huang XL, Jiang ZM, Keshang ADM, Han YC, Yu J (2023) New advances in the study of chemical constituents and pharmacological effects of safflower in traditional Chinese medicine. Chin Arch Tradit Chin Med 41(10):119\u2013126. https:\/\/doi.org\/10.13193\/j.issn.1673-7717.2023.10.024","journal-title":"Chin Arch Tradit Chin Med"},{"issue":"11","key":"1958_CR21","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.13699\/j.cnki.1001-6821.2022.11.014","volume":"38","author":"G Batu Deli","year":"2022","unstructured":"Batu Deli G, Xue L, Muren XuYH, Chen HM, Da AN, Na RS, Han ZQ (2022) Effects of Dedu Safflower-7 flavour powder on apoptotic protein expression in rats with carbon tetrachloride-induced chronic liver injury. Chin J Clin Pharmacol 38(11):1215\u20131218. https:\/\/doi.org\/10.13699\/j.cnki.1001-6821.2022.11.014","journal-title":"Chin J Clin Pharmacol"},{"issue":"5","key":"1958_CR22","doi-asserted-by":"publisher","first-page":"943","DOI":"10.3390\/nu11050943","volume":"11","author":"H Ashktorab","year":"2019","unstructured":"Ashktorab H, Soleimani A, Singh G, Amin A, Tabtabaei S, Latella G, Stein U, Akhondzadeh S, Solanki N, Gondre-Lewis MC, Habtezion A, Brim H (2019) Saffron: the golden spice with therapeutic properties on digestive diseases. Nutrients 11(5):943. https:\/\/doi.org\/10.3390\/nu11050943","journal-title":"Nutrients"},{"issue":"1","key":"1958_CR23","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3390\/molecules27010010","volume":"27","author":"O Mykhailenko","year":"2021","unstructured":"Mykhailenko O, Petrikaite V, Korinek M, Chang FR, El-Shazly M, Yen CH, Bezruk I, Chen BH, Hsieh CF, Lytkin D, Ivanauskas L, Georgiyants V, Hwang TL (2021) Pharmacological potential and chemical composition of Crocus sativus leaf extracts. Molecules 27(1):10. https:\/\/doi.org\/10.3390\/molecules27010010","journal-title":"Molecules"},{"key":"1958_CR24","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6480590","author":"Z Maqbool","year":"2022","unstructured":"Maqbool Z, Arshad MS, Ali A, Aziz A, Khalid W, Afzal MF, Bangar SP, Addi M, Hano C, Lorenzo JM (2022) Potential role of phytochemical extract from saffron in development of functional foods and protection of brain-related disorders. Oxid Med Cell Longev. https:\/\/doi.org\/10.1155\/2022\/6480590","journal-title":"Oxid Med Cell Longev"},{"issue":"5","key":"1958_CR25","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.ejps.2012.03.003","volume":"46","author":"CC Li","year":"2012","unstructured":"Li CC, Yang CZ, Li XM, Zhao XM, Zou Y, Fan L, Zhou L, Liu JC, Niu YC (2012) Hydroxysafflor yellow A induces apoptosis in activated hepatic stellate cells through ERK1\/2 pathway in vitro. Eur J Pharm Sci 46(5):397\u2013404. https:\/\/doi.org\/10.1016\/j.ejps.2012.03.003","journal-title":"Eur J Pharm Sci"},{"issue":"7","key":"1958_CR26","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.phymed.2013.02.001","volume":"20","author":"CY Wang","year":"2013","unstructured":"Wang CY, Liu Q, Huang QX, Liu JT, He YH, Lu JJ, Bai XY (2013) Activation of PPAR\u03b3 is required for hydroxysafflor yellow A of Carthamus tinctorius to attenuate hepatic fibrosis induced by oxidative stress. Phytomedicine 20(7):592\u2013599. https:\/\/doi.org\/10.1016\/j.phymed.2013.02.001","journal-title":"Phytomedicine"},{"issue":"2\u20133","key":"1958_CR27","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.ejphar.2011.04.015","volume":"660","author":"Y Zhang","year":"2011","unstructured":"Zhang Y, Guo J, Dong H, Zhao X, Zhou L, Li X, Liu J, Niu Y (2011) Hydroxysafflor yellow A protects against chronic carbon tetrachloride-induced liver fibrosis. Eur J Pharmacol 660(2\u20133):438\u2013444. https:\/\/doi.org\/10.1016\/j.ejphar.2011.04.015","journal-title":"Eur J Pharmacol"},{"issue":"24","key":"1958_CR28","doi-asserted-by":"publisher","first-page":"6249","DOI":"10.3390\/ijms20246249","volume":"20","author":"M Correia de Sousa","year":"2019","unstructured":"Correia de Sousa M, Gjorgjieva M, Dolicka D, Sobolewski C, Foti M (2019) Deciphering miRNAs\u2019 action through miRNA editing. Int J Mol Sci 20(24):6249. https:\/\/doi.org\/10.3390\/ijms20246249","journal-title":"Int J Mol Sci"},{"key":"1958_CR29","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1146\/annurev-biochem-060308-103103","volume":"79","author":"MR Fabian","year":"2010","unstructured":"Fabian MR, Sonenberg N, Filipowicz W (2010) Regulation of mrna translation and stability by micrornas. Annu Rev Biochem 79:351\u2013379. https:\/\/doi.org\/10.1146\/annurev-biochem-060308-103103","journal-title":"Annu Rev Biochem"},{"issue":"7","key":"1958_CR30","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202413525","volume":"2","author":"X Fan","year":"2025","unstructured":"Fan X, Li B, Zhang F, Liu M, Kwan HY, Liu Z, Su T (2025) FGF19-activated hepatic stellate cells release ANGPTL4 that promotes colorectal cancer liver metastasis. Adv Sci (Weinh) 2(7):e2413525. https:\/\/doi.org\/10.1002\/advs.202413525","journal-title":"Adv Sci (Weinh)"}],"container-title":["Journal of Natural Medicines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-025-01958-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11418-025-01958-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-025-01958-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T06:27:27Z","timestamp":1773383247000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11418-025-01958-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,6]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["1958"],"URL":"https:\/\/doi.org\/10.1007\/s11418-025-01958-8","relation":{},"ISSN":["1340-3443","1861-0293"],"issn-type":[{"value":"1340-3443","type":"print"},{"value":"1861-0293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,6]]},"assertion":[{"value":"24 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was approved by the Biomedical Research Ethics Committee of Inner Mongolia Medical University on March 7, 2019, with the approval number: YKD2019144, in accordance with the guidelines for the management and use of laboratory animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors indicated no potential conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}