{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:22:16Z","timestamp":1783606936889,"version":"3.55.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:00:00Z","timestamp":1780704000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:00:00Z","timestamp":1780704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Talent Cultivation Project of Beijing University of Chinese Medicine","award":["JZPY202206"],"award-info":[{"award-number":["JZPY202206"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2023-JYB-JBQN-051"],"award-info":[{"award-number":["2023-JYB-JBQN-051"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nat Med"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s11418-025-01998-0","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T18:19:31Z","timestamp":1780769971000},"page":"974-986","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Traditional Chinese medicine formula Xiang Bei San suppresses the growth and metastasis of breast cancer by regulating macrophage polarization and tumor vascularization"],"prefix":"10.1007","volume":"80","author":[{"given":"Jinxin","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuguo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiming","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejiao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4849-3353","authenticated-orcid":false,"given":"Zhongdong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,6]]},"reference":[{"key":"1998_CR1","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s12929-019-0568-z","volume":"26","author":"Y Chen","year":"2019","unstructured":"Chen Y, Song Y, Du W et al (2019) Tumor-associated macrophages: an accomplice in solid tumor progression. J Biomed Sci 26:78","journal-title":"J Biomed Sci"},{"key":"1998_CR2","doi-asserted-by":"publisher","first-page":"3354","DOI":"10.1158\/0008-5472.CAN-22-3707","volume":"83","author":"N Cohen","year":"2023","unstructured":"Cohen N, Mundhe D, Deasy SK et al (2023) Breast cancer-secreted factors promote lung metastasis by signaling systemically to induce a fibrotic premetastatic niche. Cancer Res 83:3354\u20133367","journal-title":"Cancer Res"},{"key":"1998_CR3","doi-asserted-by":"publisher","first-page":"155913","DOI":"10.1016\/j.phymed.2024.155913","volume":"133","author":"Z Feng","year":"2024","unstructured":"Feng Z, Chan YT, Lu Y et al (2024) Siwu decoction suppress myeloid-derived suppressor cells through tumour cells necroptosis to inhibit hepatocellular carcinoma. Phytomedicine 133:155913","journal-title":"Phytomedicine"},{"key":"1998_CR4","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1158\/2159-8290.CD-18-1177","volume":"9","author":"AC Garrido-Castro","year":"2019","unstructured":"Garrido-Castro AC, Lin NU, Polyak K (2019) Insights into molecular classifications of triple-negative breast cancer: improving patient selection for treatment. Cancer Discov 9:176\u2013198","journal-title":"Cancer Discov"},{"key":"1998_CR5","doi-asserted-by":"publisher","first-page":"109103","DOI":"10.1016\/j.intimp.2022.109103","volume":"111","author":"J Guo","year":"2022","unstructured":"Guo J, Shen Y, Hu S et al (2022) Neobavaisoflavone inhibits antitumor immunosuppression via myeloid-derived suppressor cells. Int Immunopharmacol 111:109103","journal-title":"Int Immunopharmacol"},{"key":"1998_CR6","doi-asserted-by":"publisher","first-page":"3370","DOI":"10.1038\/onc.2011.496","volume":"31","author":"LG Harris","year":"2012","unstructured":"Harris LG, Pannell LK, Singh S et al (2012) Increased vascularity and spontaneous metastasis of breast cancer by Hedgehog signaling mediated upregulation of cyr61. Oncogene 31:3370\u20133380","journal-title":"Oncogene"},{"key":"1998_CR7","doi-asserted-by":"publisher","first-page":"2689","DOI":"10.3748\/wjg.v30.i20.2689","volume":"30","author":"LM Huang","year":"2024","unstructured":"Huang LM, Zhang MJ (2024) Kinesin 26B modulates M2 polarization of macrophage by activating cancer-associated fibroblasts to aggravate gastric cancer occurrence and metastasis. World J Gastroenterol 30:2689\u20132708","journal-title":"World J Gastroenterol"},{"key":"1998_CR8","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1186\/s12967-023-04061-2","volume":"21","author":"Y Huo","year":"2023","unstructured":"Huo Y, Zhang H, Sa L et al (2023) M1 polarization enhances the antitumor activity of chimeric antigen receptor macrophages in solid tumors. J Transl Med 21:225","journal-title":"J Transl Med"},{"key":"1998_CR9","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/s12906-021-03318-x","volume":"21","author":"W Jia","year":"2021","unstructured":"Jia W, Luo S, Lai G et al (2021) Homogeneous Polyporus polysaccharide inhibits bladder cancer by polarizing macrophages to M1 subtype in tumor microenvironment. BMC Complement Med Ther 21:150","journal-title":"BMC Complement Med Ther"},{"key":"1998_CR10","first-page":"101","volume":"31","author":"Z Jia","year":"2024","unstructured":"Jia Z, Liu CB, Zhou Q et al (2024) Hepatic arterial intervention combined with Xiangbei San in the treatmentof refractory breast cancer with liver metastasis: a case report and literature review. Chin J Cancer Biother 31:101\u2013104","journal-title":"Chin J Cancer Biother"},{"key":"1998_CR11","first-page":"407","volume":"26","author":"F Jin","year":"2017","unstructured":"Jin F, Jiang K, Ji S et al (2017) Deficient TSC1\/TSC2-complex suppression of SOX9-osteopontin-AKT signalling cascade constrains tumour growth in tuberous sclerosis complex. Hum Mol Genet 26:407\u2013419","journal-title":"Hum Mol Genet"},{"key":"1998_CR12","doi-asserted-by":"publisher","first-page":"20049","DOI":"10.1038\/srep20049","volume":"6","author":"Y Li","year":"2016","unstructured":"Li Y, Qi W, Song X et al (2016) Huaier extract suppresses breast cancer via regulating tumor-associated macrophages. Sci Rep 6:20049","journal-title":"Sci Rep"},{"key":"1998_CR13","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.msec.2019.01.025","volume":"98","author":"W Li","year":"2019","unstructured":"Li W, Song K, Wang S et al (2019) Anti-tumor potential of astragalus polysaccharides on breast cancer cell line mediated by macrophage activation. Mater Sci Eng C Mater Biol Appl 98:685\u2013695","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"1998_CR14","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1007\/s11418-018-1173-2","volume":"72","author":"Y Liu","year":"2018","unstructured":"Liu Y, Ren W, Bai Y et al (2018) Oxyresveratrol prevents murine H22 hepatocellular carcinoma growth and lymph node metastasis via inhibiting tumor angiogenesis and lymphangiogenesis. J Nat Med 72:481\u2013492","journal-title":"J Nat Med"},{"key":"1998_CR15","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1111\/jop.13459","volume":"52","author":"AZ Lu","year":"2023","unstructured":"Lu AZ, Chandra D, Chandra SR et al (2023) Differential pericyte marker expression in craniofacial benign and malignant vascular tumors. J Oral Pathol Med 52:660\u2013665","journal-title":"J Oral Pathol Med"},{"key":"1998_CR16","doi-asserted-by":"crossref","unstructured":"Medeiros B, Allan AL (2019) Molecular mechanisms of breast cancer metastasis to the lung: clinical and experimental perspectives. Int J Mol Sci 20","DOI":"10.3390\/ijms20092272"},{"key":"1998_CR17","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/S0002-9440(10)64920-6","volume":"160","author":"S Morikawa","year":"2002","unstructured":"Morikawa S, Baluk P, Kaidoh T et al (2002) Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors. Am J Pathol 160:985\u20131000","journal-title":"Am J Pathol"},{"key":"1998_CR18","doi-asserted-by":"publisher","first-page":"3223","DOI":"10.1021\/acs.molpharmaceut.3c00279","volume":"20","author":"F Ren","year":"2023","unstructured":"Ren F, Zhu W, Yang S et al (2023) Coumarin-based fluorescent inhibitors for photocontrollable bioactivation. Mol Pharm 20:3223\u20133233","journal-title":"Mol Pharm"},{"key":"1998_CR19","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.1158\/0008-5472.CAN-20-3558","volume":"81","author":"B Segura-Collar","year":"2021","unstructured":"Segura-Collar B, Garranzo-Asensio M, Herranz B et al (2021) Tumor-derived pericytes driven by EGFR mutations govern the vascular and immune microenvironment of gliomas. Cancer Res 81:2142\u20132156","journal-title":"Cancer Res"},{"key":"1998_CR20","doi-asserted-by":"publisher","first-page":"4242","DOI":"10.1111\/cas.14648","volume":"111","author":"L Song","year":"2020","unstructured":"Song L, Chen X, Mi L et al (2020) Icariin-induced Inhibition of SIRT6\/NF-kappaB triggers redox mediated apoptosis and enhances anti-tumor immunity in triple-negative breast cancer. Cancer Sci 111:4242\u20134256","journal-title":"Cancer Sci"},{"key":"1998_CR21","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1002\/ptr.8054","volume":"38","author":"MA Thalappil","year":"2024","unstructured":"Thalappil MA, Singh P, Carcereri De Prati A et al (2024) Essential oils and their nanoformulations for breast cancer therapy. Phytother Res 38:556\u2013591","journal-title":"Phytother Res"},{"key":"1998_CR22","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.it.2004.02.013","volume":"25","author":"TC Theoharides","year":"2004","unstructured":"Theoharides TC, Conti P (2004) Mast cells: the Jekyll and Hyde of tumor growth. Trends Immunol 25:235\u2013241","journal-title":"Trends Immunol"},{"key":"1998_CR23","doi-asserted-by":"publisher","first-page":"1063051","DOI":"10.3389\/fonc.2023.1063051","volume":"13","author":"JA Thomas","year":"2023","unstructured":"Thomas JA, Gireesh Moly AG, Xavier H et al (2023) Enhancement of immune surveillance in breast cancer by targeting hypoxic tumor endothelium: can it be an immunological switch point? Front Oncol 13:1063051","journal-title":"Front Oncol"},{"key":"1998_CR24","doi-asserted-by":"publisher","first-page":"5645","DOI":"10.1038\/s41598-018-21515-6","volume":"8","author":"JB Wang","year":"2018","unstructured":"Wang JB, Cui HR, Wang RL et al (2018) A systems pharmacology-oriented discovery of a new therapeutic use of the TCM formula Liuweiwuling for liver failure. Sci Rep 8:5645","journal-title":"Sci Rep"},{"key":"1998_CR25","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1007\/s11655-019-3168-6","volume":"25","author":"XQ Wang","year":"2019","unstructured":"Wang XQ, Zhang Y, Hou W et al (2019) Association between Chinese medicine therapy and survival outcomes in postoperative patients with NSCLC: a multicenter, prospective, cohort study. Chin J Integr Med 25:812\u2013819","journal-title":"Chin J Integr Med"},{"key":"1998_CR26","doi-asserted-by":"publisher","first-page":"4205","DOI":"10.1007\/s00210-023-02871-1","volume":"397","author":"L Wang","year":"2024","unstructured":"Wang L, Guo W, Guan H et al (2024) Tramadol suppresses growth of orthotopic liver tumors via promoting M1 macrophage polarization in the tumor microenvironment. Naunyn Schmiedebergs Arch Pharmacol 397:4205\u20134218","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"1998_CR27","first-page":"1249","volume":"47","author":"JX Xie","year":"2024","unstructured":"Xie JX, Wang WY, Quan XM et al (2024) Inhibitory effect of Xiang Bei San on growth of human breast cancer cellsMCF-7 and MDA-MB-231 by activating AMPK\/mTOR signaling pathway. Drug Eval Res 47:1249\u20131258","journal-title":"Drug Eval Res"},{"key":"1998_CR28","doi-asserted-by":"publisher","first-page":"113249","DOI":"10.1016\/j.jep.2020.113249","volume":"264","author":"Z Yang","year":"2021","unstructured":"Yang Z, Zhang Q, Yu L et al (2021) The signaling pathways and targets of traditional Chinese medicine and natural medicine in triple-negative breast cancer. J Ethnopharmacol 264:113249","journal-title":"J Ethnopharmacol"},{"key":"1998_CR29","doi-asserted-by":"publisher","first-page":"7351","DOI":"10.7150\/thno.74753","volume":"12","author":"H Zeng","year":"2022","unstructured":"Zeng H, Hou Y, Zhou X et al (2022) Cancer-associated fibroblasts facilitate premetastatic niche formation through LncRNA SNHG5-mediated angiogenesis and vascular permeability in breast cancer. Theranostics 12:7351\u20137370","journal-title":"Theranostics"},{"key":"1998_CR30","doi-asserted-by":"publisher","first-page":"109636","DOI":"10.1016\/j.biopha.2019.109636","volume":"121","author":"H Zhuang","year":"2020","unstructured":"Zhuang H, Dai X, Zhang X et al (2020) Sophoridine suppresses macrophage-mediated immunosuppression through TLR4\/IRF3 pathway and subsequently upregulates CD8(+) T cytotoxic function against gastric cancer. Biomed Pharmacother 121:109636","journal-title":"Biomed Pharmacother"}],"container-title":["Journal of Natural Medicines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-025-01998-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11418-025-01998-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-025-01998-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:04:36Z","timestamp":1783605876000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11418-025-01998-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,6]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["1998"],"URL":"https:\/\/doi.org\/10.1007\/s11418-025-01998-0","relation":{},"ISSN":["1340-3443","1861-0293"],"issn-type":[{"value":"1340-3443","type":"print"},{"value":"1861-0293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,6]]},"assertion":[{"value":"23 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have declared that no competing interests exist.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}