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In this study, we investigated the anti-inflammatory effects of\n                    <jats:italic>trans<\/jats:italic>\n                    -cinnamic acid on neutrophil accumulation during inflammatory processes using both in vivo and in vitro approaches. For the in vivo experiments, LPS-induced pleurisy was used in mice pretreated with\n                    <jats:italic>trans<\/jats:italic>\n                    -cinnamic acid. Inflammatory parameters, including plasma leakage, leukocyte infiltration, and proinflammatory cytokine levels (IL-6 and TNF-\u03b1), were quantified in the pleural exudate. In vitro, the effects of\n                    <jats:italic>trans<\/jats:italic>\n                    -cinnamic acid on neutrophil chemotaxis toward CXCL1 were assessed using the Boyden chamber assay. Additionally, human endothelial EA.hy926 cells were stimulated with TNF-\u03b1 to evaluate neutrophil adhesion and the expression of the adhesion molecule ICAM-1 following\n                    <jats:italic>trans<\/jats:italic>\n                    -cinnamic acid treatment. Pretreatment with\n                    <jats:italic>trans<\/jats:italic>\n                    -cinnamic acid significantly inhibited LPS-induced pleurisy in mice by reducing protein-rich exudate formation, neutrophil infiltration, and local concentrations of TNF-\u03b1 and IL-6. In vitro,\n                    <jats:italic>trans<\/jats:italic>\n                    -cinnamic acid did not alter CXCL1-induced neutrophil chemotaxis, nor the secretion of CXCL8 produced by TNF-\u03b1-stimulated EA.hy926 cells. However, it markedly reduced neutrophil adhesion to TNF-\u03b1-activated EA.hy926 cells. This reduction was associated with the downregulation of ICAM-1 expression at both the mRNA and protein levels. Overall, these findings demonstrated that\n                    <jats:italic>trans<\/jats:italic>\n                    -cinnamic acid exerted anti-inflammatory effects by inhibiting vascular permeability and leukocyte recruitment, particularly through the suppression of ICAM-1-mediated neutrophil adhesion to endothelial cells. These results support\n                    <jats:italic>trans<\/jats:italic>\n                    -cinnamic acid as a promising candidate for the development of new therapeutic agents targeting inflammatory diseases.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphical abstract<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1007\/s11418-026-02004-x","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T18:10:46Z","timestamp":1770487846000},"page":"378-388","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti-inflammatory effects of trans-cinnamic acid through modulation of endothelial ICAM-1 expression and neutrophil recruitment"],"prefix":"10.1007","volume":"80","author":[{"given":"Mark","family":"de Sousa Pinheiro Fidelix","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam\u00e1rio Lino","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordana Rodrigues","family":"Santana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alef Batista Bezerra","family":"Barros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erick Gabriel Alves","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graziele Regina Souza","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamylle Nunes de Souza","family":"Ferro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliane Pereira","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Lagente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4956-5075","authenticated-orcid":false,"given":"Emiliano","family":"Barreto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,7]]},"reference":[{"key":"2004_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.866747","volume":"13","author":"JG Filep","year":"2022","unstructured":"Filep JG (2022) Targeting neutrophils for promoting the resolution of inflammation. 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