{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T15:13:08Z","timestamp":1779203588739,"version":"3.51.4"},"reference-count":89,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nat Med"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1007\/s11418-026-02015-8","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T01:57:24Z","timestamp":1773021444000},"page":"657-679","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Olive (Olea europaea) phenolics for the control of psoriasis via targeting SMYD2 and IL-17A protein\u2013protein interaction networks"],"prefix":"10.1007","volume":"80","author":[{"given":"Md Ashiq","family":"Mahmud","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed M.","family":"Mohyeldin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md Towhidul Islam","family":"Tarun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abu Bakar","family":"Siddique","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sitanshu S.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1456-4064","authenticated-orcid":false,"given":"Khalid A.","family":"El Sayed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"2015_CR1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1111\/ijd.17497","volume":"64","author":"S Amara","year":"2025","unstructured":"Amara S, Pasumarthi A, Parikh N, Kodali N, Lebwohl M, Monks G (2025) Psoriasis management tree based on comorbidity. Int J Dermatol 64:229\u2013245. https:\/\/doi.org\/10.1111\/ijd.17497","journal-title":"Int J Dermatol"},{"key":"2015_CR2","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.mpdhp.2024.11.005","volume":"31","author":"MT Fernandez-Figueras","year":"2024","unstructured":"Fernandez-Figueras MT, Puig L (2024) Histopathological diagnosis of psoriasis and psoriasiform dermatitides. Diagn Histopathol 31:87\u201397. https:\/\/doi.org\/10.1016\/j.mpdhp.2024.11.005","journal-title":"Diagn Histopathol"},{"key":"2015_CR3","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1007\/s10787-023-01178-0","volume":"31","author":"OY Elkhawaga","year":"2023","unstructured":"Elkhawaga OY, Ellety MM, Mofty SO, Ghanem MS, Mohamed AO (2023) Review of natural compounds for potential psoriasis treatment. Inflammopharmacology 31:1183\u20131198. https:\/\/doi.org\/10.1007\/s10787-023-01178-0","journal-title":"Inflammopharmacology"},{"key":"2015_CR4","doi-asserted-by":"publisher","first-page":"13313","DOI":"10.3390\/ijms241713313","volume":"24","author":"HJ Lee","year":"2023","unstructured":"Lee HJ, Kim M (2023) Challenges and future trends in the treatment of psoriasis. Int J Mol Sci 24:13313. https:\/\/doi.org\/10.3390\/ijms241713313","journal-title":"Int J Mol Sci"},{"key":"2015_CR5","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-019-0711-4","volume":"11","author":"X Yi","year":"2019","unstructured":"Yi X, Jiang XJ, Fang ZM (2019) Histone methyltransferase SMYD2: ubiquitous regulator of disease. Clin Epigenetics 11:112. https:\/\/doi.org\/10.1186\/s13148-019-0711-4","journal-title":"Clin Epigenetics"},{"key":"2015_CR6","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1016\/j.celrep.2019.10.004","volume":"29","author":"Y Zeng","year":"2019","unstructured":"Zeng Y, Qiu R, Yang Y, Gao T, Zheng Y, Huang W et al (2019) Regulation of EZH2 by SMYD2-mediated lysine methylation is implicated in tumorigenesis. Cell Rep 29:1482\u20131498e4. https:\/\/doi.org\/10.1016\/j.celrep.2019.10.004","journal-title":"Cell Rep"},{"key":"2015_CR7","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.591","volume":"11","author":"W Wu","year":"2021","unstructured":"Wu W, Wang J, Xiao C, Su Z, Su H, Zhong W et al (2021) SMYD2-mediated TRAF2 methylation promotes the NF-\u03baB signaling pathways in inflammatory diseases. Clin Transl Med 11:e591. https:\/\/doi.org\/10.1002\/ctm2.591","journal-title":"Clin Transl Med"},{"key":"2015_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2024.105971","volume":"202","author":"Z Zhao","year":"2024","unstructured":"Zhao Z, Yang X (2024) Inhibition of SMYD2 attenuates paraquat-induced pulmonary fibrosis by inhibiting the epithelial\u2013mesenchymal transition through the GLIPR2\/ERK\/p38 axis. Pestic Biochem Physiol 202:105971. https:\/\/doi.org\/10.1016\/j.pestbp.2024.105971","journal-title":"Pestic Biochem Physiol"},{"key":"2015_CR9","doi-asserted-by":"publisher","first-page":"5414","DOI":"10.1074\/jbc.M114.610345","volume":"290","author":"G Xu","year":"2015","unstructured":"Xu G, Liu G, Xiong S, Liu H, Chen X, Zheng B (2015) The histone methyltransferase SMYD2 is a negative regulator of macrophage activation by suppressing interleukin-6 and tumor necrosis factor-\u03b1 production. J Biol Chem 290:5414\u20135423. https:\/\/doi.org\/10.1074\/jbc.M114.610345","journal-title":"J Biol Chem"},{"key":"2015_CR10","doi-asserted-by":"publisher","first-page":"6329","DOI":"10.3390\/ijms26136329","volume":"26","author":"D Romh\u00e1nyi","year":"2025","unstructured":"Romh\u00e1nyi D, Bessenyei \u00c1, Szab\u00f3 K, Kem\u00e9ny L, Gyulai R, Groma G (2025) Unveiling the role of histone methyltransferases in psoriasis pathogenesis: insights from transcriptomic analysis. Int J Mol Sci 26:6329. https:\/\/doi.org\/10.3390\/ijms26136329","journal-title":"Int J Mol Sci"},{"key":"2015_CR11","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1111\/bph.16237","volume":"182","author":"D Dorna","year":"2025","unstructured":"Dorna D, Grabowska A, Paluszczak J (2025) Natural products modulating epigenetic mechanisms by affecting histone methylation\/demethylation: targeting cancer cells. Br J Pharmacol 182:2137\u20132158. https:\/\/doi.org\/10.1111\/bph.16237","journal-title":"Br J Pharmacol"},{"key":"2015_CR12","doi-asserted-by":"publisher","first-page":"5765","DOI":"10.1172\/JCI134217","volume":"130","author":"A M\u00fcller","year":"2020","unstructured":"M\u00fcller A, Dickmanns A, Resch C, Sch\u00e4kel K, Hailfinger S, Dobbelstein M et al (2020) The CDK4\/6\u2013EZH2 pathway is a potential therapeutic target for psoriasis. J Clin Invest 130:5765\u20135781. https:\/\/doi.org\/10.1172\/JCI134217","journal-title":"J Clin Invest"},{"key":"2015_CR13","doi-asserted-by":"publisher","first-page":"E5825","DOI":"10.1073\/pnas.1509971112","volume":"112","author":"C Johansen","year":"2015","unstructured":"Johansen C, Mose M, Ommen P, Bertelsen T, Vinter H, Hailfinger S et al (2015) I\u03baB\u03b6 is a key driver in the development of psoriasis. Proc Natl Acad Sci USA 112:E5825\u2013E5833. https:\/\/doi.org\/10.1073\/pnas.1509971112","journal-title":"Proc Natl Acad Sci USA"},{"key":"2015_CR14","doi-asserted-by":"publisher","DOI":"10.1177\/2040622320987348","volume":"12","author":"S Qu","year":"2021","unstructured":"Qu S, Liu Z, Wang B (2021) EZH2 is involved in psoriasis progression by impairing miR-125a-5p inhibition of SFMBT1 and leading to inhibition of the TGF\u03b2\/SMAD pathway. Ther Adv Chronic Dis 12:2040622320987348. https:\/\/doi.org\/10.1177\/2040622320987348","journal-title":"Ther Adv Chronic Dis"},{"key":"2015_CR15","doi-asserted-by":"publisher","first-page":"10088","DOI":"10.1073\/pnas.1801377115","volume":"115","author":"A M\u00fcller","year":"2018","unstructured":"M\u00fcller A, Hennig A, Lorscheid S, Grondona P, Schulze-Osthoff K, Hailfinger S et al (2018) I\u03baB\u03b6 is a key transcriptional regulator of IL-36-driven psoriasis-related gene expression in keratinocytes. Proc Natl Acad Sci USA 115:10088\u201310093. https:\/\/doi.org\/10.1073\/pnas.1801377115","journal-title":"Proc Natl Acad Sci USA"},{"key":"2015_CR16","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-03028-1","volume":"11","author":"T Zhang","year":"2020","unstructured":"Zhang T, Yang L, Ke Y, Lei J, Shen S, Shao S et al (2020) EZH2-dependent epigenetic modulation of histone H3 lysine-27 contributes to psoriasis by promoting keratinocyte proliferation. Cell Death Dis 11:826. https:\/\/doi.org\/10.1038\/s41419-020-03028-1","journal-title":"Cell Death Dis"},{"key":"2015_CR17","doi-asserted-by":"publisher","first-page":"4219","DOI":"10.1007\/s11033-010-0544-x","volume":"38","author":"Y Liu","year":"2011","unstructured":"Liu Y, Luo W, Chen S (2011) Comparison of gene expression profiles reveals aberrant expression of FOXO1, Aurora A\/B and EZH2 in lesional psoriatic skins. Mol Biol Rep 38:4219\u20134224. https:\/\/doi.org\/10.1007\/s11033-010-0544-x","journal-title":"Mol Biol Rep"},{"key":"2015_CR18","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1510-8","volume":"10","author":"S Sun","year":"2019","unstructured":"Sun S, Zhang X, Xu M, Zhang F, Tian F, Cui J et al (2019) Berberine downregulates CDC6 and inhibits proliferation via targeting JAK\u2013STAT3 signaling in keratinocytes. Cell Death Dis 10:274. https:\/\/doi.org\/10.1038\/s41419-019-1510-8","journal-title":"Cell Death Dis"},{"key":"2015_CR19","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1001\/jamadermatol.2018.2127","volume":"154","author":"C Phan","year":"2018","unstructured":"Phan C, Touvier M, Kesse-Guyot E, Adjibade M, Hercberg S, Wolkenstein P et al (2018) Association between Mediterranean anti-inflammatory dietary profile and severity of psoriasis. JAMA Dermatol 154:1017\u20131024. https:\/\/doi.org\/10.1001\/jamadermatol.2018.2127","journal-title":"JAMA Dermatol"},{"key":"2015_CR20","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s12967-014-0372-1","volume":"13","author":"L Barrea","year":"2015","unstructured":"Barrea L, Balato N, Di Somma C, Macchia PE, Napolitano M, Savanelli MC et al (2015) Nutrition and psoriasis: association between disease severity and adherence to the mediterranean diet. J Transl Med 13:18. https:\/\/doi.org\/10.1186\/s12967-014-0372-1","journal-title":"J Transl Med"},{"key":"2015_CR21","doi-asserted-by":"publisher","first-page":"e164","DOI":"10.1111\/ijd.14523","volume":"58","author":"A Korovesi","year":"2019","unstructured":"Korovesi A, Dalamaga M, Kotopouli M, Papadavid E (2019) Adherence to the mediterranean diet is independently associated with psoriasis risk, severity, and quality of life. Int J Dermatol 58:e164\u2013e165. https:\/\/doi.org\/10.1111\/ijd.14523","journal-title":"Int J Dermatol"},{"key":"2015_CR22","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.semcancer.2023.08.001","volume":"95","author":"E Almanza-Aguilera","year":"2023","unstructured":"Almanza-Aguilera E, Cano A, Gil-Lespinard M, Burguera N, Zamora-Ros R, Agudo A et al (2023) Mediterranean diet and Olive oil, microbiota, and obesity-related cancers. Semin Cancer Biol 95:103\u2013119. https:\/\/doi.org\/10.1016\/j.semcancer.2023.08.001","journal-title":"Semin Cancer Biol"},{"key":"2015_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.108851","volume":"108","author":"A Donato-Trancoso","year":"2022","unstructured":"Donato-Trancoso A, Correa Atella G, Romana-Souza B (2022) Dietary olive oil intake aggravates psoriatic skin inflammation in mice via Nrf2 activation. Int Immunopharmacol 108:108851. https:\/\/doi.org\/10.1016\/j.intimp.2022.108851","journal-title":"Int Immunopharmacol"},{"key":"2015_CR24","doi-asserted-by":"publisher","first-page":"205","DOI":"10.36721\/PJPS.2021.34.1.SUP.205-215.1","volume":"34","author":"SA Rashid","year":"2021","unstructured":"Rashid SA, Bashir S, Ullah H, Shah KU, Khan DH, Shah PA et al (2021) Methotrexate\u2013olive oil nano-emulsion for topical application. Pak J Pharm Sci 34:205\u2013215. https:\/\/doi.org\/10.36721\/PJPS.2021.34.1.SUP.205-215.1","journal-title":"Pak J Pharm Sci"},{"key":"2015_CR25","doi-asserted-by":"publisher","DOI":"10.3390\/nu17142334","volume":"17","author":"D De Stefanis","year":"2025","unstructured":"De Stefanis D, Costelli P (2025) Extra virgin olive oil components and pro-inflammatory cytokines. Nutrients 17:2334. https:\/\/doi.org\/10.3390\/nu17142334","journal-title":"Nutrients"},{"key":"2015_CR26","doi-asserted-by":"publisher","DOI":"10.3390\/biology10111121","volume":"10","author":"SA Rashid","year":"2021","unstructured":"Rashid SA, Bashir S, Naseem F, Farid A, Rather IA, Hakeem KR (2021) Olive oil-based methotrexate nanoemulsion gel for psoriasis. Biology (Basel) 10:1121. https:\/\/doi.org\/10.3390\/biology10111121","journal-title":"Biology (Basel)"},{"key":"2015_CR27","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.70976","volume":"13","author":"MJ Anwar","year":"2025","unstructured":"Anwar MJ, Anwar MH, Imran M, Noman AM, Hussain M, Raza H, Mohamed HM, Mohamed GA, Ibrahim SRM, Yehuala TF, Alsagaby SA, Al Abdulmonem W, Abdelgawad MA, Mostafa EM, Ghoneim MM, Selim S (2025) Olive oil polyphenols: a promising approach for cancer prevention and therapy. Food Sci Nutr 13:e70976. https:\/\/doi.org\/10.1002\/fsn3.70976","journal-title":"Food Sci Nutr"},{"key":"2015_CR28","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2020.100642","author":"Q Shi","year":"2020","unstructured":"Shi Q, He Q, Chen W, Long J, Zhang B (2020) Oleuropein modulates keratinocyte proliferation and TH17 differentiation. Arch Med Sci. https:\/\/doi.org\/10.5114\/aoms.2020.100642","journal-title":"Arch Med Sci"},{"key":"2015_CR29","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1080\/17425247.2021.1932813","volume":"18","author":"RI El-Gogary","year":"2021","unstructured":"El-Gogary RI, Ragai MH, Moftah N, Nasr M (2021) Oleuropein as a topical antipsoriatic nutraceutical. Expert Opin Drug Deliv 18:1523\u20131532. https:\/\/doi.org\/10.1080\/17425247.2021.1932813","journal-title":"Expert Opin Drug Deliv"},{"key":"2015_CR30","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.ctim.2018.12.003","volume":"42","author":"JM Segura Palacios","year":"2019","unstructured":"Segura Palacios JM, Bl\u00e1zquez S\u00e1nchez N, Rivas Ruiz F, Aguilar Bernier M, Ram\u00edrez L\u00f3pez B, de Troya Mart\u00edn M (2019) Topical oleocanthal extract reduces inflammatory reactions after photodynamic therapy. Complement Ther Med 42:298\u2013301. https:\/\/doi.org\/10.1016\/j.ctim.2018.12.003","journal-title":"Complement Ther Med"},{"key":"2015_CR31","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031206","volume":"23","author":"S Cirmi","year":"2022","unstructured":"Cirmi S, Maugeri A, Russo C, Musumeci L, Navarra M, Lombardo GE (2022) Oleacein attenuates LPS-induced inflammation in macrophages. Int J Mol Sci 23:1206. https:\/\/doi.org\/10.3390\/ijms23031206","journal-title":"Int J Mol Sci"},{"key":"2015_CR32","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1080\/08923973.2022.2143373","volume":"45","author":"C Chen","year":"2023","unstructured":"Chen C, Chen L, Zhou J, Cai R, Ye Z, Zhang D (2023) Anti-psoriasis activities of Hydroxytyrosol on HaCaT cells. Immunopharmacol Immunotoxicol 45:328\u2013333. https:\/\/doi.org\/10.1080\/08923973.2022.2143373","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"2015_CR33","doi-asserted-by":"publisher","first-page":"10200","DOI":"10.1039\/d2fo00351a","volume":"13","author":"ML Castej\u00f3n","year":"2022","unstructured":"Castej\u00f3n ML, Montoya T, Ortega-Vidal J, Altarejos J, Alarc\u00f3n-de-la-Lastra C (2022) Ligstroside aglycon prevents inflammation by regulating multiple pathways. Food Funct 13:10200\u201310209. https:\/\/doi.org\/10.1039\/d2fo00351a","journal-title":"Food Funct"},{"key":"2015_CR34","doi-asserted-by":"publisher","DOI":"10.4081\/dr.2025.10333","author":"S Amato","year":"2025","unstructured":"Amato S, Dattola A, Bennardo L, Tolone M, Nistic\u00f2 SP (2025) Polyphenol-based formulation in palmoplantar psoriasis. Dermatol Rep. https:\/\/doi.org\/10.4081\/dr.2025.10333","journal-title":"Dermatol Rep"},{"key":"2015_CR35","doi-asserted-by":"publisher","DOI":"10.3390\/nu17030397","volume":"17","author":"MTI Tarun","year":"2025","unstructured":"Tarun MTI, Elsayed HE, Ebrahim HY, El Sayed KA (2025) Oleocanthal suppresses colorectal cancer via SMYD2\u2013EZH2 modulation. Nutrients 17:397. https:\/\/doi.org\/10.3390\/nu17030397","journal-title":"Nutrients"},{"key":"2015_CR36","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14143542","volume":"14","author":"AB Siddique","year":"2022","unstructured":"Siddique AB, Ebrahim HY, Tajmim A, King JA, Abdelwahed KS, Abd Elmageed ZY, El Sayed KA (2022) Oleocanthal targets SMYD2 in prostate cancer. Cancers (Basel) 14:3542. https:\/\/doi.org\/10.3390\/cancers14143542","journal-title":"Cancers (Basel)"},{"key":"2015_CR37","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.1002\/jsfa.13139","volume":"104","author":"CG Tsiafoulis","year":"2024","unstructured":"Tsiafoulis CG, Liaggou C, Garoufis A, Magiatis P, Roussis IG (2024) NMR analysis of extra Virgin Olive oil. J Sci Food Agric 104:1992\u20132005. https:\/\/doi.org\/10.1002\/jsfa.13139","journal-title":"J Sci Food Agric"},{"key":"2015_CR38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0214798","volume":"14","author":"AB Siddique","year":"2019","unstructured":"Siddique AB, Ebrahim H, Mohyeldin M, Qusa M, Batarseh Y, Fayyad A, Tajmim A, Nazzal S, Kaddoumi A, El Sayed K (2019) Isolation of olive oil phenolics and oral anti-breast cancer activity. PLoS One 14:e0214798. https:\/\/doi.org\/10.1371\/journal.pone.0214798","journal-title":"PLoS One"},{"key":"2015_CR39","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30010139","volume":"30","author":"MA Mahmud","year":"2025","unstructured":"Mahmud MA, Siddique AB, Tajmim A, King JA, El Sayed KA (2025) Ligstroside aglycone suppresses melanoma via BRAF signaling. Molecules 30:139. https:\/\/doi.org\/10.3390\/molecules30010139","journal-title":"Molecules"},{"issue":"1","key":"2015_CR40","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1186\/s12885-018-4299-4","volume":"18","author":"H Li","year":"2018","unstructured":"Li H, Huang N, Zhu W, Wu J, Yang X, Teng W, Tian J, Fang Z, Luo Y, Chen M, Li Y (2018) Modulation the crosstalk between tumor-associated macrophages and non-small cell lung cancer to inhibit tumor migration and invasion by ginsenoside Rh2. BMC Cancer 18(1):579. https:\/\/doi.org\/10.1186\/s12885-018-4299-4","journal-title":"BMC Cancer"},{"issue":"3","key":"2015_CR41","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23030517","volume":"23","author":"X Luo","year":"2018","unstructured":"Luo X, Zhang H, Wei X, Shi M, Fan P, Xie W, Zhang Y, Xu N (2018) Aloin suppresses lipopolysaccharide-induced inflammatory response and apoptosis by inhibiting the activation of NF-\u03baB. Molecules 23(3):517. https:\/\/doi.org\/10.3390\/molecules23030517","journal-title":"Molecules"},{"key":"2015_CR42","unstructured":"Zymo Research (2025) How to extract RNA from TRIzol. Available online: https:\/\/www.zymoresearch.com"},{"key":"2015_CR43","doi-asserted-by":"publisher","first-page":"4291","DOI":"10.1021\/acs.jctc.1c00302","volume":"17","author":"C Lu","year":"2021","unstructured":"Lu C, Wu C, Ghoreishi D, Chen W, Wang L, Abel R (2021) OPLS4 force field improvement. J Chem Theory Comput 17:4291\u20134300. https:\/\/doi.org\/10.1021\/acs.jctc.1c00302","journal-title":"J Chem Theory Comput"},{"key":"2015_CR44","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1002\/ptr.5882","volume":"31","author":"AH Elmaidomy","year":"2017","unstructured":"Elmaidomy AH, Mohyeldin MM, Ibrahim MM, Hassan HM, Amin E, Rateb ME, Hetta MH, El Sayed KA (2017) Acylated iridoids and rhamnopyranoses from Premna odorata (Lamiaceae) as novel mesenchymal-epithelial transition factor receptor inhibitors for the control of breast cancer. Phytother Res 31:1546\u20131556. https:\/\/doi.org\/10.1002\/ptr.5882","journal-title":"Phytother Res"},{"key":"2015_CR45","doi-asserted-by":"publisher","first-page":"146","DOI":"10.2174\/157340911795677602","volume":"7","author":"XY Meng","year":"2011","unstructured":"Meng XY, Zhang HX, Mezei M, Cui M (2011) Molecular docking: a powerful approach for structure-based drug discovery. Curr Comput-Aided Drug Des 7:146\u2013157. https:\/\/doi.org\/10.2174\/157340911795677602","journal-title":"Curr Comput-Aided Drug Des"},{"key":"2015_CR46","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.sjbs.2020.10.023","volume":"28","author":"JJ Sahayarayan","year":"2021","unstructured":"Sahayarayan JJ, Rajan KS, Vidhyavathi R, Nachiappan M, Prabhu D, Alfarraj S, Arokiyaraj S, Daniel AN (2021) In-silico protein-ligand docking studies against the estrogen protein of breast cancer using pharmacophore based virtual screening approaches. Saudi J Biol Sci 28:400\u2013407. https:\/\/doi.org\/10.1016\/j.sjbs.2020.10.023","journal-title":"Saudi J Biol Sci"},{"key":"2015_CR47","doi-asserted-by":"publisher","first-page":"12899","DOI":"10.1039\/c0cp00151a","volume":"12","author":"SY Huang","year":"2010","unstructured":"Huang SY, Grinter SZ, Zou X (2010) Scoring functions and their evaluation methods for protein-ligand docking: recent advances and future directions. Phys Chem Chem Phys 12:12899\u201312908. https:\/\/doi.org\/10.1039\/c0cp00151a","journal-title":"Phys Chem Chem Phys"},{"key":"2015_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiolchem.2025.108344","volume":"115","author":"S M","year":"2025","unstructured":"M S, Y I, N I, S MZ (2025) Synergistic suppression of cell growth: Phenmiazine derivatives targeting p53 and MDM2 unveiled through hybrid computational method. Comput Biol Chem 115:108344. https:\/\/doi.org\/10.1016\/j.compbiolchem.2025.108344","journal-title":"Comput Biol Chem"},{"key":"2015_CR49","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1021\/ci800324m","volume":"49","author":"TA Halgren","year":"2009","unstructured":"Halgren TA (2009) Identifying and characterizing binding sites. J Chem Inf Model 49:377\u2013389. https:\/\/doi.org\/10.1021\/ci800324m","journal-title":"J Chem Inf Model"},{"key":"2015_CR50","doi-asserted-by":"publisher","DOI":"10.3390\/nu17091445","volume":"17","author":"NA Ahmed","year":"2025","unstructured":"Ahmed NA, Mohyeldin MM, Ebrahim HY, McGehee OC, Tarun MTI, El Sayed KA (2025) (-)-Oleuropein as a novel metastatic castration-resistant prostate cancer progression and recurrence suppressor via targeting PCSK9-LDLR axis. Nutrients 17:1445. https:\/\/doi.org\/10.3390\/nu17091445","journal-title":"Nutrients"},{"key":"2015_CR51","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-025-13558-3","volume":"109","author":"N Siddique","year":"2025","unstructured":"Siddique N, Rahman MM, Hasnat S, Arafat KY, Rahman ANMA, Talukder AK, Karim MR, Das ZC, Islam T, Hoque MN (2025) Probiotic potential and antimicrobial efficacy of a dairy isolate, Enterococcus faecium MBBL3. Appl Microbiol Biotech 109:176. https:\/\/doi.org\/10.1007\/s00253-025-13558-3","journal-title":"Appl Microbiol Biotech"},{"key":"2015_CR52","doi-asserted-by":"publisher","first-page":"294","DOI":"10.2174\/1568026613666131127125858","volume":"14","author":"M Alvim-Gaston","year":"2014","unstructured":"Alvim-Gaston M, Grese T, Mahoui A, Palkowitz AD, Watson I (2014) Open innovation drug discovery. Curr Top Med Chem 14:294\u2013303. https:\/\/doi.org\/10.2174\/1568026613666131127125858","journal-title":"Curr Top Med Chem"},{"key":"2015_CR53","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104847","volume":"158","author":"KS Abdelwahed","year":"2020","unstructured":"Abdelwahed KS, Siddique AB, Mohyeldin MM, Qusa MH, Goda AA, El Sayed KA (2020) Pseurotin A inhibits PCSK9. Pharmacol Res 158:104847. https:\/\/doi.org\/10.1016\/j.phrs.2020.104847","journal-title":"Pharmacol Res"},{"key":"2015_CR54","unstructured":"NCBI (2025) EIF2S2 gene. Available online: https:\/\/www.ncbi.nlm.nih.gov\/gene\/8894"},{"key":"2015_CR55","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/j.jid.2022.11.010","volume":"143","author":"M Karmon","year":"2023","unstructured":"Karmon M, Kopel E, Barzilai A, Geva P, Eisenberg E, Greenberger S (2023) Altered RNA editing in atopic dermatitis. J Invest Dermatol 143:933\u2013943. https:\/\/doi.org\/10.1016\/j.jid.2022.11.010","journal-title":"J Invest Dermatol"},{"key":"2015_CR56","doi-asserted-by":"publisher","first-page":"3867","DOI":"10.3390\/cells11233867","volume":"11","author":"S Dorai","year":"2022","unstructured":"Dorai S, Alex Anand D (2022) Cell cycle genes and STAT1\/3 in psoriasis. Cells 11:3867. https:\/\/doi.org\/10.3390\/cells11233867","journal-title":"Cells"},{"key":"2015_CR57","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/j.jid.2021.08.430","volume":"142","author":"Y Yu","year":"2022","unstructured":"Yu Y, Xue X, Tang W, Su L, Zhang L, Zhang Y (2022) STING-dependent inflammation in psoriasis. J Invest Dermatol 142:898\u2013906. https:\/\/doi.org\/10.1016\/j.jid.2021.08.430","journal-title":"J Invest Dermatol"},{"key":"2015_CR58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/cei.13455","volume":"202","author":"Y Luo","year":"2020","unstructured":"Luo Y, Hara T, Kawashima A, Suzuki K (2020) Excessive DNA triggers keratinocyte proliferation. Clin Exp Immunol 202:1\u201310. https:\/\/doi.org\/10.1111\/cei.13455","journal-title":"Clin Exp Immunol"},{"key":"2015_CR59","doi-asserted-by":"publisher","first-page":"409","DOI":"10.2147\/ITT.S240891","volume":"10","author":"M Mosca","year":"2021","unstructured":"Mosca M, Hong J, Hadeler E, Hakimi M, Liao W, Bhutani T (2021) Role of IL-17 cytokines in psoriasis. Immunotargets Ther 10:409\u2013418. https:\/\/doi.org\/10.2147\/ITT.S240891","journal-title":"Immunotargets Ther"},{"key":"2015_CR60","doi-asserted-by":"publisher","first-page":"15382","DOI":"10.1038\/ncomms15382","volume":"8","author":"LC Tsoi","year":"2017","unstructured":"Tsoi LC, Stuart PE, Tian C, Gudjonsson JE, Das S, Barker JN et al (2017) Genetic architecture of psoriasis. Nat Commun 8:15382. https:\/\/doi.org\/10.1038\/ncomms15382","journal-title":"Nat Commun"},{"key":"2015_CR61","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2020.9480","volume":"21","author":"J Zhang","year":"2021","unstructured":"Zhang J, Zhang J, Lin Q, Chen L, Song Y (2021) IL-17 promotes proliferation of HaCaT cells. Exp Ther Med 21:49. https:\/\/doi.org\/10.3892\/etm.2020.9480","journal-title":"Exp Ther Med"},{"key":"2015_CR62","doi-asserted-by":"publisher","first-page":"2585","DOI":"10.2147\/CCID.S430621","volume":"16","author":"LL Yuan","year":"2023","unstructured":"Yuan LL, Cao CY (2023) Rehmannioside A improves psoriasis via IL-17A interference. Clin Cosmet Investig Dermatol 16:2585\u20132596. https:\/\/doi.org\/10.2147\/CCID.S430621","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"2015_CR63","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1146\/annurev-immunol-032713-120225","volume":"32","author":"MA Lowes","year":"2014","unstructured":"Lowes MA, Su\u00e1rez-Fari\u00f1as M, Krueger JG (2014) Immunology of psoriasis. Annu Rev Immunol 32:227\u2013255. https:\/\/doi.org\/10.1146\/annurev-immunol-032713-120225","journal-title":"Annu Rev Immunol"},{"key":"2015_CR64","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01682","volume":"9","author":"NC Brembilla","year":"2018","unstructured":"Brembilla NC, Senra L, Boehncke WH (2018) IL-17 family cytokines in psoriasis. Front Immunol 9:1682. https:\/\/doi.org\/10.3389\/fimmu.2018.01682","journal-title":"Front Immunol"},{"key":"2015_CR65","doi-asserted-by":"publisher","first-page":"4627","DOI":"10.3892\/mmr.2018.8460","volume":"17","author":"Y Chen","year":"2018","unstructured":"Chen Y, Zhong M, Yuan G, Peng H (2018) IL-17 induces angiogenesis. Mol Med Rep 17:4627\u20134632. https:\/\/doi.org\/10.3892\/mmr.2018.8460","journal-title":"Mol Med Rep"},{"key":"2015_CR66","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1191645","volume":"14","author":"H Liang","year":"2023","unstructured":"Liang H, Li J, Zhang K (2023) Pathogenic role of S100 proteins in psoriasis. Front Immunol 14:1191645. https:\/\/doi.org\/10.3389\/fimmu.2023.1191645","journal-title":"Front Immunol"},{"key":"2015_CR67","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05321-7","volume":"13","author":"H Su","year":"2022","unstructured":"Su H, Meng C, Xu J, Su Z, Xiao C, Yang D (2022) SMYD2 regulates STAT3 phosphorylation. Cell Death Dis 13:890. https:\/\/doi.org\/10.1038\/s41419-022-05321-7","journal-title":"Cell Death Dis"},{"key":"2015_CR68","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e32015","volume":"10","author":"J Meng","year":"2024","unstructured":"Meng J, Yang W, Li C, Li F (2024) SMYD2 inhibitor BAY-598 synergy with doxorubicin. Heliyon 10:e32015. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e32015","journal-title":"Heliyon"},{"key":"2015_CR69","doi-asserted-by":"publisher","first-page":"7791","DOI":"10.4049\/jimmunol.179.11.7791","volume":"179","author":"SC Liang","year":"2007","unstructured":"Liang SC, Long AJ, Bennett F, Whitters MJ, Karim R, Collins M, Goldman SJ, Dunussi-Joannopoulos K, Williams CM, Wright JF, Fouser LA (2007) An IL-17F\/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment. The Journal of Immunology 179:7791\u20137799. https:\/\/doi.org\/10.4049\/jimmunol.179.11.7791","journal-title":"The Journal of Immunology"},{"key":"2015_CR70","doi-asserted-by":"publisher","first-page":"171","DOI":"10.2174\/1876894601002010171","volume":"2","author":"B Ciric","year":"2010","unstructured":"Ciric B, Rostami A (2010) IL-17A in autoimmune inflammation of the central nervous system: a promising therapeutic target in multiple sclerosis? Open Autoimmun J 2:171\u2013180. https:\/\/doi.org\/10.2174\/1876894601002010171","journal-title":"Open Autoimmun J"},{"key":"2015_CR71","doi-asserted-by":"publisher","first-page":"8828","DOI":"10.1021\/acs.jmedchem.2c00422","volume":"65","author":"MD Andrews","year":"2022","unstructured":"Andrews MD, Dack KN, de Groot MJ, Lambert M, Larsen M, Stahlhut M (2022) IL-17A protein\u2013protein interaction modulator. J Med Chem 65:8828\u20138842. https:\/\/doi.org\/10.1021\/acs.jmedchem.2c00422","journal-title":"J Med Chem"},{"key":"2015_CR72","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2880","volume":"4","author":"S Liu","year":"2013","unstructured":"Liu S, Song X, Chrunyk BA, Shanker S, Hoth LR, Marr ES (2013) Crystal structures of IL-17A. Nat Commun 4:1888. https:\/\/doi.org\/10.1038\/ncomms2880","journal-title":"Nat Commun"},{"key":"2015_CR73","doi-asserted-by":"publisher","DOI":"10.1007\/s11030-025-11271-x","author":"A Razzaq","year":"2025","unstructured":"Razzaq A, Sardar M, Mushtaq M, Wang Y, Ul-Haq Z (2025) IL-17A inhibitory mechanisms. Mol Divers. https:\/\/doi.org\/10.1007\/s11030-025-11271-x","journal-title":"Mol Divers"},{"key":"2015_CR74","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-08360-9","volume":"7","author":"A Goepfert","year":"2017","unstructured":"Goepfert A, Lehmann S, Wirth E, Rondeau JM (2017) IL-17A\/F heterodimer receptor recognition. Sci Rep 7:8906. https:\/\/doi.org\/10.1038\/s41598-017-08360-9","journal-title":"Sci Rep"},{"key":"2015_CR75","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1038\/s41586-022-05116-y","volume":"609","author":"SC Wilson","year":"2022","unstructured":"Wilson SC, Caveney NA, Yen M, Pollmann C, Garcia KC (2022) Structural principles of IL-17 signaling. Nature 609:622\u2013629. https:\/\/doi.org\/10.1038\/s41586-022-05116-y","journal-title":"Nature"},{"key":"2015_CR76","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-96699-9","volume":"15","author":"K Ding","year":"2025","unstructured":"Ding K, Xie R, Han B, Zheng H, Tian T (2025) SMYD2 regulates hepatic stellate cell activation. Sci Rep 15:13166. https:\/\/doi.org\/10.1038\/s41598-025-96699-9","journal-title":"Sci Rep"},{"key":"2015_CR77","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.jphs.2023.07.003","volume":"153","author":"M Chen","year":"2023","unstructured":"Chen M, Zuo S, Chen S, Li X, Zhang T, Yang D (2023) SMYD2 inhibition protects against renal fibrosis. J Pharmacol Sci 153:38\u201345. https:\/\/doi.org\/10.1016\/j.jphs.2023.07.003","journal-title":"J Pharmacol Sci"},{"key":"2015_CR78","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/j.it.2024.10.003","volume":"45","author":"RWM Kempkes","year":"2024","unstructured":"Kempkes RWM, Prinjha RK, de Winther MPJ, Neele AE (2024) Dynamic function of PRC2 in innate immunity. Trends Immunol 45:1015\u20131030. https:\/\/doi.org\/10.1016\/j.it.2024.10.003","journal-title":"Trends Immunol"},{"key":"2015_CR79","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05321-7","volume":"13","author":"H Su","year":"2022","unstructured":"Su H, Meng C, Xu J, Su Z, Xiao C, Yang D (2022) Histone methyltransferase Smyd2 drives adipogenesis via regulating STAT3 phosphorylation. Cell Death Dis 13:890. https:\/\/doi.org\/10.1038\/s41419-022-05321-7","journal-title":"Cell Death Dis"},{"key":"2015_CR80","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.ccr.2013.04.008","volume":"23","author":"E Kim","year":"2013","unstructured":"Kim E, Kim M, Woo DH, Shin Y, Shin J, Chang N, Oh YT, Kim H, Rheey J, Nakano I, Lee C, Joo KM, Rich JN, Nam DH, Lee J (2013) Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells. Cancer Cell 23:839\u2013852. https:\/\/doi.org\/10.1016\/j.ccr.2013.04.008","journal-title":"Cancer Cell"},{"key":"2015_CR81","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.1016\/j.jid.2016.07.027","volume":"136","author":"H Lee","year":"2016","unstructured":"Lee H, Ryu WI, Kim HJ, Bae HC, Ryu HJ, Shin JJ, Song KH, Kim TW, Son SW (2016) TSLP downregulates S100A7 and \u00df-defensin 2 via the JAK2\/STAT3-dependent mechanism. J Invest Dermatol 136:2427\u20132435. https:\/\/doi.org\/10.1016\/j.jid.2016.07.027","journal-title":"J Invest Dermatol"},{"key":"2015_CR82","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1002\/eji.201747017","volume":"48","author":"M Tohyama","year":"2018","unstructured":"Tohyama M, Shirakata Y, Hanakawa Y, Dai X, Shiraishi K, Murakami M, Miyawaki S, Mori H, Utsunomiya R, Masuda K, Hashimoto K, Sayama K (2018) Bcl-3 induced by IL-22 via STAT3 activation acts as a potentiator of psoriasis-related gene expression in epidermal keratinocytes. Eur J Immunol 48:168\u2013179. https:\/\/doi.org\/10.1002\/eji.201747017","journal-title":"Eur J Immunol"},{"key":"2015_CR83","doi-asserted-by":"publisher","first-page":"650","DOI":"10.3390\/antiox10050650","volume":"10","author":"T Montoya","year":"2021","unstructured":"Montoya T, S\u00e1nchez-Hidalgo M, Gonz\u00e1lez-Benjumea A, Alarc\u00f3n-de-la-Lastra C (2021) Oleocanthal prevents inflammation in arthritis. Antioxidants 10:650. https:\/\/doi.org\/10.3390\/antiox10050650","journal-title":"Antioxidants"},{"key":"2015_CR84","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2020.113248","volume":"328","author":"R Grewal","year":"2020","unstructured":"Grewal R, Reutzel M, Dilberger B, Hein H, Eckert GP (2020) Oleocanthal and ligstroside protect mitochondrial function. Exp Neurol 328:113248. https:\/\/doi.org\/10.1016\/j.expneurol.2020.113248","journal-title":"Exp Neurol"},{"key":"2015_CR85","doi-asserted-by":"publisher","DOI":"10.1177\/2041731420922701","volume":"11","author":"MC de Andr\u00e9s","year":"2020","unstructured":"de Andr\u00e9s MC, Meiss MS, S\u00e1nchez-Hidalgo M, Oreffo ROC (2020) Acetylated ligstroside aglycone for osteoarthritis. J Tissue Eng 11:2041731420922701. https:\/\/doi.org\/10.1177\/2041731420922701","journal-title":"J Tissue Eng"},{"key":"2015_CR86","doi-asserted-by":"publisher","first-page":"2414","DOI":"10.1159\/000493840","volume":"49","author":"M Scotece","year":"2018","unstructured":"Scotece M, Conde J, Abella V, L\u00f3pez V, Lago F (2018) Oleocanthal inhibits inflammatory mediators in chondrocytes. Cell Physiol Biochem 49:2414\u20132426. https:\/\/doi.org\/10.1159\/000493840","journal-title":"Cell Physiol Biochem"},{"key":"2015_CR87","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.copbio.2011.09.006","volume":"23","author":"S Cicerale","year":"2012","unstructured":"Cicerale S, Lucas LJ, Keast RSJ (2012) Phenolic activities in extra Virgin Olive oil. Curr Opin Biotechnol 23:129\u2013135. https:\/\/doi.org\/10.1016\/j.copbio.2011.09.006","journal-title":"Curr Opin Biotechnol"},{"key":"2015_CR88","doi-asserted-by":"publisher","first-page":"5552","DOI":"10.1021\/acs.jafc.9b00771","volume":"67","author":"T Montoya","year":"2019","unstructured":"Montoya T, Alarc\u00f3n-de-la-Lastra C, Castej\u00f3n ML (2019) Oleocanthal modulates macrophage activation. J Agric Food Chem 67:5552\u20135559. https:\/\/doi.org\/10.1021\/acs.jafc.9b00771","journal-title":"J Agric Food Chem"},{"key":"2015_CR89","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11010056","volume":"11","author":"T Montoya","year":"2021","unstructured":"Montoya T, Alarc\u00f3n-de-la-Lastra C, Castej\u00f3n ML (2021) (-)-methyl-oleocanthal reduces inflammatory response. Antioxidants 11:56. https:\/\/doi.org\/10.3390\/antiox11010056","journal-title":"Antioxidants"}],"container-title":["Journal of Natural Medicines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-026-02015-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11418-026-02015-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-026-02015-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T14:59:12Z","timestamp":1779202752000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11418-026-02015-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,9]]},"references-count":89,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["2015"],"URL":"https:\/\/doi.org\/10.1007\/s11418-026-02015-8","relation":{},"ISSN":["1340-3443","1861-0293"],"issn-type":[{"value":"1340-3443","type":"print"},{"value":"1861-0293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,9]]},"assertion":[{"value":"26 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}