{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T15:19:08Z","timestamp":1783610348130,"version":"3.55.0"},"reference-count":179,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nat Med"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s11418-026-02026-5","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:56:22Z","timestamp":1778644582000},"page":"1278-1300","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The interplay of Ashwagandha with hormonal dynamics and gut microbiota in women with breast cancer: a tri-axial perspective"],"prefix":"10.1007","volume":"80","author":[{"given":"Rawan R.","family":"Kawaf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayah M.","family":"Alkherat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin","family":"Shareef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loulia Khalid","family":"Jandali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rand","family":"Salamalek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarra B.","family":"Shakartalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sama S.","family":"Soliman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nashwa Ahmed","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7691-615X","authenticated-orcid":false,"given":"Sameh S. M.","family":"Soliman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"2026_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112175","volume":"143","author":"S Paul","year":"2021","unstructured":"Paul S et al (2021) Withania somnifera (L.) Dunal (Ashwagandha): a comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects. Biomed Pharmacother 143:112175","journal-title":"Biomed Pharmacother"},{"issue":"12","key":"2026_CR2","volume":"11","author":"J Salve","year":"2019","unstructured":"Salve J et al (2019) Adaptogenic and anxiolytic effects of Ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study. Cureus 11(12):e6466","journal-title":"Cureus"},{"issue":"4","key":"2026_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15041057","volume":"15","author":"P Mikulska","year":"2023","unstructured":"Mikulska P et al (2023) Ashwagandha (Withania somnifera)\u2014current research on the health-promoting activities: a narrative review. Pharmaceutics 15(4):1057","journal-title":"Pharmaceutics"},{"issue":"9","key":"2026_CR4","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.2174\/1570159X19666210712151556","volume":"19","author":"AB Speers","year":"2021","unstructured":"Speers AB et al (2021) Effects of Withania somnifera (Ashwagandha) on stress and the stress- related neuropsychiatric disorders anxiety, depression, and insomnia. Curr Neuropharmacol 19(9):1468\u20131495","journal-title":"Curr Neuropharmacol"},{"key":"2026_CR5","doi-asserted-by":"crossref","unstructured":"Bashir, A., et al., Frontiers | An updated review on phytochemistry and molecular targets of Withania somnifera (L.) Dunal (Ashwagandha). Front Pharmacol, 2023. 14.","DOI":"10.3389\/fphar.2023.1049334"},{"key":"2026_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113759","volume":"269","author":"R Vashi","year":"2021","unstructured":"Vashi R, Patel BM, Goyal RK (2021) Keeping abreast about Ashwagandha in breast cancer. J Ethnopharmacol 269:113759","journal-title":"J Ethnopharmacol"},{"issue":"24","key":"2026_CR7","doi-asserted-by":"publisher","first-page":"7696","DOI":"10.3390\/molecules26247696","volume":"26","author":"T Sultana","year":"2021","unstructured":"Sultana T et al (2021) Withaferin a: from ancient remedy to potential drug candidate. Molecules 26(24):7696","journal-title":"Molecules"},{"issue":"1","key":"2026_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1208\/s12248-013-9531-1","volume":"16","author":"AR Vyas","year":"2013","unstructured":"Vyas AR et al (2013) Molecular targets and mechanisms of cancer prevention and treatment by Withaferin A, a naturally occurring steroidal lactone. AAPS J 16(1):1\u201310","journal-title":"AAPS J"},{"key":"2026_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2023.110698","volume":"384","author":"Z Zhang","year":"2023","unstructured":"Zhang Z et al (2023) Molecular targets and mechanisms of anti-cancer effects of withanolides. Chem Biol Interact 384:110698","journal-title":"Chem Biol Interact"},{"issue":"4","key":"2026_CR10","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1177\/1534735412464551","volume":"12","author":"BM Biswal","year":"2013","unstructured":"Biswal BM et al (2013) Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients. Integr Cancer Ther 12(4):312\u2013322","journal-title":"Integr Cancer Ther"},{"key":"2026_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2020.102642","volume":"57","author":"N Verma","year":"2021","unstructured":"Verma N et al (2021) Safety of Ashwagandha root extract: a randomized, placebo-controlled, study in healthy volunteers. Complement Ther Med 57:102642","journal-title":"Complement Ther Med"},{"issue":"4","key":"2026_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaim.2024.101028","volume":"15","author":"B Patwardhan","year":"2024","unstructured":"Patwardhan B et al (2024) Danish ban on Ashwagandha: truth, evidence, ethics, and regulations. J Ayurveda Integr Med 15(4):101028","journal-title":"J Ayurveda Integr Med"},{"key":"2026_CR13","unstructured":"Shohat B Fau - Gitter S, et al. Antitumor activity of withaferin A (NSC-101088). 1967(0069\u20130112 (Print))."},{"issue":"5 Suppl","key":"2026_CR14","first-page":"208","volume":"8","author":"N Singh","year":"2011","unstructured":"Singh N et al (2011) An Overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda. African J Traditional Complementary Alternative Medi 8(5 Suppl):208","journal-title":"African J Traditional Complementary Alternative Medi"},{"key":"2026_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2023.11069","author":"Z Zhang","year":"2023","unstructured":"Zhang Z et al (2023) Molecular targets and mechanisms of anti-cancer effects of withanolides. Chem Biol Interact. https:\/\/doi.org\/10.1016\/j.cbi.2023.11069","journal-title":"Chem Biol Interact"},{"key":"2026_CR16","unstructured":"Baguley, B.C., et al., Heterogeneity of phenotype in breast cancer cell lines | intechopen. Breast cancer - carcinogenesis, cell growth and signalling pathways, 2011."},{"key":"2026_CR17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077189","author":"R Wadhwa","year":"2013","unstructured":"Wadhwa R et al (2013) Water extract of Ashwagandha leaves has anticancer activity: identification of an active component and its mechanism of action. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0077189","journal-title":"PLoS ONE"},{"issue":"1","key":"2026_CR18","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/1472-6882-11-84","volume":"11","author":"X Zhang","year":"2011","unstructured":"Zhang X et al (2011) Down-regulation of estrogen receptor-alpha and rearranged during transfection tyrosine kinase is associated with withaferin a-induced apoptosis in MCF-7 breast cancer cells. BMC Complementary Alternative Med 11(1):84","journal-title":"BMC Complementary Alternative Med"},{"key":"2026_CR19","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242216513","author":"M Wici\u0144ski","year":"2023","unstructured":"Wici\u0144ski M et al (2023) Can Ashwagandha benefit the endocrine system?\u2014a review. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms242216513","journal-title":"Int J Mol Sci"},{"key":"2026_CR20","doi-asserted-by":"publisher","DOI":"10.3923\/pjbs.2021.1256.1268","author":"HE Megahd","year":"2021","unstructured":"Megahd HE, Gabal AMS (2021) Evaluation of Matcha (*Camellia sinensis*) and Ashwagandha (*Withania somnifera*) efficacy against utero-ovarian injury in rats. Pak J Biol Sci. https:\/\/doi.org\/10.3923\/pjbs.2021.1256.1268","journal-title":"Pak J Biol Sci"},{"key":"2026_CR21","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-1510","author":"SD Stan","year":"2008","unstructured":"Stan SD et al (2008) Withaferin A causes FOXO3a- and Bim-dependent apoptosis and inhibits growth of human breast cancer cells in vivo. Cancer Res. https:\/\/doi.org\/10.1158\/0008-5472.CAN-08-1510","journal-title":"Cancer Res"},{"key":"2026_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2012.08.026","author":"E-R Hahm","year":"2013","unstructured":"Hahm E-R, Singh SV (2013) Withaferin A-induced apoptosis in human breast cancer cells is associated with suppression of inhibitor of apoptosis family protein expression. Cancer Lett. https:\/\/doi.org\/10.1016\/j.canlet.2012.08.026","journal-title":"Cancer Lett"},{"key":"2026_CR23","unstructured":"Zhao, H., et al., The Clinical Implications of RSK1\u20133 in Human Breast Cancer. 2013(1791\u20137530 (Electronic))."},{"key":"2026_CR24","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-2081","author":"A Nagalingam","year":"2014","unstructured":"Nagalingam A et al (2014) Mechanistic elucidation of the antitumor properties of Withaferin A in breast cancer. Cancer Res. https:\/\/doi.org\/10.1158\/0008-5472.CAN-13-2081","journal-title":"Cancer Res"},{"key":"2026_CR25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023354","author":"E-R Hahm","year":"2011","unstructured":"Hahm E-R et al (2011) Withaferin A-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0023354","journal-title":"PLoS ONE"},{"key":"2026_CR26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0168488","author":"K Ghosh","year":"2016","unstructured":"Ghosh K et al (2016) Withaferin A induces ROS-mediated paraptosis in human breast cancer cell-lines MCF-7 and MDA-MB-231. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0168488","journal-title":"PLoS ONE"},{"key":"2026_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2003.07.007","author":"B Jayaprakasam","year":"2003","unstructured":"Jayaprakasam B et al (2003) Growth inhibition of human tumor cell lines by withanolides from *Withania somnifera* leaves. Life Sci. https:\/\/doi.org\/10.1016\/j.lfs.2003.07.007","journal-title":"Life Sci"},{"key":"2026_CR28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030890","author":"A Grover","year":"2012","unstructured":"Grover A et al (2012) Ashwagandha derived Withanone targets TPX2-Aurora A complex: computational and experimental evidence to its anticancer activity. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0030890","journal-title":"PLoS ONE"},{"key":"2026_CR29","doi-asserted-by":"publisher","DOI":"10.1080\/01635580802381477","author":"SD Stan","year":"2008","unstructured":"Stan SD, Zeng Y, Singh SV (2008) Ayurvedic medicine constituent Withaferin A causes G2 and M phase cell cycle arrest in human breast cancer cells. Nutr Cancer. https:\/\/doi.org\/10.1080\/01635580802381477","journal-title":"Nutr Cancer"},{"key":"2026_CR30","doi-asserted-by":"publisher","first-page":"168","DOI":"10.3389\/fcell.2020.00168","volume":"8","author":"W Pu","year":"2020","unstructured":"Pu W, Zheng Y, Peng Y (2020) Frontiers | Prolyl Isomerase Pin1 in human cancer: function, mechanism, and significance. Front Cell Develop Biol 8:168","journal-title":"Front Cell Develop Biol"},{"key":"2026_CR31","doi-asserted-by":"publisher","DOI":"10.1002\/mc.22814","author":"SK Samanta","year":"2018","unstructured":"Samanta SK et al (2018) Peptidyl\u2010prolyl cis\/trans isomerase Pin1 regulates Withaferin A\u2010mediated cell cycle arrest in human breast cancer cells. Mol Carcinog. https:\/\/doi.org\/10.1002\/mc.22814","journal-title":"Mol Carcinog"},{"key":"2026_CR32","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.496844","author":"ML Antony","year":"2014","unstructured":"Antony ML et al (2014) Growth arrest by the antitumor steroidal lactone Withaferin A in human breast cancer cells is associated with down-regulation and covalent binding at Cysteine 303 of \u03b2-Tubulin *. J Biol Chem. https:\/\/doi.org\/10.1074\/jbc.M113.496844","journal-title":"J Biol Chem"},{"key":"2026_CR33","doi-asserted-by":"publisher","DOI":"10.2174\/15680096113139990039","author":"E-R Hahm","year":"2013","unstructured":"Hahm E-R, Singh SV (2013) Autophagy fails to alter Withaferin A-mediated lethality in human breast cancer cells. Curr Cancer Drug Targets. https:\/\/doi.org\/10.2174\/15680096113139990039","journal-title":"Curr Cancer Drug Targets"},{"key":"2026_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2017.07.025","author":"K Ghosh","year":"2017","unstructured":"Ghosh K et al (2017) Withaferin A induced impaired autophagy and unfolded protein response in human breast cancer cell-lines MCF-7 and MDA-MB-231. Toxicol In Vitro. https:\/\/doi.org\/10.1016\/j.tiv.2017.07.025","journal-title":"Toxicol In Vitro"},{"key":"2026_CR35","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2013-0314TR","author":"ME Kidd","year":"2014","unstructured":"Kidd ME, Shumaker DK, Ridge KM (2014) The role of Vimentin intermediate filaments in the progression of lung cancer. Am J Respir Cell Mol Biol. https:\/\/doi.org\/10.1165\/rcmb.2013-0314TR","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"6","key":"2026_CR36","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1002\/mc.22110","volume":"54","author":"J Lee","year":"2015","unstructured":"Lee J et al (2015) Withaferin A inhibits experimental epithelial\u2013mesenchymal transition in MCF-10A cells and suppresses vimentin protein level in vivo in breast tumors. Mol Carcinogenesis 54(6):417","journal-title":"Mol Carcinogenesis"},{"issue":"1","key":"2026_CR37","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s10549-012-2239-6","volume":"136","author":"J Lee","year":"2012","unstructured":"Lee J et al (2012) Withaferin A causes activation of Notch2 and Notch4 in human breast cancer cells. Breast Cancer Res Treatment 136(1):45","journal-title":"Breast Cancer Res Treatment"},{"key":"2026_CR38","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25938","author":"JT Thaiparambil","year":"2011","unstructured":"Thaiparambil JT et al (2011) Withaferin A inhibits breast cancer invasion and metastasis at sub\u2010cytotoxic doses by inducing Vimentin disassembly and Serine 56 phosphorylation. Int J Cancer. https:\/\/doi.org\/10.1002\/ijc.25938","journal-title":"Int J Cancer"},{"key":"2026_CR39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037764","author":"H-C Wang","year":"2012","unstructured":"Wang H-C et al (2012) Withanolides-induced breast cancer cell death is correlated with their ability to inhibit heat protein 90. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0037764","journal-title":"PLoS ONE"},{"key":"2026_CR40","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210477","author":"M Moasser","year":"2007","unstructured":"Moasser M (2007) The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis. Oncogene. https:\/\/doi.org\/10.1038\/sj.onc.1210477","journal-title":"Oncogene"},{"issue":"1","key":"2026_CR41","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1093\/jnci\/59.1.221","volume":"59","author":"J Fogh","year":"1977","unstructured":"Fogh J, Fogh J, Orfeo T (1977) One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. J Natl Cancer Inst 59(1):221","journal-title":"J Natl Cancer Inst"},{"key":"2026_CR42","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2016.0340","author":"HS Schmucker","year":"2017","unstructured":"Schmucker HS et al (2017) RNA expression profiling reveals differentially regulated growth factor and receptor expression in redirected cancer cells. Stem Cells Dev. https:\/\/doi.org\/10.1089\/scd.2016.0340","journal-title":"Stem Cells Dev"},{"key":"2026_CR43","unstructured":"Khazal, K.F., D.L. Hill, and C.J. Grubbs, Effect of Withania somnifera root extract on spontaneous estrogen receptor-negative mammary cancer in MMTV\/Neu mice. 2015(1791\u20137530 (Electronic))."},{"key":"2026_CR44","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djt153","author":"E-R Hahm","year":"2013","unstructured":"Hahm E-R et al (2013) Metabolic alterations in mammary cancer prevention by Withaferin A in a clinically relevant mouse model. JNCI J Natl Cancer Inst. https:\/\/doi.org\/10.1093\/jnci\/djt153","journal-title":"JNCI J Natl Cancer Inst"},{"key":"2026_CR45","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-13-0445","author":"S-H Kim","year":"2014","unstructured":"Kim S-H, Singh SV (2014) Mammary cancer chemoprevention by Withaferin A is accompanied by in vivo suppression of self-renewal of cancer stem cells. Cancer Prev Res. https:\/\/doi.org\/10.1158\/1940-6207.CAPR-13-0445","journal-title":"Cancer Prev Res"},{"key":"2026_CR46","doi-asserted-by":"publisher","DOI":"10.3233\/BD-2010-0307","author":"K Chavez","year":"2010","unstructured":"Chavez K, Garimella S, Lipkowitz S (2010) Triple negative breast cancer cell lines: one tool in the search for better treatment of triple negative breast cancer. Breast Dis. https:\/\/doi.org\/10.3233\/BD-2010-0307","journal-title":"Breast Dis"},{"key":"2026_CR47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075069","author":"Y Zhen","year":"2013","unstructured":"Zhen Y et al (2013) Withania somnifera root extract inhibits mammary cancer metastasis and epithelial to mesenchymal transition. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0075069","journal-title":"PLoS ONE"},{"issue":"2","key":"2026_CR48","doi-asserted-by":"publisher","first-page":"94","DOI":"10.4103\/2394-4722.157601","volume":"1","author":"KF Khazal","year":"2015","unstructured":"Khazal KF et al (2015) Withania somnifera extract reduces the invasiveness of MDA-MB-231 breast cancer and inhibits cytokines associated with metastasis. J Cancer Metastasis Treat 1(2):94","journal-title":"J Cancer Metastasis Treat"},{"key":"2026_CR49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087850","author":"KSv Szic","year":"2014","unstructured":"Szic KSv et al (2014) Pharmacological levels of Withaferin A (Withania somnifera) trigger clinically relevant anticancer effects specific to triple negative breast cancer cells. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0087850","journal-title":"PLoS ONE"},{"key":"2026_CR50","doi-asserted-by":"publisher","DOI":"10.4048\/jbc.2013.16.1.23","author":"S Mirza","year":"2013","unstructured":"Mirza S et al (2013) Expression of DNA methyltransferases in breast cancer patients and to analyze the effect of natural compounds on DNA methyltransferases and associated proteins. J Breast Cancer. https:\/\/doi.org\/10.4048\/jbc.2013.16.1.23","journal-title":"J Breast Cancer"},{"key":"2026_CR51","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(95)01318-0","author":"M Ziauddin","year":"1996","unstructured":"Ziauddin M et al (1996) Studies on the immunomodulatory effects of Ashwagandha. J Ethnopharmacol. https:\/\/doi.org\/10.1016\/0378-8741(95)01318-0","journal-title":"J Ethnopharmacol"},{"key":"2026_CR52","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18071474","author":"SA Jassam","year":"2017","unstructured":"Jassam SA et al (2017) CD15s\/CD62E interaction mediates the adhesion of non-small cell lung cancer cells on brain endothelial cells: implications for cerebral metastasis. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms18071474","journal-title":"Int J Mol Sci"},{"key":"2026_CR53","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(02)02472-4","author":"T Iuvone","year":"2003","unstructured":"Iuvone T et al (2003) Induction of nitric oxide synthase expression by Withania somnifera in macrophages. Life Sci. https:\/\/doi.org\/10.1016\/S0024-3205(02)02472-4","journal-title":"Life Sci"},{"key":"2026_CR54","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01657-08","author":"MN Ndlovu","year":"2009","unstructured":"Ndlovu MN et al (2009) Hyperactivated NF-\u03baB and AP-1 transcription factors promote highly accessible chromatin and constitutive transcription across the interleukin-6 gene promoter in metastatic breast cancer cells. Mol Cell Biol. https:\/\/doi.org\/10.1128\/MCB.01657-08","journal-title":"Mol Cell Biol"},{"key":"2026_CR55","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10163644","author":"A Tharakan","year":"2021","unstructured":"Tharakan A et al (2021) Immunomodulatory effect of Withania somnifera (Ashwagandha) extract\u2014a randomized, double-blind, placebo controlled trial with an open label extension on healthy participants. J Clin Med. https:\/\/doi.org\/10.3390\/jcm10163644","journal-title":"J Clin Med"},{"key":"2026_CR56","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13133357","author":"H Zheng","year":"2021","unstructured":"Zheng H et al (2021) Tumor microenvironment: key players in triple negative breast cancer immunomodulation. Cancers Basel. https:\/\/doi.org\/10.3390\/cancers13133357","journal-title":"Cancers Basel"},{"key":"2026_CR57","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.799428","author":"M Xiao","year":"2021","unstructured":"Xiao M et al (2021) Tumor-associated macrophages: critical players in drug resistance of breast cancer. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2021.799428","journal-title":"Front Immunol"},{"issue":"11","key":"2026_CR58","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1007\/s00262-013-1470-2","volume":"62","author":"S Pratima","year":"2013","unstructured":"Pratima S, Suzanne O-R (2013) Myeloid-derived suppressor cell function is reduced by Withaferin A, a potent and abundant component of Withania somnifera root extract. Cancer Immunol Immunotherapy CII 62(11):1663","journal-title":"Cancer Immunol Immunotherapy CII"},{"key":"2026_CR59","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100587","author":"C Corzo","year":"2010","unstructured":"Corzo C et al (2010) HIF-1\u03b1 regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. J Exp Med. https:\/\/doi.org\/10.1084\/jem.20100587","journal-title":"J Exp Med"},{"key":"2026_CR60","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2018.1444305","author":"X Mu","year":"2018","unstructured":"Mu X et al (2018) Tumor-derived lactate induces M2 macrophage polarization via the activation of the ERK\/STAT3 signaling pathway in breast cancer. Cell Cycle. https:\/\/doi.org\/10.1080\/15384101.2018.1444305","journal-title":"Cell Cycle"},{"key":"2026_CR61","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15123089","author":"R Khalil","year":"2023","unstructured":"Khalil R et al (2023) Withaferin A increases the effectiveness of immune checkpoint blocker for the treatment of non-small cell lung cancer. Cancers. https:\/\/doi.org\/10.3390\/cancers15123089","journal-title":"Cancers"},{"key":"2026_CR62","doi-asserted-by":"publisher","DOI":"10.21037\/apm-21-2062","author":"W Zhu","year":"2021","unstructured":"Zhu W, Jin X (2021) A narrative review of combination therapy of PD-1\/PD-L1 blockade with standard approaches for the treatment of breast cancer: clinical application and immune mechanism. Ann Palliat Med. https:\/\/doi.org\/10.21037\/apm-21-2062","journal-title":"Ann Palliat Med"},{"key":"2026_CR63","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nem184","author":"R Aalinkeel","year":"2010","unstructured":"Aalinkeel R et al (2010) Genomic analysis highlights the role of the JAK-STAT signaling in the anti-proliferative effects of dietary flavonoid-\u2019Ashwagandha\u2019 in prostate cancer cells. Evid Based Complement Alternat Med. https:\/\/doi.org\/10.1093\/ecam\/nem184","journal-title":"Evid Based Complement Alternat Med"},{"key":"2026_CR64","doi-asserted-by":"crossref","unstructured":"Fasoulakis, Z., et al., Interleukins Associated with Breast Cancer. Cureus, 2018. 10(11).","DOI":"10.7759\/cureus.3549"},{"key":"2026_CR65","doi-asserted-by":"publisher","DOI":"10.3390\/molecules14072373","author":"M Mirjalili","year":"2009","unstructured":"Mirjalili M et al (2009) Steroidal lactones from Withania somnifera, an ancient plant for novel medicine. Molecules. https:\/\/doi.org\/10.3390\/molecules14072373","journal-title":"Molecules"},{"key":"2026_CR66","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12030550","author":"M Polumackanycz","year":"2023","unstructured":"Polumackanycz M et al (2023) Withania somnifera L.: phenolic compounds composition and biological activity of commercial samples and its aqueous and hydromethanolic extracts. Antioxidants. https:\/\/doi.org\/10.3390\/antiox12030550","journal-title":"Antioxidants"},{"key":"2026_CR67","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11091761","author":"D Lee","year":"2022","unstructured":"Lee D et al (2022) Antitumor potential of withanolide glycosides from Ashwagandha (Withania somnifera) on apoptosis of human hepatocellular carcinoma cells and tube formation in human umbilical vein endothelial cells. Antioxidants. https:\/\/doi.org\/10.3390\/antiox11091761","journal-title":"Antioxidants"},{"key":"2026_CR68","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26247696","author":"T Sultana","year":"2021","unstructured":"Sultana T et al (2021) Withaferin A: from ancient remedy to potential drug candidate. Molecules. https:\/\/doi.org\/10.3390\/molecules26247696","journal-title":"Molecules"},{"key":"2026_CR69","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.08.133","author":"HJ Um","year":"2012","unstructured":"Um HJ et al (2012) Withaferin A inhibits JAK\/STAT3 signaling and induces apoptosis of human renal carcinoma Caki cells. Biochem Biophys Res Commun. https:\/\/doi.org\/10.1016\/j.bbrc.2012.08.133","journal-title":"Biochem Biophys Res Commun"},{"key":"2026_CR70","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2024.07.912","author":"YJ Wang","year":"2024","unstructured":"Wang YJ, Liu SY, Lai JM (2024) Enhancing cancer therapy: synergistic effects of Withaferin A and ionizing radiation on lung cancer cells. Int J Radiat Oncol Biol Phys. https:\/\/doi.org\/10.1016\/j.ijrobp.2024.07.912","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2026_CR71","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-013-9531","author":"AR Vyas","year":"2013","unstructured":"Vyas AR et al (2013) Molecular targets and mechanisms of cancer prevention and treatment by Withaferin A, a naturally occurring steroidal lactone. AAPS J. https:\/\/doi.org\/10.1208\/s12248-013-9531","journal-title":"AAPS J"},{"issue":"12","key":"2026_CR72","first-page":"1501","volume":"23","author":"S Saleem","year":"2020","unstructured":"Saleem S et al (2020) Withania somnifera L.: Insights into the phytochemical profile, therapeutic potential, clinical trials, and future prospective. Iranian J Basic Med Sci 23(12):1501","journal-title":"Iranian J Basic Med Sci"},{"key":"2026_CR73","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2012.08.027","author":"WV Berghe","year":"2012","unstructured":"Berghe WV et al (2012) Molecular insight in the multifunctional activities of Withaferin A. Biochem Pharmacol. https:\/\/doi.org\/10.1016\/j.bcp.2012.08.027","journal-title":"Biochem Pharmacol"},{"key":"2026_CR74","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-90181-y","author":"K Kumano","year":"2021","unstructured":"Kumano K et al (2021) Withaferin A inhibits lymphocyte proliferation, dendritic cell maturation in vitro and prolongs islet allograft survival. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-021-90181-y","journal-title":"Sci Rep"},{"key":"2026_CR75","doi-asserted-by":"publisher","DOI":"10.1007\/s10870-005-9041-9","author":"P Bandhoria","year":"2006","unstructured":"Bandhoria P et al (2006) 6\u03b1,7\u03b1-epoxy-5\u03b1,17\u03b1,dihydroxy-1-oxo-22R-witha-2,24-dienolide in leaves of Withania somnifera: isolation and its crystal structure. J Chem Crystallogr. https:\/\/doi.org\/10.1007\/s10870-005-9041-9","journal-title":"J Chem Crystallogr"},{"key":"2026_CR76","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044419","author":"K Vaishnavi","year":"2012","unstructured":"Vaishnavi K et al (2012) Differential activities of the two closely related withanolides, Withaferin A and Withanone: bioinformatics and experimental evidences. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0044419","journal-title":"PLoS ONE"},{"key":"2026_CR77","doi-asserted-by":"publisher","DOI":"10.1016\/j.crtox.2021.02.002","author":"S Siddiqui","year":"2021","unstructured":"Siddiqui S et al (2021) DNA damage by Withanone as a potential cause of liver toxicity observed for herbal products of Withania somnifera (Ashwagandha). Curr Res Toxicol. https:\/\/doi.org\/10.1016\/j.crtox.2021.02.002","journal-title":"Curr Res Toxicol"},{"key":"2026_CR78","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01468","author":"J Lacombe","year":"2020","unstructured":"Lacombe J et al (2020) Withanolide D enhances radiosensitivity of human cancer cells by inhibiting DNA damage Non-homologous End Joining Repair Pathway. Front Oncol. https:\/\/doi.org\/10.3389\/fonc.2019.01468","journal-title":"Front Oncol"},{"key":"2026_CR79","doi-asserted-by":"publisher","DOI":"10.3390\/plants11060767","author":"J Ha","year":"2022","unstructured":"Ha J et al (2022) Structural characterization of withanolide glycosides from the roots of Withania somnifera and their potential biological activities. Plants Basel. https:\/\/doi.org\/10.3390\/plants11060767","journal-title":"Plants Basel"},{"key":"2026_CR80","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117603","author":"V Vaidya","year":"2024","unstructured":"Vaidya V et al (2024) Clinical pharmacokinetic evaluation of Withania somnifera (L.) Dunal root extract in healthy human volunteers: a non-randomized, single dose study utilizing UHPLC-MS\/MS analysis. J Ethnopharmacol. https:\/\/doi.org\/10.1016\/j.jep.2023.117603","journal-title":"J Ethnopharmacol"},{"key":"2026_CR81","doi-asserted-by":"publisher","DOI":"10.4103\/2231-4040.165023","author":"ST Devkar","year":"2015","unstructured":"Devkar ST et al (2015) Evaluation of the bioavailability of major withanolides of Withania somnifera using an in vitro absorption model system. J Adv Pharm Technol Res. https:\/\/doi.org\/10.4103\/2231-4040.165023","journal-title":"J Adv Pharm Technol Res"},{"key":"2026_CR82","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27051476","author":"SJ Modi","year":"2022","unstructured":"Modi SJ et al (2022) Pharmacokinetic study of withanosides and withanolides from Withania somnifera using ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS\/MS). Molecules. https:\/\/doi.org\/10.3390\/molecules27051476","journal-title":"Molecules"},{"key":"2026_CR83","doi-asserted-by":"publisher","DOI":"10.3390\/plants13060771","author":"V Lerose","year":"2024","unstructured":"Lerose V et al (2024) Withania somnifera (L.) Dunal, a potential source of phytochemicals for treating neurodegenerative diseases: a systematic review. Plants Basel. https:\/\/doi.org\/10.3390\/plants13060771","journal-title":"Plants Basel"},{"key":"2026_CR84","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28031208","author":"H Gaurav","year":"2023","unstructured":"Gaurav H et al (2023) Biodiversity, biochemical profiling, and pharmaco-commercial applications of Withania somnifera: a review. Molecules. https:\/\/doi.org\/10.3390\/molecules28031208","journal-title":"Molecules"},{"key":"2026_CR85","doi-asserted-by":"publisher","DOI":"10.14233\/ajchem.2017.20536","author":"S Gulati","year":"2017","unstructured":"Gulati S et al (2017) Chemical and phytochemical composition of Ashwagandha (Withania somnifera L.) roots. Asian J Chem. https:\/\/doi.org\/10.14233\/ajchem.2017.20536","journal-title":"Asian J Chem"},{"key":"2026_CR86","doi-asserted-by":"publisher","DOI":"10.1159\/000527656","author":"A Orr\u00f9","year":"2023","unstructured":"Orr\u00f9 A, Marchese G, Ruiu S (2023) Alkaloids in Withania somnifera (L.) Dunal root extract contribute to its anti-inflammatory activity. Pharmacology. https:\/\/doi.org\/10.1159\/000527656","journal-title":"Pharmacology"},{"issue":"6","key":"2026_CR87","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1351\/PAC-CON-11-10-08","volume":"84","author":"H Zhang","year":"2012","unstructured":"Zhang H et al (2012) Anti-proliferative withanolides from the Solanaceae: a structure-activity study. Pure Appl Chem. Chimie pure et appliquee 84(6):1353","journal-title":"Pure Appl Chem. Chimie pure et appliquee"},{"issue":"1","key":"2026_CR88","first-page":"31","volume":"31","author":"J Fuska","year":"1984","unstructured":"Fuska J et al (1984) Novel cytotoxic and antitumor agents. IV. Withaferin A: relation of its structure to the in vitro cytotoxic effects on P388 cells. Neoplasma 31(1):31\u201336","journal-title":"Neoplasma"},{"key":"2026_CR89","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-53568-6","author":"A Chaudhary","year":"2019","unstructured":"Chaudhary A et al (2019) 2, 3-Dihydro-3\u03b2-methoxy Withaferin-A lacks anti-metastasis potency: Bioinformatics and experimental evidences. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-019-53568-6","journal-title":"Sci Rep"},{"key":"2026_CR90","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2011.05.012","author":"SK Yousuf","year":"2011","unstructured":"Yousuf SK et al (2011) Ring A structural modified derivatives of withaferin A and the evaluation of their cytotoxic potential. Steroids. https:\/\/doi.org\/10.1016\/j.steroids.2011.05.012","journal-title":"Steroids"},{"key":"2026_CR91","doi-asserted-by":"publisher","DOI":"10.1021\/np9006734","author":"RP Machin","year":"2010","unstructured":"Machin RP et al (2010) Antiproliferative activity of withanolides against human breast cancer cell lines. J Nat Prod. https:\/\/doi.org\/10.1021\/np9006734","journal-title":"J Nat Prod"},{"key":"2026_CR92","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2009.02.061","author":"Y-H Lan","year":"2009","unstructured":"Lan Y-H et al (2009) New cytotoxic withanolides from Physalis peruviana. Food Chem. https:\/\/doi.org\/10.1016\/j.foodchem.2009.02.061","journal-title":"Food Chem"},{"key":"2026_CR93","doi-asserted-by":"publisher","DOI":"10.1021\/np0701374","author":"AG Damu","year":"2007","unstructured":"Damu AG et al (2007) Isolation, structures, and structure\u2212cytotoxic activity relationships of withanolides and physalins from Physalis angulata. J Nat Prod. https:\/\/doi.org\/10.1021\/np0701374","journal-title":"J Nat Prod"},{"key":"2026_CR94","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2013.10.008","author":"P Joshi","year":"2014","unstructured":"Joshi P et al (2014) Epoxide group relationship with cytotoxicity in withanolide derivatives from Withania somnifera. Steroids. https:\/\/doi.org\/10.1016\/j.steroids.2013.10.008","journal-title":"Steroids"},{"issue":"219","key":"2026_CR95","first-page":"2167","volume":"4","author":"C Huang","year":"2015","unstructured":"Huang C, Vaishnavi K, Rajkumar K (2015) 3\u03b2-Methoxy derivation of Withaferin-a Attenuates its anticancer potency: bioinformatics and molecular evidences. Med Aromatic Plants 4(219):2167","journal-title":"Med Aromatic Plants"},{"key":"2026_CR96","doi-asserted-by":"crossref","unstructured":"White PT et al. (2016) Natural Withanolides in the treatment of chronic diseases. Adv Exp Med Biol.","DOI":"10.1007\/978-3-319-41334-1_14"},{"key":"2026_CR97","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00146","author":"N Perestelo","year":"2019","unstructured":"Perestelo N et al (2019) Expanding the chemical space of Withaferin A by incorporating silicon to improve its clinical potential on human ovarian carcinoma cells. J Med Chem. https:\/\/doi.org\/10.1021\/acs.jmedchem.9b00146","journal-title":"J Med Chem"},{"key":"2026_CR98","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/j.bbrc.2020.10.064","volume":"534","author":"K Baghel","year":"2021","unstructured":"Baghel K, Srivastava R (2021) Photoperiod dependent expression of estrogen receptor alpha in testes of Japanese quail: involvement of Withania somnifera in apoptosis amelioration. Biochem Biophys Res Commun 534:957\u2013965","journal-title":"Biochem Biophys Res Commun"},{"issue":"10","key":"2026_CR99","volume":"14","author":"A Ajgaonkar","year":"2022","unstructured":"Ajgaonkar A, Jain M, Debnath K (2022) Efficacy and safety of Ashwagandha (Withania somnifera) root extract for improvement of sexual health in healthy women: a prospective, randomized, placebo-controlled study. Cureus 14(10):e30787","journal-title":"Cureus"},{"issue":"37","key":"2026_CR100","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000017186","volume":"98","author":"AL Lopresti","year":"2019","unstructured":"Lopresti AL et al (2019) An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Medicine 98(37):e17186","journal-title":"Medicine"},{"issue":"3","key":"2026_CR101","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1089\/acm.2017.0183","volume":"24","author":"AK Sharma","year":"2017","unstructured":"Sharma AK, Basu I, Singh S (2017) Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial. J Altern Complement Med 24(3):243\u2013248","journal-title":"J Altern Complement Med"},{"key":"2026_CR102","first-page":"1","volume-title":"Encyclopedia of Personality and Individual Differences","author":"L Janes","year":"2016","unstructured":"Janes L (2016) Hypothalamic-Pituitary-Gonadal (HPG) Axis. In: Zeigler-Hill V, Shackelford TK (eds) Encyclopedia of Personality and Individual Differences. Springer International Publishing, Cham, pp 1\u20132"},{"issue":"10","key":"2026_CR103","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12590","volume":"30","author":"A Acevedo-Rodriguez","year":"2018","unstructured":"Acevedo-Rodriguez A et al (2018) Emerging insights into hypothalamic-pituitary-gonadal axis regulation and interaction with stress signalling. J Neuroendocrinol 30(10):e12590","journal-title":"J Neuroendocrinol"},{"issue":"4","key":"2026_CR104","doi-asserted-by":"publisher","first-page":"R51","DOI":"10.1186\/bcr1756","volume":"9","author":"D Piersma","year":"2007","unstructured":"Piersma D et al (2007) GnRH and LHRgene variants predict adverse outcome in premenopausal breast cancer patients. Breast Cancer Res 9(4):R51","journal-title":"Breast Cancer Res"},{"key":"2026_CR105","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.neuint.2015.08.001","volume":"89","author":"H Kataria","year":"2015","unstructured":"Kataria H et al (2015) *Withania somnifera* aqueous extract facilitates the expression and release of GnRH: in vitro and in vivo study. Neurochem Int 89:111\u2013119","journal-title":"Neurochem Int"},{"issue":"8","key":"2026_CR106","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1002\/mc.20760","volume":"50","author":"ER Hahm","year":"2011","unstructured":"Hahm ER et al (2011) Withaferin A suppresses estrogen receptor-\u03b1 expression in human breast cancer cells. Mol Carcinog 50(8):614\u2013624","journal-title":"Mol Carcinog"},{"key":"2026_CR107","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3389\/fendo.2019.00059","volume":"10","author":"E Krashin","year":"2019","unstructured":"Krashin E et al (2019) Thyroid hormones and cancer: a comprehensive review of preclinical and clinical studies. Front Endocrinol (Lausanne) 10:59","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2026_CR108","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2024.1439294","volume":"11","author":"S Guo","year":"2024","unstructured":"Guo S, Rezaei MJ (2024) The benefits of ashwagandha (Withania somnifera) supplements on brain function and sports performance. Front Nutr 11:2024","journal-title":"Front Nutr"},{"issue":"21","key":"2026_CR109","doi-asserted-by":"publisher","first-page":"5310","DOI":"10.3390\/ijms20215310","volume":"20","author":"R Dutta","year":"2019","unstructured":"Dutta R et al (2019) Withania Somnifera (Ashwagandha) and Withaferin A: Potential in Integrative Oncology. Int J Mol Sci 20(21):5310","journal-title":"Int J Mol Sci"},{"issue":"6","key":"2026_CR110","doi-asserted-by":"publisher","DOI":"10.1016\/j.explore.2024.103062","volume":"20","author":"V Arumugam","year":"2024","unstructured":"Arumugam V et al (2024) Effects of Ashwagandha (*Withania somnifera*) on stress and anxiety: a systematic review and meta-analysis. Explore (NY) 20(6):103062","journal-title":"Explore (NY)"},{"key":"2026_CR111","doi-asserted-by":"publisher","DOI":"10.1016\/j.hermed.2021.100434","volume":"28","author":"AL Lopresti","year":"2021","unstructured":"Lopresti AL, Smith SJJJoHM (2021) Ashwagandha (Withania somnifera) for the treatment and enhancement of mental and physical conditions: a systematic review of human trials. J Herb Med 28:100434","journal-title":"J Herb Med"},{"key":"2026_CR112","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.mib.2020.09.001","volume":"56","author":"NV Andreeva","year":"2020","unstructured":"Andreeva NV, Gabbasova RR, Grivennikov SI (2020) Microbiome in cancer progression and therapy. Curr Opin Microbiol 56:118\u2013126","journal-title":"Curr Opin Microbiol"},{"issue":"1","key":"2026_CR113","doi-asserted-by":"publisher","DOI":"10.1016\/j.phyplu.2025.100731","volume":"5","author":"B Jangra","year":"2025","unstructured":"Jangra B et al (2025) The role of gut microbiota in disease management: Ayurvedic perspectives on metabolic diseases and health. Phytomedicine Plus 5(1):100731","journal-title":"Phytomedicine Plus"},{"issue":"2","key":"2026_CR114","doi-asserted-by":"publisher","DOI":"10.1177\/1557988319835985","volume":"13","author":"AL Lopresti","year":"2019","unstructured":"Lopresti AL, Drummond PD, Smith SJJAjomsh (2019) A randomized, double-blind, placebo-controlled, crossover study examining the hormonal and vitality effects of ashwagandha (Withania somnifera) in aging, overweight males. Am J Mens Health 13(2):1557988319835985","journal-title":"Am J Mens Health"},{"key":"2026_CR115","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2023.100579","volume":"27","author":"D La Torre","year":"2023","unstructured":"La Torre D et al (2023) Psychosocial stress-induced intestinal permeability in healthy humans: What is the evidence? Neurobiol Stress 27:100579","journal-title":"Neurobiol Stress"},{"key":"2026_CR116","doi-asserted-by":"publisher","first-page":"598","DOI":"10.3389\/fimmu.2017.00598","volume":"8","author":"Q Mu","year":"2017","unstructured":"Mu Q et al (2017) Leaky gut as a danger signal for autoimmune diseases. Front Immunol 8:598","journal-title":"Front Immunol"},{"key":"2026_CR117","doi-asserted-by":"publisher","first-page":"1491989","DOI":"10.3389\/fvets.2024.1491989","volume":"11","author":"KK Bharani","year":"2024","unstructured":"Bharani KK et al (2024) The role of Ashwagandha in modulating gut parameters in dogs-a randomized double-blind placebo-controlled trial. Front Vet Sci 11:1491989","journal-title":"Front Vet Sci"},{"key":"2026_CR118","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01429","author":"MMM Kaisar","year":"2017","unstructured":"Kaisar MMM et al (2017) Butyrate conditions human dendritic cells to prime type 1 regulatory T cells via both histone deacetylase inhibition and G protein-coupled receptor 109A signaling. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2017.01429. (- 2017)","journal-title":"Front Immunol"},{"key":"2026_CR119","doi-asserted-by":"publisher","DOI":"10.3390\/nu16142228","author":"I Zajkowska","year":"2024","unstructured":"Zajkowska I et al (2024) Investigating the impacts of diet, supplementation, microbiota, gut-brain axis on schizophrenia: a narrative review. Nutrients. https:\/\/doi.org\/10.3390\/nu16142228","journal-title":"Nutrients"},{"issue":"1","key":"2026_CR120","doi-asserted-by":"publisher","first-page":"2236749","DOI":"10.1080\/19490976.2023.2236749","volume":"15","author":"S Hu","year":"2023","unstructured":"Hu S et al (2023) Gut microbial beta-glucuronidase: a vital regulator in female estrogen metabolism. Gut Microbes 15(1):2236749","journal-title":"Gut Microbes"},{"key":"2026_CR121","doi-asserted-by":"publisher","DOI":"10.1155\/ijfo\/9922626","volume":"2025","author":"SK Singirala","year":"2025","unstructured":"Singirala SK, Dubey PK, Roy S (2025) Extraction of bioactive compounds from Withania somnifera: the biological activities and potential application in the food industry: a review. Int J Food Sci 2025:9922626","journal-title":"Int J Food Sci"},{"issue":"8","key":"2026_CR122","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1007\/s00018-013-1376-3","volume":"71","author":"Z Zhou","year":"2014","unstructured":"Zhou Z et al (2014) Regulation of estrogen receptor signaling in breast carcinogenesis and breast cancer therapy. Cell Mol Life Sci 71(8):1549","journal-title":"Cell Mol Life Sci"},{"issue":"16","key":"2026_CR123","doi-asserted-by":"publisher","first-page":"5039","DOI":"10.1128\/AEM.01235-16","volume":"82","author":"C Urbaniak","year":"2016","unstructured":"Urbaniak C et al (2016) The microbiota of breast tissue and its association with breast cancer. Appl Environ Microbiol 82(16):5039\u20135048","journal-title":"Appl Environ Microbiol"},{"issue":"6","key":"2026_CR124","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/j.ajpath.2021.02.020","volume":"191","author":"S Dieleman","year":"2021","unstructured":"Dieleman S et al (2021) Exploring the potential of breast microbiota as biomarker for breast cancer and therapeutic response. Am J Pathol 191(6):968\u2013982","journal-title":"Am J Pathol"},{"issue":"24","key":"2026_CR125","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1056\/NEJMra1600266","volume":"375","author":"SV Lynch","year":"2016","unstructured":"Lynch SV, Pedersen O (2016) The human intestinal microbiome in health and disease. N Engl J Med 375(24):2369\u20132379","journal-title":"N Engl J Med"},{"key":"2026_CR126","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114101","author":"VK Joshi","year":"2021","unstructured":"Joshi VK, Joshi A (2021) Rational use of ashwagandha in Ayurveda (traditional Indian medicine) for health and healing. J Ethnopharmacol. https:\/\/doi.org\/10.1016\/j.jep.2021.114101","journal-title":"J Ethnopharmacol"},{"key":"2026_CR127","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-14944-x","author":"A Balkrishna","year":"2022","unstructured":"Balkrishna A et al (2022) Withania somnifera (L.) Dunal whole-plant extract demonstrates acceptable non-clinical safety in rat 28-day subacute toxicity evaluation under GLP-compliance. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-022-14944-x","journal-title":"Sci Rep"},{"key":"2026_CR128","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/8832166","author":"L Lingfa","year":"2023","unstructured":"Lingfa L, Tirumala A, Ankanagari S (2023) In vitro cytotoxicity of reproductive stage Withania somnifera leaf and stem on HepG2 cell line. Evid Based Complement Alternat Med. https:\/\/doi.org\/10.1155\/2023\/8832166","journal-title":"Evid Based Complement Alternat Med"},{"key":"2026_CR129","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.4573","author":"T Dai","year":"2019","unstructured":"Dai T et al (2019) Studies on oral bioavailability and first-pass metabolism of withaferin A in rats using LC-MS\/MS and Q-TRAP. Biomed Chromatogr. https:\/\/doi.org\/10.1002\/bmc.4573","journal-title":"Biomed Chromatogr"},{"key":"2026_CR130","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e22843","author":"S Kim","year":"2023","unstructured":"Kim S et al (2023) Pharmacokinetics and bioequivalence of Withania somnifera (ashwagandha) extracts - a double blind, crossover study in healthy adults. Heliyon. https:\/\/doi.org\/10.1016\/j.heliyon.2023.e22843","journal-title":"Heliyon"},{"key":"2026_CR131","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166945","author":"SC Kaul","year":"2016","unstructured":"Kaul SC et al (2016) Novel methods to generate active ingredients-enriched ashwagandha leaves and extracts. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0166945","journal-title":"PLoS ONE"},{"key":"2026_CR132","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.jpba.2013.03.001","volume":"80","author":"D Patil","year":"2013","unstructured":"Patil D et al (2013) Determination of withaferin A and withanolide A in mice plasma using high-performance liquid chromatography-tandem mass spectrometry: application to pharmacokinetics after oral administration of Withania somnifera aqueous extract. J Pharm Biomed Anal 80:203\u2013212 ((1873-264X (Electronic)))","journal-title":"J Pharm Biomed Anal"},{"key":"2026_CR133","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.113819","volume":"270","author":"SK Singh","year":"2021","unstructured":"Singh SK et al (2021) Elucidation of plasma protein binding, blood partitioning, permeability, CYP phenotyping and CYP inhibition studies of Withanone using validated UPLC method: an active constituent of neuroprotective herb Ashwagandha. J Ethnopharmacol 270:113819 ((1872-7573 (Electronic)))","journal-title":"J Ethnopharmacol"},{"issue":"4","key":"2026_CR134","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/S2221-1691(13)60060-X","volume":"3","author":"K Kesarwani","year":"2013","unstructured":"Kesarwani K, Gupta R (2013) Bioavailability enhancers of herbal origin: an overview. Asian Pac J Trop Biomed 3(4):253\u2013266","journal-title":"Asian Pac J Trop Biomed"},{"issue":"7","key":"2026_CR135","doi-asserted-by":"publisher","first-page":"7668","DOI":"10.3390\/cimb46070454","volume":"46","author":"R Ko\u0142odziejska","year":"2024","unstructured":"Ko\u0142odziejska R et al (2024) Ashwagandha-induced programmed cell death in the treatment of breast cancer. Curr Issues Mol Biol 46(7):7668\u20137685","journal-title":"Curr Issues Mol Biol"},{"issue":"1","key":"2026_CR136","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s12986-025-00902-7","volume":"22","author":"M Sprengel","year":"2025","unstructured":"Sprengel M, Laskowski R, Jost Z (2025) Withania somnifera (Ashwagandha) supplementation: a review of its mechanisms, health benefits, and role in sports performance. Nutr Metab (Lond) 22(1):9","journal-title":"Nutr Metab (Lond)"},{"key":"2026_CR137","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.toxrep.2023.12.005","volume":"12","author":"P Kalaivani","year":"2024","unstructured":"Kalaivani P et al (2024) Mutagenicity and safety evaluation of Ashwagandha (Withania somnifera) root aqueous extract in different models. Toxicol Rep 12:41\u201347","journal-title":"Toxicol Rep"},{"issue":"1","key":"2026_CR138","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaim.2023.100859","volume":"15","author":"VG Vaidya","year":"2024","unstructured":"Vaidya VG et al (2024) Clinical safety and tolerability evaluation of Withania somnifera (L.) Dunal (Ashwagandha) root extract in healthy human volunteers. J Ayurveda Integr Med 15(1):100859","journal-title":"J Ayurveda Integr Med"},{"key":"2026_CR139","doi-asserted-by":"publisher","DOI":"10.1007\/s40495-024-00384-w","author":"A Ramachandran","year":"2024","unstructured":"Ramachandran A et al (2024) The therapeutic potential of Withania somnifera in breast cancer: a comprehensive review. Curr Pharmacol Rep. https:\/\/doi.org\/10.1007\/s40495-024-00384-w","journal-title":"Curr Pharmacol Rep"},{"key":"2026_CR140","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.toxrep.2023.09.004","volume":"11","author":"P Kalaivani","year":"2023","unstructured":"Kalaivani P et al (2023) Ninety-day repeated dose toxicity of Ashwagandha (Withania somnifera) root extract in Wistar rats. Toxicol Rep 11:189\u2013198","journal-title":"Toxicol Rep"},{"issue":"12","key":"2026_CR141","doi-asserted-by":"publisher","first-page":"41","DOI":"10.22159\/ijpps.2018v10i12.29493","volume":"10","author":"B Antony","year":"2018","unstructured":"Antony B et al (2018) Acute and sub chronic toxicity studies of purified Withania somnifera extract in rats. Int J Pharm Pharm Sci 10(12):41\u201346","journal-title":"Int J Pharm Pharm Sci"},{"issue":"10","key":"2026_CR142","volume":"16","author":"F Almuzghi","year":"2024","unstructured":"Almuzghi F, Abdelmalik A, Abuhlaiga M (2024) Ashwagandha-induced hepatic injury: a case report. Cureus 16(10):e71576","journal-title":"Cureus"},{"issue":"4","key":"2026_CR143","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1111\/liv.14393","volume":"40","author":"HK Bj\u00f6rnsson","year":"2020","unstructured":"Bj\u00f6rnsson HK et al (2020) Ashwagandha-induced liver injury: a case series from Iceland and the US Drug-Induced Liver Injury Network. Liver Int 40(4):825\u2013829","journal-title":"Liver Int"},{"issue":"47","key":"2026_CR144","first-page":"2637","volume":"149","author":"CS van der Hooft","year":"2005","unstructured":"van der Hooft CS et al (2005) Thyrotoxicosis following the use of ashwagandha. Ned Tijdschr Geneeskd 149(47):2637\u20132638","journal-title":"Ned Tijdschr Geneeskd"},{"issue":"3","key":"2026_CR145","volume":"14","author":"HI Kamal","year":"2022","unstructured":"Kamal HI et al (2022) Ashwagandha as a Unique Cause of Thyrotoxicosis Presenting With Supraventricular Tachycardia. Cureus 14(3):e23494","journal-title":"Cureus"},{"issue":"3","key":"2026_CR146","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1093\/advances\/nmaa134","volume":"12","author":"SJ Smith","year":"2021","unstructured":"Smith SJ et al (2021) Examining the effects of herbs on testosterone concentrations in men: a systematic review. Adv Nutr 12(3):744\u2013765","journal-title":"Adv Nutr"},{"key":"2026_CR147","doi-asserted-by":"publisher","DOI":"10.3390\/ph16020160","author":"S Kumar","year":"2023","unstructured":"Kumar S et al (2023) Withaferin A: a pleiotropic anticancer agent from the Indian medicinal plant Withania somnifera (L.) Dunal. Pharmaceuticals (Basel). https:\/\/doi.org\/10.3390\/ph16020160","journal-title":"Pharmaceuticals (Basel)"},{"issue":"9","key":"2026_CR148","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1158\/1940-6207.CAPR-20-0259","volume":"13","author":"ER Hahm","year":"2020","unstructured":"Hahm ER et al (2020) A comprehensive review and perspective on anticancer mechanisms of Withaferin A in breast cancer. Cancer Prev Res (Phila) 13(9):721\u2013734","journal-title":"Cancer Prev Res (Phila)"},{"key":"2026_CR149","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2024.116405","volume":"226","author":"C Bailly","year":"2024","unstructured":"Bailly C (2024) Covalent binding of withanolides to cysteines of protein targets. Biochem Pharmacol 226:116405","journal-title":"Biochem Pharmacol"},{"key":"2026_CR150","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2025.108844","volume":"132","author":"GJQ Palomino","year":"2025","unstructured":"Palomino GJQ et al (2025) Investigations on the effects of in vitro exposure of mouse ovaries to Withaferin A, a new candidate for chemotherapy. Reprod Toxicol 132:108844","journal-title":"Reprod Toxicol"},{"issue":"1","key":"2026_CR151","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1039\/C6MD00410E","volume":"8","author":"ME Issa","year":"2017","unstructured":"Issa ME, Cuendet M (2017) Withaferin A induces cell death and differentiation in multiple myeloma cancer stem cells. Medchemcomm 8(1):112\u2013121","journal-title":"Medchemcomm"},{"key":"2026_CR152","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242115976","author":"S Orzetti","year":"2023","unstructured":"Orzetti S, Baldo P (2023) Toxicity derived from interaction between natural compounds and cancer therapeutic drugs metabolized by CYP3A4: lessons learned from two clinical case reports. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms242115976","journal-title":"Int J Mol Sci"},{"issue":"10","key":"2026_CR153","doi-asserted-by":"publisher","first-page":"e0270","DOI":"10.1097\/HC9.0000000000000270","volume":"7","author":"CA Philips","year":"2023","unstructured":"Philips CA et al (2023) Ashwagandha-induced liver injury-A case series from India and literature review. Hepatol Commun 7(10):e0270","journal-title":"Hepatol Commun"},{"key":"2026_CR154","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4137\/BCI.S18863","volume":"7","author":"LP Yco","year":"2014","unstructured":"Yco LP et al (2014) Withaferin A inhibits STAT3 and induces tumor cell death in neuroblastoma and multiple myeloma. Biochem Insights 7:1\u201313","journal-title":"Biochem Insights"},{"issue":"4","key":"2026_CR155","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.bcp.2014.08.004","volume":"91","author":"K Heyninck","year":"2014","unstructured":"Heyninck K et al (2014) Withaferin A inhibits NF-kappaB activation by targeting cysteine 179 in IKK\u03b2. Biochem Pharmacol 91(4):501\u2013509","journal-title":"Biochem Pharmacol"},{"issue":"18","key":"2026_CR156","doi-asserted-by":"publisher","first-page":"14509","DOI":"10.18632\/oncotarget.24429","volume":"9","author":"C Subramanian","year":"2018","unstructured":"Subramanian C et al (2018) Novel natural withanolides induce apoptosis and inhibit migration of neuroblastoma cells through down regulation of N-myc and suppression of Akt\/mTOR\/NF-\u03baB activation. Oncotarget 9(18):14509\u201314523","journal-title":"Oncotarget"},{"issue":"2","key":"2026_CR157","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1177\/1534735413503551","volume":"13","author":"D Patil","year":"2014","unstructured":"Patil D et al (2014) Effect of botanical immunomodulators on human CYP3A4 inhibition: implications for concurrent use as adjuvants in cancer therapy. Integr Cancer Ther 13(2):167\u2013175","journal-title":"Integr Cancer Ther"},{"issue":"4","key":"2026_CR158","doi-asserted-by":"publisher","first-page":"54","DOI":"10.4314\/ajtcam.v11i4.9","volume":"11","author":"PS Fasinu","year":"2014","unstructured":"Fasinu PS, Bouic PJ, Rosenkranz B (2014) The inhibitory activity of the extracts of popular medicinal herbs on CYP1A2, 2C9, 2C19 and 3A4 and the implications for herb-drug interaction. Afr J Tradit Complement Altern Med 11(4):54\u201361","journal-title":"Afr J Tradit Complement Altern Med"},{"issue":"5","key":"2026_CR159","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1097\/PPO.0000000000000403","volume":"25","author":"YN Hou","year":"2019","unstructured":"Hou YN, Deng G, Mao JJ (2019) Practical application of \u201cAbout Herbs\u201d Website: herbs and dietary supplement use in oncology settings. Cancer J 25(5):357\u2013366","journal-title":"Cancer J"},{"key":"2026_CR160","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2025.1658265","volume":"12","author":"Y Ronen","year":"2025","unstructured":"Ronen Y et al (2025) Comprehensive safety evaluation of Withania somnifera (ashwagandha): an AI-driven meta-analysis and quantitative structure-activity relationship based toxicity assessment. Front Nutr 12:1658265","journal-title":"Front Nutr"},{"issue":"1","key":"2026_CR161","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19390211.2024.2419434","volume":"22","author":"TC Wallace","year":"2025","unstructured":"Wallace TC, Koturbash I (2025) DSHEA 1994 \u2013 celebrating 30 years of dietary supplement regulation in the United States. J Diet Suppl 22(1):1\u20138","journal-title":"J Diet Suppl"},{"issue":"3","key":"2026_CR162","doi-asserted-by":"publisher","first-page":"119","DOI":"10.3390\/livers2030011","volume":"2","author":"A Khan","year":"2022","unstructured":"Khan A et al (2022) A comprehensive review on the use of herbal dietary supplements in the USA reasons for their use, and review of potential hepatotoxicity. Livers 2(3):119\u2013138","journal-title":"Livers"},{"key":"2026_CR163","doi-asserted-by":"publisher","first-page":"1523904","DOI":"10.3389\/fphar.2025.1523904","volume":"16","author":"KGM Lenssen","year":"2025","unstructured":"Lenssen KGM, de Boer A (2025) Bridging regulation and practice: CJEU and Dutch case law on botanical health claims. Front Pharmacol 16:1523904","journal-title":"Front Pharmacol"},{"issue":"1","key":"2026_CR164","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-019-2693-3","volume":"19","author":"NM Abdulla","year":"2019","unstructured":"Abdulla NM et al (2019) Heavy metal content of herbal health supplement products in Dubai \u2013 UAE: a cross-sectional study. BMC Complement Altern Med 19(1):276","journal-title":"BMC Complement Altern Med"},{"issue":"1","key":"2026_CR165","first-page":"39","volume":"32","author":"AH Alostad","year":"2018","unstructured":"Alostad AH, Steinke DT, Schafheutle EI (2018) International comparison of five herbal medicine registration systems to inform regulation development: United Kingdom, Germany, United States of America, United Arab Emirates and Kingdom of Bahrain. Pharmaceut Med 32(1):39\u201349","journal-title":"Pharmaceut Med"},{"issue":"5\u20136","key":"2026_CR166","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1002\/elps.202400188","volume":"46","author":"L Zellner","year":"2025","unstructured":"Zellner L et al (2025) Determination of Withanolides and Withanosides in Ashwagandha based products using HPLC-drift-tube-ion-mobility quadrupole time-of-flight mass spectrometry. Electrophoresis 46(5\u20136):340\u2013346","journal-title":"Electrophoresis"},{"key":"2026_CR167","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.112725","volume":"256","author":"N Amritha","year":"2020","unstructured":"Amritha N, Bhooma V, Parani M (2020) Authentication of the market samples of Ashwagandha by DNA barcoding reveals that powders are significantly more adulterated than roots. J Ethnopharmacol 256:112725","journal-title":"J Ethnopharmacol"},{"issue":"9","key":"2026_CR168","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.3390\/diagnostics12092045","volume":"12","author":"M Yesiladali","year":"2022","unstructured":"Yesiladali M et al (2022) Differentiating polycystic ovary syndrome from adrenal disorders. Diagnostics 12(9):2045","journal-title":"Diagnostics"},{"key":"2026_CR169","doi-asserted-by":"publisher","DOI":"10.3390\/nu16091293","author":"S Pandit","year":"2024","unstructured":"Pandit S et al (2024) Effects of Withania somnifera extract in chronically stressed adults: a randomized controlled trial. Nutrients. https:\/\/doi.org\/10.3390\/nu16091293","journal-title":"Nutrients"},{"key":"2026_CR170","doi-asserted-by":"crossref","unstructured":"Pires Bicho M, Pereira da Silva Oliveira A, do C\u00e9u Costa M (2023) Use of medicinal plants: interindividual variability of their effects from a genetic and anthropological perspective, in medicinal plants - chemical, biochemical, and pharmacological approaches, M.S. de Oliveira, et al., Editors. IntechOpen: Rijeka","DOI":"10.5772\/intechopen.113841"},{"issue":"3","key":"2026_CR171","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.1074\/jbc.M113.496844","volume":"289","author":"ML Antony","year":"2014","unstructured":"Antony ML et al (2014) Growth arrest by the antitumor steroidal lactone Withaferin A in Human breast cancer cells is associated with down-regulation and covalent binding at cysteine 303 of \u03b2-tubulin. J Biol Chem 289(3):1852","journal-title":"J Biol Chem"},{"issue":"6","key":"2026_CR172","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1124\/mol.119.117812","volume":"96","author":"J Yang","year":"2019","unstructured":"Yang J et al (2019) The natural compound Withaferin A covalently binds to Cys239 of \u03b2-Tubulin to promote tubulin degradation. Mol Pharmacol 96(6):711","journal-title":"Mol Pharmacol"},{"key":"2026_CR173","doi-asserted-by":"publisher","DOI":"10.4103\/pm.pm_5_19","author":"V Pai","year":"2019","unstructured":"Pai V et al (2019) High-performance thin-layer chromatography marker-based standardization of Piperine, Asiaticoside, and Withanolide-A in the developed polyherbal formulation and in vitro evaluation of acetylcholinesterase inhibition. Pharmacogn Mag. https:\/\/doi.org\/10.4103\/pm.pm_5_19","journal-title":"Pharmacogn Mag"},{"key":"2026_CR174","doi-asserted-by":"publisher","DOI":"10.1017\/jns.2017.48","author":"M Singh","year":"2017","unstructured":"Singh M, Ramassamy C (2017) In vitro screening of neuroprotective activity of Indian medicinal plant Withania somnifera. J Nutr Sci. https:\/\/doi.org\/10.1017\/jns.2017.48","journal-title":"J Nutr Sci"},{"issue":"4","key":"2026_CR175","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.imr.2016.10.002","volume":"5","author":"A Saiyed","year":"2016","unstructured":"Saiyed A et al (2016) Effect of combination of Withania somnifera Dunal and Tribulus terrestris Linn on letrozole induced polycystic ovarian syndrome in rats. Integr Med Res 5(4):293\u2013300","journal-title":"Integr Med Res"},{"key":"2026_CR176","first-page":"4076430","volume":"1","author":"R Nasimi Doost Azgomi","year":"2018","unstructured":"Nasimi Doost Azgomi R et al (2018) (2018) Effects of Withania somnifera on reproductive system: a systematic review of the available evidence. BioMed Res Int 1:4076430","journal-title":"BioMed Res Int"},{"issue":"3","key":"2026_CR177","doi-asserted-by":"publisher","first-page":"255","DOI":"10.4103\/0253-7176.106022","volume":"34","author":"K Chandrasekhar","year":"2012","unstructured":"Chandrasekhar K, Kapoor J, Anishetty S (2012) A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med 34(3):255\u2013262","journal-title":"Indian J Psychol Med"},{"issue":"1","key":"2026_CR178","doi-asserted-by":"publisher","first-page":"12091","DOI":"10.1038\/s41598-024-62084-1","volume":"14","author":"MM Rahman","year":"2024","unstructured":"Rahman MM, Wu H, Tollefsbol TO (2024) A novel combinatorial approach using sulforaphane- and Withaferin A-rich extracts for prevention of estrogen receptor-negative breast cancer through epigenetic and gut microbial mechanisms. Sci Rep 14(1):12091","journal-title":"Sci Rep"},{"issue":"5","key":"2026_CR179","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.62347\/NUZN4999","volume":"16","author":"H Saini","year":"2024","unstructured":"Saini H (2024) Therapeutic and pharmacological efficacy of plant-derived bioactive compounds in targeting breast cancer. Am J Transl Res 16(5):1499\u20131520","journal-title":"Am J Transl Res"}],"container-title":["Journal of Natural Medicines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-026-02026-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11418-026-02026-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-026-02026-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T15:02:27Z","timestamp":1783609347000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11418-026-02026-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,13]]},"references-count":179,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["2026"],"URL":"https:\/\/doi.org\/10.1007\/s11418-026-02026-5","relation":{},"ISSN":["1340-3443","1861-0293"],"issn-type":[{"value":"1340-3443","type":"print"},{"value":"1861-0293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,13]]},"assertion":[{"value":"11 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}}]}}