{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T16:30:03Z","timestamp":1793464203371,"version":"4.5.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nat Med"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1007\/s11418-026-02069-8","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T08:41:08Z","timestamp":1788856868000},"page":"1626-1637","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lusitropic effect of Aurantii Fructus Immaturus extract on isolated mouse ventricular myocardium"],"prefix":"10.1007","volume":"80","author":[{"given":"Maika","family":"Seki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuna","family":"Shiota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaka","family":"Konno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouharu","family":"Otsuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Hamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iyuki","family":"Namekata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikaru","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"2069_CR1","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1016\/s0140-6736(14)60107-0","volume":"383","author":"G Heusch","year":"2014","unstructured":"Heusch G, Libby P, Gersh B, Yellon D, B\u00f6hm M, Lopaschuk G et al (2014) Cardiovascular remodelling in coronary artery disease and heart failure. Lancet 383:1933\u20131943. https:\/\/doi.org\/10.1016\/s0140-6736(14)60107-0","journal-title":"Lancet"},{"key":"2069_CR2","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/s41569-020-0339-2","volume":"17","author":"Y Tan","year":"2020","unstructured":"Tan Y, Zhang Z, Zheng C, Wintergerst KA, Keller BB, Cai L (2020) Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence. Nat Rev Cardiol 17:585\u2013607. https:\/\/doi.org\/10.1038\/s41569-020-0339-2","journal-title":"Nat Rev Cardiol"},{"key":"2069_CR3","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/nrcardio.2017.65","volume":"14","author":"SM Dunlay","year":"2017","unstructured":"Dunlay SM, Roger VL, Redfield MM (2017) Epidemiology of heart failure with preserved ejection fraction. Nat Rev Cardiol 14:591\u2013602. https:\/\/doi.org\/10.1038\/nrcardio.2017.65","journal-title":"Nat Rev Cardiol"},{"key":"2069_CR4","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1248\/bpb.b20-00701","volume":"44","author":"I Namekata","year":"2021","unstructured":"Namekata I, Odaka R, Hamazaki S, Nisaka H, Hamaguchi S, Tanaka H (2021) Fluorescence Discrimination of Pharmacological Effects on the Na+-Ca2+ Exchanger and Sarco-Endoplasmic Reticulum Ca2+-ATPase in Mouse Ventricular Cardiomyocytes. Biol Pharm Bull 44:154\u2013157. https:\/\/doi.org\/10.1248\/bpb.b20-00701","journal-title":"Biol Pharm Bull"},{"key":"2069_CR5","doi-asserted-by":"publisher","first-page":"701","DOI":"10.9748\/hcs.2018.701","volume":"28","author":"I Namekata","year":"2018","unstructured":"Namekata I, Hiiro H, Kanae H, Yoshino A, Kazama A, Hamaguchi S et al (2018) Acceleratory effect of ellagic acid on sarcoplasmic reticulum Ca2+ uptake and myocardial relaxation. Int J Hum Cult Stud 28:701\u2013707. https:\/\/doi.org\/10.9748\/hcs.2018.701","journal-title":"Int J Hum Cult Stud"},{"key":"2069_CR6","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1007\/s10741-022-10238-6","volume":"28","author":"A Palazzuoli","year":"2023","unstructured":"Palazzuoli A, Iacoviello M (2023) Diabetes leading to heart failure and heart failure leading to diabetes: epidemiological and clinical evidence. Heart Fail Rev 28:585\u2013596. https:\/\/doi.org\/10.1007\/s10741-022-10238-6","journal-title":"Heart Fail Rev"},{"key":"2069_CR7","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1007\/s00125-023-06068-2","volume":"67","author":"AG Hoek","year":"2024","unstructured":"Hoek AG, Dal Canto E, Wenker E, Bindraban N, Handoko ML, Elders PJM et al (2024) Epidemiology of heart failure in diabetes: a disease in disguise. Diabetologia 67:574\u2013601. https:\/\/doi.org\/10.1007\/s00125-023-06068-2","journal-title":"Diabetologia"},{"key":"2069_CR8","doi-asserted-by":"publisher","first-page":"R1787","DOI":"10.1152\/ajpregu.00059.2007","volume":"293","author":"VA Lacombe","year":"2007","unstructured":"Lacombe VA, Viatchenko-Karpinski S, Terentyev D, Sridhar A, Emani S, Bonagura JD et al (2007) Mechanisms of impaired calcium handling underlying subclinical diastolic dysfunction in diabetes. Am J Physiol Regul Integr Comp Physiol 293:R1787\u2013R1797. https:\/\/doi.org\/10.1152\/ajpregu.00059.2007","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2069_CR9","doi-asserted-by":"publisher","first-page":"H976","DOI":"10.1152\/ajpheart.00088.2002","volume":"283","author":"LM Semeniuk","year":"2002","unstructured":"Semeniuk LM, Kryski AJ, Severson DL (2002) Echocardiographic assessment of cardiac function in diabetic db\/db and transgenic db\/db-hGLUT4 mice. Am J Physiol Heart Circ Physiol 283:H976\u2013H982. https:\/\/doi.org\/10.1152\/ajpheart.00088.2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2069_CR10","doi-asserted-by":"publisher","first-page":"839714","DOI":"10.3389\/fcvm.2022.839714","volume":"9","author":"D Lohr","year":"2022","unstructured":"Lohr D, Thiele A, Stahnke M, Braun V, Smeir E, Spranger J et al (2022) Assessment of Myocardial Microstructure in a Murine Model of Obesity-Related Cardiac Dysfunction by Diffusion Tensor Magnetic Resonance Imaging at 7T. Front Cardiovasc Med 9:839714. https:\/\/doi.org\/10.3389\/fcvm.2022.839714","journal-title":"Front Cardiovasc Med"},{"key":"2069_CR11","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.ejphar.2013.02.045","volume":"706","author":"I Namekata","year":"2013","unstructured":"Namekata I, Hamaguchi S, Wakasugi Y, Ohhara M, Hirota Y, Tanaka H (2013) Ellagic acid and gingerol, activators of the sarco-endoplasmic reticulum Ca\u00b2\u207a-ATPase, ameliorate diabetes mellitus-induced diastolic dysfunction in isolated murine ventricular myocardia. Eur J Pharmacol 706:48\u201355. https:\/\/doi.org\/10.1016\/j.ejphar.2013.02.045","journal-title":"Eur J Pharmacol"},{"key":"2069_CR12","doi-asserted-by":"publisher","first-page":"947","DOI":"10.2337\/db10-1145","volume":"60","author":"CH Shao","year":"2011","unstructured":"Shao CH, Capek HL, Patel KP, Wang M, Tang K, DeSouza C et al (2011) Carbonylation contributes to SERCA2a activity loss and diastolic dysfunction in a rat model of type 1 diabetes. Diabetes 60:947\u2013959. https:\/\/doi.org\/10.2337\/db10-1145","journal-title":"Diabetes"},{"key":"2069_CR13","doi-asserted-by":"publisher","first-page":"8703","DOI":"10.1038\/s41598-017-09037-z","volume":"7","author":"R Guo","year":"2017","unstructured":"Guo R, Hua Y, Rogers O, Brown TE, Ren J, Nair S (2017) Cathepsin K knockout protects against cardiac dysfunction in diabetic mice. Sci Rep 7:8703. https:\/\/doi.org\/10.1038\/s41598-017-09037-z","journal-title":"Sci Rep"},{"key":"2069_CR14","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1124\/jpet.122.001446","volume":"384","author":"R Avvisato","year":"2023","unstructured":"Avvisato R, Jankauskas SS, Santulli G (2023) Istaroxime and Beyond: New Therapeutic Strategies to Specifically Activate SERCA and Treat Heart Failure. J Pharmacol Exp Ther 384:227\u2013230. https:\/\/doi.org\/10.1124\/jpet.122.001446","journal-title":"J Pharmacol Exp Ther"},{"key":"2069_CR15","doi-asserted-by":"publisher","first-page":"pgad453","DOI":"10.1093\/pnasnexus\/pgad453","volume":"3","author":"J \u0160eflov\u00e1","year":"2024","unstructured":"\u0160eflov\u00e1 J, Cruz-Cort\u00e9s C, Guerrero-Serna G, Robia SL, Espinoza-Fonseca LM (2024) Mechanisms for cardiac calcium pump activation by its substrate and a synthetic allosteric modulator using fluorescence lifetime imaging. PNAS Nexus 3:pgad453. https:\/\/doi.org\/10.1093\/pnasnexus\/pgad453","journal-title":"PNAS Nexus"},{"key":"2069_CR16","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1089\/cbr.2020.4267","volume":"38","author":"M Gao","year":"2023","unstructured":"Gao M, Yang W (2023) Effects of Citrus aurantium L. on Gastrointestinal Motility and Gastric Cancer Cell Proliferation. Cancer Biother Radiopharm 38:111\u2013115. https:\/\/doi.org\/10.1089\/cbr.2020.4267","journal-title":"Cancer Biother Radiopharm"},{"key":"2069_CR17","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.biopha.2016.05.030","volume":"82","author":"P Kang","year":"2016","unstructured":"Kang P, Ryu KH, Lee JM, Kim HK, Seol GH (2016) Endothelium- and smooth muscle-dependent vasodilator effects of Citrus aurantium L. var. amara: Focus on Ca2+ modulation. Biomed Pharmacother 82:467\u2013471. https:\/\/doi.org\/10.1016\/j.biopha.2016.05.030","journal-title":"Biomed Pharmacother"},{"key":"2069_CR18","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1021\/np9904509","volume":"63","author":"PG Pietta","year":"2000","unstructured":"Pietta PG (2000) Flavonoids as antioxidants. J Nat Prod 63:1035\u20131042. https:\/\/doi.org\/10.1021\/np9904509","journal-title":"J Nat Prod"},{"key":"2069_CR19","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1039\/c0fo00103a","volume":"1","author":"MH Pan","year":"2010","unstructured":"Pan MH, Lai CS, Ho CT (2010) Anti-inflammatory activity of natural dietary flavonoids. Food Funct 1:15\u201331. https:\/\/doi.org\/10.1039\/c0fo00103a","journal-title":"Food Funct"},{"key":"2069_CR20","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1007\/s12263-014-0400-z","volume":"9","author":"ML Mansuri","year":"2014","unstructured":"Mansuri ML, Parihar P, Solanki I, Parihar MS (2014) Flavonoids in modulation of cell survival signalling pathways. Genes Nutr 9:400. https:\/\/doi.org\/10.1007\/s12263-014-0400-z","journal-title":"Genes Nutr"},{"key":"2069_CR21","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1248\/bpb.b23-00386","volume":"46","author":"K Noguchi","year":"2023","unstructured":"Noguchi K, Ueda C, Watanabe M, Goma M, Umeda S, Tabira S et al (2023) Endothelium-Independent Vasorelaxant Effects of Sudachitin and Demethoxysudachitin, Polymethoxyflavone from the Peel of Citrus sudachi on Isolated Rat Aorta. Biol Pharm Bull 46:1583\u20131591. https:\/\/doi.org\/10.1248\/bpb.b23-00386","journal-title":"Biol Pharm Bull"},{"key":"2069_CR22","doi-asserted-by":"publisher","first-page":"2138","DOI":"10.1248\/bpb.b24-00695","volume":"47","author":"R Odaka","year":"2024","unstructured":"Odaka R, Saito T, Seki M, Iinuma A, Takatsu K, Hamaguchi S et al (2024) Selective Inhibitory Effect of Hesperetin on the Automaticity of the Guinea Pig Pulmonary Vein Myocardium. Biol Pharm Bull 47:2138\u20132142. https:\/\/doi.org\/10.1248\/bpb.b24-00695","journal-title":"Biol Pharm Bull"},{"key":"2069_CR23","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.1248\/bpb.b21-00580","volume":"44","author":"S Hamaguchi","year":"2021","unstructured":"Hamaguchi S, Abe K, Komatsu M, Kainuma J, Namekata I, Tanaka H (2021) Positive Lusitropic Effect of Quercetin on Isolated Ventricular Myocardia from Normal and Streptozotocin-Induced Diabetic Mice. Biol Pharm Bull 44:1894\u20131897. https:\/\/doi.org\/10.1248\/bpb.b21-00580","journal-title":"Biol Pharm Bull"},{"key":"2069_CR24","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.jacc.2020.11.044","volume":"77","author":"M Frisk","year":"2021","unstructured":"Frisk M, Le C, Shen X, R\u00f8e \u00c5 T, Hou Y, Manfra O et al (2021) Etiology-Dependent Impairment of Diastolic Cardiomyocyte Calcium Homeostasis in Heart Failure With Preserved Ejection Fraction. J Am Coll Cardiol 77:405\u2013419. https:\/\/doi.org\/10.1016\/j.jacc.2020.11.044","journal-title":"J Am Coll Cardiol"},{"key":"2069_CR25","doi-asserted-by":"publisher","first-page":"2002","DOI":"10.1039\/C0AY00455C","volume":"2","author":"X Xu","year":"2010","unstructured":"Xu X, Jiang J, Liang Y, Yi L, Cheng J (2010) Chemical fingerprint analysis for quality control of Fructus Aurantii Immaturus based on HPLC-DAD combined with chemometric methods. Anal Methods 2:2002\u20132010. https:\/\/doi.org\/10.1039\/C0AY00455C","journal-title":"Anal Methods"},{"key":"2069_CR26","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.3390\/molecules23092189","volume":"23","author":"Y He","year":"2018","unstructured":"He Y, Li Z, Wang W, Sooranna SR, Shi Y, Chen Y et al (2018) Chemical Profiles and Simultaneous Quantification of Aurantii fructus by Use of HPLC-Q-TOF-MS Combined with GC-MS and HPLC Methods. Molecules 23:2189. https:\/\/doi.org\/10.3390\/molecules23092189","journal-title":"Molecules"},{"key":"2069_CR27","doi-asserted-by":"publisher","first-page":"1407138","DOI":"10.3389\/fcvm.2024.1407138","volume":"11","author":"X Yuan","year":"2024","unstructured":"Yuan X, Yu T, Zhang Z, Li S (2024) Non-invasive assessment of proarrhythmic risks associated with isoprenaline and the dietary supplement ingredient synephrine using human induced pluripotent stem cell-derived cardiomyocytes. Front Cardiovasc Med 11:1407138. https:\/\/doi.org\/10.3389\/fcvm.2024.1407138","journal-title":"Front Cardiovasc Med"},{"key":"2069_CR28","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1210\/en.2009-0633","volume":"151","author":"H Takeda","year":"2010","unstructured":"Takeda H, Muto S, Hattori T, Sadakane C, Tsuchiya K, Katsurada T et al (2010) Rikkunshito ameliorates the aging-associated decrease in ghrelin receptor reactivity via phosphodiesterase III inhibition. Endocrinology 151:244\u2013252 DOI 10.1210\/en.2009\u2009\u2013\u20090633","journal-title":"Endocrinology"},{"key":"2069_CR29","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1271\/bbb.110800","volume":"76","author":"K Yuasa","year":"2012","unstructured":"Yuasa K, Tada K, Harita G, Fujimoto T, Tsukayama M, Tsuji A (2012) Sudachitin, a polymethoxyflavone from Citrus sudachi, suppresses lipopolysaccharide-induced inflammatory responses in mouse macrophage-like RAW264 cells. Biosci Biotechnol Biochem 76:598\u2013600. https:\/\/doi.org\/10.1271\/bbb.110800","journal-title":"Biosci Biotechnol Biochem"},{"key":"2069_CR30","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1055\/s-2005-837774","volume":"71","author":"F Orallo","year":"2005","unstructured":"Orallo F, Cami\u00f1a M, Alvarez E, Basaran H, Lugnier C (2005) Implication of cyclic nucleotide phosphodiesterase inhibition in the vasorelaxant activity of the citrus-fruits flavonoid (+\/-)-naringenin. Planta Med 71:99\u2013107. https:\/\/doi.org\/10.1055\/s-2005-837774","journal-title":"Planta Med"},{"key":"2069_CR31","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1016\/j.bcp.2004.06.030","volume":"68","author":"WC Ko","year":"2004","unstructured":"Ko WC, Shih CM, Lai YH, Chen JH, Huang HL (2004) Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationships. Biochem Pharmacol 68:2087\u20132094. https:\/\/doi.org\/10.1016\/j.bcp.2004.06.030","journal-title":"Biochem Pharmacol"},{"key":"2069_CR32","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/bf00172781","volume":"352","author":"A Daul","year":"1995","unstructured":"Daul A, Elter-Schulz M, Poller U, Jockenh\u00f6vel F, P\u00f6nicke K, Boomsma F et al (1995) Dose-dependent separation of dopaminergic and adrenergic effects of epinine in healthy volunteers. Naunyn Schmiedebergs Arch Pharmacol 352:429\u2013437. https:\/\/doi.org\/10.1007\/bf00172781","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"2069_CR33","doi-asserted-by":"publisher","first-page":"R1439","DOI":"10.1152\/ajpregu.00736.2007","volume":"295","author":"J Suarez","year":"2008","unstructured":"Suarez J, Scott B, Dillmann WH (2008) Conditional increase in SERCA2a protein is able to reverse contractile dysfunction and abnormal calcium flux in established diabetic cardiomyopathy. Am J Physiol Regul Integr Comp Physiol 295:R1439\u2013R1445. https:\/\/doi.org\/10.1152\/ajpregu.00736.2007","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2069_CR34","doi-asserted-by":"publisher","first-page":"10709","DOI":"10.1021\/acs.jafc.0c04425","volume":"68","author":"M Zhang","year":"2020","unstructured":"Zhang M, Xin Y, Feng K, Yin B, Kan Q, Xiao J et al (2020) Comparative Analyses of Bioavailability, Biotransformation, and Excretion of Nobiletin in Lean and Obese Rats. J Agric Food Chem 68:10709\u201310718. https:\/\/doi.org\/10.1021\/acs.jafc.0c04425","journal-title":"J Agric Food Chem"},{"key":"2069_CR35","first-page":"2326","volume":"28","author":"JH Hengstmann","year":"1978","unstructured":"Hengstmann JH, Aulepp H (1978) [Pharmacokinetics and metabolism of 3H-synephrine (author\u2019s transl)]. Arzneimittelforschung 28:2326\u20132331","journal-title":"Arzneimittelforschung"},{"key":"2069_CR36","doi-asserted-by":"publisher","first-page":"3793","DOI":"10.1002\/jps.22585","volume":"100","author":"S Onoue","year":"2011","unstructured":"Onoue S, Uchida A, Takahashi H, Seto Y, Kawabata Y, Ogawa K et al (2011) Development of high-energy amorphous solid dispersion of nanosized nobiletin, a citrus polymethoxylated flavone, with improved oral bioavailability. J Pharm Sci 100:3793\u20133801. https:\/\/doi.org\/10.1002\/jps.22585","journal-title":"J Pharm Sci"}],"container-title":["Journal of Natural Medicines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-026-02069-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11418-026-02069-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-026-02069-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T15:32:58Z","timestamp":1793460778000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11418-026-02069-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,8]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["2069"],"URL":"https:\/\/doi.org\/10.1007\/s11418-026-02069-8","relation":{},"ISSN":["1340-3443","1861-0293"],"issn-type":[{"value":"1340-3443","type":"print"},{"value":"1861-0293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,8]]},"assertion":[{"value":"8 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}