{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T16:30:00Z","timestamp":1793464200829,"version":"4.5.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Joint Plan of Liaoning Province Science and Technology Program","award":["2024-MSLH-435"],"award-info":[{"award-number":["2024-MSLH-435"]}]},{"name":"Open Project of Key Laboratory of High-Altitude Medicine","award":["2025-KF-02"],"award-info":[{"award-number":["2025-KF-02"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nat Med"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1007\/s11418-026-02083-w","type":"journal-article","created":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:14:16Z","timestamp":1791152056000},"page":"1706-1721","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Extracts of okra mucilage protect intestinal homeostasis through gut microbiota and immune responses"],"prefix":"10.1007","volume":"80","author":[{"given":"Mengli","family":"Qing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benyue","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyi","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qidong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"key":"2083_CR1","doi-asserted-by":"publisher","unstructured":"Dantas TL, Alonso Buriti FC, Florentino ER (2021) Okra (Abelmoschus esculentus L.) as a Potential Functional Food Source of Mucilage and Bioactive Compounds with Technological Applications and Health Benefits. Plants (Basel) 10(8). https:\/\/doi.org\/10.3390\/plants10081683","DOI":"10.3390\/plants10081683"},{"key":"2083_CR2","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1002\/jsfa.2740280609","volume":"28","author":"L Mark","year":"1977","unstructured":"Mark L, Woolfe MFCGO (1977) Studies on the mucilages extracted from okra fruits (Hibiscus esculentus L.) and baobab leaves (Adansonia digitata L). J Sci Food Agricultural 28:519\u2013529","journal-title":"J Sci Food Agricultural"},{"key":"2083_CR3","doi-asserted-by":"publisher","first-page":"1305617","DOI":"10.3389\/fmicb.2024.1305617","volume":"15","author":"YK Hsiao","year":"2024","unstructured":"Hsiao YK, Lee BH, Wu SC (2024) Lactiplantibacillus plantarum-encapsulated microcapsules prepared from okra polysaccharides improved intestinal microbiota in Alzheimer\u2019s disease mice. Front Microbiol 15:1305617. https:\/\/doi.org\/10.3389\/fmicb.2024.1305617","journal-title":"Front Microbiol"},{"key":"2083_CR4","doi-asserted-by":"publisher","first-page":"9855411","DOI":"10.1155\/2022\/9855411","volume":"2022","author":"J Wu","year":"2022","unstructured":"Wu J, Cao M, Hu M et al (2022) Intervention Effects of Okra Extract on Brain-Gut Peptides and Intestinal Microorganisms in Sleep Deprivation Rats. Evid Based Complement Alternat Med 2022:9855411. https:\/\/doi.org\/10.1155\/2022\/9855411","journal-title":"Evid Based Complement Alternat Med"},{"issue":"1","key":"2083_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/01652176.2025.2452169","volume":"45","author":"P Chen","year":"2025","unstructured":"Chen P, Rehman MU, He Y et al (2025) Exploring the interplay between Eimeria spp. infection and the host: understanding the dynamics of gut barrier function. Vet Q 45(1):1\u201322. https:\/\/doi.org\/10.1080\/01652176.2025.2452169","journal-title":"Vet Q"},{"issue":"1","key":"2083_CR6","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1017\/S0007114516004037","volume":"117","author":"PA Bron","year":"2017","unstructured":"Bron PA, Kleerebezem M, Brummer RJ et al (2017) Can probiotics modulate human disease by impacting intestinal barrier function? Br J Nutr 117(1):93\u2013107. https:\/\/doi.org\/10.1017\/S0007114516004037","journal-title":"Br J Nutr"},{"key":"2083_CR7","doi-asserted-by":"publisher","first-page":"e928478","DOI":"10.12659\/MSM.928478","volume":"27","author":"YJ Weng","year":"2021","unstructured":"Weng YJ, Jiang DX, Liang J et al (2021) Effects of Pretreatment with Bifidobacterium bifidum Using 16S Ribosomal RNA Gene Sequencing in a Mouse Model of Acute Colitis Induced by Dextran Sulfate Sodium. Med Sci Monit 27:e928478. https:\/\/doi.org\/10.12659\/MSM.928478","journal-title":"Med Sci Monit"},{"issue":"1","key":"2083_CR8","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1186\/s13063-019-3493-2","volume":"20","author":"Q Wang","year":"2019","unstructured":"Wang Q, Guo BY, Zhao QC et al (2019) Safety of early oral feeding after total laparoscopic radical gastrectomy for gastric cancer (SOFTLY): Study protocol for a randomized controlled trial. Trials 20(1):384. https:\/\/doi.org\/10.1186\/s13063-019-3493-2","journal-title":"Trials"},{"issue":"4","key":"2083_CR9","doi-asserted-by":"publisher","first-page":"272","DOI":"10.2174\/1874467212666190308103448","volume":"12","author":"H Park","year":"2019","unstructured":"Park H, Kim W, Kim D, Jeong S, Jung Y (2019) Mesalazine Activates Adenosine Monophosphate-activated Protein Kinase: Implication in the Anti-inflammatory Activity of this Anti-colitic Drug. Curr Mol Pharmacol 12(4):272\u2013280. https:\/\/doi.org\/10.2174\/1874467212666190308103448","journal-title":"Curr Mol Pharmacol"},{"key":"2083_CR10","doi-asserted-by":"publisher","first-page":"153836","DOI":"10.1016\/j.phymed.2021.153836","volume":"94","author":"Y Feng","year":"2022","unstructured":"Feng Y, Li Y, Zhou D, Li B, Chen G, Li N (2022) Glycyrrhetinic acid reverses antibiotic-induced intestinal epithelial injury through RNA-binding protein human antigen R (HuR). Phytomedicine 94:153836. https:\/\/doi.org\/10.1016\/j.phymed.2021.153836","journal-title":"Phytomedicine"},{"issue":"12","key":"2083_CR11","doi-asserted-by":"publisher","first-page":"5225","DOI":"10.7150\/thno.43716","volume":"10","author":"YJ Liu","year":"2020","unstructured":"Liu YJ, Tang B, Wang FC et al (2020) Parthenolide ameliorates colon inflammation through regulating Treg\/Th17 balance in a gut microbiota-dependent manner. Theranostics 10(12):5225\u20135241. https:\/\/doi.org\/10.7150\/thno.43716","journal-title":"Theranostics"},{"issue":"7","key":"2083_CR12","doi-asserted-by":"publisher","first-page":"2138","DOI":"10.1021\/acs.jafc.0c07046","volume":"69","author":"Y Yao","year":"2021","unstructured":"Yao Y, Liu T, Yin L, Man S, Ye S, Ma L (2021) Polyphenol-Rich Extract from Litchi chinensis Seeds Alleviates Hypertension-Induced Renal Damage in Rats. J Agric Food Chem 69(7):2138\u20132148. https:\/\/doi.org\/10.1021\/acs.jafc.0c07046","journal-title":"J Agric Food Chem"},{"issue":"2","key":"2083_CR13","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/s41419-022-05482-5","volume":"14","author":"Y Yao","year":"2023","unstructured":"Yao Y, Feng S, Li X et al (2023) Litchi procyanidins inhibit colon cancer proliferation and metastasis by triggering gut-lung axis immunotherapy. Cell Death Dis 14(2):109. https:\/\/doi.org\/10.1038\/s41419-022-05482-5","journal-title":"Cell Death Dis"},{"key":"2083_CR14","doi-asserted-by":"publisher","unstructured":"Elkhalifa AEO, Al-Shammari E, Adnan M et al (2021) Development and Characterization of Novel Biopolymer Derived from Abelmoschus esculentus L. Extract and Its Antidiabetic Potential. Molecules 26(12). https:\/\/doi.org\/10.3390\/molecules26123609","DOI":"10.3390\/molecules26123609"},{"key":"2083_CR15","doi-asserted-by":"publisher","first-page":"181","DOI":"10.2147\/CEG.S62823","volume":"7","author":"BW Petschow","year":"2014","unstructured":"Petschow BW, Burnett B, Shaw AL, Weaver EM, Klein GL (2014) Serum-derived bovine immunoglobulin\/protein isolate: postulated mechanism of action for management of enteropathy. Clin Exp Gastroenterol 7:181\u2013190. https:\/\/doi.org\/10.2147\/CEG.S62823","journal-title":"Clin Exp Gastroenterol"},{"issue":"1","key":"2083_CR16","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s13052-025-02188-0","volume":"52","author":"DU De Rose","year":"2026","unstructured":"De Rose DU, Aceti A, Liotto N et al (2026) Nutritional management of neonates who undergo major surgery for gastrointestinal disorders: a joint position paper of the Italian Society of Neonatology (SIN), the Italian Society of Pediatric Surgery (SICP), and the Italian Society of Pediatric Nutrition (SINUPE). Ital J Pediatr 52(1):29. https:\/\/doi.org\/10.1186\/s13052-025-02188-0","journal-title":"Ital J Pediatr"},{"key":"2083_CR17","doi-asserted-by":"publisher","first-page":"1401070","DOI":"10.3389\/fendo.2024.1401070","volume":"15","author":"R Jiang","year":"2024","unstructured":"Jiang R, Cong Z, Zheng L et al (2024) Global research trends in regulating gut microbiome to improve type 2 diabetes mellitus: bibliometrics and visual analysis. Front Endocrinol (Lausanne) 15:1401070. https:\/\/doi.org\/10.3389\/fendo.2024.1401070","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"8","key":"2083_CR18","doi-asserted-by":"publisher","first-page":"3390","DOI":"10.7150\/ijbs.69833","volume":"18","author":"H Xiang","year":"2022","unstructured":"Xiang H, Liu Z, Xiang H et al (2022) Dynamics of the gut-liver axis in rats with varying fibrosis severity. Int J Biol Sci 18(8):3390\u20133404. https:\/\/doi.org\/10.7150\/ijbs.69833","journal-title":"Int J Biol Sci"},{"key":"2083_CR19","doi-asserted-by":"publisher","first-page":"1055725","DOI":"10.3389\/fnut.2022.1055725","volume":"9","author":"S Jiang","year":"2022","unstructured":"Jiang S, Dong W, Zhang Z et al (2022) A new iron supplement: The chelate of pig skin collagen peptide and Fe(2+) can treat iron-deficiency anemia by modulating intestinal flora. Front Nutr 9:1055725. https:\/\/doi.org\/10.3389\/fnut.2022.1055725","journal-title":"Front Nutr"},{"key":"2083_CR20","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.3389\/fphys.2018.01180","volume":"9","author":"C Rennert","year":"2018","unstructured":"Rennert C, Vlaic S, Marbach-Breitruck E et al (2018) The Diurnal Timing of Starvation Differently Impacts Murine Hepatic Gene Expression and Lipid Metabolism - A Systems Biology Analysis Using Self-Organizing Maps. Front Physiol 9:1180. https:\/\/doi.org\/10.3389\/fphys.2018.01180","journal-title":"Front Physiol"},{"issue":"1","key":"2083_CR21","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s00018-024-05501-y","volume":"82","author":"YH Lin","year":"2024","unstructured":"Lin YH, Lian WS, Wu RW et al (2024) Trimethylamine-N-oxide accelerates osteoporosis by PERK activation of ATF5 unfolding. Cell Mol Life Sci 82(1):13. https:\/\/doi.org\/10.1007\/s00018-024-05501-y","journal-title":"Cell Mol Life Sci"},{"issue":"27","key":"2083_CR22","doi-asserted-by":"publisher","first-page":"16890","DOI":"10.1021\/acs.jafc.5c00835","volume":"73","author":"S Liu","year":"2025","unstructured":"Liu S, Wang M, Meng X et al (2025) Flavonoids from Shiliangcha (Chimonanthus salicifolius) Alleviate Brain Aging in d-Galactose-Induced Senescent Mice through Gut Microbiota. J Agric Food Chem 73(27):16890\u201316905. https:\/\/doi.org\/10.1021\/acs.jafc.5c00835","journal-title":"J Agric Food Chem"},{"issue":"4","key":"2083_CR23","doi-asserted-by":"publisher","first-page":"e0048622","DOI":"10.1128\/spectrum.00486-22","volume":"10","author":"CY Lin","year":"2022","unstructured":"Lin CY, Cheng HT, Kuo CJ et al (2022) Proton Pump Inhibitor-Induced Gut Dysbiosis Increases Mortality Rates for Patients with Clostridioides difficile Infection. Microbiol Spectr 10(4):e0048622. https:\/\/doi.org\/10.1128\/spectrum.00486-22","journal-title":"Microbiol Spectr"},{"issue":"5","key":"2083_CR24","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1038\/s41385-018-0035-2","volume":"11","author":"CA Harrison","year":"2018","unstructured":"Harrison CA, Laubitz D, Ohland CL et al (2018) Microbial dysbiosis associated with impaired intestinal Na(+)\/H(+) exchange accelerates and exacerbates colitis in ex-germ free mice. Mucosal Immunol 11(5):1329\u20131341. https:\/\/doi.org\/10.1038\/s41385-018-0035-2","journal-title":"Mucosal Immunol"},{"key":"2083_CR25","doi-asserted-by":"publisher","first-page":"746923","DOI":"10.3389\/fphar.2021.746923","volume":"12","author":"Z Zhen","year":"2021","unstructured":"Zhen Z, Xia L, You H et al (2021) An Integrated Gut Microbiota and Network Pharmacology Study on Fuzi-Lizhong Pill for Treating Diarrhea-Predominant Irritable Bowel Syndrome. Front Pharmacol 12:746923. https:\/\/doi.org\/10.3389\/fphar.2021.746923","journal-title":"Front Pharmacol"},{"issue":"1","key":"2083_CR26","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1080\/07853890.2022.2081871","volume":"54","author":"A Samaddar","year":"2022","unstructured":"Samaddar A, van Nispen J, Armstrong A et al (2022) Lower systemic inflammation is associated with gut firmicutes dominance and reduced liver injury in a novel ambulatory model of parenteral nutrition. Ann Med 54(1):1701\u20131713. https:\/\/doi.org\/10.1080\/07853890.2022.2081871","journal-title":"Ann Med"},{"key":"2083_CR27","doi-asserted-by":"publisher","unstructured":"Mandic M, Mitic K, Nedeljkovic P et al (2022) Vitamin B Complex and Experimental Autoimmune Encephalomyelitis -Attenuation of the Clinical Signs and Gut Microbiota Dysbiosis. Nutrients 14(6). https:\/\/doi.org\/10.3390\/nu14061273","DOI":"10.3390\/nu14061273"},{"key":"2083_CR28","doi-asserted-by":"publisher","first-page":"9047","DOI":"10.1038\/srep09047","volume":"5","author":"T Ren","year":"2015","unstructured":"Ren T, Tian T, Feng X et al (2015) An adenosine A3 receptor agonist inhibits DSS-induced colitis in mice through modulation of the NF-kappaB signaling pathway. Sci Rep 5:9047. https:\/\/doi.org\/10.1038\/srep09047","journal-title":"Sci Rep"},{"key":"2083_CR29","doi-asserted-by":"publisher","first-page":"746492","DOI":"10.3389\/fimmu.2021.746492","volume":"12","author":"JC Balandran","year":"2021","unstructured":"Balandran JC, Davila-Velderrain J, Sandoval-Cabrera A et al (2021) Patient-Derived Bone Marrow Spheroids Reveal Leukemia-Initiating Cells Supported by Mesenchymal Hypoxic Niches in Pediatric B-ALL. Front Immunol 12:746492. https:\/\/doi.org\/10.3389\/fimmu.2021.746492","journal-title":"Front Immunol"}],"container-title":["Journal of Natural Medicines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-026-02083-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11418-026-02083-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-026-02083-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T15:32:55Z","timestamp":1793460775000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11418-026-02083-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,5]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["2083"],"URL":"https:\/\/doi.org\/10.1007\/s11418-026-02083-w","relation":{},"ISSN":["1340-3443","1861-0293"],"issn-type":[{"value":"1340-3443","type":"print"},{"value":"1861-0293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,5]]},"assertion":[{"value":"5 August 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that there are no conflicts of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The protocols for animal experiments were approved by the experimental animal ethics committee of Shenyang Pharmaceutical University (No. SYPU-IACUC-S2026-0107-116).","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}]}}