{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T16:30:00Z","timestamp":1793464200841,"version":"4.5.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Natural Science Foundation of Henan Province of China","award":["252300423832"],"award-info":[{"award-number":["252300423832"]}]},{"name":"Henan Provincial Key Scientific Research Projects for Higher Education Institutions","award":["24A360022"],"award-info":[{"award-number":["24A360022"]}]},{"name":"Talent Introduction Scientific Research Foundation of Pingdingshan University","award":["PXY-BSQD-2022040, PXY-HX-2025073"],"award-info":[{"award-number":["PXY-BSQD-2022040, PXY-HX-2025073"]}],"id":[{"id":"https:\/\/ror.org\/026c29h90","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nat Med"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1007\/s11418-026-02088-5","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:18:26Z","timestamp":1790777906000},"page":"1755-1763","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Three new phenolic glycosides from root bark of Periploca sepium and their hypoglycemic activity"],"prefix":"10.1007","volume":"80","author":[{"given":"Cai-lian","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang-hang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-heng","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7649-9037","authenticated-orcid":false,"given":"Wei-wu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"issue":"1","key":"2088_CR1","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/s41392-025-02401-w","volume":"11","author":"LJ Zhao","year":"2026","unstructured":"Zhao LJ, Yuan JM, Yang Q et al (2026) Diabetes and its complications: molecular mechanisms, prevention and treatment. Signal Transduct Target Ther 11(1):22. https:\/\/doi.org\/10.1038\/s41392-025-02401-w","journal-title":"Signal Transduct Target Ther"},{"issue":"13","key":"2088_CR2","doi-asserted-by":"publisher","first-page":"6203","DOI":"10.1080\/07391102.2022.2104375","volume":"41","author":"HA Oyewusi","year":"2023","unstructured":"Oyewusi HA, Wu YS, Safi SZ et al (2023) Molecular dynamics simulations reveal the inhibitory mechanism of Withanolide A against \u03b1-glucosidase and \u03b1-amylase. J Biomol Struct Dyn 41(13):6203\u20136218. https:\/\/doi.org\/10.1080\/07391102.2022.2104375","journal-title":"J Biomol Struct Dyn"},{"issue":"25","key":"2088_CR3","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.2174\/1568026622666220831092855","volume":"22","author":"N Agrawal","year":"2022","unstructured":"Agrawal N, Sharma M, Singh S et al (2022) Recent advances of \u03b1-glucosidase inhibitors: a comprehensive review. Curr Top Med Chem 22(25):2069\u20132086. https:\/\/doi.org\/10.2174\/1568026622666220831092855","journal-title":"Curr Top Med Chem"},{"issue":"4","key":"2088_CR4","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1021\/acs.jnatprod.1c00765","volume":"85","author":"TK Le","year":"2023","unstructured":"Le TK, Danova A, Aree T et al (2023) \u03b1-Glucosidase Inhibitors from the stems of Knema globularia. J Nat Prod 85(4):776\u2013786. https:\/\/doi.org\/10.1021\/acs.jnatprod.1c00765","journal-title":"J Nat Prod"},{"issue":"20","key":"2088_CR5","doi-asserted-by":"publisher","first-page":"2722","DOI":"10.3390\/plants11202722","volume":"11","author":"H Kashtoh","year":"2022","unstructured":"Kashtoh H, Baek KH (2022) Recent updates on phytoconstituent alpha-glucosidase inhibitors: an approach towards the treatment of type two diabetes. Plants (Basel) 11(20):2722. https:\/\/doi.org\/10.3390\/plants11202722","journal-title":"Plants (Basel)"},{"issue":"10","key":"2088_CR6","doi-asserted-by":"publisher","first-page":"4065","DOI":"10.1002\/jsfa.11755","volume":"102","author":"H Wu","year":"2022","unstructured":"Wu H, Shu LP, Liang T et al (2022) Extraction optimization, physicochemical property, antioxidant activity, and \u03b1-glucosidase inhibitory effect of polysaccharides from lotus seedpods. J Sci Food Agric 102(10):4065\u20134078. https:\/\/doi.org\/10.1002\/jsfa.11755","journal-title":"J Sci Food Agric"},{"issue":"22","key":"2088_CR7","doi-asserted-by":"publisher","first-page":"3934","DOI":"10.1080\/14786419.2023.2269591","volume":"38","author":"ZH Shu","year":"2024","unstructured":"Shu ZH, Chen M, Li Y et al (2024) C21 steroidal glycosides from the root bark of Periploca sepium and their NO production inhibitory and cytotoxic activity. Nat Prod Res 38(22):3934\u20133940. https:\/\/doi.org\/10.1080\/14786419.2023.2269591","journal-title":"Nat Prod Res"},{"issue":"15","key":"2088_CR8","doi-asserted-by":"publisher","first-page":"2749","DOI":"10.3390\/molecules24152749","volume":"24","author":"MJ Huang","year":"2019","unstructured":"Huang MJ, Shen SM, Luo CL et al (2019) Genus Periploca (Apocynaceae): a review of its classification, phytochemistry, biological activities and toxicology. Molecules 24(15):2749. https:\/\/doi.org\/10.3390\/molecules24152749","journal-title":"Molecules"},{"key":"2088_CR9","doi-asserted-by":"publisher","first-page":"113345","DOI":"10.1016\/j.jep.2020.113345","volume":"265","author":"ZM Lin","year":"2021","unstructured":"Lin ZM, Liu YT, Huang YT et al (2021) Anti-nociceptive, anti-inflammatory and anti-arthritic activities of pregnane glycosides from the root bark of Periploca sepium Bunge. J Ethnopharmacol 265:113345. https:\/\/doi.org\/10.1016\/j.jep.2020.113345","journal-title":"J Ethnopharmacol"},{"key":"2088_CR10","doi-asserted-by":"publisher","first-page":"104254","DOI":"10.1016\/j.fitote.2019.104254","volume":"137","author":"W Zhao","year":"2019","unstructured":"Zhao W, Chen HL, Hong L et al (2019) Five new polyphenolic derivatives with antimicrobial activities from the root barks of Periploca sepium. Fitoterapia 137:104254. https:\/\/doi.org\/10.1016\/j.fitote.2019.104254","journal-title":"Fitoterapia"},{"key":"2088_CR11","doi-asserted-by":"publisher","first-page":"153535","DOI":"10.1016\/j.phymed.2021.153535","volume":"85","author":"ZT Li","year":"2021","unstructured":"Li ZT, Zhang FX, Fan CL et al (2021) Discovery of potential Q-marker of traditional Chinese medicine based on plant metabolomics and network pharmacology: Periplocae Cortex as an example. Phytomedicine 85:153535. https:\/\/doi.org\/10.1016\/j.phymed.2021.153535","journal-title":"Phytomedicine"},{"key":"2088_CR12","doi-asserted-by":"crossref","unstructured":"Yang XW, He HP, Ma YL et al (2010) Three new vanilloid derivatives from the stems of Baccaurea ramiflora. Planta Medica 76(01):88\u201390. https:\/\/www.thieme-connect.de\/rss\/thieme\/en\/10.1055-s-00000058.xml","DOI":"10.1055\/s-0029-1185901"},{"key":"2088_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2025.107042","author":"CL Fan","year":"2025","unstructured":"Fan CL, Ou ZJ, Shu ZH et al (2025) Targeted isolation of new di\/trinormonoterpenoid glucosides as cyclooxygenase-2 inhibitors from Periplocae Cortex using molecular networking. Fitoterapia. https:\/\/doi.org\/10.1016\/j.fitote.2025.107042","journal-title":"Fitoterapia"},{"issue":"09","key":"2088_CR14","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.16333\/j.1001-6880.2020.9.004","volume":"32","author":"H Zhu","year":"2020","unstructured":"Zhu H, Liu LS, Xiong L et al (2020) Constituents of angelica oil and their neuroprotective effects. Nat Prod Res Dev 32(09):1477\u20131483. https:\/\/doi.org\/10.16333\/j.1001-6880.2020.9.004","journal-title":"Nat Prod Res Dev"},{"issue":"07","key":"2088_CR15","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1055\/s-2006-962173","volume":"55","author":"J Msonthi","year":"1989","unstructured":"Msonthi J, Toyota M, Marston A et al (1989) A novel phenolic glycoside from Mondia whytei. Planta Med 55(07):618\u2013618. https:\/\/doi.org\/10.1055\/s-2006-962173","journal-title":"Planta Med"},{"issue":"08","key":"2088_CR16","first-page":"1254","volume":"41","author":"LP Kang","year":"2010","unstructured":"Kang LP, Liu YX, Tong ZQ et al (2010) NMR data analysis of a pregnane glycoside from Qiliqiangxin capsules. Chin Traditional Herb Drugs 41(08):1254\u20131258","journal-title":"Chin Traditional Herb Drugs"},{"issue":"4","key":"2088_CR17","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1016\/0031-9422(88)80297-8","volume":"27","author":"H Itokawa","year":"1988","unstructured":"Itokawa H, Xu JP, Takeya K (1988) Pregnane glycosides from an antitumour fraction of Periploca sepium. Phytochemistry 27(4):1173\u20131179. https:\/\/doi.org\/10.1016\/0031-9422(88)80297-8","journal-title":"Phytochemistry"},{"issue":"1","key":"2088_CR18","doi-asserted-by":"publisher","first-page":"59","DOI":"10.12677\/HJFNS.2020.91007","volume":"9","author":"SJ Fu","year":"2020","unstructured":"Fu SJ, Yang L, Li JL (2020) Isolation of mulberry leaf polysaccharide and its hypoglycemic and lipid-lowering activity. Hans J Food Nutr Sci 9(1):59\u201366. https:\/\/doi.org\/10.12677\/HJFNS.2020.91007","journal-title":"Hans J Food Nutr Sci"}],"container-title":["Journal of Natural Medicines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-026-02088-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11418-026-02088-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-026-02088-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T15:32:51Z","timestamp":1793460771000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11418-026-02088-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["2088"],"URL":"https:\/\/doi.org\/10.1007\/s11418-026-02088-5","relation":{},"ISSN":["1340-3443","1861-0293"],"issn-type":[{"value":"1340-3443","type":"print"},{"value":"1861-0293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"assertion":[{"value":"27 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All authors declare no conflicts of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}