{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T16:30:03Z","timestamp":1793464203386,"version":"4.5.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nat Med"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1007\/s11418-026-02091-w","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:38:02Z","timestamp":1791941882000},"page":"1764-1777","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["LC\u2013MS profiling and antiulcer mechanisms of\u00a0Rumex pictus\u00a0extract and its isolated emodin-8-O-\u03b2-glucoside against ethanol-induced gastric damage"],"prefix":"10.1007","volume":"80","author":[{"given":"Enaam M.","family":"AbouZeid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamia T.","family":"Abou El-Kassem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally A.","family":"El Awdan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5742-059X","authenticated-orcid":false,"given":"Usama W.","family":"Hawas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagwa M.","family":"Ammar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"issue":"10","key":"2091_CR1","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1001\/jama.2024.27195","volume":"333","author":"R Voelker","year":"2025","unstructured":"Voelker R (2025) Peptic ulcer disease. JAMA 333(10):917. https:\/\/doi.org\/10.1001\/jama.2024.27195","journal-title":"JAMA"},{"issue":"8","key":"2091_CR2","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1111\/jgh.12229","volume":"28","author":"R Al Batran","year":"2013","unstructured":"Al Batran R, Al-Bayaty F, Abdulla MA, Al-Obaidi MMJ, Hajrezaie M, Hassandarvish P, Fouad M, Golbabapour S, Talaee S (2013) Gastroprotective effects of Corchorus olitorius leaf extract against ethanol-induced gastric mucosal hemorrhagic lesions in rats. J Gastroenterol Hepatol 28(8):1321\u20131329. https:\/\/doi.org\/10.1111\/jgh.12229","journal-title":"J Gastroenterol Hepatol"},{"issue":"9","key":"2091_CR3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0157431","volume":"11","author":"NS Al-Wajeeh","year":"2016","unstructured":"Al-Wajeeh NS, Halabi MF, Hajrezaie M, Dhiyaaldeen SM, Bardi DA, Salama SM, Rouhollahi E, Karimian H, Abdolmalaki R, Azizan AHS, Ali HM, Noor SM, Abdulla MA (2016) The gastroprotective effect of Vitex pubescens leaf extract against ethanol-provoked gastric mucosal damage in Sprague-Dawley rats. PLoS ONE 11(9):e0157431. https:\/\/doi.org\/10.1371\/journal.pone.0157431","journal-title":"PLoS ONE"},{"issue":"2","key":"2091_CR4","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1111\/bcpt.13023","volume":"123","author":"PF Haastrup","year":"2018","unstructured":"Haastrup PF, Thompson W, S\u00f8ndergaard J, Jarb\u00f8l DE (2018) Side effects of long-term proton pump inhibitor use: a review. Basic Clin Pharmacol Toxicol 123(2):114\u2013121. https:\/\/doi.org\/10.1111\/bcpt.13023","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"2091_CR5","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-69800-2_5","volume-title":"Drug interactions in gastroenterology. Clinical gastroenterology","author":"R Smoli\u0107","year":"2024","unstructured":"Smoli\u0107 R, Vukadin S, Kuna L (2024) Antisecretory drugs. In: Bani\u0107 M, Erceg D (eds) Drug interactions in gastroenterology. Clinical gastroenterology. Humana, Cham. https:\/\/doi.org\/10.1007\/978-3-031-69800-2_5"},{"key":"2091_CR6","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1201\/9781003243472-25","volume-title":"Ancient and traditional foods, plants, herbs and spices used in the Middle East","author":"E AbouZeid","year":"2023","unstructured":"AbouZeid E, Abou El-Kassem L, Ammar N (2023) Veined dock (Rumex pictus Forssk.) usage in the Middle East. In: Rajendram R, Preedy VR, Patel VB (eds) Ancient and traditional foods, plants, herbs and spices used in the Middle East. CRC Press, Boca Raton, pp 343\u2013351. https:\/\/doi.org\/10.1201\/9781003243472-25"},{"issue":"3","key":"2091_CR7","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1002\/ptr.5275","volume":"29","author":"O Orb\u00e1n-Gyapai","year":"2015","unstructured":"Orb\u00e1n-Gyapai O, Lajter I, Hohmann J, Jakab G, Vasas A (2015) Xanthine oxidase-inhibitory activity of extracts prepared from Polygonaceae species. Phytother Res 29(3):459\u2013465. https:\/\/doi.org\/10.1002\/ptr.5275","journal-title":"Phytother Res"},{"key":"2091_CR8","doi-asserted-by":"publisher","first-page":"113509","DOI":"10.1016\/j.phytochem.2022.113509","volume":"205","author":"K Aierken","year":"2023","unstructured":"Aierken K, Li J, Xu N, Wu T, Zang D, Aisa HA (2023) Chemical constituents of Rumex dentatus L. and their antimicrobial and anti-inflammatory activities. Phytochem 205:113509. https:\/\/doi.org\/10.1016\/j.phytochem.2022.113509","journal-title":"Phytochem"},{"issue":"6","key":"2091_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/nu17061069","volume":"17","author":"K Komolafe","year":"2025","unstructured":"Komolafe K, Komolafe TR, Crown OO, Ajiboye B, Noubissi F, Ogungbe IV, Graham B (2025) Natural products in the management of gastroesophageal reflux disease: mechanisms, efficacy, and future directions. Nutrients 17(6):1069. https:\/\/doi.org\/10.3390\/nu17061069","journal-title":"Nutrients"},{"issue":"5","key":"2091_CR10","doi-asserted-by":"publisher","first-page":"469","DOI":"10.4196\/kjpp.2013.17.5.469","volume":"17","author":"SE Lee","year":"2013","unstructured":"Lee SE, Song HJ, Park SY, Nam Y, Min CH, Lee DY et al (2013) Effect of ECQ on iodoacetamide-induced chronic gastritis in rats. Korean J Physiol Pharmacol 17(5):469\u2013477. https:\/\/doi.org\/10.4196\/kjpp.2013.17.5.469","journal-title":"Korean J Physiol Pharmacol"},{"issue":"4","key":"2091_CR11","doi-asserted-by":"publisher","first-page":"425","DOI":"10.4062\/biomolther.2012.20.4.425","volume":"20","author":"JY Bae","year":"2012","unstructured":"Bae JY, Rhee YS, Han SY, Jeong EJ, Lee MK, Kong JY, Lee DH, Cho KJ, Lee HS, Ahn MJ (2012) A comparison between water and ethanol extracts of Rumex acetosa for protective effects on gastric ulcers in mice. Biomol Ther 20(4):425\u2013430. https:\/\/doi.org\/10.4062\/biomolther.2012.20.4.425","journal-title":"Biomol Ther"},{"issue":"3","key":"2091_CR12","first-page":"553","volume":"26","author":"D Ahmed","year":"2013","unstructured":"Ahmed D, Mughal QM, Younas S, Ikram M (2013) Study of phenolic content and urease and alpha-amylase inhibitory activities of methanolic extract of Rumex acetosella roots and its sub-fractions in different solvents. Pak J Pharm Sci 26(3):553\u2013559","journal-title":"Pak J Pharm Sci"},{"issue":"1","key":"2091_CR13","doi-asserted-by":"publisher","first-page":"116","DOI":"10.34172\/jhp.2021.12","volume":"10","author":"NM Ammar","year":"2021","unstructured":"Ammar NM, Abou El-Kassem LT, Ayoub NA, El-Ahmady SH, Moharam ME, AbouZeid EM (2021) Anti-inflammatory and antimicrobial activities of the successive extracts of the aerial parts of Rumex pictus Forssk. growing in Egypt. J Herbmed Pharmacol 10(1):116\u2013122. https:\/\/doi.org\/10.34172\/jhp.2021.12","journal-title":"J Herbmed Pharmacol"},{"key":"2091_CR14","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3643824","author":"SB Almasaudi","year":"2016","unstructured":"Almasaudi SB, El-Shitany NA, Abbas AT, Abdel-dayem UA, Ali SS, Al Jaouni SK, Harakeh S (2016) Antioxidant, anti-inflammatory, and antiulcer potential of manuka honey against gastric ulcer in rats. Oxid Med Cell Longev. https:\/\/doi.org\/10.1155\/2016\/3643824","journal-title":"Oxid Med Cell Longev"},{"key":"2091_CR15","first-page":"882","volume":"61","author":"E Beutler","year":"1963","unstructured":"Beutler E, Duron O, Kelly BM (1963) Improved method for the determination of blood glutathione. J Lab Clin Med 61:882\u2013888","journal-title":"J Lab Clin Med"},{"key":"2091_CR16","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/0003-2697(78)90342-1","volume":"86","author":"M Mihara","year":"1978","unstructured":"Mihara M, Uchiyama M (1978) Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 86:271\u2013278","journal-title":"Anal Biochem"},{"key":"2091_CR17","doi-asserted-by":"publisher","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","volume":"249","author":"WH Habig","year":"1974","unstructured":"Habig WH, Pabst MJ, Jakoby WB (1974) Glutathione S-transferases: the first enzymatic step in mercapturic acid formation. J Biol Chem 249:7130\u20137139. https:\/\/doi.org\/10.1016\/S0021-9258(19)42083-8","journal-title":"J Biol Chem"},{"key":"2091_CR18","first-page":"452","volume":"35","author":"PC Konturek","year":"2002","unstructured":"Konturek PC, Duda A, Brzozowski T, Konturek SJ, Kwiecien S, Drozdowicz D, Pajdo R, Meixner H, Hahn EG (2002) Activation of genes for superoxide dismutase, interleukin-1h, tumor necrosis factor alpha (TNF-\u03b1), and intercellular adhesion molecule-1 during healing of ischemia\u2014reperfusion-induced gastric injury. Scand J Gastroenterol 35:452\u2013463","journal-title":"Scand J Gastroenterol"},{"key":"2091_CR19","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0014-2999(99)00681-0","volume":"385","author":"T Brzozowski","year":"1999","unstructured":"Brzozowski T, Konturek PCh, Konturek SJ, Sliwowski Z, Drozdowicz D, Stachura J, Pajdo R, Hahn E (1999) Role of prostaglandins generated by cyclooxygenase-1 and cyclooxygenase-2 in healing of ischemia\u2014reperfusion-induced gastric lesions. Eur J Pharmacol 385:47\u201361","journal-title":"Eur J Pharmacol"},{"key":"2091_CR20","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.jep.2015.09.001","volume":"175","author":"A Vasas","year":"2015","unstructured":"Vasas A, Orb\u00e1n-Gyapai O, Hohmann J (2015) The genus Rumex: review of traditional uses, phytochemistry and pharmacology. J Ethnopharmacol 175:198\u2013228. https:\/\/doi.org\/10.1016\/j.jep.2015.09.001","journal-title":"J Ethnopharmacol"},{"key":"2091_CR21","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s10600-008-9026-y","volume":"44","author":"YA Litvinenko","year":"2008","unstructured":"Litvinenko YA, Muzychkina RA (2008) New antioxidant phytopreparation from Rumex thyrsiflorus roots. Chem Nat Compd 44:239\u2013240. https:\/\/doi.org\/10.1007\/s10600-008-9026-y","journal-title":"Chem Nat Compd"},{"key":"2091_CR22","doi-asserted-by":"publisher","DOI":"10.1007\/s13659-022-00346-z","volume":"12","author":"JJ Li","year":"2022","unstructured":"Li JJ, Li YX, Li N et al (2022) The genus Rumex (Polygonaceae): an ethnobotanical, phytochemical and pharmacological review. Nat Prod Bioprospect 12:21. https:\/\/doi.org\/10.1007\/s13659-022-00346-z","journal-title":"Nat Prod Bioprospect"},{"issue":"5","key":"2091_CR23","doi-asserted-by":"publisher","first-page":"616","DOI":"10.4274\/tjps.galenos.2021.33958","volume":"18","author":"G G\u00f6ger","year":"2021","unstructured":"G\u00f6ger G, K\u00f6se YB, Demirci F, G\u00f6ger F (2021) Phytochemical characterization of phenolic compounds by LC-MS\/MS and biological activities of Ajuga reptans L., Ajuga salicifolia (L.) Schreber and Ajuga genevensis L. from Turkey. Turk J Pharm Sci 18(5):616\u2013627. https:\/\/doi.org\/10.4274\/tjps.galenos.2021.33958","journal-title":"Turk J Pharm Sci"},{"key":"2091_CR24","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.carres.2017.05.023","volume":"448","author":"WA El-Kashak","year":"2017","unstructured":"El-Kashak WA, Elshamy AI, Mohamed TA, El Gendy AEG, Saleh IA, Umeyama A (2017) Rumpictuside A: unusual 9,10-anthraquinone glucoside from Rumex pictus Forssk. Carbohydr Res 448:74\u201378. https:\/\/doi.org\/10.1016\/j.carres.2017.05.023","journal-title":"Carbohydr Res"},{"issue":"5","key":"2091_CR25","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1021\/np000549b","volume":"64","author":"A Kuru\u00fcz\u00fcm","year":"2001","unstructured":"Kuru\u00fcz\u00fcm A, Demirezer LO, Bergere I, Zeeck A (2001) Two new chlorinated naphthalene glycosides from Rumex patientia. J Nat Prod 64(5):688\u2013690. https:\/\/doi.org\/10.1021\/np000549b","journal-title":"J Nat Prod"},{"issue":"2","key":"2091_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4314\/ajtcam.v13i2.1","volume":"13","author":"W Bi","year":"2016","unstructured":"Bi W, Man H, Hu L, Man MQ (2016) Antiulcerogenic benefits of herbal ingredients in ethanol-induced animal models. Afr J Tradit Complement Altern Med 13(2):1\u201324. https:\/\/doi.org\/10.4314\/ajtcam.v13i2.1","journal-title":"Afr J Tradit Complement Altern Med"},{"key":"2091_CR27","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.intimp.2016.03.006","volume":"34","author":"K Amirshahrokhi","year":"2016","unstructured":"Amirshahrokhi K, Khalili AR (2016) Gastroprotective effect of 2-mercaptoethane sulfonate against acute gastric mucosal damage induced by ethanol. Int Immunopharmacol 34:183\u2013188. https:\/\/doi.org\/10.1016\/j.intimp.2016.03.006","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"2091_CR28","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1515\/biol-2021-0075","volume":"16","author":"H Zhao","year":"2021","unstructured":"Zhao H, Zhang X, Zhang B, Qu X (2021) Gastroprotective effects of diosgenin against HCl\/ethanol-induced gastric mucosal injury through suppression of NF-\u03ba\u03b2 and myeloperoxidase activities. Open Life Sci 16(1):719\u2013727. https:\/\/doi.org\/10.1515\/biol-2021-0075","journal-title":"Open Life Sci"},{"issue":"10","key":"2091_CR29","doi-asserted-by":"publisher","first-page":"2488","DOI":"10.3390\/molecules13102488","volume":"13","author":"Y Kadoma","year":"2008","unstructured":"Kadoma Y, Fujisawa S (2008) A comparative study of the radical-scavenging activity of the phenolcarboxylic acids caffeic acid, p-coumaric acid, chlorogenic acid and ferulic acid, with or without 2-mercaptoethanol, a thiol, using the induction period method. Molecules 13(10):2488\u20132499. https:\/\/doi.org\/10.3390\/molecules13102488","journal-title":"Molecules"},{"issue":"6","key":"2091_CR30","doi-asserted-by":"publisher","first-page":"882","DOI":"10.3390\/foods11060882","volume":"11","author":"L Xie","year":"2022","unstructured":"Xie L, Deng Z, Zhang J, Dong H, Wang W, Xing B, Liu X (2022) Comparison of flavonoid O-glycoside, C-glycoside and their aglycones on antioxidant capacity and metabolism during in vitro digestion and in vivo. Foods 11(6):882. https:\/\/doi.org\/10.3390\/foods11060882","journal-title":"Foods"},{"issue":"1","key":"2091_CR31","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3390\/molecules26010229","volume":"26","author":"T Meng","year":"2021","unstructured":"Meng T, Xiao D, Muhammed A, Deng J, Chen L, He J (2021) Anti-inflammatory action and mechanisms of resveratrol. Molecules 26(1):229. https:\/\/doi.org\/10.3390\/molecules26010229","journal-title":"Molecules"},{"issue":"3","key":"2091_CR32","doi-asserted-by":"publisher","first-page":"4519","DOI":"10.1007\/s00210-025-04701-y","volume":"399","author":"SJ Sharif","year":"2026","unstructured":"Sharif SJ, Kadhim HM, Ahmed BS, Ridha-Salman H (2026) Gastroprotective and therapeutic effects of emodin on rat model of diclofenac-induced gastric ulceration. Naunyn Schmiedebergs Arch Pharmacol 399(3):4519\u20134536. https:\/\/doi.org\/10.1007\/s00210-025-04701-y","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"2091_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2025.116734","volume":"258","author":"X Wu","year":"2025","unstructured":"Wu X, Yu Q, Hou Y, Zhang X, Ocholi SS, Wang L, Yan Z, Li J, Han L (2025) Emodin-8-O-\u03b2-D-glucopyranoside alleviates cholestasis by maintaining intestinal homeostasis and regulating lipids and bile acids metabolism in mice. J Pharm Biomed Anal 258:116734. https:\/\/doi.org\/10.1016\/j.jpba.2025.116734","journal-title":"J Pharm Biomed Anal"}],"container-title":["Journal of Natural Medicines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-026-02091-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11418-026-02091-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11418-026-02091-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T15:32:46Z","timestamp":1793460766000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11418-026-02091-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,13]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["2091"],"URL":"https:\/\/doi.org\/10.1007\/s11418-026-02091-w","relation":{},"ISSN":["1340-3443","1861-0293"],"issn-type":[{"value":"1340-3443","type":"print"},{"value":"1861-0293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,13]]},"assertion":[{"value":"3 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest relating to the article.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}