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Although the nephrotoxic mechanisms of EG are well characterized, its acute hepatotoxic potential remains underexplored.\u00a0This study investigated histopathological and molecular alterations in the liver of rats following acute administration of EG. Possible dysfunction of an anti-oxidative pathway involving ferroptosis (glutathione peroxidase 4, Gpx4; solute carrier family 7 member 11, SLC7A11) is also examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Male rats (8-week-old, male) were orally administered EG (8\u00a0g\/kg) and euthanized at 2 and 5\u00a0days post-exposure by an administration of an overdose of anesthetic (40\u00a0mg\/kg sodium pentobarbital). Serological analysis was performed to assess liver function. Liver tissues were evaluated by histology, transmission electron microscopy, and transcriptome analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Serological findings indicated transient liver damage at 2\u00a0days post-exposure, followed by recovery at 5\u00a0days. Transmission electron microscopy revealed glycogen accumulation, corroborated by periodic acid\u2013Schiff and periodic acid-methenamine silver staining. Histological analysis revealed an increased number of nucleoli, correlating with upregulation of ribosomal genes on microarray analysis, particularly at 5\u00a0days post-exposure. In addition, significant decreases in Gpx4 and SLC7A11 expression were observed in rat livers treated with EG and Huh-7 human hepatoma cells, suggesting reduced cellular antioxidative capacity as a contributing factor to transient liver damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings reveal a pathway underlying EG-induced transient liver damage and suggest a possible mechanism of recovery, thereby providing new insights into EG poisoning.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11419-026-00757-4","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T13:57:52Z","timestamp":1770127072000},"page":"313-326","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Possible role of ribosome biogenesis in the recovery from transient hepatic damage caused by ethylene glycol in rats"],"prefix":"10.1007","volume":"44","author":[{"given":"Kana","family":"Unuma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4410-6432","authenticated-orcid":false,"given":"Toshihiko","family":"Aki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Isa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Tojo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"issue":"11","key":"757_CR1","doi-asserted-by":"publisher","first-page":"4218","DOI":"10.1039\/c2cs15359a","volume":"41","author":"H Yue","year":"2012","unstructured":"Yue H, Zhao Y, Ma X, Gong J (2012) Ethylene glycol: properties, synthesis, and applications. 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