{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T21:04:30Z","timestamp":1774645470660,"version":"3.50.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. China Life Sci."],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1007\/s11427-010-4056-7","type":"journal-article","created":{"date-parts":[[2010,11,22]],"date-time":"2010-11-22T17:59:53Z","timestamp":1290448793000},"page":"1065-1072","source":"Crossref","is-referenced-by-count":14,"title":["A genome-wide association analysis implicates SOX6 as a candidate gene for wrist bone mass"],"prefix":"10.1007","volume":"53","author":[{"given":"LiJun","family":"Tan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ShuFeng","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TieLin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YuFang","family":"Pei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YinPin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HongGang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shawn","family":"Levy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HongWen","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,11,23]]},"reference":[{"key":"4056_CR1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1359\/jbmr.1997.12.1.24","volume":"12","author":"N. F. Ray","year":"1997","unstructured":"Ray N F, Chan J K, Thamer M, et al. Medical expenditures for the treatment of osteoporotic fractures in the United States in 1995: report from the National Osteoporosis Foundation. J Bone Miner Res, 1997, 12: 24\u201335 1:STN:280:DyaK2szot1Oguw%3D%3D, 10.1359\/jbmr.1997.12.1.24, 9240722","journal-title":"J Bone Miner Res"},{"key":"4056_CR2","unstructured":"Public Health Service Office of the Surgeon General Public Health Service Office of the Surgeon General. 2004"},{"key":"4056_CR3","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0029-6465(22)02570-1","volume":"36","author":"G. Ioannidis","year":"2001","unstructured":"Ioannidis G, Gordon M, Adachi J D. Quality of life in osteoporosis. Nurs Clin North Am, 2001, 36: 481\u2013489 1:STN:280:DC%2BD3MvptFSgtA%3D%3D, 11532662","journal-title":"Nurs Clin North Am"},{"key":"4056_CR4","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1359\/JBMR.041025","volume":"20","author":"J. T. Schousboe","year":"2005","unstructured":"Schousboe J T, Fink H A, Taylor B C, et al. Association between self-reported prior wrist fractures and risk of subsequent hip and radiographic vertebral fractures in older women: a prospective study. J Bone Miner Res, 2005, 20: 100\u2013106 10.1359\/JBMR.041025, 15619675","journal-title":"J Bone Miner Res"},{"key":"4056_CR5","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.gene.2005.07.016","volume":"361","author":"T. Niu","year":"2005","unstructured":"Niu T, Rosen C J. The insulin-like growth factor-I gene and osteoporosis: a critical appraisal. Gene, 2005, 361: 38\u201356 1:CAS:528:DC%2BD2MXhtFGhsbjJ, 10.1016\/j.gene.2005.07.016, 16183214","journal-title":"Gene"},{"key":"4056_CR6","doi-asserted-by":"crossref","first-page":"5151","DOI":"10.1210\/jc.2002-020474","volume":"87","author":"H. W. Deng","year":"2002","unstructured":"Deng H W, Xu F H, Huang Q Y, et al. A whole-genome linkage scan suggests several genomic regions potentially containing quantitative trait loci for osteoporosis. J Clin Endocrinol Metab, 2002, 87: 5151\u20135159 1:CAS:528:DC%2BD38Xos1ynt7s%3D, 10.1210\/jc.2002-020474, 12414886","journal-title":"J Clin Endocrinol Metab"},{"key":"4056_CR7","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1136\/jmg.2004.020396","volume":"41","author":"H. Shen","year":"2004","unstructured":"Shen H, Zhang Y Y, Long J R, et al. A genome-wide linkage scan for bone mineral density in an extended sample: evidence for linkage on 11q23 and Xq27. J Med Genet, 2004, 41: 743\u2013751 1:CAS:528:DC%2BD2cXpsl2gsbk%3D, 10.1136\/jmg.2004.020396, 15466007","journal-title":"J Med Genet"},{"key":"4056_CR8","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1093\/hmg\/ddi088","volume":"14","author":"S. H. Ralston","year":"2005","unstructured":"Ralston S H, Galwey N, MacKay I, et al. Loci for regulation of bone mineral density in men and women identified by genome wide linkage scan: the FAMOS study. Hum Mol Genet, 2005, 14: 943\u2013951 1:CAS:528:DC%2BD2MXis1yjt7Y%3D, 10.1093\/hmg\/ddi088, 15746152","journal-title":"Hum Mol Genet"},{"key":"4056_CR9","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.1210\/jc.2004-2143","volume":"90","author":"M. Peacock","year":"2005","unstructured":"Peacock M, Koller D L, Fishburn T, et al. Sex-specific and non-sex-specific quantitative trait loci contribute to normal variation in bone mineral density in men. J Clin Endocrinol Metab, 2005, 90: 3060\u20133066 1:CAS:528:DC%2BD2MXkt1Wgurg%3D, 10.1210\/jc.2004-2143, 15741260","journal-title":"J Clin Endocrinol Metab"},{"key":"4056_CR10","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1359\/JBMR.041129","volume":"20","author":"H. Shen","year":"2005","unstructured":"Shen H, Liu Y, Liu P, et al. Nonreplication in genetic studies of complex diseases-lessons learned from studies of osteoporosis and tentative remedies. J Bone Miner Res, 2005, 20: 365\u2013376 1:CAS:528:DC%2BD2MXis1Kntbs%3D, 10.1359\/JBMR.041129, 15746981","journal-title":"J Bone Miner Res"},{"key":"4056_CR11","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1359\/JBMR.0301265","volume":"19","author":"A. Thakkinstian","year":"2004","unstructured":"Thakkinstian A, D\u2019Este C, Eisman J, et al. Meta-analysis of molecular association studies: vitamin D receptor gene polymorphisms and BMD as a case study. J Bone Miner Res, 2004, 19: 419\u2013428 1:CAS:528:DC%2BD2cXisFCrsb0%3D, 10.1359\/JBMR.0301265, 15040830","journal-title":"J Bone Miner Res"},{"key":"4056_CR12","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1359\/JBMR.050906","volume":"21","author":"H. M. Macdonald","year":"2006","unstructured":"Macdonald H M, McGuigan F E, Stewart A, et al. Large-scale population-based study shows no evidence of association between common polymorphism of the VDR gene and BMD in British women. J Bone Miner Res, 2006, 21: 151\u2013162 1:CAS:528:DC%2BD28Xpt1SmsA%3D%3D, 10.1359\/JBMR.050906, 16355284","journal-title":"J Bone Miner Res"},{"key":"4056_CR13","first-page":"943","volume":"14","author":"S. H. Ralston","year":"2006","unstructured":"Ralston S H, Uitterlinden A G, Brandi M L, et al. Large-scale evidence for the effect of the COLIA1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS study. PLoS, 2006, 14: 943\u2013951","journal-title":"PLoS"},{"key":"4056_CR14","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/nrg1521","volume":"6","author":"J. N. Hirschhorn","year":"2005","unstructured":"Hirschhorn J N, Daly M J. Genome-wide association studies for common diseases and complex traits. Nat Rev Genet, 2005, 6: 95\u2013108 1:CAS:528:DC%2BD2MXhtFyjsr8%3D, 10.1038\/nrg1521, 15716906","journal-title":"Nat Rev Genet"},{"key":"4056_CR15","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1093\/nar\/24.13.2623","volume":"24","author":"S. J. Ahn","year":"1996","unstructured":"Ahn S J, Costa J, Emanuel J R. PicoGreen quantitation of DNA: effective evaluation of samples pre- or post-PCR. Nucleic Acids Res, 1996, 24: 2623\u20132625 1:CAS:528:DyaK28XksVyjt7o%3D, 10.1093\/nar\/24.13.2623, 8692708","journal-title":"Nucleic Acids Res"},{"key":"4056_CR16","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1006\/abio.1997.2177","volume":"249","author":"V. L. Singer","year":"1997","unstructured":"Singer V L, Jones L J, Yue S T, et al. Characterization of PicoGreen reagent and development of a fluorescence-based solution assay for double-stranded DNA quantitation. Anal Biochem, 1997, 249: 228\u2013238 1:CAS:528:DyaK2sXktF2rsbo%3D, 10.1006\/abio.1997.2177, 9212875","journal-title":"Anal Biochem"},{"key":"4056_CR17","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1093\/bioinformatics\/bti275","volume":"21","author":"X. Di","year":"2005","unstructured":"Di X, Matsuzaki H, Webster T A, et al. Dynamic model based algorithms for screening and genotyping over 100 K SNPs on oligonucleotide microarrays. Bioinformatics, 2005, 21: 1958\u20131963 1:CAS:528:DC%2BD2MXjsl2nsLc%3D, 10.1093\/bioinformatics\/bti275, 15657097","journal-title":"Bioinformatics"},{"key":"4056_CR18","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/bioinformatics\/bti741","volume":"22","author":"N. Rabbee","year":"2005","unstructured":"Rabbee N, Speed T P. A genotype calling algorithm for affymetrix SNP arrays. Bioinformatics, 2005, 22: 7\u201312 10.1093\/bioinformatics\/bti741, 16267090","journal-title":"Bioinformatics"},{"key":"4056_CR19","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1159\/000057986","volume":"53","author":"D. V. Zaykin","year":"2002","unstructured":"Zaykin D V, Westfall P H, Young S S, et al. Testing association of statistically inferred haplotypes with discrete and continuous traits in samples of unrelated individuals. Hum Hered, 2002, 53: 79\u201391 10.1159\/000057986, 12037407","journal-title":"Hum Hered"},{"key":"4056_CR20","volume-title":"Genetic Data Analysis III","author":"B. Weir","year":"2007","unstructured":"Weir B. Genetic Data Analysis III. Sunderland: Sinauer Associates, 2007"},{"key":"4056_CR21","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/ng1847","volume":"38","author":"A. L. Price","year":"2006","unstructured":"Price A L, Patterson N J, Plenge R M, et al. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet, 2006, 38: 904\u2013909 1:CAS:528:DC%2BD28XnsVCgsrg%3D, 10.1038\/ng1847, 16862161","journal-title":"Nat Genet"},{"key":"4056_CR22","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","volume":"21","author":"J. C. Barrett","year":"2005","unstructured":"Barrett J C, Fry B, Maller J, et al. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics, 2005, 21: 263\u2013265 1:CAS:528:DC%2BD2MXkt1WitQ%3D%3D, 10.1093\/bioinformatics\/bth457, 15297300","journal-title":"Bioinformatics"},{"key":"4056_CR23","doi-asserted-by":"crossref","first-page":"W635","DOI":"10.1093\/nar\/gkl236","volume":"34","author":"H. Y. Yuan","year":"2006","unstructured":"Yuan H Y, Chiou J J, Tseng W H, et al. FASTSNP: an always up-to-date and extendable service for SNP function analysis and prioritization. Nucleic Acids Res, 2006, 34: W635\u2013W641 1:CAS:528:DC%2BD28Xps1yhs7c%3D, 10.1093\/nar\/gkl236, 16845089","journal-title":"Nucleic Acids Res"},{"key":"4056_CR24","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1111\/j.1420-9101.2005.00917.x","volume":"18","author":"M. C. Whitlock","year":"2005","unstructured":"Whitlock M C. Combining probability from independent tests: the weighted Z-method is superior to Fisher\u2019s approach. J Evol Biol, 2005, 18: 1368\u20131373 1:STN:280:DC%2BD2Mvmsl2hug%3D%3D, 10.1111\/j.1420-9101.2005.00917.x, 16135132","journal-title":"J Evol Biol"},{"key":"4056_CR25","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1359\/jbmr.060806","volume":"22","author":"J. P. Loannidis","year":"2007","unstructured":"Loannidis J P, Ng M Y, Sham P C, et al. Meta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone mass. J Bone Miner Res, 2007, 22: 173\u201383 10.1359\/jbmr.060806","journal-title":"J Bone Miner Res"},{"key":"4056_CR26","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/sj.ejhg.5201814","volume":"15","author":"C. Vidal","year":"2007","unstructured":"Vidal C, Galea R, Brincat M, et al. Linkage to chromosome 11p12 in two Maltese families with a highly penetrant form of osteoporosis. Eur J Hum Genet, 2007, 15: 800\u2013809 1:CAS:528:DC%2BD2sXmslSrsbk%3D, 10.1038\/sj.ejhg.5201814, 17377523","journal-title":"Eur J Hum Genet"},{"key":"4056_CR27","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/S0959-437X(97)80147-5","volume":"7","author":"L. H. Pevny","year":"1997","unstructured":"Pevny L H, Lovell-Badge R. Sox genes find their feet. Curr Opin Genet Dev, 1997, 7: 338\u2013344 1:CAS:528:DyaK2sXksVyntr8%3D, 10.1016\/S0959-437X(97)80147-5, 9229109","journal-title":"Curr Opin Genet Dev"},{"key":"4056_CR28","doi-asserted-by":"crossref","first-page":"5718","DOI":"10.1093\/emboj\/17.19.5718","volume":"17","author":"V. Lefebvre","year":"1998","unstructured":"Lefebvre V, Li P, de C B. A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene. EMBO J, 1998, 17: 5718\u20135733 1:CAS:528:DyaK1cXmvVyjsLs%3D, 10.1093\/emboj\/17.19.5718, 9755172","journal-title":"EMBO J"},{"key":"4056_CR29","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0945-053X(00)00094-9","volume":"19","author":"C. B. De","year":"2000","unstructured":"De C B, Lefebvre V, Behringer R R, et al. Transcriptional mechanisms of chondrocyte differentiation. Matrix Biol, 2000, 19: 389\u2013394 10.1016\/S0945-053X(00)00094-9","journal-title":"Matrix Biol"},{"key":"4056_CR30","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1053\/joca.2001.0447","volume":"9","author":"V. Lefebvre","year":"2001","unstructured":"Lefebvre V, Behringer R R, {fnde} C B. L-Sox5, Sox6 and Sox9 control essential steps of the chondrocyte differentiation pathway. Osteoarthritis Cartilage, 2001, 9: S69\u2013S75 10.1053\/joca.2001.0447, 11680692","journal-title":"Osteoarthritis Cartilage"},{"key":"4056_CR31","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1359\/jbmr.2001.16.10.1837","volume":"16","author":"H. Uusitalo","year":"2001","unstructured":"Uusitalo H, Hiltunen A, Ahonen M, et al. Accelerated up-regulation of L-Sox5, Sox6, and Sox9 by BMP-2 gene transfer during murine fracture healing. J Bone Miner Res, 2001, 16: 1837\u20131845 1:CAS:528:DC%2BD3MXnsVKqtL8%3D, 10.1359\/jbmr.2001.16.10.1837, 11585348","journal-title":"J Bone Miner Res"},{"key":"4056_CR32","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S1534-5807(01)00003-X","volume":"1","author":"P. Smits","year":"2001","unstructured":"Smits P, Li P, Mandel J, et al. The transcription factors L-Sox5 and Sox6 are essential for cartilage formation. Dev Cell, 2001, 1: 277\u2013290 1:CAS:528:DC%2BD3MXntVGrsLs%3D, 10.1016\/S1534-5807(01)00003-X, 11702786","journal-title":"Dev Cell"},{"key":"4056_CR33","doi-asserted-by":"crossref","first-page":"23500","DOI":"10.1074\/jbc.M700680200","volume":"282","author":"A. Woods","year":"2007","unstructured":"Woods A, Wang G, Dupuis H, et al. Rac1 signaling stimulates N-cadherin expression, mesenchymal condensation and chondrogenesis. J Biol Chem, 2007, 282: 23500\u201323508 1:CAS:528:DC%2BD2sXosVyrtrY%3D, 10.1074\/jbc.M700680200, 17573353","journal-title":"J Biol Chem"}],"container-title":["Science China Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-010-4056-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11427-010-4056-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-010-4056-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T07:57:18Z","timestamp":1685865438000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11427-010-4056-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":33,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["4056"],"URL":"https:\/\/doi.org\/10.1007\/s11427-010-4056-7","relation":{},"ISSN":["1674-7305","1869-1889"],"issn-type":[{"value":"1674-7305","type":"print"},{"value":"1869-1889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9]]}}}