{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T12:14:50Z","timestamp":1765368890257},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2013,8,8]],"date-time":"2013-08-08T00:00:00Z","timestamp":1375920000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. China Life Sci."],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1007\/s11427-013-4533-x","type":"journal-article","created":{"date-parts":[[2013,8,8]],"date-time":"2013-08-08T11:51:42Z","timestamp":1375962702000},"page":"818-822","source":"Crossref","is-referenced-by-count":3,"title":["Effects of external stimuli on the pacemaker function of the sinoatrial node in sodium channel gene mutations models"],"prefix":"10.1007","volume":"56","author":[{"given":"JiQian","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LiSi","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ShouFang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HengGui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,8,8]]},"reference":[{"key":"4533_CR1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/ng.784","volume":"43","author":"S Heribert","year":"2011","unstructured":"Heribert S, Konig I R, Sekar K, et al. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet, 2011, 43: 333\u2013338","journal-title":"Nat Genet"},{"key":"4533_CR2","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s11427-007-0072-7","volume":"50","author":"Y F Yang","year":"2007","unstructured":"Yang Y F, Zhu Y C, Li D Y, et al. Characterization of glucose-6-phosphate dehydrogenase deficiency and identification of a novel haplotype 487G>A\/IVS5-612(G>C) in the Achang population of southwestern China. Sci China Ser C-Life Sci, 2007, 50: 479\u2013485","journal-title":"Sci China Ser C-Life Sci"},{"key":"4533_CR3","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.yjmcc.2003.11.014","volume":"36","author":"L J Herfst","year":"2004","unstructured":"Herfst L J, Book M B, Jongsma H J. Trafficking and functional expression of cardiac Na+ channels. J Mod Cell Cardiol, 2004, 36: 185\u2013193","journal-title":"J Mod Cell Cardiol"},{"key":"4533_CR4","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/ncpcardio0268","volume":"2","author":"W Shimizu","year":"2005","unstructured":"Shimizu W, Aiba T, Kamakura S. Mechanisms of disease: current understanding and future challenges in Brugada syndrome. Nat Clin Pract Cardiovasc Med, 2005, 2: 408\u2013414","journal-title":"Nat Clin Pract Cardiovasc Med"},{"key":"4533_CR5","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1159\/000076693","volume":"101","author":"J M Juang","year":"2004","unstructured":"Juang J M, Huang S K. Brugada syndrome\u2014an under-recognized electrical disease in patients with sudden cardiac death. Cardiology, 2004, 101: 157\u2013169","journal-title":"Cardiology"},{"key":"4533_CR6","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/hmg\/11.3.337","volume":"11","author":"M Vatta","year":"2002","unstructured":"Vatta M, Dumaine R, Varghese G, et al. Genetic and biophysical basis of sudden unexplained nocturnal death syndrome (SUNDS), a disease allelic to Brugada syndrome. Hum Mol Genet, 2002, 11: 337\u2013345","journal-title":"Hum Mol Genet"},{"key":"4533_CR7","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1172\/JCI200318062","volume":"112","author":"D W Benson","year":"2003","unstructured":"Benson D W, Wang D W, Dyment M, et al. Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A). J Clin Invest, 2003, 112: 1019\u20131028","journal-title":"J Clin Invest"},{"key":"4533_CR8","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1161\/CIRCULATIONAHA.106.616011","volume":"115","author":"H Dobrzynski","year":"2007","unstructured":"Dobrzynski H, Boyeet M R, Anderson R H. New insights into pacemaker activity: promoting understanding of sick sinus syndrome. Circulation, 2007, 115: 1921\u20131932","journal-title":"Circulation"},{"key":"4533_CR9","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/12618","volume":"23","author":"J J Schott","year":"1999","unstructured":"Schott J J, Alshinawi C, Kyndt F, et al. Cardiac conduction defects associated with mutations in SCN5A. Nat Genet, 1999, 23: 20\u201321","journal-title":"Nat Genet"},{"key":"4533_CR10","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1097\/01.crd.0000123842.42287.cf","volume":"12","author":"C E Chiang","year":"2004","unstructured":"Chiang C E. Congenital and acquired long QT syndrome: current concepts and management. Cardiol Rev, 2004, 12: 222\u2013234","journal-title":"Cardiol Rev"},{"key":"4533_CR11","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0002-9343(00)00715-4","volume":"110","author":"A Towbin J","year":"2001","unstructured":"Towbin J A, Vatta M. Molecular biology and the prolonged QT syndromes. Am J Med, 2001, 110: 385\u2013398","journal-title":"Am J Med"},{"key":"4533_CR12","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1001\/jama.286.18.2264","volume":"286","author":"M J Ackerman","year":"2001","unstructured":"Ackerman M J, Siu B L, Sturner W Q, et al. Postmortem molecular analysis of SCN5A defects in sudden infant death syndrome. JAMA, 2001, 286: 2264\u20132269","journal-title":"JAMA"},{"key":"4533_CR13","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1172\/JCI25618","volume":"116","author":"L D Plant","year":"2006","unstructured":"Plant L D, Bowers P N, Liu Q, et al. A common cardiac sodium channel variant associated with sudden infant death in African Americans, SCN5A S1103Y. J Clin Invest, 2006, 116: 430\u2013435","journal-title":"J Clin Invest"},{"key":"4533_CR14","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.tcm.2003.10.001","volume":"14","author":"P C Viswanathan","year":"2004","unstructured":"Viswanathan P C, Balser J R. Inherited sodium channelopathies: a continuum of channel dysfunction. Trends Cardiovasc Med, 2004, 14: 28\u201335","journal-title":"Trends Cardiovasc Med"},{"key":"4533_CR15","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.bpc.2006.10.001","volume":"125","author":"H S Chen","year":"2007","unstructured":"Chen H S, Zhang J Q, Liu J Q. Selective effects of external noise on Ca2+ signal in mesoscopic scale biochemical cell systems. Biophys Chem, 2007, 125: 397\u2013402","journal-title":"Biophys Chem"},{"key":"4533_CR16","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0301-4622(01)00233-2","volume":"94","author":"J Q Zhang","year":"2001","unstructured":"Zhang J Q, Qi F, Xin H W, Effects of noise on the off rate of Ca2+ binding proteins in a coupled biochemical cell system. Biophys Chem, 2001, 94: 201\u2013207","journal-title":"Biophys Chem"},{"key":"4533_CR17","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1152\/ajpheart.2000.279.1.H397","volume":"279","author":"H Zhang","year":"2000","unstructured":"Zhang H, Holden A V, Kodama I, et al. Mathematical models of action potentials in the periphery and center of the rabbit sinoatrial node. Am J Physiol Heart Circ Physiol, 2000, 279: 397\u2013421","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"4533_CR18","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1152\/ajpheart.01101.2005","volume":"292","author":"H Zhang","year":"2007","unstructured":"Zhang H, Zhao Y, Lei M, et al. Computational evaluation of the roles of Na+ current, INa, and cell death in cardiac pacemaking and driving. Am J Physiol Heart Circ Physiol, 2007, 292: 165\u2013174","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"4533_CR19","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1161\/CIRCRESAHA.110.219949","volume":"107","author":"D B Timothy","year":"2010","unstructured":"Timothy D B, Oleg V A, Shin I, et al. Mechanistic links between Na+ channel (SCN5A) mutations and impaired cardiac pacemaking in sick sinus syndrome. Circ Res, 2010, 107: 126\u2013137","journal-title":"Circ Res"},{"key":"4533_CR20","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1113\/jphysiol.1996.sp021728","volume":"496","author":"H Honjo","year":"1996","unstructured":"Honjo H, Boyett M R, Kodama I, et al. Correlation between electrical activity and the size of rabbit sino-atrial node cells. J Physiol, 1996, 496: 795\u2013808","journal-title":"J Physiol"},{"key":"4533_CR21","first-page":"323","volume":"26","author":"B A Wani","year":"2005","unstructured":"Wani B A, Khalil M Z, Al-Nozha M M, et al. Aborted sudden nocturnal cardiac death in a young man with structurally normal heart. Saudi Med J, 2005, 26: 323\u2013325","journal-title":"Saudi Med J"},{"key":"4533_CR22","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1016\/S0006-3495(00)76738-5","volume":"78","author":"P D Brian","year":"2000","unstructured":"Brian P D, Jonathan S. pH modification of human T-type calcium channel gating. Biophys J, 2000, 78: 1895\u20131905","journal-title":"Biophys J"},{"key":"4533_CR23","first-page":"351","volume":"110","author":"A G Pakhcmov","year":"2000","unstructured":"Pakhcmov A G, Mathur S P, Doyle J, et al. Comparative effects of extremely high power microwave pulses and brief CW irradiation on pacemaker function in isolated frog heart slices. Bioelectromagnetics, 2000, 110: 351\u2013360","journal-title":"Bioelectromagnetics"},{"key":"4533_CR24","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1161\/01.CIR.91.10.2582","volume":"91","author":"C Tei","year":"1995","unstructured":"Tei C, Horikiri Y, Park J C, et al. Acute hemodynamic improvement by thermal vasodilation in congestive heart failure. Circulation, 1995, 91: 2582\u20132590","journal-title":"Circulation"},{"key":"4533_CR25","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1089\/acm.1999.5.301","volume":"5","author":"T Boone","year":"1999","unstructured":"Boone T, Westendorf T, Ayres P. Cardiovascular responses to a hot tub bath. J Alternat Compl Med, 1999, 5: 301\u2013304","journal-title":"J Alternat Compl Med"},{"key":"4533_CR26","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0896-6273(04)00199-0","volume":"42","author":"T Rosenbaum","year":"2004","unstructured":"Rosenbaum T, Gordon S E. Quickening the pace: looking into the heart of HCN channels. Neuron, 2004, 42: 193\u2013196","journal-title":"Neuron"}],"container-title":["Science China Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-013-4533-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11427-013-4533-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-013-4533-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,20]],"date-time":"2019-07-20T16:00:41Z","timestamp":1563638441000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11427-013-4533-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,8]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["4533"],"URL":"https:\/\/doi.org\/10.1007\/s11427-013-4533-x","relation":{},"ISSN":["1674-7305","1869-1889"],"issn-type":[{"value":"1674-7305","type":"print"},{"value":"1869-1889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,8]]}}}