{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:06:12Z","timestamp":1791396372922,"version":"4.3.3"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,12,26]],"date-time":"2013-12-26T00:00:00Z","timestamp":1388016000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. China Life Sci."],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1007\/s11427-013-4585-y","type":"journal-article","created":{"date-parts":[[2013,12,26]],"date-time":"2013-12-26T02:10:31Z","timestamp":1388023831000},"page":"107-116","source":"Crossref","is-referenced-by-count":86,"title":["Cidea controls lipid droplet fusion and lipid storage in brown and white adipose tissue"],"prefix":"10.1007","volume":"57","author":[{"given":"LiZhen","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LinKang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JingYi","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,12,26]]},"reference":[{"key":"4585_CR1","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1210\/er.2008-0024","volume":"29","author":"MA Cornier","year":"2008","unstructured":"Cornier MA, Dabelea D, Hernandez TL, Lindstrom RC, Steig AJ, Stob NR, Van Pelt RE, Wang H, Eckel RH. The metabolic syndrome. Endocr Rev, 2008, 29:777\u2013822","journal-title":"Endocr Rev"},{"key":"4585_CR2","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1172\/JCI10842","volume":"106","author":"BB Kahn","year":"2000","unstructured":"Kahn BB, Flier JS. Obesity and insulin resistance. J Clin Invest, 2000, 106:473\u2013481","journal-title":"J Clin Invest"},{"key":"4585_CR3","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.cell.2009.11.005","volume":"139","author":"RV Farese Jr.","year":"2009","unstructured":"Farese RV, Jr., Walther TC. Lipid droplets finally get a little R-E-S-P-E-C-T. Cell, 2009, 139:855\u2013860","journal-title":"Cell"},{"key":"4585_CR4","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1146\/annurev-biochem-061009-102430","volume":"81","author":"TC Walther","year":"2012","unstructured":"Walther TC, Farese RV, Jr. Lipid droplets and cellular lipid metabolism. Annu Rev Biochem, 2012, 81:687\u2013714","journal-title":"Annu Rev Biochem"},{"key":"4585_CR5","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.ceb.2012.05.012","volume":"24","author":"H Yang","year":"2012","unstructured":"Yang H, Galea A, Sytnyk V, Crossley M. Controlling the size of lipid droplets: lipid and protein factors. Curr Opin Cell Biol, 2012, 24:509\u2013516","journal-title":"Curr Opin Cell Biol"},{"key":"4585_CR6","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1002\/emmm.201100671","volume":"5","author":"N Krahmer","year":"2013","unstructured":"Krahmer N, Farese RV, Jr., Walther TC. Balancing the fat: lipid droplets and human disease. EMBO Mol Med, 2013, 5:905\u2013915","journal-title":"EMBO Mol Med"},{"key":"4585_CR7","doi-asserted-by":"crossref","first-page":"e2890","DOI":"10.1371\/journal.pone.0002890","volume":"3","author":"SY Toh","year":"2008","unstructured":"Toh SY, Gong J, Du G, Li JZ, Yang S, Ye J, Yao H, Zhang Y, Xue B, Li Q, Yang H, Wen Z, Li P. Up-regulation of mitochondrial activity and acquirement of brown adipose tissue-like property in the white adipose tissue of fsp27 deficient mice. PLoS ONE, 2008, 3:e2890","journal-title":"PLoS ONE"},{"key":"4585_CR8","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1083\/jcb.201104142","volume":"195","author":"J Gong","year":"2011","unstructured":"Gong J, Sun Z, Wu L, Xu W, Schieber N, Xu D, Shui G, Yang H, Parton RG, Li P. Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites. J Cell Biol, 2011, 195:953\u2013963","journal-title":"J Cell Biol"},{"key":"4585_CR9","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1038\/ncomms2581","volume":"4","author":"Z Sun","year":"2013","unstructured":"Sun Z, Gong J, Wu H, Xu W, Wu L, Xu D, Gao J, Wu JW, Yang H, Yang M, Li P. Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes. Nat Commun, 2013, 4: 1594","journal-title":"Nat Commun"},{"key":"4585_CR10","first-page":"2808","volume":"118","author":"N Nishino","year":"2008","unstructured":"Nishino N, Tamori Y, Tateya S, Kawaguchi T, Shibakusa T, Mizunoya W, Inoue K, Kitazawa R, Kitazawa S, Matsuki Y, Hiramatsu R, Masubuchi S, Omachi A, Kimura K, Saito M, Amo T, Ohta S, Yamaguchi T, Osumi T, Cheng J, Fujimoto T, Nakao H, Nakao K, Aiba A, Okamura H, Fushiki T, Kasuga M. FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets. J Clin Invest, 2008, 118:2808\u20132821","journal-title":"J Clin Invest"},{"key":"4585_CR11","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/1471-2148-8-159","volume":"8","author":"C Wu","year":"2008","unstructured":"Wu C, Zhang Y, Sun Z, Li P. Molecular evolution of Cide family proteins: novel domain formation in early vertebrates and the subsequent divergence. BMC Evol Biol, 2008, 8:159","journal-title":"BMC Evol Biol"},{"key":"4585_CR12","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/ng1225","volume":"35","author":"Z Zhou","year":"2003","unstructured":"Zhou Z, Yon Toh S, Chen Z, Guo K, Ng CP, Ponniah S, Lin SC, Hong W, Li P. Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat Genet, 2003, 35:49\u201356","journal-title":"Nat Genet"},{"key":"4585_CR13","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nm.2614","volume":"18","author":"W Wang","year":"2012","unstructured":"Wang W, Lv N, Zhang S, Shui G, Qian H, Zhang J, Chen Y, Ye J, Xie Y, Shen Y, Wenk MR, Li P. Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids. Nat Med, 2012, 18:235\u2013243","journal-title":"Nat Med"},{"key":"4585_CR14","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.cmet.2008.03.003","volume":"7","author":"K Matsusue","year":"2008","unstructured":"Matsusue K, Kusakabe T, Noguchi T, Takiguchi S, Suzuki T, Yamano S, Gonzalez FJ. Hepatic steatosis in leptin-deficient mice is promoted by the PPARgamma target gene Fsp27. Cell Metab, 2008, 7:302\u2013311","journal-title":"Cell Metab"},{"key":"4585_CR15","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/hep.25611","volume":"56","author":"L Zhou","year":"2012","unstructured":"Zhou L, Xu L, Ye J, Li D, Wang W, Li X, Wu L, Wang H, Guan F, Li P. Cidea promotes hepatic steatosis by sensing dietary fatty acids. Hepatology, 2012, 56:95\u2013107","journal-title":"Hepatology"},{"key":"4585_CR16","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1038\/emboj.2008.92","volume":"27","author":"J Qi","year":"2008","unstructured":"Qi J, Gong J, Zhao T, Zhao J, Lam P, Ye J, Li JZ, Wu J, Zhou HM, Li P. Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue. EMBO J, 2008, 27:1537\u20131548","journal-title":"EMBO J"},{"key":"4585_CR17","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1097\/01.mco.0000232904.82038.db","volume":"9","author":"K Reue","year":"2006","unstructured":"Reue K, Phan J. Metabolic consequences of lipodystrophy in mouse models. Curr Opin Clin Nutr Metab Care, 2006, 9:436\u2013441","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"4585_CR18","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1101\/gad.12.20.3182","volume":"12","author":"I Shimomura","year":"1998","unstructured":"Shimomura I, Hammer RE, Richardson JA, Ikemoto S, Bashmakov Y, Goldstein JL, Brown MS. Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes Dev, 1998, 12:3182\u20133194","journal-title":"Genes Dev"},{"key":"4585_CR19","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0092-8674(01)00474-3","volume":"106","author":"A Cederberg","year":"2001","unstructured":"Cederberg A, Gronning LM, Ahren B, Tasken K, Carlsson P, Enerback S. FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance. Cell, 2001, 106:563\u2013573","journal-title":"Cell"},{"key":"4585_CR20","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1194\/jlr.M002147","volume":"51","author":"M Ito","year":"2010","unstructured":"Ito M, Nagasawa M, Hara T, Ide T, Murakami K. Differential roles of CIDEA and CIDEC in insulin-induced anti-apoptosis and lipid droplet formation in human adipocytes. J Lipid Res, 2010, 51:1676\u20131684","journal-title":"J Lipid Res"},{"key":"4585_CR21","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.2337\/diabetes.54.6.1726","volume":"54","author":"EA Nordstrom","year":"2005","unstructured":"Nordstrom EA, Ryden M, Backlund EC, Dahlman I, Kaaman M, Blomqvist L, Cannon B, Nedergaard J, Arner P. A human-specific role of cell death-inducing DFFA (DNA fragmentation factor-alpha)-like effector A (CIDEA) in adipocyte lipolysis and obesity. Diabetes, 2005, 54:1726\u20131734","journal-title":"Diabetes"}],"container-title":["Science China Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-013-4585-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11427-013-4585-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-013-4585-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T04:55:51Z","timestamp":1498107351000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11427-013-4585-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,26]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["4585"],"URL":"https:\/\/doi.org\/10.1007\/s11427-013-4585-y","relation":{},"ISSN":["1674-7305","1869-1889"],"issn-type":[{"value":"1674-7305","type":"print"},{"value":"1869-1889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,26]]}}}