{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:06:44Z","timestamp":1791176804556,"version":"4.1.0"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci. China Life Sci."],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1007\/s11427-014-4693-3","type":"journal-article","created":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T18:48:42Z","timestamp":1407437322000},"page":"802-808","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["ACE2\/Ang-(1\u20137) signaling and vascular remodeling"],"prefix":"10.1007","volume":"57","author":[{"given":"ZhenZhou","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LaiJiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JiuChang","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PingJin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin Y.","family":"Oudit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,8,8]]},"reference":[{"key":"4693_CR1","doi-asserted-by":"crossref","first-page":"e38502","DOI":"10.1371\/journal.pone.0038502","volume":"7","author":"HY Jin","year":"2012","unstructured":"Jin HY, Song B, Oudit GY, Davidge ST, Yu HM, Jiang YY, Gao PJ, Zhu DL, Ning G, Kassiri Z, Penninger JM, Zhong JC. ACE2 deficiency enhances angiotensin II-mediated aortic profilin-1 expression, inflammation and peroxynitrite production. PLoS ONE, 2012, 7: e38502","journal-title":"PLoS ONE"},{"key":"4693_CR2","doi-asserted-by":"crossref","first-page":"5203","DOI":"10.1172\/JCI69608","volume":"123","author":"T Sato","year":"2013","unstructured":"Sato T, Suzuki T, Watanabe H, Kadowaki A, Fukamizu A, Liu PP, Kimura A, Ito H, Penninger JM, Imai Y, Kuba K. Apelin is a positive regulator of ACE2 in failing hearts. J Clin Invest, 2013, 123: 5203\u20135211","journal-title":"J Clin Invest"},{"key":"4693_CR3","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1161\/HYPERTENSIONAHA.111.187021","volume":"59","author":"EL Schiffrin","year":"2012","unstructured":"Schiffrin EL. Vascular remodeling in hypertension: mechanisms and treatment. Hypertension, 2012, 59: 367\u2013374","journal-title":"Hypertension"},{"key":"4693_CR4","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1161\/CIRCRESAHA.112.268029","volume":"110","author":"VB Patel","year":"2012","unstructured":"Patel VB, Bodiga S, Basu R, Das SK, Wang W, Wang Z, Lo J, Grant MB, Zhong J, Kassiri Z, Oudit GY. Loss of angiotensin-converting enzyme-2 exacerbates diabetic cardiovascular complications and leads to systolic and vascular dysfunction: a critical role of the angiotensin II\/AT1 receptor axis. Circ Res, 2012, 110: 1322\u20131335","journal-title":"Circ Res"},{"key":"4693_CR5","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1161\/CIRCRESAHA.107.148338","volume":"101","author":"S Heeneman","year":"2007","unstructured":"Heeneman S, Sluimer JC, Daemen MJ. Angiotensin-converting enzyme and vascular remodeling. Circ Res, 2007, 101: 441\u2013454","journal-title":"Circ Res"},{"key":"4693_CR6","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.regpep.2013.06.007","volume":"185","author":"B Song","year":"2013","unstructured":"Song B, Jin H, Yu X, Zhang Z, Yu H, Ye J, Xu Y, Zhou T, Oudit GY, Ye JY, Chen C, Gao P, Zhu D, Penninger JM, Zhong JC. Angiotensin-converting enzyme 2 attenuates oxidative stress and VSMC proliferation via the JAK2\/STAT3\/SOCS3 and profilin-1\/MAPK signaling pathways. Regul Pept, 2013, 185: 44\u201351","journal-title":"Regul Pept"},{"key":"4693_CR7","doi-asserted-by":"crossref","first-page":"H435","DOI":"10.1152\/ajpheart.00262.2004","volume":"287","author":"EL Schiffrin","year":"2004","unstructured":"Schiffrin EL, Touyz RM. From bedside to bench to bedside: role of renin-angiotensin-aldosterone system in remodeling of resistance arteries in hypertension. Am J Physiol Heart Circ Physiol, 2004, 287: H435\u2013446","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"4693_CR8","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.regpep.2007.06.010","volume":"144","author":"JC Zhong","year":"2007","unstructured":"Zhong JC, Huang Y, Yung LM, Lau CW, Leung FP, Wong WT, Lin SG, Yu XY. The novel peptide apelin regulates intrarenal artery tone in diabetic mice. Regul Pept, 2007, 144: 109\u2013114","journal-title":"Regul Pept"},{"key":"4693_CR9","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/cvr\/cvr036","volume":"91","author":"S Bodiga","year":"2011","unstructured":"Bodiga S, Zhong JC, Wang W, Basu R, Lo J, Liu GC, Guo D, Holland SM, Scholey JW, Penninger JM, Kassiri Z, Oudit GY. Enhanced susceptibility to biomechanical stress in ACE2 null mice is prevented by loss of the p47(phox) NADPH oxidase subunit. Cardiovasc Res, 2011, 91: 151\u2013161","journal-title":"Cardiovasc Res"},{"key":"4693_CR10","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1161\/HYPERTENSIONAHA.110.164244","volume":"57","author":"J Zhong","year":"2011","unstructured":"Zhong J, Guo D, Chen CB, Wang W, Schuster M, Loibner H, Penninger JM, Scholey JW, Kassiri Z, Oudit GY. Prevention of angiotensin II-mediated renal oxidative stress, inflammation and fibrosis by angiotensin-converting enzyme 2. Hypertension, 2011, 57: 314\u2013322","journal-title":"Hypertension"},{"key":"4693_CR11","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1161\/01.HYP.0000146400.57221.74","volume":"44","author":"JC Zhong","year":"2004","unstructured":"Zhong JC, Huang DY, Yang YM, Li YF, Liu GF, Song XH, Du K. Upregulation of angiotensin-converting enzyme 2 by all-trans retinoic acid in spontaneously hypertensive rats. Hypertension, 2004, 44: 907\u2013912","journal-title":"Hypertension"},{"key":"4693_CR12","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1161\/CIRCULATIONAHA.110.955369","volume":"122","author":"J Zhong","year":"2010","unstructured":"Zhong J, Basu R, Guo D, Chow FL, Byrns S, Schuster M, Loibner H, Wang XH, Penninger JM, Kassiri Z, Oudit GY. Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction. Circulation, 2010, 122: 717\u2013728","journal-title":"Circulation"},{"key":"4693_CR13","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1253\/circj.CJ-13-0805","volume":"77","author":"B Song","year":"2013","unstructured":"Song B, Zhang ZZ, Zhong JC, Yu XY, Oudit GY, Jin HY, Lu L, Xu YL, Kassiri Z, Shen WF, Gao PJ, Zhu DL. Loss of angiotensin-converting enzyme 2 exacerbates myocardial injury via activation of the CTGF-fractalkine signaling pathway. Circ J, 2013, 77: 2997\u20133006","journal-title":"Circ J"},{"key":"4693_CR14","doi-asserted-by":"crossref","first-page":"14838","DOI":"10.1074\/jbc.M200581200","volume":"277","author":"C Vickers","year":"2002","unstructured":"Vickers C, Hales P, Kaushik V, Dick L, Gavin J, Tang J, Godbout K, Parsons T, Baronas E, Hsieh F, Acton S, Patane M, Nichols A, Tummino P. Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase. J Biol Chem, 2002, 277: 14838\u201314843","journal-title":"J Biol Chem"},{"key":"4693_CR15","first-page":"e141","volume":"9","author":"VB Patel","year":"2014","unstructured":"Patel VB, Putko B, Wang Z, Zhong JC, Oudit GY. Manipulating angiotensin metabolism with angiotensin converting enzyme 2 (ACE2) in heart failure. Drug Discov Today: Therapeutic Strategies, 2014, 9: e141\u2013148","journal-title":"Drug Discov Today: Therapeutic Strategies"},{"key":"4693_CR16","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1161\/CIRCHEARTFAILURE.108.840124","volume":"2","author":"Z Kassiri","year":"2009","unstructured":"Kassiri Z, Zhong J, Guo D, Basu R, Wang X, Liu PP, Scholey JW, Penninger JM, Oudit GY. Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction. Circ Heart Fail, 2009, 2: 446\u2013455","journal-title":"Circ Heart Fail"},{"key":"4693_CR17","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/1479-5876-11-229","volume":"11","author":"ZZ Zhang","year":"2013","unstructured":"Zhang ZZ, Shang QH, Jin HY, Song B, Oudit GY, Lu L, Zhou T, Xu YL, Gao PJ, Zhu DL, Penninger JM, Zhong JC. Cardiac protective effects of irbesartan via the PPAR-gamma signaling pathway in angiotensin-converting enzyme 2-deficient mice. J Transl Med, 2013, 11: 229","journal-title":"J Transl Med"},{"key":"4693_CR18","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1161\/01.RES.87.5.e1","volume":"87","author":"M Donoghue","year":"2000","unstructured":"Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, Donovan M, Woolf B, Robison K, Jeyaseelan R, Breitbart RE, Acton S. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1\u20139. Circ Res, 2000, 87: E1\u20139","journal-title":"Circ Res"},{"key":"4693_CR19","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1161\/HYPERTENSIONAHA.112.191650","volume":"59","author":"VB Patel","year":"2012","unstructured":"Patel VB, Bodiga S, Fan D, Das SK, Wang Z, Wang W, Basu R, Zhong J, Kassiri Z, Oudit GY. Cardioprotective effects mediated by angiotensin II type 1 receptor blockade and enhancing angiotensin 1\u20137 in experimental heart failure in angiotensin-converting enzyme 2-null mice. Hypertension, 2012, 59: 1195\u20131203","journal-title":"Hypertension"},{"key":"4693_CR20","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1097\/MNH.0b013e328341164a","volume":"20","author":"C Tikellis","year":"2011","unstructured":"Tikellis C, Bernardi S, Burns WC. Angiotensin-converting enzyme 2 is a key modulator of the renin-angiotensin system in cardiovascular and renal disease. Curr Opin Nephrol Hypertens, 2011, 20: 62\u201368","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"4693_CR21","first-page":"227","volume":"31","author":"KB Brosnihan","year":"1998","unstructured":"Brosnihan KB, Li P, Tallant EA, Ferrario CM. Angiotensin-(1\u20137): a novel vasodilator of the coronary circulation. Biol Res, 1998, 31: 227\u2013234","journal-title":"Biol Res"},{"key":"4693_CR22","doi-asserted-by":"crossref","first-page":"C82","DOI":"10.1152\/ajpcell.00287.2006","volume":"292","author":"PK Mehta","year":"2007","unstructured":"Mehta PK, Griendling KK. Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system. Am J Physiol Cell Physiol, 2007, 292: C82\u201397","journal-title":"Am J Physiol Cell Physiol"},{"key":"4693_CR23","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1053\/j.ackd.2005.01.008","volume":"12","author":"MC Thomas","year":"2005","unstructured":"Thomas MC, Burns WC, Cooper ME. Tubular changes in early diabetic nephropathy. Adv Chronic Kidney Dis, 2005, 12: 177\u2013186","journal-title":"Adv Chronic Kidney Dis"},{"key":"4693_CR24","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1164\/rccm.200811-1678OC","volume":"179","author":"AJ Ferreira","year":"2009","unstructured":"Ferreira AJ, Shenoy V, Yamazato Y, Sriramula S, Francis J, Yuan L, Castellano RK, Ostrov DA, Oh SP, Katovich MJ, Raizada MK. Evidence for angiotensin-converting enzyme 2 as a therapeutic target for the prevention of pulmonary hypertension. Am J Respir Crit Care Med, 2009, 179: 1048\u20131054","journal-title":"Am J Respir Crit Care Med"},{"key":"4693_CR25","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1161\/01.HYP.33.1.207","volume":"33","author":"WB Strawn","year":"1999","unstructured":"Strawn WB, Ferrario CM, Tallant EA. Angiotensin-(1\u20137) reduces smooth muscle growth after vascular injury. Hypertension, 1999, 33:207\u2013211","journal-title":"Hypertension"},{"key":"4693_CR26","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1161\/01.ATV.0000153090.21990.8c","volume":"25","author":"EJ Landon","year":"2005","unstructured":"Landon EJ, Inagami T. Beyond the G protein: the saga of the type 2 angiotensin II receptor. Arterioscler Thromb Vasc Biol, 2005, 25: 15\u201316","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"4693_CR27","doi-asserted-by":"crossref","first-page":"L631","DOI":"10.1152\/ajplung.90415.2008","volume":"297","author":"R Zhang","year":"2009","unstructured":"Zhang R, Wu Y, Zhao M, Liu C, Zhou L, Shen S, Liao S, Yang K, Li Q, Wan H. Role of HIF-1alpha in the regulation ACE and ACE2 expression in hypoxic human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol, 2009, 297: L631\u2013640","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"4693_CR28","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1089\/ars.2005.7.1302","volume":"7","author":"RM Touyz","year":"2005","unstructured":"Touyz RM. Reactive oxygen species as mediators of calcium signaling by angiotensin II: implications in vascular physiology and pathophysiology. Antioxid Redox Signal, 2005, 7: 1302\u20131314","journal-title":"Antioxid Redox Signal"},{"key":"4693_CR29","doi-asserted-by":"crossref","first-page":"C812","DOI":"10.1152\/ajpcell.00347.2005","volume":"290","author":"K Nishimura","year":"2006","unstructured":"Nishimura K, Li W, Hoshino Y, Kadohama T, Asada H, Ohgi S, Sumpio BE. Role of AKT in cyclic strain-induced endothelial cell proliferation and survival. Am J Physiol Cell Physiol, 2006, 290: C812\u2013821","journal-title":"Am J Physiol Cell Physiol"},{"key":"4693_CR30","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1038\/hr.2010.147","volume":"33","author":"N Hayashi","year":"2010","unstructured":"Hayashi N, Yamamoto K, Ohishi M, Tatara Y, Takeya Y, Shiota A, Oguro R, Iwamoto Y, Takeda M, Rakugi H. The counterregulating role of ACE2 and ACE2-mediated angiotensin 1\u20137 signaling against angiotensin II stimulation in vascular cells. Hypertens Res, 2010, 33: 1182\u20131185","journal-title":"Hypertens Res"},{"key":"4693_CR31","doi-asserted-by":"crossref","first-page":"15886","DOI":"10.1073\/pnas.1001253107","volume":"107","author":"C Zhang","year":"2010","unstructured":"Zhang C, Zhao YX, Zhang YH, Zhu L, Deng BP, Zhou ZL, Li SY, Lu XT, Song LL, Lei XM, Tang WB, Wang N, Pan CM, Song HD, Liu CX, Dong B, Zhang Y, Cao Y. Angiotensin-converting enzyme 2 attenuates atherosclerotic lesions by targeting vascular cells. Proc Natl Acad Sci USA, 2010, 107: 15886\u201315891","journal-title":"Proc Natl Acad Sci USA"},{"key":"4693_CR32","doi-asserted-by":"crossref","first-page":"e13608","DOI":"10.1371\/journal.pone.0013608","volume":"5","author":"E Caglayan","year":"2010","unstructured":"Caglayan E, Romeo GR, Kappert K, Odenthal M, S\u00fcdkamp M, Body SC, Shernan SK, Hackbusch D, Vantler M, Kazlauskas A, Rosenkranz S. Profilin-1 is expressed in human atherosclerotic plaques and induces atherogenic effects on vascular smooth muscle cells. PLoS ONE, 2010, 5: e13608","journal-title":"PLoS ONE"},{"key":"4693_CR33","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.vph.2011.04.003","volume":"55","author":"JF Cheng","year":"2011","unstructured":"Cheng JF, Ni GH, Chen MF, Li YJ, Wang YJ, Wang CL, Yuan Q, Shi RZ, Hu CP, Yang TL. Involvement of profilin-1 in angiotensin II-induced vascular smooth muscle cell proliferation. Vascul Pharmacol, 2011, 55: 34\u201341","journal-title":"Vascul Pharmacol"},{"key":"4693_CR34","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1097\/FJC.0b013e318271225d","volume":"60","author":"MT Elnakish","year":"2012","unstructured":"Elnakish MT, Hassanain HH, Janssen PM. Vascular remodeling-associated hypertension leads to left ventricular hypertrophy and contractile dysfunction in profilin-1 transgenic mice. J Cardiovasc Pharmacol, 2012, 60: 544\u2013552","journal-title":"J Cardiovasc Pharmacol"},{"key":"4693_CR35","doi-asserted-by":"crossref","first-page":"37632","DOI":"10.1074\/jbc.M703227200","volume":"282","author":"M Moustafa-Bayoumi","year":"2007","unstructured":"Moustafa-Bayoumi M, Alhaj MA, El-Sayed O, Wisel S, Chotani MA, Abouelnaga ZA, Hassona MD, Rigatto K, Morris M, Nuovo G, Zweier JL, Goldschmidt-Clermont P, Hassanain H. Vascular hypertrophy and hypertension caused by transgenic overexpression of profilin 1. J Biol Chem, 2007, 282: 37632\u201337639","journal-title":"J Biol Chem"},{"key":"4693_CR36","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1161\/01.ATV.20.12.2539","volume":"20","author":"S Kim","year":"2000","unstructured":"Kim S, Zhan Y, Izumi Y, Yasumoto H, Yano M, Iwao H. In vivo activation of rat aortic platelet-derived growth factor and epidermal growth factor receptors by angiotensin II and hypertension. Arterioscler Thromb Vasc Biol, 2000, 20: 2539\u20132545","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"4693_CR37","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1161\/01.HYP.21.6.900","volume":"21","author":"N Jaiswal","year":"1993","unstructured":"Jaiswal N, Jaiswal RK, Tallant EA, Diz DI, Ferrario CM. Alterations in prostaglandin production in spontaneously hypertensive rat smooth muscle cells. Hypertension, 1993, 21: 900\u2013905","journal-title":"Hypertension"},{"key":"4693_CR38","doi-asserted-by":"crossref","first-page":"H1013","DOI":"10.1152\/ajpheart.00068.2005","volume":"289","author":"M Igase","year":"2005","unstructured":"Igase M, Strawn WB, Gallagher PE, Geary RL, Ferrario CM. Angiotensin II AT1 receptors regulate ACE2 and angiotensin-(1\u20137) expression in the aorta of spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol, 2005, 289: H1013\u20131019","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"4693_CR39","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1161\/HYPERTENSIONAHA.113.02426","volume":"63","author":"K Ohshima","year":"2014","unstructured":"Ohshima K, Mogi M, Nakaoka H, Iwanami J, Min LJ, Kanno H, Tsukuda K, Chisaka T, Bai HY, Wang XL, Ogimoto A, Higaki J, Horiuchi M. Possible role of angiotensin-converting enzyme 2 and activation of angiotensin II type 2 receptor by angiotensin-(1\u20137) in improvement of vascular remodeling by angiotensin II type 1 receptor blockade. Hypertension, 2014, 63: e53\u201359","journal-title":"Hypertension"},{"key":"4693_CR40","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1161\/01.ATV.20.10.2175","volume":"20","author":"KK Griendling","year":"2000","unstructured":"Griendling KK, Sorescu D, Lass\u00e8gue B, Ushio-Fukai M. Modulation of protein kinase activity and gene expression by reactive oxygen species and their role in vascular physiology and pathophysiology. Arterioscler Thromb Vasc Biol, 2000, 20: 2175\u20132183","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"4693_CR41","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1042\/CS20060342","volume":"112","author":"S Higuchi","year":"2007","unstructured":"Higuchi S, Ohtsu H, Suzuki H, Shirai H, Frank GD, Eguchi S. Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology. Clin Sci (Lond), 2007, 112: 417\u2013428","journal-title":"Clin Sci (Lond)"},{"key":"4693_CR42","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s11906-011-0187-x","volume":"13","author":"A Nguyen Dinh Cat","year":"2011","unstructured":"Nguyen Dinh Cat A, Touyz RM. Cell signaling of angiotensin II on vascular tone: novel mechanisms. Curr Hypertens Rep, 2011, 13: 122\u2013128","journal-title":"Curr Hypertens Rep"},{"key":"4693_CR43","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1161\/HYPERTENSIONAHA.111.00627","volume":"61","author":"RA Fraga-Silva","year":"2013","unstructured":"Fraga-Silva RA, Costa-Fraga FP, Mur\u00e7a TM, Moraes PL, Martins Lima A, Lautner RQ, Castro CH, Soares CM, Borges CL, Nadu AP, Oliveira ML, Shenoy V, Katovich MJ, Santos RA, Raizada MK, Ferreira AJ. Angiotensin-converting enzyme 2 activation improves endothelial function. Hypertension, 2013, 61: 1233\u20131238","journal-title":"Hypertension"},{"key":"4693_CR44","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1161\/CIRCRESAHA.107.151399","volume":"101","author":"GR Romeo","year":"2007","unstructured":"Romeo GR, Moulton KS, Kazlauskas A. Attenuated expression of profilin-1 confers protection from atherosclerosis in the LDL receptor null mouse. Circ Res, 2007, 101: 357\u2013367","journal-title":"Circ Res"},{"key":"4693_CR45","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1113\/expphysiol.2012.067165","volume":"98","author":"J Lo","year":"2013","unstructured":"Lo J, Patel VB, Wang Z, Levasseur J, Kaufman S, Penninger JM, Oudit GY. Angiotensin-converting enzyme 2 antagonizes angiotensin II-induced pressor response and NADPH oxidase activation in Wistar-Kyoto rats and spontaneously hypertensive rats. Exp Physiol, 2013, 98: 109\u2013122","journal-title":"Exp Physiol"},{"key":"4693_CR46","doi-asserted-by":"crossref","first-page":"H1560","DOI":"10.1152\/ajpheart.00941.2004","volume":"289","author":"EA Tallant","year":"2005","unstructured":"Tallant EA, Ferrario CM, Gallagher PE. Angiotensin-(1\u20137) inhibits growth of cardiac myocytes through activation of the mas receptor. Am J Physiol Heart Circ Physiol, 2005, 289: H1560\u20131566","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"4693_CR47","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1161\/01.HYP.0000251865.35728.2f","volume":"49","author":"WO Sampaio","year":"2007","unstructured":"Sampaio WO, Souza dos Santos RA, Faria-Silva R, da Mata Machado LT, Schiffrin EL, Touyz RM. Angiotensin-(1\u20137) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways. Hypertension, 2007, 49: 185\u2013192","journal-title":"Hypertension"},{"key":"4693_CR48","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1161\/01.ATV.20.3.645","volume":"20","author":"ME Pueyo","year":"2000","unstructured":"Pueyo ME, Gonzalez W, Nicoletti A, Savoie F, Arnal JF, Michel JB. Angiotensin II stimulates endothelial vascular cell adhesion molecule-1 via nuclear factor-kappaB activation induced by intracellular oxidative stress. Arterioscler Thromb Vasc Biol, 2000, 20: 645\u2013651","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"4693_CR49","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1161\/hy1201.100589","volume":"38","author":"M Ruiz-Ortega","year":"2001","unstructured":"Ruiz-Ortega M, Lorenzo O, Rup\u00e9rez M, Esteban V, Suzuki Y, Mezzano S, Plaza JJ, Egido J. Role of the renin-angiotensin system in vascular diseases: expanding the field. Hypertension, 2001, 38: 1382\u20131387","journal-title":"Hypertension"},{"key":"4693_CR50","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/cvr\/cvt245","volume":"101","author":"M Sahara","year":"2014","unstructured":"Sahara M, Ikutomi M, Morita T, Minami Y, Nakajima T, Hirata Y, Nagai R, Sata M. Deletion of angiotensin-converting enzyme 2 promotes the development of atherosclerosis and arterial neointima formation. Cardiovasc Res, 2014, 101: 236\u2013246","journal-title":"Cardiovasc Res"},{"key":"4693_CR51","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1111\/j.1476-5381.2012.02105.x","volume":"167","author":"T Jiang","year":"2012","unstructured":"Jiang T, Gao L, Guo J, Lu J, Wang Y, Zhang Y. Suppressing inflammation by inhibiting the NF-\u03baB pathway contributes to the neuroprotective effect of angiotensin-(1\u20137) in rats with permanent cerebral ischaemia. Br J Pharmacol, 2012, 167: 1520\u20131532","journal-title":"Br J Pharmacol"},{"key":"4693_CR52","doi-asserted-by":"crossref","first-page":"5569","DOI":"10.4049\/jimmunol.1000314","volume":"185","author":"KD Silveira da","year":"2010","unstructured":"da Silveira KD, Coelho FM, Vieira AT, Sachs D, Barroso LC, Costa VV, Bretas TL, Bader M, de Sousa LP, da Silva TA, dos Santos RA, Sim\u00f5es e Silva AC, Teixeira MM. Anti-inflammatory effects of the activation of the angiotensin-(1\u20137) receptor, MAS, in experimental models of arthritis. J Immunol, 2010, 185: 5569\u20135576","journal-title":"J Immunol"},{"key":"4693_CR53","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/bph.12159","volume":"169","author":"AC Sim\u00f5es e Silva","year":"2013","unstructured":"Sim\u00f5es e Silva AC, Silveira KD, Ferreira AJ, Teixeira MM. ACE2, angiotensin-(1\u20137) and Mas receptor axis in inflammation and fibrosis. Br J Pharmacol, 2013, 169: 477\u2013492","journal-title":"Br J Pharmacol"},{"key":"4693_CR54","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1161\/CIRCRESAHA.110.219279","volume":"107","author":"MC Thomas","year":"2010","unstructured":"Thomas MC, Pickering RJ, Tsorotes D, Koitka A, Sheehy K, Bernardi S, Toffoli B, Nguyen-Huu TP, Head GA, Fu Y, Chin-Dusting J, Cooper ME, Tikellis C. Genetic Ace2 deficiency accentuates vascular inflammation and atherosclerosis in the ApoE knockout mouse. Circ Res, 2010, 107: 888\u2013897","journal-title":"Circ Res"},{"key":"4693_CR55","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1159\/000320358","volume":"48","author":"BC Tieu","year":"2011","unstructured":"Tieu BC, Ju X, Lee C, Sun H, Lejeune W, Recinos A 3rd, Brasier AR, Tilton RG. Aortic adventitial fibroblasts participate in angiotensin-induced vascular wall inflammation and remodeling. J Vasc Res, 2011, 48: 261\u2013272","journal-title":"J Vasc Res"},{"key":"4693_CR56","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.arcmed.2007.07.010","volume":"39","author":"YJ Guo","year":"2008","unstructured":"Guo YJ, Li WH, Wu R, Xie Q, Cui LQ. ACE2 overexpression inhibits angiotensin II-induced monocyte chemoattractant protein-1 expression in macrophages. Arch Med Res, 2008, 39: 149\u2013154","journal-title":"Arch Med Res"},{"key":"4693_CR57","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.yjmcc.2010.01.006","volume":"48","author":"M Wang","year":"2010","unstructured":"Wang M, Zhang J, Walker SJ, Dworakowski R, Lakatta EG, Shah AM. Involvement of NADPH oxidase in age-associated cardiac remodeling. J Mol Cell Cardiol, 2010, 48: 765\u2013772","journal-title":"J Mol Cell Cardiol"},{"key":"4693_CR58","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1253\/circj.CJ-12-1544","volume":"77","author":"K Kuba","year":"2013","unstructured":"Kuba K, Imai Y, Penninger JM. Multiple functions of angiotensin-converting enzyme 2 and its relevance in cardiovascular diseases. Circ J, 2013, 77: 301\u2013308","journal-title":"Circ J"},{"key":"4693_CR59","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1161\/HYPERTENSIONAHA.110.159889","volume":"57","author":"T Ebrahimian","year":"2011","unstructured":"Ebrahimian T, Li MW, Lemari\u00e9 CA, Simeone SM, Pagano PJ, Gaestel M, Paradis P, Wassmann S, Schiffrin EL. Mitogen-activated protein kinase-activated protein kinase 2 in angiotensin II-induced inflammation and hypertension: regulation of oxidative stress. Hypertension, 2011, 57: 245\u2013254","journal-title":"Hypertension"},{"key":"4693_CR60","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1161\/CIRCRESAHA.110.217737","volume":"106","author":"A Leask","year":"2010","unstructured":"Leask A. Potential therapeutic targets for cardiac fibrosis: TGF-beta, angiotensin, endothelin, CCN2, and PDGF, partners in fibroblast activation. Circ Res, 2010, 106: 1675\u20131680","journal-title":"Circ Res"},{"key":"4693_CR61","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/jcb.240550113","volume":"55","author":"TR Polte","year":"1994","unstructured":"Polte TR, Naftilan AJ, Hanks SK. Focal adhesion kinase is abundant in developing blood vessels and elevation of its phosphotyrosine content in vascular smooth muscle cells is a rapid response to angiotensin II. J Cell Biochem, 1994, 55: 106\u2013119","journal-title":"J Cell Biochem"},{"key":"4693_CR62","doi-asserted-by":"crossref","first-page":"H1075","DOI":"10.1152\/ajpheart.00913.2007","volume":"294","author":"P Rose","year":"2008","unstructured":"Rose P, Bond J, Tighe S, Toth MJ, Wellman TL, Briso de Montiano EM, Lewinter MM, Lounsbury KM. Genes overexpressed in cerebral arteries following salt-induced hypertensive diseases are regulated by angiotensin II, JunB, and CREB. Am J Physiol Heart Circ Physiol, 2008, 294: H1075\u20131085","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"4693_CR63","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1161\/01.HYP.0000215289.51180.5c","volume":"47","author":"RA Santos","year":"2006","unstructured":"Santos RA, Castro CH, Gava E, Pinheiro SV, Almeida AP, Paula RD, Cruz JS, Ramos AS, Rosa KT, Irigoyen MC, Bader M, Alenina N, Kitten GT, Ferreira AJ. Impairment of in vitro and in vivo heart function in angiotensin-(1\u20137) receptor MAS knockout mice. Hypertension, 2006, 47: 996\u20131002","journal-title":"Hypertension"},{"key":"4693_CR64","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1161\/ATVBAHA.110.204453","volume":"30","author":"S Tesanovic","year":"2010","unstructured":"Tesanovic S, Vinh A, Gaspari TA, Casley D, Widdop RE. Vasoprotective and atheroprotective effects of angiotensin (1\u20137) in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol, 2010, 30: 1606\u20131613","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"4693_CR65","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1161\/01.HYP.0000174594.17052.33","volume":"46","author":"R Faria-Silva","year":"2005","unstructured":"Faria-Silva R, Duarte FV, Santos RA. Short-term angiotensin(1\u20137) receptor MAS stimulation improves endothelial function in normotensive rats. Hypertension, 2005, 46: 948\u2013952","journal-title":"Hypertension"},{"key":"4693_CR66","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1161\/HYPERTENSIONAHA.114.03388","volume":"64","author":"VB Patel","year":"2014","unstructured":"Patel VB, Zhong JC, Fan D, Basu R, Morton JS, Parajuli N, McMurtry MS, Davidge ST, Kassiri Z, Oudit GY. Aangiotensin-converting enzyme 2 is a critical determinant of angiotensin II-induced loss of vascular smooth muscle cells and adverse vascular remodeling. Hypertension, 2014, 64: 157\u2013164","journal-title":"Hypertension"}],"container-title":["Science China Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-014-4693-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11427-014-4693-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-014-4693-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T18:05:31Z","timestamp":1498154731000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11427-014-4693-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":66,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["4693"],"URL":"https:\/\/doi.org\/10.1007\/s11427-014-4693-3","relation":{},"ISSN":["1674-7305","1869-1889"],"issn-type":[{"value":"1674-7305","type":"print"},{"value":"1869-1889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8]]}}}