{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:19:41Z","timestamp":1773307181191,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"11","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci. China Life Sci."],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1007\/s11427-015-4904-6","type":"journal-article","created":{"date-parts":[[2015,8,5]],"date-time":"2015-08-05T15:56:34Z","timestamp":1438790194000},"page":"1126-1134","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Hydrogen sulfide suppresses transforming growth factor-\u03b21-induced differentiation of human cardiac fibroblasts into myofibroblasts"],"prefix":"10.1007","volume":"58","author":[{"given":"YouEn","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JiaNing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LiangJun","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JunBo","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,8,5]]},"reference":[{"key":"4904_CR1","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1161\/CIRCRESAHA.109.209809","volume":"105","author":"CA Souders","year":"2009","unstructured":"Souders CA, Bowers SL, Baudino TA. Cardiac fibroblast: the renaissance cell. Circ Res, 2009, 105: 1164\u20131176","journal-title":"Circ Res"},{"key":"4904_CR2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/nrcardio.2012.158","volume":"10","author":"KT Weber","year":"2013","unstructured":"Weber KT, Sun Y, Bhattacharya SK, Ahokas RA, Gerling IC. Myofibroblast- mediated mechanisms of pathological remodelling of the heart. Nat Rev Cardiol, 2013, 10: 15\u201326","journal-title":"Nat Rev Cardiol"},{"key":"4904_CR3","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s11427-014-4730-2","volume":"57","author":"X Liu","year":"2014","unstructured":"Liu X, Huang Q, Li F, Li CY. Enhancing the efficiency of direct reprogramming of human primary fibroblasts into dopaminergic neuron- like cells through p53 suppression. Sci China Life Sci, 2014, 57: 867\u2013875","journal-title":"Sci China Life Sci"},{"key":"4904_CR4","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1089\/ars.2009.2938","volume":"12","author":"R Wang","year":"2010","unstructured":"Wang R. Hydrogen sulfide: the third gasotransmitter in biology and medicine. Antioxid Redox Signal, 2010, 12: 1061\u20131064","journal-title":"Antioxid Redox Signal"},{"key":"4904_CR5","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1111\/j.1476-5381.2012.02187.x","volume":"168","author":"BJ White","year":"2013","unstructured":"White BJ, Smith PA, Dunn WR. Hydrogen sulphide-mediated vasodilatation involves the release of neurotransmitters from sensory nerves in pressurized mesenteric small arteries isolated from rats. Br J Pharmacol, 2013, 168: 785\u2013793","journal-title":"Br J Pharmacol"},{"key":"4904_CR6","doi-asserted-by":"crossref","first-page":"H474","DOI":"10.1152\/ajpheart.00013.2002","volume":"283","author":"W Zhao","year":"2002","unstructured":"Zhao W, Wang R. H2S-induced vasorelaxation and underlying cellular and molecular mechanisms. Am J Physiol Heart Circ Physiol, 2002, 283: H474\u2013H480","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"4904_CR7","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.atherosclerosis.2010.12.037","volume":"215","author":"W Li","year":"2011","unstructured":"Li W, Tang C, Jin H, Du J. Regulatory effects of sulfur dioxide on the development of atherosclerotic lesions and vascular hydrogen sulfide in atherosclerotic rats. Atherosclerosis, 2011, 215: 323\u2013330","journal-title":"Atherosclerosis"},{"key":"4904_CR8","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1620\/tjem.226.29","volume":"226","author":"X Xie","year":"2012","unstructured":"Xie X, Sun A, Zhu W, Huang Z, Hu X, Jia J, Zou Y, Ge J. Transplantation of mesenchymal stem cells preconditioned with hydrogen sulfide enhances repair of myocardial infarction in rats. Tohoku J Exp Med, 2012, 226: 29\u201336","journal-title":"Tohoku J Exp Med"},{"key":"4904_CR9","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1161\/01.RES.0000187457.24338.3D","volume":"97","author":"I Cucoranu","year":"2005","unstructured":"Cucoranu I, Clempus R, Dikalova A, Phelan PJ, Ariyan S, Dikalov S, Sorescu D. NAD(P)H oxidase 4 mediates transforming growth factor- beta1-induced differentiation of cardiac fibroblasts into myofibroblasts. Circ Res, 2005, 97: 900\u2013907","journal-title":"Circ Res"},{"key":"4904_CR10","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1161\/CIRCRESAHA.111.300502","volume":"112","author":"Y Ma","year":"2013","unstructured":"Ma Y, Halade GV, Zhang J, Ramirez TA, Levin D, Voorhees A, Jin YF, Han HC, Manicone AM, Lindsey ML. Matrix metalloproteinase-28 deletion exacerbates cardiac dysfunction and rupture after myocardial infarction in mice by inhibiting M2 macrophage activation. Circ Res, 2013, 112: 675\u2013688","journal-title":"Circ Res"},{"key":"4904_CR11","doi-asserted-by":"crossref","first-page":"9375","DOI":"10.1074\/jbc.M413081200","volume":"280","author":"Z Gao","year":"2005","unstructured":"Gao Z, Sasaoka T, Fujimori T, Oya T, Ishii Y, Sabit H, Kawaguchi M, Kurotaki Y, Naito M, Wada T, Ishizawa S, Kobayashi M, Nabeshima Y, Sasahara M. Deletion of the PDGFR-\u03b2 gene affects key fibroblast functions important for wound healing. J Biol Chem, 2005, 280: 9375\u20139389","journal-title":"J Biol Chem"},{"key":"4904_CR12","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.resuscitation.2011.01.034","volume":"82","author":"YE Zhang","year":"2011","unstructured":"Zhang YE, Fu SZ, Li XQ, Chen P, Wang JL, Che J, Tang JM, Chen SY, Wang JN. PEP-1-SOD1 protects brain from ischemic insult following asphyxial cardiac arrest in rats. Resuscitation, 2011, 82: 1081\u20131086","journal-title":"Resuscitation"},{"key":"4904_CR13","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.ijcard.2012.10.022","volume":"168","author":"G Zhao","year":"2013","unstructured":"Zhao G, Wang S, Wang Z, Sun A, Yang X, Qiu Z, Wu C, Zhang W, Li H, Zhang Y, Zhao J, Zou Y, Ge J. CXCR6 deficiency ameliorated myocardial ischemia\/reperfusion injury by inhibiting infiltration of monocytes and IFN-\u03b3-dependent autophagy. Int J Cardiol, 2013, 168: 853\u2013862","journal-title":"Int J Cardiol"},{"key":"4904_CR14","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1161\/CIRCRESAHA.109.201400","volume":"105","author":"P Snider","year":"2009","unstructured":"Snider P, Standley KN, Wang J, Azhar M, Doetschman T, Conway SJ. Origin of cardiac fibroblasts and the role of periostin. Circ Res, 2009, 105: 934\u2013947","journal-title":"Circ Res"},{"key":"4904_CR15","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1093\/europace\/eus052","volume":"14","author":"M Kiryu","year":"2012","unstructured":"Kiryu M, Niwano S, Niwano H, Kishihara J, Aoyama Y, Fukaya H, Masaki Y, Izumi T. Angiotensin II-mediated up-regulation of connective tissue growth factor promotes atrial tissue fibrosis in the canine atrial fibrillation model. Europace, 2012, 14: 1206\u20131214","journal-title":"Europace"},{"key":"4904_CR16","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1161\/01.CIR.83.6.1849","volume":"83","author":"KT Weber","year":"1991","unstructured":"Weber KT, Brilla CG. Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system. Circulation, 1991, 83: 1849\u20131865","journal-title":"Circulation"},{"key":"4904_CR17","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1242\/jcs.142075","volume":"127","author":"MA Scharenberg","year":"2014","unstructured":"Scharenberg MA, Pippenger BE, Sack R, Zingg D, Ferralli J, Schenk S, Martin I, Chiquet-Ehrismann R. TGF-\u03b2-induced differentiation into myofibroblasts involves specific regulation of two MKL1 isoforms. J Cell Sci, 2014, 127: 1079\u20131091","journal-title":"J Cell Sci"},{"key":"4904_CR18","volume-title":"J Mol Cell Cardiol","author":"AV Shinde","year":"2013","unstructured":"Shinde AV, Frangogiannis NG. Fibroblasts in myocardial infarction: a role in inflammation and repair. J Mol Cell Cardiol, 2013"},{"key":"4904_CR19","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1126\/science.282.5393.1497","volume":"282","author":"F Bunz","year":"1998","unstructured":"Bunz F, Dutriaux A, Lengauer C, Waldman T, Zhou S, Brown JP, Sedivy JM, Kinzler KW, Vogelstein B. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science, 1998, 282: 1497\u20131501","journal-title":"Science"},{"key":"4904_CR20","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1126\/science.7997877","volume":"266","author":"LH Hartwell","year":"1994","unstructured":"Hartwell LH, Kastan MB. Cell cycle control and cancer. Science, 1994, 266: 1821\u20131828","journal-title":"Science"},{"key":"4904_CR21","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1096\/fj.02-0883fje","volume":"17","author":"B Deplancke","year":"2003","unstructured":"Deplancke B, Gaskins HR. Hydrogen sulfide induces serumindependent cell cycle entry in nontransformed rat intestinal epithelial cells. FASEB J, 2003, 17: 1310\u20131312","journal-title":"FASEB J"},{"key":"4904_CR22","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1096\/fj.04-2279fje","volume":"18","author":"G Yang","year":"2004","unstructured":"Yang G, Sun X, Wang R. Hydrogen sulfide-induced apoptosis of human aorta smooth muscle cells via the activation of mitogenactivated protein kinases and caspase-3. FASEB J, 2004, 18: 1782\u20131784","journal-title":"FASEB J"},{"key":"4904_CR23","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1096\/fj.06-6255com","volume":"21","author":"R Baskar","year":"2007","unstructured":"Baskar R, Li L, Moore PK. Hydrogen sulfide-induces DNA damage and changes in apoptotic gene expression in human lung fibroblast cells. FASEB J, 2007, 21: 247\u2013255","journal-title":"FASEB J"},{"key":"4904_CR24","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.cardiores.2004.04.030","volume":"63","author":"S Rosenkranz","year":"2004","unstructured":"Rosenkranz S. TGF-beta1 and angiotensin networking in cardiac remodeling. Cardiovasc Res, 2004, 63: 423\u2013432","journal-title":"Cardiovasc Res"},{"key":"4904_CR25","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s11427-010-0087-3","volume":"53","author":"Y Lan","year":"2010","unstructured":"Lan Y, Yang X. The role of smad signaling in vascular and hematopoietic development revealed by studies using genetic mouse models. Sci China Life Sci, 2010, 53: 485\u2013489","journal-title":"Sci China Life Sci"},{"key":"4904_CR26","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1161\/01.CIR.0000020689.12472.E0","volume":"106","author":"F Kuwahara","year":"2002","unstructured":"Kuwahara F, Kai H, Tokuda K, Kai M, Takeshita A, Egashira K, Imaizumi T. Transforming growth factor-beta function blocking prevents myocardial fibrosis and diastolic dysfunction in pressureoverloaded rats. Circulation, 2002, 106: 130\u2013135","journal-title":"Circulation"},{"key":"4904_CR27","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.pupt.2009.07.003","volume":"22","author":"LP Fang","year":"2009","unstructured":"Fang LP, Lin Q, Tang CS, Liu XM. Hydrogen sulfide suppresses migration, proliferation and myofibroblast transdifferentiation of human lung fibroblasts. Pulm Pharmacol Ther, 2009, 22: 554\u2013561","journal-title":"Pulm Pharmacol Ther"},{"key":"4904_CR28","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00380-003-0743-7","volume":"19","author":"J Du","year":"2004","unstructured":"Du J, Hui Y, Cheung Y, Bin G, Jiang H, Chen X, Tang C. The possible role of hydrogen sulfide as a smooth muscle cell proliferation inhibitor in rat cultured cells. Heart Vessels, 2004, 19: 75\u201380","journal-title":"Heart Vessels"},{"key":"4904_CR29","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1111\/jcmm.12114","volume":"17","author":"J Sheng","year":"2013","unstructured":"Sheng J, Shim W, Wei H, Lim SY, Liew R, Lim TS, Ong BH, Chua YL, Wong P. Hydrogen sulphide suppresses human atrial fibroblast proliferation and transformation to myofibroblasts. J Cell Mol Med, 2013, 17: 1345\u20131354","journal-title":"J Cell Mol Med"},{"key":"4904_CR30","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1111\/j.1582-4934.2012.01538.x","volume":"16","author":"S Wang","year":"2012","unstructured":"Wang S, Sun A, Li L, Zhao G, Jia J, Wang K, Ge J, Zou Y. Up-regulation of BMP-2 antagonizes TGF-beta1\/ROCK-enhanced cardiac fibrotic signalling through activation of Smurf1\/Smad6 complex. J Cell Mol Med, 2012, 16: 2301\u20132310","journal-title":"J Cell Mol Med"}],"container-title":["Science China Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-015-4904-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T02:48:14Z","timestamp":1567046894000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11427-015-4904-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,5]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["4904"],"URL":"https:\/\/doi.org\/10.1007\/s11427-015-4904-6","relation":{},"ISSN":["1674-7305","1869-1889"],"issn-type":[{"value":"1674-7305","type":"print"},{"value":"1869-1889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,5]]}}}