{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T02:28:07Z","timestamp":1771036087341,"version":"3.50.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"10","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci. China Life Sci."],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1007\/s11427-016-0037-y","type":"journal-article","created":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T06:26:53Z","timestamp":1466663213000},"page":"1042-1047","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Eplerenone inhibits atrial fibrosis in mutant TGF-\u03b21 transgenic mice"],"prefix":"10.1007","volume":"59","author":[{"given":"Xiaoqing","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wuchang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengzhong","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,6,22]]},"reference":[{"key":"37_CR1","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.ahj.2015.09.018","volume":"6","author":"J. Aulin","year":"2015","unstructured":"Aulin, J., Siegbahn, A., Hijazi, Z., Ezekowitz, M.D., Andersson, U., Connolly, S.J., Huber, K., Reilly, P.A., Wallentin, L., and Oldgren, J. (2015). Interleukin-6 and C-reactive protein and risk for death and cardiovascular events in patients with atrial fibrillation. Am Heart J 6, 1151\u20131160.","journal-title":"Am Heart J"},{"key":"37_CR2","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.jacc.2007.09.064","volume":"8","author":"B. Burstein","year":"2008","unstructured":"Burstein, B., and Nattel, S. (2008). Atrial fibrosis: mechanisms and clinical relevance in atrial fibrillation. J Am Coll Cardiol 8, 802\u2013809.","journal-title":"J Am Coll Cardiol"},{"key":"37_CR3","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.yexcr.2014.08.021","volume":"1","author":"X. Chen","year":"2015","unstructured":"Chen, X., Liu, X., Wang, Q., Zhang, M., Guo, M., Liu, F., Jiang, W., and Zhou, L. (2015a). Pioglitazone inhibits angiotensin II-induced atrial fibroblasts proliferation via NF-kappaB\/TGF-beta1\/TRIF\/TRAF6 pathway. Exp Cell Res 1, 43\u201355.","journal-title":"Exp Cell Res"},{"key":"37_CR4","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.bbrc.2015.05.131","volume":"1","author":"X. Chen","year":"2015","unstructured":"Chen, X., Zhang, D., Zhang, M., Guo, M., Zhan, Y., Liu, F., Jiang, W., Zhou, L., Zhao, L., Wang, Q., and Liu, X. (2015b). TRIF promotes angiotensin II-induced cross-talk between fibroblasts and macrophages in atrial fibrosis. Biochem Biophys Res Commun 1, 100\u2013105.","journal-title":"Biochem Biophys Res Commun"},{"key":"37_CR5","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/j.amjcard.2010.07.037","volume":"11","author":"R. Dabrowski","year":"2010","unstructured":"Dabrowski, R., Borowiec, A., Smolis-Bak, E., Kowalik, I., Sosnowski, C., Kraska, A., Kazimierska, B., Wozniak, J., Zareba, W., and Szwed, H. (2010). Effect of combined spironolactone-beta-blocker +\/- enalapril treatment on occurrence of symptomatic atrial fibrillation episodes in patients with a history of paroxysmal atrial fibrillation (SPIR-AF study). Am J Cardiol 11, 1609\u20131614.","journal-title":"Am J Cardiol"},{"key":"37_CR6","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s11427-014-4691-5","volume":"57","author":"S. Duan","year":"2014","unstructured":"Duan, S. (2014). Mineralocorticoid receptor: a critical player in vascular remodeling. Sci China Life Sci 57, 809\u2013817.","journal-title":"Sci China Life Sci"},{"key":"37_CR7","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/eurheartj\/ehi668","volume":"5","author":"J.R. Ehrlich","year":"2006","unstructured":"Ehrlich, J.R., Hohnloser, S.H., and Nattel, S. (2006). Role of angiotensin system and effects of its inhibition in atrial fibrillation: clinical and experimental evidence. Eur Heart J 5, 512\u2013518.","journal-title":"Eur Heart J"},{"key":"37_CR8","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1161\/01.RES.86.5.571","volume":"86","author":"H. Nakajima","year":"2000","unstructured":"Nakajima, H., Nakajima, H.O., Salcher, O., Ditti\u00e8, A.S., Dembowsky, K., Jing, S., and Field, L.J. (2000). Atrial but notventricular fibrosis in mice expressing a mutant transforming growthfactor-beta(1) transgene in the heart. Circ Res 86, 571\u2013579.","journal-title":"Circ Res"},{"key":"37_CR9","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1111\/j.1476-5381.2009.00551.x","volume":"159","author":"J. Zhao","year":"2010","unstructured":"Zhao, J., Li, J., Li, W., Li, Y., Shan, H., Gong, Y., and Yang, B. (2010). Effects of spironolactone on atrial structuralremodelling in a canine model of atrial fibrillation produced byprolonged atrial pacing. Br J Pharmacol 159, 1584\u20131594.","journal-title":"Br J Pharmacol"},{"key":"37_CR10","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1161\/HYPERTENSIONAHA.115.06015","volume":"6","author":"G. Jia","year":"2015","unstructured":"Jia, G., Habibi, J., DeMarco, V.G., Martinez-Lemus, L.A., Ma, L., Whaley-Connell, A.T., Aroor, A.R., Domeier, T.L., Zhu, Y., Meininger, G.A., Barrett Mueller, K., Jaffe, I.Z., and Sowers, J.R. (2015). Endothelial mineralocorticoid receptor deletion prevents diet-Induced cardiac diastolic dysfunction in females. Hypertension 6, 1159\u20131167.","journal-title":"Hypertension"},{"key":"37_CR11","doi-asserted-by":"crossref","first-page":"349","DOI":"10.4049\/jimmunol.1301906","volume":"1","author":"P. Kothari","year":"2014","unstructured":"Kothari, P., Pestana, R., Mesraoua, R., Elchaki, R., Khan, K.M., Dannenberg, A.J., and Falcone, D.J. (2014). IL-6-mediated induction of matrix metalloproteinase-9 is modulated by JAK-dependent IL-10 expression in macrophages. J Immunol 1, 349\u2013357.","journal-title":"J Immunol"},{"key":"37_CR12","doi-asserted-by":"crossref","first-page":"6656","DOI":"10.1074\/jbc.M113.519256","volume":"10","author":"D. Lavall","year":"2014","unstructured":"Lavall, D., Selzer, C., Schuster, P., Lenski, M., Adam, O., Schafers, H.J., Bohm, M., and Laufs, U. (2014). The mineralocorticoid receptor promotes fibrotic remodeling in atrial fibrillation. J Biological Chem 10, 6656\u20136668.","journal-title":"J Biological Chem"},{"key":"37_CR13","doi-asserted-by":"crossref","first-page":"e35144","DOI":"10.1371\/journal.pone.0035144","volume":"5","author":"F. Ma","year":"2012","unstructured":"Ma, F., Li, Y., Jia, L., Han, Y., Cheng, J., Li, H., Qi, Y., and Du, J. (2012). Macrophage-stimulated cardiac fibroblast production of IL-6 is essential for TGF beta\/Smad activation and cardiac fibrosis induced by angiotensin II. PLoS One 5, e35144.","journal-title":"PLoS One"},{"key":"37_CR14","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0008-6363(02)00258-4","volume":"54","author":"M. Allessie","year":"2002","unstructured":"Allessie, M., Ausma, J., and Schotten, U. (2002). Electrical, contractile and structural remodeling during atrial fibrillation. Cardiovasc Res 54, 230\u2013246.","journal-title":"Cardiovasc Res"},{"key":"37_CR15","doi-asserted-by":"crossref","first-page":"5135","DOI":"10.1016\/j.ijcard.2013.08.022","volume":"6","author":"F. Mayyas","year":"2013","unstructured":"Mayyas, F., Alzoubi, K.H., and Van Wagoner, D.R. (2013). Impact of aldosterone antagonists on the substrate for atrial fibrillation: aldosterone promotes oxidative stress and atrial structural\/electrical remodeling. Int J Cardiol 6, 5135\u20135142.","journal-title":"Int J Cardiol"},{"key":"37_CR16","first-page":"219","volume-title":"Nature","author":"S. Nattel","year":"2002","unstructured":"Nattel, S. (2002). New ideas about atrial fibrillation 50 years on. Nature, 219\u2013226."},{"key":"37_CR17","first-page":"2193","volume-title":"Eur Heart J","author":"P. Milliez","year":"2005","unstructured":"Milliez, P., Deangelis, N., Rucker-Martin, C., Leenhardt, A., Vicaut, E., Robidel, E., Beaufils, P., Delcayre, C., and Hatem, S.N. (2005). Spironolactone reduces fibrosis of dilated atria during heart failure in rats with myocardial infarction. Eur Heart J, 2193\u20132199."},{"key":"37_CR18","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1111\/j.1538-7836.2012.04812.x","volume":"8","author":"V. Roldan","year":"2012","unstructured":"Roldan, V., Marin, F., Diaz, J., Gallego, P., Jover, E., Romera, M., Manzano-Fernandez, S., Casas, T., Valdes, M., Vicente, V., and Lip, G.Y. (2012). High sensitivity cardiac troponin T and interleukin-6 predict adverse cardiovascular events and mortality in anticoagulated patients with atrial fibrillation. J Thromb Haemost 8, 1500\u20131507.","journal-title":"J Thromb Haemost"},{"key":"37_CR19","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.ejheart.2004.04.013","volume":"5","author":"A.D. Struthers","year":"2004","unstructured":"Struthers, A.D. (2004). The clinical implications of aldosterone escape in congestive heart failure. Eur J Heart Fail 5, 539\u2013545.","journal-title":"Eur J Heart Fail"},{"key":"37_CR20","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1016\/j.jacc.2011.11.063","volume":"18","author":"K. Swedberg","year":"2012","unstructured":"Swedberg, K., Zannad, F., McMurray, J.J., Krum, H., van Veldhuisen, D.J., Shi, H., Vincent, J., Pitt, B., and EMPHASIS-HF Study Investigators. (2012). Eplerenone and atrial fibrillation in mild systolic heart failure: results from the EMPHASIS-HF (Eplerenone in Mild Patients Hospitalization And SurvIval Study in Heart Failure) study. J Am Coll Cardiol 18, 1598\u20131603.","journal-title":"J Am Coll Cardiol"},{"key":"37_CR21","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.1172\/JCI41080","volume":"9","author":"M.G. Usher","year":"2010","unstructured":"Usher, M.G., Duan, S.Z., Ivaschenko, C.Y., Frieler, R.A., Berger, S., Schutz, G., Lumeng, C.N., and Mortensen, R.M. (2010). Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice. J Clin Invest 9, 3350\u20133364.","journal-title":"J Clin Invest"},{"key":"37_CR22","doi-asserted-by":"crossref","first-page":"818","DOI":"10.2353\/ajpath.2007.060547","volume":"3","author":"M.J. Amerongen van","year":"2007","unstructured":"van Amerongen, M.J., Harmsen, M.C., van Rooijen, N., Petersen, A.H., and van Luyn, M.J. (2007). Macrophage depletion impairs wound healing and increases left ventricular remodeling after myocardial injury in mice. Am J Pathol 3, 818\u2013829.","journal-title":"Am J Pathol"},{"key":"37_CR23","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1172\/JCI31487","volume":"3","author":"T.A. Wynn","year":"2007","unstructured":"Wynn, T.A. (2007). Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. J Clin Invest 3, 524\u2013529.","journal-title":"J Clin Invest"},{"key":"37_CR24","first-page":"893","volume":"8","author":"W. Zhang","year":"2015","unstructured":"Zhang, W., Zheng, X., Du, L., Sun, J., Shen, Z., Shi, C., Sun, S., Zhang, Z., Chen, X., Qin, M., Liu, X., Tao, J., Jia, L., Fan, H., Zhou, B., Yu, Y., Ying, H., Hui, L., Liu, X., Yi, X., Liu, X., Zhang, L., and Duan, S. (2015a). High salt primes a specific activation state of macrophages, M(Na). Cell Res 8, 893\u2013910.","journal-title":"Cell Res"},{"key":"37_CR25","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1007\/s11427-015-4904-6","volume":"58","author":"Y. Zhang","year":"2015","unstructured":"Zhang, Y., Wang, J., Li, H., Yuan, L., Wang, L., Wu, B., and Ge, J. (2015b). Hydrogen sulfide suppresses transforming growth factor-\u03b21-induced differentiation of human cardiac fibroblasts into myofibroblasts. Sci China Life Sci 58, 1126\u20131134.","journal-title":"Sci China Life Sci"}],"container-title":["Science China Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-016-0037-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T02:32:20Z","timestamp":1568082740000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11427-016-0037-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,22]]},"references-count":25,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["37"],"URL":"https:\/\/doi.org\/10.1007\/s11427-016-0037-y","relation":{},"ISSN":["1674-7305","1869-1889"],"issn-type":[{"value":"1674-7305","type":"print"},{"value":"1869-1889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,22]]}}}