{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T13:50:09Z","timestamp":1771336209533,"version":"3.50.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"11","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci. China Life Sci."],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1007\/s11427-016-0131-4","type":"journal-article","created":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T13:57:03Z","timestamp":1472565423000},"page":"1115-1122","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Human paraoxonase gene cluster overexpression alleviates angiotensin II-induced cardiac hypertrophy in mice"],"prefix":"10.1007","volume":"59","author":[{"given":"Jian-Fei","family":"Pei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Fei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqiang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shen-Shen","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhu-Qin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hou-Zao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De-Pei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,8,30]]},"reference":[{"key":"131_CR1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.freeradbiomed.2010.09.002","volume":"50","author":"S.P. Deakin","year":"2011","unstructured":"Deakin, S.P., Bioletto, S., Bochaton-Piallat, M.L., and James, R.W. (2011). HDL-associated paraoxonase-1 can redistribute to cell membranes and influence sensitivity to oxidative stress. Free Radic Biol Med 50, 102\u2013109.","journal-title":"Free Radic Biol Med"},{"key":"131_CR2","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1089\/ars.2010.3430","volume":"14","author":"A. Devarajan","year":"2011","unstructured":"Devarajan, A., Bourquard, N., Hama, S., Navab, M., Grijalva, V.R., Morvardi, S., Clarke, C.F., Vergnes, L., Reue, K., Teiber, J.F., and Reddy, S.T. (2011). Paraoxonase 2 deficiency alters mitochondrial function and exacerbates the development of atherosclerosis. Antioxid Redox Signal 14, 341\u2013351.","journal-title":"Antioxid Redox Signal"},{"key":"131_CR3","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1161\/01.CIR.0000120390.68287.BB","volume":"109","author":"N. Frey","year":"2004","unstructured":"Frey, N., Katus, H.A., Olson, E.N., and Hill, J.A. (2004). Hypertrophy of the heart: a new therapeutic target? Circulation 109, 1580\u20131589.","journal-title":"Circulation"},{"key":"131_CR4","volume-title":"Chem Biol Interact","author":"C.E. Furlong","year":"2016","unstructured":"Furlong, C.E., Marsillach, J., Jarvik, G.P., and Costa, L.G. (2016). Paraoxonases-1, -2 and -3: What are their functions? Chem Biol Interact doi: 10.1016\/j.cbi.2016.05.036."},{"key":"131_CR5","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1001\/jama.292.19.2396","volume":"292","author":"J.M. Gardin","year":"2004","unstructured":"Gardin, J.M., and Lauer, M.S. (2004). Left ventricular hypertrophy: the next treatable, silent killer? JAMA 292, 2396\u20132398.","journal-title":"JAMA"},{"key":"131_CR6","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3109\/13813451003652997","volume":"116","author":"S. Givvimani","year":"2010","unstructured":"Givvimani, S., Tyagi, N., Sen, U., Mishra, P.K., Qipshidze, N., Munjal, C., Vacek, J.C., Abe, O.A., and Tyagi, S.C. (2010). MMP-2\/TIMP-2\/TIMP-4 versus MMP-9\/TIMP-3 in transition from compensatory hypertrophy and angiogenesis to decompensatory heart failure. Arch Physiol Biochem 116, 63\u201372.","journal-title":"Arch Physiol Biochem"},{"key":"131_CR7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0002-9440(10)62228-6","volume":"166","author":"S. Heymans","year":"2005","unstructured":"Heymans, S., Lupu, F., Terclavers, S., Vanwetswinkel, B., Herbert, J.M., Baker, A., Collen, D., Carmeliet, P., and Moons, L. (2005a). Loss or inhibition of uPA or MMP-9 attenuates LVremodeling and dysfunction after acute pressure overload in mice. Am J Pathol 166, 15\u201325.","journal-title":"Am J Pathol"},{"key":"131_CR8","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1161\/CIRCULATIONAHA.104.516963","volume":"112","author":"S. Heymans","year":"2005","unstructured":"Heymans, S., Schroen, B., Vermeersch, P., Milting, H., Gao, F., Kassner, A., Gillijns, H., Herijgers, P., Flameng, W., Carmeliet, P., Van de Werf, F., Pinto, Y.M., and Janssens, S. (2005b). Increased cardiac expression of tissue inhibitor of metalloproteinase-1 and tissue inhibitor of metalloproteinase-2 is related to cardiac fibrosis and dysfunction in the chronic pressure-overloaded human heart. Circulation 112, 1136\u20131144.","journal-title":"Circulation"},{"key":"131_CR9","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1161\/CIRCRESAHA.110.237875","volume":"108","author":"L. Li","year":"2011","unstructured":"Li, L., Zhang, H.N., Chen, H.Z., Gao, P., Zhu, L.H., Li, H.L., Lv, X., Zhang, Q.J., Zhang, R., Wang, Z., She, Z.G., Zhang, R., Wei, Y.S., Du, G.H., Liu, D.P., and Liang, C.C. (2011). SIRT1 acts as a modulator of neointima formation following vascular injury in mice. Circ Res 108, 1180\u20131189.","journal-title":"Circ Res"},{"key":"131_CR10","volume-title":"Eur Heart J","author":"Y.X. Luo","year":"2016","unstructured":"Luo, Y.X., Tang, X., An, X.Z., Xie, X.M., Chen, X.F., Zhao, X., Hao, D.L., Chen, H.Z., and Liu, D.P. (2016). Sirt4 accelerates Ang II-induced pathological cardiac hypertrophy by inhibiting manganese superoxide dismutase activity. Eur Heart J doi: 10.1093\/eurheartj\/ehw138."},{"key":"131_CR11","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/00041433-200208000-00002","volume":"13","author":"B. Mackness","year":"2002","unstructured":"Mackness, B., Durrington, P.N., and Mackness, M.I. (2002). The paraoxonase gene family and coronary heart disease. Curr Opin Lipidol 13, 357\u2013362.","journal-title":"Curr Opin Lipidol"},{"key":"131_CR12","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1161\/01.CIR.98.17.1699","volume":"98","author":"D.L. Mann","year":"1998","unstructured":"Mann, D.L., and Spinale, F.G. (1998). Activation of matrix metalloproteinases in the failing human heart: breaking the tie that binds. Circulation 98, 1699\u20131702.","journal-title":"Circulation"},{"key":"131_CR13","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.freeradbiomed.2008.03.023","volume":"45","author":"J. Marsillach","year":"2008","unstructured":"Marsillach, J., Mackness, B., Mackness, M., Riu, F., Beltran, R., Joven, J., and Camps, J. (2008). Immunohistochemical analysis of paraoxonases-1, 2, and 3 expression in normal mouse tissues. Free Radic Biol Med 45, 146\u2013157.","journal-title":"Free Radic Biol Med"},{"key":"131_CR14","doi-asserted-by":"crossref","first-page":"29491","DOI":"10.1074\/jbc.M605379200","volume":"281","author":"C.J. Ng","year":"2006","unstructured":"Ng, C.J., Bourquard, N., Grijalva, V., Hama, S., Shih, D.M., Navab, M., Fogelman, A.M., Lusis, A.J., Young, S., and Reddy, S.T. (2006). Paraoxonase-2 deficiency aggravates atherosclerosis in mice despite lower apolipoprotein-B-containing lipoproteins: anti-atherogenic role for paraoxonase-2. J Biol Chem 281, 29491\u201329500.","journal-title":"J Biol Chem"},{"key":"131_CR15","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.freeradbiomed.2004.09.035","volume":"38","author":"C.J. Ng","year":"2005","unstructured":"Ng, C.J., Shih, D.M., Hama, S.Y., Villa, N., Navab, M., and Reddy, S.T. (2005). The paraoxonase gene family and atherosclerosis. Free Radic Biol Med 38, 153\u2013163.","journal-title":"Free Radic Biol Med"},{"key":"131_CR16","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1291\/hypres.24.635","volume":"24","author":"E.N. Obineche","year":"2001","unstructured":"Obineche, E.N., Frossard, P.M., and Bokhari, A.M. (2001). An association study of five genetic loci and left ventricular hypertrophy amongst Gulf Arabs. Hypertens Res 24, 635\u2013639.","journal-title":"Hypertens Res"},{"key":"131_CR17","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1006\/geno.1996.0225","volume":"33","author":"S.L. Primo-Parmo","year":"1996","unstructured":"Primo-Parmo, S.L., Sorenson, R.C., Teiber, J., and La Du, B.N. (1996). The human serum paraoxonase\/arylesterase gene (PON1) is one member of a multigene family. Genomics 33, 498\u2013507.","journal-title":"Genomics"},{"key":"131_CR18","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1006\/jmcc.1999.1052","volume":"32","author":"L. Roten","year":"2000","unstructured":"Roten, L., Nemoto, S., Simsic, J., Coker, M.L., Rao, V., Baicu, S., Defreyte, G., Soloway, P.J., Zile, M.R., and Spinale, F.G. (2000). Effects of gene deletion of the tissue inhibitor of the matrix metalloproteinase-type 1 (TIMP-1) on left ventricular geometry and function in mice. J Mol Cell Cardiol 32, 109\u2013120.","journal-title":"J Mol Cell Cardiol"},{"key":"131_CR19","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.yjmcc.2014.02.002","volume":"73","author":"C.M. Sag","year":"2014","unstructured":"Sag, C.M., Santos, C.X., and Shah, A.M. (2014). Redox regulation of cardiac hypertrophy. J Mol Cell Cardiol 73, 103\u2013111.","journal-title":"J Mol Cell Cardiol"},{"key":"131_CR20","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1161\/ATVBAHA.110.214601","volume":"31","author":"K. Satoh","year":"2011","unstructured":"Satoh, K., Nigro, P., Zeidan, A., Soe, N.N., Jaffre, F., Oikawa, M., O'Dell, M.R., Cui, Z., Menon, P., Lu, Y., Mohan, A., Yan, C., Blaxall, B.C., and Berk, B.C. (2011). Cyclophilin A promotes cardiac hypertrophy in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 31, 1116\u20131123.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"131_CR21","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1161\/CIRCRESAHA.108.192229","volume":"104","author":"Z.G. She","year":"2009","unstructured":"She, Z.G., Zheng, W., Wei, Y.S., Chen, H.Z., Wang, A.B., Li, H.L., Liu, G., Zhang, R., Liu, J.J., Stallcup, W.B., Zhou, Z., Liu, D.P., and Liang, C.C. (2009). Human paraoxonase gene cluster transgenic overexpression represses atherogenesis and promotes atherosclerotic plaque stability in ApoE-null mice. Circ Res 104, 1160\u20131168.","journal-title":"Circ Res"},{"key":"131_CR22","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/28406","volume":"394","author":"D.M. Shih","year":"1998","unstructured":"Shih, D.M., Gu, L., Xia, Y.R., Navab, M., Li, W.F., Hama, S., Castellani, L.W., Furlong, C.E., Costa, L.G., Fogelman, A.M., and Lusis, A.J. (1998). Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis. Nature 394, 284\u2013287.","journal-title":"Nature"},{"key":"131_CR23","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1096\/fj.14-260570","volume":"29","author":"D.M. Shih","year":"2015","unstructured":"Shih, D.M., Yu, J.M., Vergnes, L., Dali-Youcef, N., Champion, M.D., Devarajan, A., Zhang, P., Castellani, L.W., Brindley, D.N., Jamey, C., Auwerx, J., Reddy, S.T., Ford, D.A., Reue, K., and Lusis, A.J. (2015). PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis. FASEB J 29, 1185\u20131197.","journal-title":"FASEB J"},{"key":"131_CR24","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1152\/physrev.00012.2007","volume":"87","author":"F.G. Spinale","year":"2007","unstructured":"Spinale, F.G. (2007). Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function. Physiol Rev 87, 1285\u20131342.","journal-title":"Physiol Rev"},{"key":"131_CR25","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1161\/CIRCHEARTFAILURE.110.958348","volume":"4","author":"W.H. Tang","year":"2011","unstructured":"Tang, W.H., Wu, Y., Mann, S., Pepoy, M., Shrestha, K., Borowski, A.G., and Hazen, S.L. (2011). Diminished antioxidant activity of high-density lipoprotein-associated proteins in systolic heart failure. Circ Heart Fail 4, 59\u201364.","journal-title":"Circ Heart Fail"},{"key":"131_CR26","volume-title":"Sci China Life Sci","author":"F. Wang","year":"2016","unstructured":"Wang, F., Chen, H., Yan, Y., Liu, Y., Zhang, S., and Liu, D. (2016). Baicalein protects against the development of angiotensin II-induced abdominal aortic aneurysms by blocking JNK and p38 MAPK signaling. Sci China Life Sci doi: 10.1007\/s11427-015-0277-8."},{"key":"131_CR27","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ejphar.2005.02.024","volume":"512","author":"Y.X. Wang","year":"2005","unstructured":"Wang, Y.X., da Cunha, V., Martin-McNulty, B., Vincelette, J., Li, W., Choy, D.F., Halks-Miller, M., Mahmoudi, M., Schroeder, M., Johns, A., Light, D.R., and Dole, W.P. (2005). Inhibition of Rho-kinase by fasudil attenuated angiotensin II-induced cardiac hypertrophy in apolipoprotein E deficient mice. Eur J Pharmacol 512, 215\u2013222.","journal-title":"Eur J Pharmacol"},{"key":"131_CR28","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1161\/CIRCRESAHA.111.243592","volume":"109","author":"S. Zhou","year":"2011","unstructured":"Zhou, S., Chen, H.Z., Wan, Y.Z., Zhang, Q.J., Wei, Y.S., Huang, S., Liu, J.J., Lu, Y.B., Zhang, Z.Q., and Yang, R.F. (2011). Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction. Circ Res 109, 639\u2013648.","journal-title":"Circ Res"}],"container-title":["Science China Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-016-0131-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T21:38:51Z","timestamp":1498340331000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11427-016-0131-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,30]]},"references-count":28,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["131"],"URL":"https:\/\/doi.org\/10.1007\/s11427-016-0131-4","relation":{},"ISSN":["1674-7305","1869-1889"],"issn-type":[{"value":"1674-7305","type":"print"},{"value":"1869-1889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,30]]}}}