{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T10:08:03Z","timestamp":1782727683306,"version":"3.54.5"},"reference-count":85,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T00:00:00Z","timestamp":1516665600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci. China Life Sci."],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1007\/s11427-017-9223-x","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T04:36:23Z","timestamp":1517373383000},"page":"266-276","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Post-infarct cardiac injury, protection and repair: roles of non-cardiomyocyte multicellular and acellular components"],"prefix":"10.1007","volume":"61","author":[{"given":"Xiaojun","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,1,23]]},"reference":[{"key":"9223_CR1","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.yjmcc.2014.01.005","volume":"68","author":"M. Abrial","year":"2014","unstructured":"Abrial, M., Da Silva, C.C., Pillot, B., Augeul, L., Ivanes, F., Teixeira, G., Cartier, R., Angoulvant, D., Ovize, M., and Ferrera, R. (2014). Cardiac fibroblasts protect cardiomyocytes against lethal ischemia-reperfusion injury. J Mol Cell Cardiol 68, 56\u201365.","journal-title":"J Mol Cell Cardiol"},{"key":"9223_CR2","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s12265-015-9668-7","volume":"9","author":"R. Agarwal","year":"2016","unstructured":"Agarwal, R., Mokelke, E., Ruble, S.B., and Stolen, C.M. (2016). Vagal nerve stimulation evoked heart rate changes and protection from cardiac remodeling. J Cardiovasc Trans Res 9, 67\u201376.","journal-title":"J Cardiovasc Trans Res"},{"key":"9223_CR3","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1084\/jem.20021426","volume":"197","author":"A.T. Askari","year":"2003","unstructured":"Askari, A.T., Brennan, M.L., Zhou, X., Drinko, J., Morehead, A., Thomas, J.D., Topol, E.J., Hazen, S.L., and Penn, M.S. (2003). Myeloperoxidase and plasminogen activator inhibitor 1 play a central role in ventricular remodeling after myocardial infarction. J Exp Med 197, 615\u2013624.","journal-title":"J Exp Med"},{"key":"9223_CR4","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1172\/JCI72181","volume":"124","author":"A.B. Aurora","year":"2014","unstructured":"Aurora, A.B., Porrello, E.R., Tan, W., Mahmoud, A.I., Hill, J.A., Bassel- Duby, R., Sadek, H.A., and Olson, E.N. (2014). Macrophages are required for neonatal heart regeneration. J Clin Invest 124, 1382\u20131392.","journal-title":"J Clin Invest"},{"key":"9223_CR5","doi-asserted-by":"publisher","first-page":"e81","DOI":"10.1161\/CIRCRESAHA.115.306146","volume":"116","author":"E. Avolio","year":"2015","unstructured":"Avolio, E., Meloni, M., Spencer, H.L., Riu, F., Katare, R., Mangialardi, G., Oikawa, A., Rodriguez-Arabaolaza, I., Dang, Z., Mitchell, K., Reni, C., Alvino, V.V., Rowlinson, J., Livi, U., Cesselli, D., Angelini, G., Emanueli, C., Beltrami, A.P., and Madeddu, P. (2015). Combined intramyocardial delivery of human pericytes and cardiac stem cells additively improves the healing of mouse infarcted hearts through stimulation of vascular and muscular repair. Circul Res 116, e81\u2013e94.","journal-title":"Circul Res"},{"key":"9223_CR6","doi-asserted-by":"publisher","first-page":"H1198","DOI":"10.1152\/ajpheart.00393.2015","volume":"309","author":"E. Beaumont","year":"2015","unstructured":"Beaumont, E., Southerland, E.M., Hardwick, J.C., Wright, G.L., Ryan, S., Li, Y., KenKnight, B.H., Armour, J.A., and Ardell, J.L. (2015). Vagus nerve stimulation mitigates intrinsic cardiac neuronal and adverse myocyte remodeling postmyocardial infarction. Am J Physiol Heart Circ Physiol 309, H1198\u2013H1206.","journal-title":"J Physiol Heart Circ Physiol"},{"key":"9223_CR7","doi-asserted-by":"publisher","first-page":"e002834","DOI":"10.1161\/JAHA.115.002834","volume":"5","author":"D. Carrick","year":"2016","unstructured":"Carrick, D., Haig, C., Ahmed, N., Rauhalammi, S., Clerfond, G., Carberry, J., Mordi, I., McEntegart, M., Petrie, M.C., Eteiba, H., Hood, S., Watkins, S., Lindsay, M.M., Mahrous, A., Welsh, P., Sattar, N., Ford, I., Oldroyd, K.G., Radjenovic, A., and Berry, C. (2016). Temporal evolution of myocardial hemorrhage and edema in patients after acute ST segment elevation myocardial infarction: pathophysiological insights and clinical implications. J Am Heart Assoc 5, e002834.","journal-title":"J Am Heart Assoc"},{"key":"9223_CR8","doi-asserted-by":"publisher","first-page":"2073","DOI":"10.1161\/01.CIR.85.6.2073","volume":"85","author":"G.C. Casolo","year":"1992","unstructured":"Casolo, G.C., Stroder, P., Signorini, C., Calzolari, F., Zucchini, M., Balli, E., Sulla, A., and Lazzerini, S. (1992). Heart rate variability during the acute phase of myocardial infarction. Circulation 85, 2073\u20132079.","journal-title":"Circulation"},{"key":"9223_CR9","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.ijcard.2017.03.125","volume":"240","author":"G. Cerisano","year":"2017","unstructured":"Cerisano, G., Buonamici, P., Parodi, G., Santini, A., Moschi, G., Valenti, R., Migliorini, A., Colonna, P., Bellandi, B., Gori, A.M., and Antoniucci, D. (2017). Early changes of left ventricular filling pattern after reperfused ST-elevation myocardial infarction and doxycycline therapy: insights from the TIPTOP trial. Int J Cardiol 240, 43\u201348.","journal-title":"Int J Cardiol"},{"key":"9223_CR10","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1093\/cvr\/cvx001","volume":"113","author":"Z. Chen","year":"2017","unstructured":"Chen, Z., Xie, J., Hao, H., Lin, H., Wang, L., Zhang, Y., Chen, L., Cao, S., Huang, X., Liao, W., Bin, J., and Liao, Y. (2017). Ablation of periostin inhibits post-infarction myocardial regeneration in neonatal mice mediated by the phosphatidylinositol 3 kinase\/glycogen synthase kinase 3\u03b2\/cyclin D1 signalling pathway. Cardiovasc Res 113, 620\u2013632.","journal-title":"Cardiovasc Res"},{"key":"9223_CR11","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1097\/00005344-199806000-00019","volume":"31","author":"X.J. Du","year":"1998","unstructured":"Du, X.J., Cox, H.S., Dart, A.M., and Esler, M.D. (1998). Depression of efferent parasympathetic control of heart rate in rats with myocardial infarction: effect of losartan. J Cardiovasc Pharmacol 31, 937\u2013944.","journal-title":"J Cardiovasc Pharmacol"},{"key":"9223_CR12","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1160\/TH10-07-0449","volume":"105","author":"X.J. Du","year":"2011","unstructured":"Du, X.J., Shan, L., Gao, X.M., Kiriazis, H., Liu, Y., Lobo, A., Head, G.A., and Dart, A.M. (2011). Role of intramural platelet thrombus in the pathogenesis of wall rupture and intra-ventricular thrombosis following acute myocardial infarction. Thromb Haemost 105, 356\u2013364.","journal-title":"Thromb Haemost"},{"key":"9223_CR13","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1161\/CIRCIMAGING.110.960500","volume":"4","author":"I. Eitel","year":"2011","unstructured":"Eitel, I., Kubusch, K., Strohm, O., Desch, S., Mikami, Y., de Waha, S., Gutberlet, M., Schuler, G., Friedrich, M.G., and Thiele, H. (2011). Prognostic value and determinants of a hypointense infarct core in T2- weighted cardiac magnetic resonance in acute reperfused ST-elevationmyocardial infarction. Circul Cardiovasc Imag 4, 354\u2013362.","journal-title":"Circul Cardiovasc Imag"},{"key":"9223_CR14","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.yjmcc.2007.06.011","volume":"43","author":"L. Fang","year":"2007","unstructured":"Fang, L., Gao, X.M., Moore, X.L., Kiriazis, H., Su, Y., Ming, Z., Lim, Y.L., Dart, A.M., and Du, X.J. (2007). Differences in inflammation, MMP activation and collagen damage account for gender difference in murine cardiac rupture following myocardial infarction. J Mol Cell Cardiol 43, 535\u2013544.","journal-title":"J Mol Cell Cardiol"},{"key":"9223_CR15","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1002\/cphy.c150006","volume":"5","author":"N.G. Frangogiannis","year":"2015","unstructured":"Frangogiannis, N.G. (2015). Pathophysiology of myocardial infarction. Compr Physiol 5, 1841\u20131875.","journal-title":"Compr Physiol"},{"key":"9223_CR16","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1093\/ejechocard\/jer009","volume":"12","author":"S. Funaro","year":"2011","unstructured":"Funaro, S., Galiuto, L., Boccalini, F., Cimino, S., Canali, E., Evangelio, F., DeLuca, L., Paraggio, L., Mattatelli, A., Gnessi, L., and Agati, L. (2011). Determinants of microvascular damage recovery after acute myocardial infarction: results from the acute myocardial infarction contrast imaging (AMICI) multi-centre study. Eur J Echocard 12, 306\u2013312.","journal-title":"Eur J Echocard"},{"key":"9223_CR17","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1161\/CIRCULATIONAHA.111.049072","volume":"125","author":"A. Galaup","year":"2012","unstructured":"Galaup, A., Gomez, E., Souktani, R., Durand, M., Cazes, A., Monnot, C., Teillon, J., Le Jan, S., Bouleti, C., Briois, G., Philippe, J., Pons, S., Martin, V., Assaly, R., Bonnin, P., Ratajczak, P., Janin, A., Thurston, G., Valenzuela, D.M., Murphy, A.J., Yancopoulos, G.D., Tissier, R., Berdeaux, A., Ghaleh, B., and Germain, S. (2012). Protection against myocardial infarction and no-reflow through preservation of vascular integrity by angiopoietin-like 4. Circulation 125, 140\u2013149.","journal-title":"Circulation"},{"key":"9223_CR18","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/j.yjmcc.2010.12.022","volume":"50","author":"X.M. Gao","year":"2011","unstructured":"Gao, X.M., Liu, Y., White, D., Su, Y., Drew, B.G., Bruce, C.R., Kiriazis, H., Xu, Q., Jennings, N., Bobik, A., Febbraio, M.A., Kingwell, B.A., Bucala, R., Fingerle-Rowson, G., Dart, A.M., Morand, E.F., and Du, X. J. (2011). Deletion of macrophage migration inhibitory factor protects the heart from severe ischemia-reperfusion injury: a predominant role of anti-inflammation. J Mol Cell Cardiol 50, 991\u2013999.","journal-title":"J Mol Cell Cardiol"},{"key":"9223_CR19","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1042\/CS20160234","volume":"130","author":"X.M. Gao","year":"2016","unstructured":"Gao, X.M., Moore, X.L., Liu, Y., Wang, X.Y., Han, L.P., Su, Y., Tsai, A., Xu, Q., Zhang, M., Lambert, G.W., Kiriazis, H., Gao, W., Dart, A.M., and Du, X.J. (2016). Splenic release of platelets contributes to increased circulating platelet size and inflammation after myocardial infarction. Clin Sci 130, 1089\u20131104.","journal-title":"Clin Sci"},{"key":"9223_CR20","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.pharmthera.2011.12.010","volume":"134","author":"X.M. Gao","year":"2012","unstructured":"Gao, X.M., White, D.A., Dart, A.M., and Du, X.J. (2012). Post-infarct cardiac rupture: recent insights on pathogenesis and therapeutic interventions. Pharmacol Therapeut 134, 156\u2013179.","journal-title":"Pharmacol Therapeut"},{"key":"9223_CR21","doi-asserted-by":"crossref","unstructured":"Gao, X.M., Wu, Q.Z., Kiriazis, H., Su, Y., Han, L.P., Pearson, J.T., Taylor, A.J., and Du, X.J. (2017). Microvascular leakage in acute myocardial infarction: characterization by histology, biochemistry, and magnetic resonance imaging. Am J Physiol Heart Circ Physiol 312, H1068\u2013H-1075.","DOI":"10.1152\/ajpheart.00073.2017"},{"key":"9223_CR22","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.cardiores.2004.10.014","volume":"65","author":"X.M. Gao","year":"2005","unstructured":"Gao, X.M., Xu, Q., Kiriazis, H., Dart, A.M., and Du, X.J. (2005). Mouse model of post-infarct ventricular rupture: time course, strain- and gender- dependency, tensile strength, and histopathology. Cardiovasc Res 65, 469\u2013477.","journal-title":"Cardiovasc Res"},{"key":"9223_CR23","doi-asserted-by":"publisher","first-page":"3378","DOI":"10.1172\/JCI27196","volume":"115","author":"M. Gawaz","year":"2005","unstructured":"Gawaz, M., Langer, H., and May, A.E. (2005). Platelets in inflammation and atherogenesis. J Clin Investig 115, 3378\u20133384.","journal-title":"J Clin Investig"},{"key":"9223_CR24","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1111\/1440-1681.12465","volume":"42","author":"D. Goltz","year":"2015","unstructured":"Goltz, D., Huss, S., Ramadori, E., B\u00fcttner, R., Diehl, L., and Meyer, R. (2015). Immunomodulation by splenectomy or by FTY720 protects the heart against ischemia reperfusion injury. Clin Exp Pharmacol Physiol 42, 1168\u20131177.","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"9223_CR25","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1161\/CIRCULATIONAHA.116.022304","volume":"134","author":"L.A. Grisanti","year":"2016","unstructured":"Grisanti, L.A., Gumpert, A.M., Traynham, C.J., Gorsky, J.E., Repas, A.A., Gao, E., Carter, R.L., Yu, D., Calvert, J.W., Garc\u00eda, A.P., Ib\u00e1\u00f1ez, B., Rabinowitz, J.E., Koch, W.J., and Tilley, D.G. (2016). Leukocyte-expressed \u03b22-adrenergic receptors are essential for survival after acute myocardial injury clinical perspective. Circulation 134, 153\u2013167.","journal-title":"Circulation"},{"key":"9223_CR26","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1161\/CIRCRESAHA.115.306874","volume":"118","author":"J.P. Guyette","year":"2016","unstructured":"Guyette, J.P., Charest, J.M., Mills, R.W., Jank, B.J., Moser, P.T., Gilpin, S. E., Gershlak, J.R., Okamoto, T., Gonzalez, G., Milan, D.J., Gaudette, G. R., and Ott, H.C. (2016). Bioengineering human myocardium on native extracellular matrixnovelty and significance. Circul Res 118, 56\u201372.","journal-title":"Circul Res"},{"key":"9223_CR27","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1016\/j.jcmg.2014.06.012","volume":"7","author":"Y.S. Hamirani","year":"2014","unstructured":"Hamirani, Y.S., Wong, A., Kramer, C.M., and Salerno, M. (2014). Effect of microvascular obstruction and intramyocardial hemorrhage by CMR on LV remodeling and outcomes after myocardial infarction. JACC Cardiovasc Imag 7, 940\u2013952.","journal-title":"JACC Cardiovasc Imag"},{"key":"9223_CR28","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1007\/s00395-016-0588-8","volume":"111","author":"D.J. Hausenloy","year":"2016","unstructured":"Hausenloy, D.J., Barrabes, J.A., B\u00f8tker, H.E., Davidson, S.M., Di Lisa, F., Downey, J., Engstrom, T., Ferdinandy, P., Carbrera-Fuentes, H.A., Heusch, G., Ibanez, B., Iliodromitis, E.K., Inserte, J., Jennings, R., Kalia, N., Kharbanda, R., Lecour, S., Marber, M., Miura, T., Ovize, M., Perez-Pinzon, M.A., Piper, H.M., Przyklenk, K., Schmidt, M.R., Redington, A., Ruiz-Meana, M., Vilahur, G., Vinten-Johansen, J., Yellon, D.M., and Garcia-Dorado, D. (2016). Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery. Basic Res Cardiol 111, 70.","journal-title":"Basic Res Cardiol"},{"key":"9223_CR29","first-page":"935","volume":"38","author":"D.J. Hausenloy","year":"2017","unstructured":"Hausenloy, D.J., Botker, H.E., Engstrom, T., Erlinge, D., Heusch, G., Ibanez, B., Kloner, R.A., Ovize, M., Yellon, D.M., and Garcia-Dorado, D. (2017). Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: trials and tribulations. Eur Heart J 38, 935\u2013941.","journal-title":"Eur Heart J"},{"key":"9223_CR30","first-page":"774","volume":"38","author":"G. Heusch","year":"2017","unstructured":"Heusch, G., and Gersh, B.J. (2017). The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge. Eur Heart J 38, 774\u2013784.","journal-title":"Eur Heart J"},{"key":"9223_CR31","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1161\/CIRCRESAHA.116.308736","volume":"119","author":"G. Heusch","year":"2016","unstructured":"Heusch, G., and Rassaf, T. (2016). Time to give up on cardioprotection? Circ Res 119, 676\u2013695.","journal-title":"Circ Res"},{"key":"9223_CR32","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1038\/13459","volume":"5","author":"S. Heymans","year":"1999","unstructured":"Heymans, S., Luttun, A., Nuyens, D., Theilmeier, G., Creemers, E., Moons, L., Dyspersin, G.D., Cleutjens, J.P.M., Shipley, M., Angellilo, A., Levi, M., N\u00fc\u03b2e, O., Baker, A., Keshet, E., Lupu, F., Herbert, J.M., Smits, J.F. M., Shapiro, S.D., Baes, M., Borgers, M., Collen, D., Daemen, M.J.A. P., and Carmeliet, P. (1999). Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure. Nat Med 5, 1135\u20131142.","journal-title":"Nat Med"},{"key":"9223_CR33","doi-asserted-by":"publisher","first-page":"H499","DOI":"10.1152\/ajpheart.00325.2011","volume":"302","author":"T. Hirase","year":"2012","unstructured":"Hirase, T., and Node, K. (2012). Endothelial dysfunction as a cellular mechanism for vascular failure. AJP-Heart Circul Physiol 302, H499\u2013H505.","journal-title":"AJP-Heart Circul Physiol"},{"key":"9223_CR34","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1161\/CIRCRESAHA.115.305373","volume":"118","author":"C.P. Hodgkinson","year":"2016","unstructured":"Hodgkinson, C.P., Bareja, A., Gomez, J.A., and Dzau, V.J. (2016). Emerging concepts in paracrine mechanisms in regenerative cardiovascular medicine and biology. Circul Res 118, 95\u2013107.","journal-title":"Circul Res"},{"key":"9223_CR35","doi-asserted-by":"publisher","first-page":"4667","DOI":"10.1182\/blood-2010-10-316356","volume":"117","author":"R. Huggenberger","year":"2011","unstructured":"Huggenberger, R., Siddiqui, S.S., Brander, D., Ullmann, S., Zimmermann, K., Antsiferova, M., Werner, S., Alitalo, K., and Detmar, M. (2011). An important role of lymphatic vessel activation in limiting acute inflammation. Blood 117, 4667\u20134678.","journal-title":"Blood"},{"key":"9223_CR36","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.yjmcc.2015.11.015","volume":"93","author":"M. Hulsmans","year":"2016","unstructured":"Hulsmans, M., Sam, F., and Nahrendorf, M. (2016). Monocyte and macrophage contributions to cardiac remodeling. J Mol Cell Cardiol 93, 149\u2013155.","journal-title":"J Mol Cell Cardiol"},{"key":"9223_CR37","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1161\/01.RES.62.6.1111","volume":"62","author":"H. Inoue","year":"1988","unstructured":"Inoue, H., and Zipes, D.P. (1988). Time course of denervation of efferent sympathetic and vagal nerves after occlusion of the coronary artery in the canine heart. Circul Res 62, 1111\u20131120.","journal-title":"Circul Res"},{"key":"9223_CR38","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1111\/j.1365-2559.2007.02785.x","volume":"51","author":"Y. Ishikawa","year":"2007","unstructured":"Ishikawa, Y., Akishima-Fukasawa, Y., Ito, K., Akasaka, Y., Tanaka, M., Shimokawa, R., Kimura-Matsumoto, M., Morita, H., Sato, S., Kamata, I., and Ishii, T. (2007). Lymphangiogenesis in myocardial remodelling after infarction. Histopathology 51, 345\u2013353.","journal-title":"Histopathology"},{"key":"9223_CR39","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.yjmcc.2016.10.005","volume":"100","author":"R.P. Iyer","year":"2016","unstructured":"Iyer, R.P., de Castro Br\u00e1s, L.E., Patterson, N.L., Bhowmick, M., Flynn, E. R., Asher, M., Cannon, P.L., Deleon-Pennell, K.Y., Fields, G.B., and Lindsey, M.L. (2016). Early matrix metalloproteinase-9 inhibition postmyocardial infarction worsens cardiac dysfunction by delaying inflammation resolution. J Mol Cell Cardiol 100, 109\u2013117.","journal-title":"J Mol Cell Cardiol"},{"key":"9223_CR40","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1161\/CIRCRESAHA.116.305462","volume":"116","author":"S.P. Jones","year":"2015","unstructured":"Jones, S.P., Tang, X.L., Guo, Y., Steenbergen, C., Lefer, D.J., Kukreja, R. C., Kong, M., Li, Q., Bhushan, S., Zhu, X., Du, J., Nong, Y., Stowers, H.L., Kondo, K., Hunt, G.N., Goodchild, T.T., Orr, A., Chang, C.C., Ockaili, R., Salloum, F.N., and Bolli, R. (2015). The NHLBI-sponsored consortium for preclinical assessment of cardioprotective therapies (-CAESAR): a new paradigm for rigorous, accurate, and reproducible evaluation of putative infarct-sparing interventions in mice, rabbits, and pigs. Circul Res 116, 572\u2013586.","journal-title":"Circul Res"},{"key":"9223_CR41","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s00011-016-0931-4","volume":"65","author":"W.M.C. Jong","year":"2016","unstructured":"Jong, W.M.C., Ten Cate, H., Linnenbank, A.C., de Boer, O.J., Reitsma, P. H., de Winter, R.J., and Zuurbier, C.J. (2016). Reduced acute myocardial ischemia-reperfusion injury in IL-6-deficient mice employing a closed-chest model. Inflamm Res 65, 489\u2013499.","journal-title":"Inflamm Res"},{"key":"9223_CR42","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1161\/CIRCHEARTFAILURE.114.001484","volume":"8","author":"H. Kanazawa","year":"2015","unstructured":"Kanazawa, H., Tseliou, E., Malliaras, K., Yee, K., Dawkins, J.F., De Couto, G., Smith, R.R., Kreke, M., Seinfeld, J., Middleton, R.C., Gallet, R., Cheng, K., Luthringer, D., Valle, I., Chowdhury, S., Fukuda, K., Makkar, R.R., Marb\u00e1n, L., and Marb\u00e1n, E. (2015). Cellular postconditioning: allogeneic cardiosphere-derived cells reduce infarct size and attenuate microvascular obstruction when administered after reperfusion in pigs with acute myocardial infarction. Circul Heart Failure 8, 322\u2013332.","journal-title":"Circul Heart Failure"},{"key":"9223_CR43","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/S1471-4914(00)01864-5","volume":"7","author":"M.J. Karkkainen","year":"2001","unstructured":"Karkkainen, M.J., Jussila, L., Alitalo, K., Ferrell, R.E., and Finegold, D.N. (2001). Molecular regulation of lymphangiogenesis and targets for tissue oedema. Trends Mol Med 7, 18\u201322.","journal-title":"Trends Mol Med"},{"key":"9223_CR44","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1161\/CIRCRESAHA.111.251546","volume":"109","author":"R. Katare","year":"2011","unstructured":"Katare, R., Riu, F., Mitchell, K., Gubernator, M., Campagnolo, P., Cui, Y., Fortunato, O., Avolio, E., Cesselli, D., Beltrami, A.P., Angelini, G., Emanueli, C., and Madeddu, P. (2011). Transplantation of human pericyte progenitor cells improves the repair of infarcted heart through activation of an angiogenic program involving micro-RNA-132. Circul Res 109, 894\u2013906.","journal-title":"Circul Res"},{"key":"9223_CR45","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1161\/CIRCULATIONAHA.110.982777","volume":"123","author":"M. Kawaguchi","year":"2011","unstructured":"Kawaguchi, M., Takahashi, M., Hata, T., Kashima, Y., Usui, F., Morimoto, H., Izawa, A., Takahashi, Y., Masumoto, J., Koyama, J., Hongo, M., Noda, T., Nakayama, J., Sagara, J., Taniguchi, S., and Ikeda, U. (2011). Inflammasome activation of cardiac fibroblasts is essential for myocardial ischemia\/reperfusion injury. Circulation 123, 594\u2013604.","journal-title":"Circulation"},{"key":"9223_CR46","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1177\/1074248411405990","volume":"16","author":"R.A. Kloner","year":"2011","unstructured":"Kloner, R.A. (2011). No-reflow phenomenon: maintaining vascular integrity. J Cardiovasc Pharmacol Ther 16, 244\u2013250.","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"9223_CR47","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1161\/CIRCRESAHA.112.300627","volume":"113","author":"R.A. Kloner","year":"2013","unstructured":"Kloner, R.A. (2013). Current state of clinical translation of cardioprotective agents for acute myocardial infarction. Circul Res 113, 451\u2013463.","journal-title":"Circul Res"},{"key":"9223_CR48","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/nature14483","volume":"522","author":"L. Klotz","year":"2015","unstructured":"Klotz, L., Norman, S., Vieira, J.M., Masters, M., Rohling, M., Dub\u00e9, K.N., Bollini, S., Matsuzaki, F., Carr, C.A., and Riley, P.R. (2015). Cardiac lymphatics are heterogeneous in origin and respond to injury. Nature 522, 62\u201367.","journal-title":"Nature"},{"key":"9223_CR49","first-page":"1713","volume":"68","author":"G.A. Laine","year":"1991","unstructured":"Laine, G.A., and Allen, S.J. (1991). Left ventricular myocardial edema. Lymph flow, interstitial fibrosis, and cardiac function. Circ Res 68, 1713\u20131721.","journal-title":"Lymph flow, interstitial fibrosis, and cardiac function. Circ Res"},{"key":"9223_CR50","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1177\/1074248411414155","volume":"16","author":"D.J. Lefer","year":"2011","unstructured":"Lefer, D.J., and Bolli, R. (2011). Development of an NIH consortium for preclinical assessment of cardioprotective therapies (CAESAR): a paradigm shift in studies of infarct size limitation. J Cardiovasc Pharmacol Ther 16, 332\u2013339.","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"9223_CR51","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1161\/01.CIR.0000105721.71640.DA","volume":"109","author":"M. Li","year":"2004","unstructured":"Li, M., Zheng, C., Sato, T., Kawada, T., Sugimachi, M., and Sunagawa, K. (2004). Vagal nerve stimulation markedly improves long-term survival after chronic heart failure in rats. Circulation 109, 120\u2013124.","journal-title":"Circulation"},{"key":"9223_CR52","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.3892\/mmr.2015.3597","volume":"12","author":"Y. Li","year":"2015","unstructured":"Li, Y., Xuan, Y.H., Liu, S.S., Dong, J., Luo, J.Y., and Sun, Z.J. (2015). Short-term vagal nerve stimulation improves left ventricular function following chronic heart failure in rats. Mol Med Rep 12, 1709\u20131716.","journal-title":"Mol Med Rep"},{"key":"9223_CR53","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1161\/ATVBAHA.110.220467","volume":"31","author":"Y. Liu","year":"2011","unstructured":"Liu, Y., Gao, X.M., Fang, L., Jennings, N.L., Su, Y., Q, X., Samson, A.L., Kiriazis, H., Wang, X.F., Shan, L., Sturgeon, S.A., Medcalf, R.L., Jackson, S.P., Dart, A.M., and Du, X.J. (2011). Novel role of platelets in mediating inflammatory responses and ventricular rupture or remodeling following myocardial infarction. Arteriosclerosis Thrombosis Vascular Biol 31, 834\u2013841.","journal-title":"Arteriosclerosis Thrombosis Vascular Biol"},{"key":"9223_CR54","doi-asserted-by":"publisher","first-page":"499","DOI":"10.4049\/jimmunol.1401948","volume":"194","author":"J. Lugrin","year":"2015","unstructured":"Lugrin, J., Parapanov, R., Rosenblatt-Velin, N., Rignault-Clerc, S., Feihl, F., Waeber, B., M\u00fcller, O., Vergely, C., Zeller, M., Tardivel, A., Schneider, P., Pacher, P., and Liaudet, L. (2015). Cutting edge: IL-1\u03b1 is a crucial danger signal triggering acute myocardial inflammation during myocardial infarction. J Immunol 194, 499\u2013503.","journal-title":"J Immunol"},{"key":"9223_CR55","doi-asserted-by":"publisher","first-page":"265","DOI":"10.15252\/emmm.201606602","volume":"9","author":"M. Malek Mohammadi","year":"2017","unstructured":"Malek Mohammadi, M., Kattih, B., Grund, A., Froese, N., Korf-Klingebiel, M., Gigina, A., Schrameck, U., Rudat, C., Liang, Q., Kispert, A., Wollert, K.C., Bauersachs, J., and Heineke, J. (2017). The transcription factor GATA4 promotes myocardial regeneration in neonatal mice. EMBO Mol Med 9, 265\u2013279.","journal-title":"EMBO Mol Med"},{"key":"9223_CR56","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1172\/JCI22304","volume":"115","author":"S. Matsumura","year":"2005","unstructured":"Matsumura, S., Iwanaga, S., Mochizuki, S., Okamoto, H., Ogawa, S., and Okada, Y. (2005). Targeted deletion or pharmacological inhibition of MMP-2 prevents cardiac rupture after myocardial infarction in mice. J Clin Invest 115, 599\u2013609.","journal-title":"J Clin Invest"},{"key":"9223_CR57","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1161\/CIRCRESAHA.113.300890","volume":"112","author":"M. Nahrendorf","year":"2013","unstructured":"Nahrendorf, M., and Swirski, F.K. (2013). Monocyte and macrophage heterogeneity in the heart. Circul Res 112, 1624\u20131633.","journal-title":"Circul Res"},{"key":"9223_CR58","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1093\/eurheartj\/ehv453","volume":"37","author":"M. Nahrendorf","year":"2016","unstructured":"Nahrendorf, M., and Swirski, F.K. (2016). Innate immune cells in ischaemic heart disease: does myocardial infarction beget myocardial infarction? Eur Heart J 37, 868\u2013872.","journal-title":"Eur Heart J"},{"key":"9223_CR59","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1161\/CIRCRESAHA.108.177568","volume":"103","author":"M. Nakagawa","year":"2008","unstructured":"Nakagawa, M., Takemura, G., Kanamori, H., Goto, K., Maruyama, R., Tsujimoto, A., Ohno, T., Okada, H., Ogino, A., Esaki, M., Miyata, S., Li, L., Ushikoshi, H., Aoyama, T., Kawasaki, M., Nagashima, K., Fujiwara, T., Minatoguchi, S., and Fujiwara, H. (2008). Mechanisms by which late coronary reperfusion mitigates postinfarction cardiac remodeling. Circul Res 103, 98\u2013106.","journal-title":"Circul Res"},{"key":"9223_CR60","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.ijcard.2008.02.007","volume":"129","author":"K. Nakamura","year":"2008","unstructured":"Nakamura, K., and Rockson, S.G. (2008). The role of the lymphatic circulation in the natural history and expression of cardiovascular disease. Int J Cardiol 129, 309\u2013317.","journal-title":"Int J Cardiol"},{"key":"9223_CR61","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1016\/j.jacc.2009.12.054","volume":"55","author":"G. Ndrepepa","year":"2010","unstructured":"Ndrepepa, G., Tiroch, K., Fusaro, M., Keta, D., Seyfarth, M., Byrne, R.A., Pache, J., Alger, P., Mehilli, J., Sch\u00f6mig, A., and Kastrati, A. (2010). 5-Year prognostic value of no-reflow phenomenon after percutaneous coronary intervention in patients with acute myocardial infarction. J Am College Cardiol 55, 2383\u20132389.","journal-title":"J Am College Cardiol"},{"key":"9223_CR62","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.smim.2014.01.003","volume":"26","author":"C.J. Padro","year":"2014","unstructured":"Padro, C.J., and Sanders, V.M. (2014). Neuroendocrine regulation of inflammation. Semin Immunol 26, 357\u2013368.","journal-title":"Semin Immunol"},{"key":"9223_CR63","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1161\/CIRCRESAHA.115.307778","volume":"118","author":"A.R. Pinto","year":"2016","unstructured":"Pinto, A.R., Ilinykh, A., Ivey, M.J., Kuwabara, J.T., D\u2019Antoni, M.L., Debuque, R., Chandran, A., Wang, L., Arora, K., Rosenthal, N.A., and Tallquist, M.D. (2016). Revisiting cardiac cellular compositionnovelty and significance. Circ Res 118, 400\u2013409.","journal-title":"Circ Res"},{"key":"9223_CR64","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1126\/science.1200708","volume":"331","author":"E.R. Porrello","year":"2011","unstructured":"Porrello, E.R., Mahmoud, A.I., Simpson, E., Hill, J.A., Richardson, J.A., Olson, E.N., and Sadek, H.A. (2011). Transient regenerative potential of the neonatal mouse heart. Science 331, 1078\u20131080.","journal-title":"Science"},{"key":"9223_CR65","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1177\/1074248412475158","volume":"18","author":"L. Portal","year":"2013","unstructured":"Portal, L., Martin, V., Assaly, R., d\u2019Anglemont de Tassigny, A., Michineau, S., Berdeaux, A., Ghaleh, B., and Pons, S. (2013). A model of hypoxiareoxygenation on isolated adult mouse cardiomyocytes. J Cardiovasc Pharmacol Ther 18, 367\u2013375.","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"9223_CR66","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1161\/CIRCULATIONAHA.117.028252","volume":"136","author":"G.A. Quaife-Ryan","year":"2017","unstructured":"Quaife-Ryan, G.A., Sim, C.B., Ziemann, M., Kaspi, A., Rafehi, H., Ramialison, M., El-Osta, A., Hudson, J.E., and Porrello, E.R. (2017). Multicellular transcriptional analysis of mammalian heart regeneration. Circulation 136, 1123\u20131139.","journal-title":"Circulation"},{"key":"9223_CR67","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1093\/cvr\/cvu047","volume":"102","author":"A.A. Ramkisoensing","year":"2014","unstructured":"Ramkisoensing, A.A., de Vries, A.A.F., Atsma, D.E., Schalij, M.J., and Pijnappels, D.A. (2014). Interaction between myofibroblasts and stem cells in the fibrotic heart: balancing between deterioration and regeneration. Cardiovasc Res 102, 224\u2013231.","journal-title":"Cardiovasc Res"},{"key":"9223_CR68","doi-asserted-by":"publisher","first-page":"2911","DOI":"10.1161\/01.CIR.0000101917.80668.E1","volume":"108","author":"T. Reffelmann","year":"2003","unstructured":"Reffelmann, T., Hale, S.L., Dow, J.S., and Kloner, R.A. (2003). No-reflow phenomenon persists long-term after ischemia\/reperfusion in the rat and predicts infarct expansion. Circulation 108, 2911\u20132917.","journal-title":"Circulation"},{"key":"9223_CR69","doi-asserted-by":"publisher","first-page":"G13","DOI":"10.1016\/0002-9149(93)90102-I","volume":"72","author":"K.A. Reimer","year":"1993","unstructured":"Reimer, K.A., Heide, R.S.V., and Richard, V.J. (1993). Reperfusion in acute myocardial infarction: effect of timing and modulating factors in experimental models. Am J Cardiol 72, G13\u2013G21.","journal-title":"Am J Cardiol"},{"key":"9223_CR70","first-page":"969","volume":"78","author":"P.J. Schwartz","year":"1988","unstructured":"Schwartz, P.J., Vanoli, E., Stramba-Badiale, M., De Ferrari, G.M., Billman, G.E., and Foreman, R.D. (1988). Autonomic mechanisms and sudden death. New insights from analysis of baroreceptor reflexes in conscious dogs with and without a myocardial infarction. Circulation 78, 969\u2013979.","journal-title":"New insights from analysis of baroreceptor reflexes in conscious dogs with and without a myocardial infarction. Circulation"},{"key":"9223_CR71","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1161\/CIRCRESAHA.111.249052","volume":"109","author":"V.F.M. Segers","year":"2011","unstructured":"Segers, V.F.M., and Lee, R.T. (2011). Biomaterials to enhance stem cell function in the heart. Circul Res 109, 910\u2013922.","journal-title":"Circul Res"},{"key":"9223_CR72","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1016\/j.jacc.2014.01.014","volume":"63","author":"I.M. Seropian","year":"2014","unstructured":"Seropian, I.M., Toldo, S., Van Tassell, B.W., and Abbate, A. (2014). Anti-inflammatory strategies for ventricular remodeling following ST-segment elevation acute myocardial infarction. J Am College Cardiol 63, 1593\u20131603.","journal-title":"J Am College Cardiol"},{"key":"9223_CR73","first-page":"173","volume":"27","author":"F. Solti","year":"1994","unstructured":"Solti, F., Lengyel, E., Jellinek, H., Schneider, F., Juhasz-Nagy, A., and Kekesi, V. (1994). Coronary arteriopathy after lymphatic blockade: an experimental study in dogs. Lymphology 27, 173\u2013180.","journal-title":"Lymphology"},{"key":"9223_CR74","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1161\/CIRCRESAHA.116.309916","volume":"119","author":"F.G. Spinale","year":"2016","unstructured":"Spinale, F.G., Frangogiannis, N.G., Hinz, B., Holmes, J.W., Kassiri, Z., and Lindsey, M.L. (2016). Crossing into the next frontier of cardiac extracellular matrix research. Circ Res 119, 1040\u20131045.","journal-title":"Circ Res"},{"key":"9223_CR75","doi-asserted-by":"publisher","first-page":"3221","DOI":"10.1161\/01.CIR.0000147233.10318.23","volume":"110","author":"M. Sun","year":"2004","unstructured":"Sun, M., Dawood, F., Wen, W.H., Chen, M., Dixon, I., Kirshenbaum, L.A., and Liu, P.P. (2004). Excessive tumor necrosis factor activation after infarction contributes to susceptibility of myocardial rupture and left ventricular dysfunction. Circulation 110, 3221\u20133228.","journal-title":"Circulation"},{"key":"9223_CR76","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1126\/science.1175202","volume":"325","author":"F.K. Swirski","year":"2009","unstructured":"Swirski, F.K., Nahrendorf, M., Etzrodt, M., Wildgruber, M., Cortez-Retamozo, V., Panizzi, P., Figueiredo, J.L., Kohler, R.H., Chudnovskiy, A., Waterman, P., Aikawa, E., Mempel, T.R., Libby, P., Weissleder, R., and Pittet, M.J. (2009). Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science 325, 612\u2013616.","journal-title":"Science"},{"key":"9223_CR77","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1093\/cvr\/cvp032","volume":"83","author":"G. Takemura","year":"2009","unstructured":"Takemura, G., Nakagawa, M., Kanamori, H., Minatoguchi, S., and Fujiwara, H. (2009). Benefits of reperfusion beyond infarct size limitation. Cardiovasc Res 83, 269\u2013276.","journal-title":"Cardiovasc Res"},{"key":"9223_CR78","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1161\/CIRCRESAHA.116.309959","volume":"120","author":"D.A. Taylor","year":"2017","unstructured":"Taylor, D.A., Chandler, A.M., Gobin, A.S., and Sampaio, L.C. (2017). Maximizing cardiac repair: should we focus on the cells or on the matrix? Circ Res 120, 30\u201332.","journal-title":"Circ Res"},{"key":"9223_CR79","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1093\/cvr\/cvs018","volume":"94","author":"L. Timmers","year":"2012","unstructured":"Timmers, L., Pasterkamp, G., de Hoog, V.C., Arslan, F., Appelman, Y., and de Kleijn, D.P.V. (2012). The innate immune response in reperfused myocardium. Cardiovasc Res 94, 276\u2013283.","journal-title":"Cardiovasc Res"},{"key":"9223_CR80","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.cardfail.2010.03.001","volume":"16","author":"K. Uemura","year":"2010","unstructured":"Uemura, K., Zheng, C., Li, M., Kawada, T., and Sugimachi, M. (2010). Early short-term vagal nerve stimulation attenuates cardiac remodeling after reperfused myocardial infarction. J Cardiac Failure 16, 689\u2013699.","journal-title":"J Cardiac Failure"},{"key":"9223_CR81","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/j.bbadis.2013.02.004","volume":"1832","author":"R. Vivar","year":"2013","unstructured":"Vivar, R., Humeres, C., Ayala, P., Olmedo, I., Catal\u00e1n, M., Garc\u00eda, L., Lavandero, S., and D\u00edaz-Araya, G. (2013). TGF-\u03b21 prevents simulated ischemia\/reperfusion-induced cardiac fibroblast apoptosis by activation of both canonical and non-canonical signaling pathways. Biochim Biophys Acta 1832, 754\u2013762.","journal-title":"Biochim Biophys Acta"},{"key":"9223_CR82","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.yjmcc.2014.01.015","volume":"69","author":"D.A. White","year":"2014","unstructured":"White, D.A., Su, Y., Kanellakis, P., Kiriazis, H., Morand, E.F., Bucala, R., Dart, A.M., Gao, X.M., and Du, X.J. (2014). Differential roles of cardiac and leukocyte derived macrophage migration inhibitory factor in inflammatory responses and cardiac remodelling post myocardial infarction. J Mol Cell Cardiol 69, 32\u201342.","journal-title":"J Mol Cell Cardiol"},{"key":"9223_CR83","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1161\/CIRCRESAHA.115.307465","volume":"117","author":"I.A. White","year":"2015","unstructured":"White, I.A., Gordon, J., Balkan, W., and Hare, J.M. (2015). Sympathetic reinnervation is required for mammalian cardiac regeneration. Circ Res 117, 990\u2013994.","journal-title":"Circ Res"},{"key":"9223_CR84","doi-asserted-by":"publisher","first-page":"H732","DOI":"10.1152\/ajpheart.00703.2015","volume":"310","author":"Y. Yu","year":"2016","unstructured":"Yu, Y., Wei, S.G., Zhang, Z.H., Weiss, R.M., and Felder, R.B. (2016). ERK1\/2 MAPK signaling in hypothalamic paraventricular nucleus contributes to sympathetic excitation in rats with heart failure after myocardial infarction. Am J Physiol Heart Circ Physiol 310, H732\u2013H739.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"9223_CR85","unstructured":"Zhu, Y., and Ai, D. (2014). Overview of vasculature. In: Vascilar Biology. E.D. Dong, and Y.Y. Zhang, eds. (Medical Publishing House of Peking University), PP. 9\u201327."}],"container-title":["Science China Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11427-017-9223-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-017-9223-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-017-9223-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T00:42:56Z","timestamp":1570668176000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11427-017-9223-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,23]]},"references-count":85,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["9223"],"URL":"https:\/\/doi.org\/10.1007\/s11427-017-9223-x","relation":{},"ISSN":["1674-7305","1869-1889"],"issn-type":[{"value":"1674-7305","type":"print"},{"value":"1869-1889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,23]]}}}