{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T17:39:39Z","timestamp":1789839579992,"version":"4.0.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T00:00:00Z","timestamp":1573516800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T00:00:00Z","timestamp":1573516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci. China Life Sci."],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1007\/s11427-018-9559-x","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T05:41:27Z","timestamp":1573796487000},"page":"290-300","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Decreasing intraocular pressure significantly improves retinal vessel density, cytoarchitecture and visual function in rodent oxygen induced retinopathy"],"prefix":"10.1007","volume":"63","author":[{"given":"Rui","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,12]]},"reference":[{"key":"9559_CR1","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.disamonth.2014.03.009","volume":"60","author":"MK Asano","year":"2014","unstructured":"Asano, M.K., and Dray, P.B. (2014). Retinopathy of prematurity. Dis Mon 60, 282\u2013291.","journal-title":"Dis Mon"},{"key":"9559_CR2","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1136\/bjo.38.7.385","volume":"38","author":"N Ashton","year":"1954","unstructured":"Ashton, N. (1954). Pathological basis of retrolental fibroplasia. Br J Ophthalmol 38, 385\u2013396.","journal-title":"Br J Ophthalmol"},{"key":"9559_CR3","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1136\/bjo.37.9.513","volume":"37","author":"N Ashton","year":"1953","unstructured":"Ashton, N., Ward, B., Serpell, G. (1953). Role of oxygen in the genesis of retrolental fibroplasia.; Ashton, N., Ward, B., and Serpell, G. ((1953))). Role of oxygen in the genesis of retrolental fibroplasia: a preliminary report. Br J Ophthalmol 37, 513\u2013520.","journal-title":"Br J Ophthalmol"},{"key":"9559_CR4","doi-asserted-by":"crossref","first-page":"48","DOI":"10.5694\/j.1326-5377.1951.tb109040.x","volume":"2","author":"K Campbell","year":"1951","unstructured":"Campbell, K. (1951). Intensive oxygen therapy as a possible cause of retrolental fibroplasia; a clinical approach. Med J Aust 2, 48.","journal-title":"Med J Aust"},{"key":"9559_CR5","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1007\/s00417-007-0661-y","volume":"245","author":"EJ Chung","year":"2007","unstructured":"Chung, E.J., Kim, J.H., Ahn, H.S., and Koh, H.J. (2007). Combination of laser photocoagulation and intravitreal bevacizumab (Avastin\u00ae) for aggressive zone I retinopathy of prematurity. Graefes Arch Clin Exp Ophthalmol 245, 1727\u20131730.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"9559_CR6","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1038\/nprot.2009.187","volume":"4","author":"KM Connor","year":"2009","unstructured":"Connor, K.M., Krah, N.M., Dennison, R.J., Aderman, C.M., Chen, J., Guerin, K.I., Sapieha, P., Stahl, A., Willett, K.L., and Smith, L.E.H. (2009). Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis. Nat Protoc 4, 1565\u20131573.","journal-title":"Nat Protoc"},{"key":"9559_CR7","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1001\/archopht.121.12.1684","volume":"121","author":"Early Treatment for Retinopathy of Prematurity Cooperative Group","year":"2003","unstructured":"Early Treatment for Retinopathy of Prematurity Cooperative Group. (2003). Revised indications for the treatment of retinopathy of prematurity: results of the early treatment for retinopathy of prematurity randomized trial. Arch Ophthalmol (Chicago, Ill: 1960) 121, 1684.","journal-title":"Arch Ophthalmol (Chicago, Ill: 1960)"},{"key":"9559_CR8","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1542\/peds.81.5.697","volume":"81","author":"F Elsas","year":"1988","unstructured":"Elsas, F., Botsford, J., Braune, K., Cassady, G., Jones, J., Kimble, J., Kline, L., Lampton, G., Witherspoon, D., and Young, M. (1988). Multicenter trial of cryotherapy for retinopathy of prematurity: preliminary results. Pediatrics 81, 697\u2013706.","journal-title":"Pediatrics"},{"key":"9559_CR9","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1001\/archopht.119.8.1110","volume":"119","author":"F Elsas","year":"2001","unstructured":"Elsas, F, Collins, M, Jones, J, Kimble, J, Kline, L, Witherspoon, D, Roth, A, Demorest, B, Gilbert, W, and Plotsky, D (2001). Multicenter trial of cryotherapy for retinopathy of prematurity. Arch Ophthalmol 119, 1110\u20131118.","journal-title":"Arch Ophthalmol"},{"key":"9559_CR10","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/cne.903610310","volume":"361","author":"T Euler","year":"1995","unstructured":"Euler, T., and W\u00e4ssle, H. (1995). Immunocytochemical identification of cone bipolar cells in the rat retina. J Comp Neurol 361, 461\u2013478.","journal-title":"J Comp Neurol"},{"key":"9559_CR11","first-page":"207","volume":"49","author":"JS Friedenwald","year":"1951","unstructured":"Friedenwald, J.S., Owens, W.C., and Owens, E.U. (1951). Retrolental fibroplasia in premature infants. III. The pathology of the disease. Trans Am Soc Ophthalmol Otolaryngol Allergy 49, 207\u2013234.","journal-title":"Trans Am Soc Ophthalmol Otolaryngol Allergy"},{"key":"9559_CR12","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/cne.10985","volume":"469","author":"KK Ghosh","year":"2004","unstructured":"Ghosh, K.K., Bujan, S., Haverkamp, S., Feigenspan, A., and W\u00e4ssle, H. (2004). Types of bipolar cells in the mouse retina. J Comp Neurol 469, 70\u201382.","journal-title":"J Comp Neurol"},{"key":"9559_CR13","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(08)60074-4","volume":"371","author":"RL Goldenberg","year":"2008","unstructured":"Goldenberg, R.L., Culhane, J.F., Iams, J.D., and Romero, R. (2008). Epidemiology and causes of preterm birth. Lancet 371, 75\u201384.","journal-title":"Lancet"},{"key":"9559_CR14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.901550102","volume":"155","author":"H Kolb","year":"1974","unstructured":"Kolb, H. (1974). The connections between horizontal cells and photoreceptors in the retina of the cat: electron microscopy of Golgi preparations. J Comp Neurol 155, 1\u201314.","journal-title":"J Comp Neurol"},{"key":"9559_CR15","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1001\/archopht.1946.00890210395001","volume":"36","author":"AC Krause","year":"1946","unstructured":"Krause, A.C. (1946). Congenital encephalo-ophthalmic dysplasia. Arch Ophthalmol 36, 387\u2013444.","journal-title":"Arch Ophthalmol"},{"key":"9559_CR16","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1007\/s00417-009-1116-4","volume":"247","author":"C Lange","year":"2009","unstructured":"Lange, C., Ehlken, C., Stahl, A., Martin, G., Hansen, L., and Agostini, H.T. (2009). Kinetics of retinal vaso-obliteration and neovascularisation in the oxygen-induced retinopathy (OIR) mouse model. Graefes Arch Clin Exp Ophthalmol 247, 1205\u20131211.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"9559_CR17","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1007\/s11427-018-9332-8","volume":"62","author":"L Liu","year":"2019","unstructured":"Liu, L., Li, X., Killer, H.E., Cao, K., Li, J., and Wang, N. (2019). Changes in retinal and choroidal morphology after cerebrospinal fluid pressure reduction: a Beijing iCOP study. Sci China Life Sci 62, 268\u2013271.","journal-title":"Sci China Life Sci"},{"key":"9559_CR18","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1007\/s00417-009-1077-7","volume":"247","author":"B Lorenz","year":"2009","unstructured":"Lorenz, B., Spasovska, K., Elflein, H., and Schneider, N. (2009). Wide-field digital imaging based telemedicine for screening for acute retinopathy of prematurity (ROP). Six-year results of a multicentre field study. Graefes Arch Clin Exp Ophthalmol 247, 1251\u20131262.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"9559_CR19","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1167\/iovs.03-0964","volume":"45","author":"TJ McGill","year":"2004","unstructured":"McGill, T.J., Douglas, R.M., Lund, R.D., and Prusky, G.T. (2004). Quantification of spatial vision in the Royal College of Surgeons rat. Invest Ophthalmol Vis Sci 45, 932\u2013936.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"9559_CR20","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/S0161-6420(91)32247-4","volume":"98","author":"JA McNamara","year":"1991","unstructured":"McNamara, J.A., Tasman, W., Brown, G.C., and Federman, J.L. (1991). Laser photocoagulation for stage 3+ retinopathy of prematurity. Ophthalmology 98, 576\u2013580.","journal-title":"Ophthalmology"},{"key":"9559_CR21","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1056\/NEJMoa1007374","volume":"364","author":"HA Mintz-Hittner","year":"2011","unstructured":"Mintz-Hittner, H.A., Kennedy, K.A., Chuang, A.Z., and Chuang, A.Z. (2011). Efficacy of intravitreal bevacizumab for stage 3+ retinopathy of prematurity. N Engl J Med 364, 603\u2013615.","journal-title":"N Engl J Med"},{"key":"9559_CR22","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/01.OPX.0000159367.23221.2D","volume":"82","author":"A Moskowitz","year":"2005","unstructured":"Moskowitz, A., Hansen, R., and Fulton, A. (2005). Early ametropia and rod photoreceptor function in retinopathy of prematurity. Optom Vis Sci 82, 307\u2013317.","journal-title":"Optom Vis Sci"},{"key":"9559_CR23","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1136\/bjo.2003.035154","volume":"88","author":"AR O\u2019Connor","year":"2004","unstructured":"O\u2019Connor, A.R., Stephenson, T.J., Johnson, A., Tobin, M.J., Ratib, S., Moseley, M., and Fielder, A.R. (2004). Visual function in low birthweight children. Br J Ophthalmol 88, 1149\u20131153.","journal-title":"Br J Ophthalmol"},{"key":"9559_CR24","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0002-9394(54)90845-4","volume":"38","author":"A Patz","year":"1954","unstructured":"Patz, A. (1954). Oxygen studies in retrolental fibroplasia. IV. Clinical and experimental observations. Am J Ophthalmol 38, 291\u2013308.","journal-title":"Am J Ophthalmol"},{"key":"9559_CR25","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/0002-9394(82)90297-5","volume":"94","author":"A Patz","year":"1982","unstructured":"Patz, A. (1982). Clinical and experimental studies on retinal neovascularization. Am J Ophthalmol 94, 715\u2013743.","journal-title":"Am J Ophthalmol"},{"key":"9559_CR26","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/0002-9394(53)91779-6","volume":"36","author":"A Patz","year":"1953","unstructured":"Patz, A., Eastham, A., Higginbotham, D.H., and Kleh, T. (1953). Oxygen studies in retrolental fibroplasia. II. The production of the microscopic changes of retrolental fibroplasia in experimental animals. Am J Ophthalmol 36, 1511\u20131522.","journal-title":"Am J Ophthalmol"},{"key":"9559_CR27","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/0002-9394(52)91140-9","volume":"35","author":"A Patz","year":"1952","unstructured":"Patz, A., Hoeck, L.E., and De La Cruz, E. (1952). Studies on the effect of high oxygen administration in retrolental fibroplasia. I. Nursery observations. Am J Ophthalmol 35, 1248\u20131253.","journal-title":"Am J Ophthalmol"},{"key":"9559_CR28","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1523\/JNEUROSCI.13-09-04091.1993","volume":"13","author":"L Peichl","year":"1993","unstructured":"Peichl, L., and Gonzalez-Soriano, J. (1993). Unexpected presence of neurofilaments in axon-bearing horizontal cells of the mammalian retina. J Neurosci 13, 4091\u20134100.","journal-title":"J Neurosci"},{"key":"9559_CR29","first-page":"576","volume":"34","author":"JS Penn","year":"1993","unstructured":"Penn, J.S., Tolman, B.L., and Lowery, L.A. (1993). Variable oxygen exposure causes preretinal neovascularization in the newborn rat. Invest Ophthalmol Vis Sci 34, 576\u2013585.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"9559_CR30","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1016\/S0042-6989(00)00081-X","volume":"40","author":"GT Prusky","year":"2000","unstructured":"Prusky, G.T., West, P.W.R., and Douglas, R.M. (2000). Behavioral assessment of visual acuity in mice and rats. Vis Res 40, 2201\u20132209.","journal-title":"Vis Res"},{"key":"9559_CR31","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1007\/s11427-018-9484-6","volume":"62","author":"L Qiao","year":"2019","unstructured":"Qiao, L., Zhang, X., Jan, C., Li, X., Li, M., and Wang, H. (2019). Macular retinal thickness and flow density change by optical coherence tomography angiography after posterior scleral reinforcement. Sci China Life Sci 62, 930\u2013936.","journal-title":"Sci China Life Sci"},{"key":"9559_CR32","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1167\/iovs.11-8484","volume":"53","author":"R Ren","year":"2012","unstructured":"Ren, R., Li, Y., Liu, Z., Liu, K., and He, S. (2012). Long-term rescue of rat retinal ganglion cells and visual function by AAV-mediated BDNF expression after acute elevation of intraocular pressure. Invest Ophthalmol Vis Sci 53, 1003\u20131011.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"9559_CR33","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/BF02482606","volume":"74","author":"B Ricci","year":"1990","unstructured":"Ricci, B. (1990). Oxygen-induced retinopathy in the rat model. Doc Ophthalmol 74, 171\u2013177.","journal-title":"Doc Ophthalmol"},{"key":"9559_CR34","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/BF00154877","volume":"77","author":"B Ricci","year":"1991","unstructured":"Ricci, B., Calogero, G., Caprilli, A., and Quaranta-Leoni, F.M. (1991). Reduced severity of oxygen-induced retinopathy in the newborn rat after topical administration of timolol maleate. Doc Ophthalmol 77, 47\u201356.","journal-title":"Doc Ophthalmol"},{"key":"9559_CR35","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1017\/S0952523800008610","volume":"13","author":"D Sandman","year":"1996","unstructured":"Sandman, D., Boycott, B.B., and Peichl, L. (1996). The horizontal cells of artiodactyl retinae: a comparison with Cajal\u2019s descriptions. Vis Neurosci 13, 735\u2013746.","journal-title":"Vis Neurosci"},{"key":"9559_CR36","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","volume":"9","author":"CA Schneider","year":"2012","unstructured":"Schneider, C.A., Rasband, W.S., and Eliceiri, K.W. (2012). NIH Image to ImageJ: 25 years of image analysis. Nat Methods 9, 671\u2013675.","journal-title":"Nat Methods"},{"key":"9559_CR37","doi-asserted-by":"crossref","first-page":"75","DOI":"10.4103\/0301-4738.29505","volume":"55","author":"PK Shah","year":"2007","unstructured":"Shah, P.K., Narendran, V., Tawansy, K.A., Raghuram, A., and Narendran, K. (2007). Intravitreal bevacizumab (Avastin) for post laser anterior segment ischemia in aggressive posterior retinopathy of prematurity. Ind J Ophthalmol 55, 75\u201376.","journal-title":"Ind J Ophthalmol"},{"key":"9559_CR38","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S1084-2756(03)00119-2","volume":"8","author":"LEH Smith","year":"2003","unstructured":"Smith, L.E.H. (2003). Pathogenesis of retinopathy of prematurity. Semin Neonatol 8, 469\u2013473.","journal-title":"Semin Neonatol"},{"key":"9559_CR39","first-page":"101","volume":"35","author":"LE Smith","year":"1994","unstructured":"Smith, L.E., Wesolowski, E., Mclellan, A., Kostyk, S.K., D\u2019amato, R., Sullivan, R., and D\u2019amore, P.A. (1994). Oxygen-induced retinopathy in the mouse. Invest Ophthalmol Vis Sci 35, 101\u2013111.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"9559_CR40","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1001\/jamapediatrics.2017.4838","volume":"172","author":"A Stahl","year":"2018","unstructured":"Stahl, A., Krohne, T.U., Eter, N., Oberacher-Velten, I., Guthoff, R., Meltendorf, S., Ehrt, O., Aisenbrey, S., Roider, J., Gerding, H., et al. (2018). Comparing alternative ranibizumab dosages for safety and efficacy in retinopathy of prematurity. JAMA Pediatr 172, 278\u2013286.","journal-title":"JAMA Pediatr"},{"key":"9559_CR41","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1523\/JNEUROSCI.06-04-01122.1986","volume":"6","author":"H Suzuki","year":"1986","unstructured":"Suzuki, H., and Pinto, L. (1986). Response properties of horizontal cells in the isolated retina of wild- type and pearl mutant mice. J Neurosci 6, 1122\u20131128.","journal-title":"J Neurosci"},{"key":"9559_CR42","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0014-4835(92)90090-F","volume":"55","author":"\u00c1 Sz\u00e9l","year":"1992","unstructured":"Sz\u00e9l, \u00c1., and R\u00f6hlich, P. (1992). Two cone types of rat retina detected by anti-visual pigment antibodies. Exp Eye Res 55, 47\u201352.","journal-title":"Exp Eye Res"},{"key":"9559_CR43","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s11427-018-9337-0","volume":"62","author":"X Wang","year":"2019","unstructured":"Wang, X., Shen, K., Lu, F., and He, S. (2019). Long-lasting impairments in rodent oxygen-induced retinopathy measured by retinal vessel density and visual function. Sci China Life Sci 62, 681\u2013690.","journal-title":"Sci China Life Sci"},{"key":"9559_CR44","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1007\/s11427-017-9140-8","volume":"61","author":"C Xin","year":"2018","unstructured":"Xin, C., Tian, N., Li, M., Wang, H., and Wang, N. (2018). Mechanism of the reconstruction of aqueous outflow drainage. Sci China Life Sci 61, 534\u2013540.","journal-title":"Sci China Life Sci"},{"key":"9559_CR45","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s11427-018-9374-2","volume":"62","author":"J Zhang","year":"2019","unstructured":"Zhang, J., Jia, H., Wang, J., Xiong, Y., Li, J., Li, X., Zhao, J., Zhang, X., You, Q., Zhu, G., et al. (2019). A novel deletion mutation, c.1296delT in the BCOR gene, is associated with oculo-facio-cardio-dental syndrome. Sci China Life Sci 62, 119\u2013125.","journal-title":"Sci China Life Sci"},{"key":"9559_CR46","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1007\/s11427-017-9261-9","volume":"61","author":"X Zhang","year":"2018","unstructured":"Zhang, X., Yuan, Q., and Gao, X. (2018). Assessment of the MT1-MMP expression level of different cell lines by the naked eye. Sci China Life Sci 61, 492\u2013500.","journal-title":"Sci China Life Sci"},{"key":"9559_CR47","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1007\/s11427-017-9106-6","volume":"60","author":"Y Zhou","year":"2017","unstructured":"Zhou, Y., Xiao, C., and Pu, M. (2017). High glucose levels impact visual response properties of retinal ganglion cells in C57 mice\u2014An in vitro physiological study. Sci China Life Sci 60, 1428\u20131435.","journal-title":"Sci China Life Sci"}],"container-title":["Science China Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-018-9559-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11427-018-9559-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-018-9559-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T09:29:43Z","timestamp":1664962183000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11427-018-9559-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,12]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["9559"],"URL":"https:\/\/doi.org\/10.1007\/s11427-018-9559-x","relation":{},"ISSN":["1674-7305","1869-1889"],"issn-type":[{"value":"1674-7305","type":"print"},{"value":"1869-1889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,12]]},"assertion":[{"value":"25 June 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The author(s) declare that they have no conflict of interest. All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest, or non-financial interest in the subject matter or materials discussed in this manuscript. All procedures performed in studies involving animals were in accordance with the ethical standards of the institution or practice at which the studies were conducted.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance and ethics"}}]}}