{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T05:32:07Z","timestamp":1794029527177,"version":"4.8.0"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:00:00Z","timestamp":1708473600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:00:00Z","timestamp":1708473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci. China Life Sci."],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1007\/s11427-023-2473-x","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T04:37:01Z","timestamp":1708663021000},"page":"733-744","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Slc43a2+ T cell metastasis from spleen to brain in RGNNV infected teleost"],"prefix":"10.1007","volume":"67","author":[{"given":"Qing","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minlin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiantao","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaowen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianze","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiwei","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,21]]},"reference":[{"key":"2473_CR1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1053\/j.semdp.2019.12.003","volume":"37","author":"NS Aguilera","year":"2020","unstructured":"Aguilera, N.S., and Auerbach, A. (2020). T-cell lymphoproliferative processes in the spleen. Semin Diagn Pathol 37, 47\u201356.","journal-title":"Semin Diagn Pathol"},{"key":"2473_CR2","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1002\/eji.200425864","volume":"35","author":"A Archambault","year":"2005","unstructured":"Archambault, A., Sim, J., Gimenez, M., and Russell, J. (2005). Defining antigen-dependent stages of T cell migration from the blood to the central nervous system parenchyma. Eur J Immunol 35, 1076\u20131085.","journal-title":"Eur J Immunol"},{"key":"2473_CR3","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.immuni.2018.02.012","volume":"48","author":"GR Bantug","year":"2018","unstructured":"Bantug, G.R., Fischer, M., Gr\u00e4hlert, J., Balmer, M.L., Unterstab, G., Develioglu, L., Steiner, R., Zhang, L., Costa, A.S.H., Gubser, P.M., et al. (2018). Mitochondria-endoplasmic reticulum contact sites function as immunometabolic hubs that orchestrate the rapid recall response of memory CD8+ T cells. Immunity 48, 542\u2013555.e6.","journal-title":"Immunity"},{"key":"2473_CR4","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/nature08478","volume":"462","author":"I Bartholom\u00e4us","year":"2009","unstructured":"Bartholom\u00e4us, I., Kawakami, N., Odoardi, F., Schl\u00e4ger, C., Miljkovic, D., Ellwart, J.W., Klinkert, W.E.F., Fl\u00fcgel-Koch, C., Issekutz, T.B., Wekerle, H., et al. (2009). Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions. Nature 462, 94\u201398.","journal-title":"Nature"},{"key":"2473_CR5","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/s41586-020-2682-1","volume":"585","author":"Y Bian","year":"2020","unstructured":"Bian, Y., Li, W., Kremer, D.M., Sajjakulnukit, P., Li, S., Crespo, J., Nwosu, Z.C., Zhang, L., Czerwonka, A., Paw\u0142owska, A., et al. (2020). Cancer SLC43A2 alters T cell methionine metabolism and histone methylation. Nature 585, 277\u2013282.","journal-title":"Nature"},{"key":"2473_CR6","doi-asserted-by":"publisher","first-page":"12002","DOI":"10.1074\/jbc.M408638200","volume":"280","author":"S Bodoy","year":"2005","unstructured":"Bodoy, S., Mart\u00edn, L., Zorzano, A., Palac\u00edn, M., Est\u00e9vez, R., and Bertran, J. (2005). Identification of LAT4, a novel amino acid transporter with system L activity. J Biol Chem 280, 12002\u201312011.","journal-title":"J Biol Chem"},{"key":"2473_CR7","doi-asserted-by":"publisher","first-page":"6202","DOI":"10.4049\/jimmunol.167.11.6202","volume":"167","author":"P Boudinot","year":"2001","unstructured":"Boudinot, P., Boubekeur, S., and Benmansour, A. (2001). Rhabdovirus infection induces public and private T cell responses in teleost fish. J Immunol 167, 6202\u20136209.","journal-title":"J Immunol"},{"key":"2473_CR8","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.fsi.2005.02.003","volume":"19","author":"T Bowden","year":"2005","unstructured":"Bowden, T., Cook, P., and Rombout, J. (2005). Development and function of the thymus in teleosts. Fish Shellfish Immunol 19, 413\u2013427.","journal-title":"Fish Shellfish Immunol"},{"key":"2473_CR9","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/nbt.4096","volume":"36","author":"A Butler","year":"2018","unstructured":"Butler, A., Hoffman, P., Smibert, P., Papalexi, E., and Satija, R. (2018). Integrating single-cell transcriptomic data across different conditions, technologies, and species. Nat Biotechnol 36, 411\u2013420.","journal-title":"Nat Biotechnol"},{"key":"2473_CR10","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1038\/nature22796","volume":"546","author":"JG Camp","year":"2017","unstructured":"Camp, J.G., Sekine, K., Gerber, T., Loeffler-Wirth, H., Binder, H., Gac, M., Kanton, S., Kageyama, J., Damm, G., Seehofer, D., et al. (2017). Multilineage communication regulates human liver bud development from pluripotency. Nature 546, 533\u2013538.","journal-title":"Nature"},{"key":"2473_CR11","series-title":"Methods in Molecular Biology","first-page":"171","volume-title":"Chemokines","author":"M Carson","year":"2010","unstructured":"Carson, M., and Wilson, E. (2010). Visualizing chemokine-dependent T cell activation and migration in response to central nervous system infection. In: Cardona, A., and Ubogu, E., eds. Chemokines. Methods in Molecular Biology. Totowa: Humana Press. 171\u2013183."},{"key":"2473_CR12","doi-asserted-by":"publisher","first-page":"eabo7649","DOI":"10.1126\/science.abo7649","volume":"380","author":"G Castellani","year":"2023","unstructured":"Castellani, G., Croese, T., Peralta Ramos, J.M., and Schwartz, M. (2023). Transforming the understanding of brain immunity. Science 380, eabo7649.","journal-title":"Science"},{"key":"2473_CR13","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1128\/JVI.02523-14","volume":"89","author":"JS Chang","year":"2015","unstructured":"Chang, J.S, and Chi, S.C. (2015). GHSC70 is involved in the cellular entry of nervous necrosis virus. J Virol 89, 61\u201370.","journal-title":"J Virol"},{"key":"2473_CR14","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/s41577-019-0203-y","volume":"20","author":"NM Chapman","year":"2020","unstructured":"Chapman, N.M., Boothby, M.R., and Chi, H. (2020). Metabolic coordination of T cell quiescence and activation. Nat Rev Immunol 20, 55\u201370.","journal-title":"Nat Rev Immunol"},{"key":"2473_CR15","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1093\/toxsci\/kfy246","volume":"167","author":"L Chen","year":"2019","unstructured":"Chen, L., and Wang, H. (2019). Nicotine promotes human papillomavirus (HPV)-immortalized cervical epithelial cells (H8) proliferation by activating RPS27a-Mdm2-P53 pathway in vitro. Toxicol Sci 167, 408\u2013418.","journal-title":"Toxicol Sci"},{"key":"2473_CR16","doi-asserted-by":"publisher","first-page":"6588","DOI":"10.1128\/IAI.69.11.6588-6596.2001","volume":"69","author":"A Cordeiro-Da-Silva","year":"2001","unstructured":"Cordeiro-Da-Silva, A., Borges, M., Guilvard, E., and Ouaissi, A. (2001). Dual role of the Leishmania major ribosomal protein S3a homologue in regulation of T- and B-cell activation. Infect Immun 69, 6588\u20136596.","journal-title":"Infect Immun"},{"key":"2473_CR17","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.fsi.2016.03.033","volume":"53","author":"JZ Costa","year":"2016","unstructured":"Costa, J.Z., and Thompson, K.D. (2016). Understanding the interaction between Betanodavirus and its host for the development of prophylactic measures for viral encephalopathy and retinopathy. Fish Shellfish Immunol 53, 35\u201349.","journal-title":"Fish Shellfish Immunol"},{"key":"2473_CR18","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/nrn2297","volume":"9","author":"R Dantzer","year":"2008","unstructured":"Dantzer, R., O\u2019Connor, J.C., Freund, G.G., Johnson, R.W., and Kelley, K.W. (2008). From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 9, 46\u201356.","journal-title":"Nat Rev Neurosci"},{"key":"2473_CR19","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s13195-019-0524-x","volume":"11","author":"JL Del-Aguila","year":"2019","unstructured":"Del-Aguila, J.L., Li, Z., Dube, U., Mihindukulasuriya, K.A., Budde, J.P., Fernandez, M. V., Ibanez, L., Bradley, J., Wang, F., Bergmann, K., et al. (2019). A single-nuclei RNA sequencing study of mendelian and sporadic AD in the human brain. Alzheimers Res Ther 11, 71.","journal-title":"Alzheimers Res Ther"},{"key":"2473_CR20","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.vetimm.2010.11.005","volume":"140","author":"CL Fellman","year":"2011","unstructured":"Fellman, C.L., Stokes, J.V., Archer, T.M., Pinchuk, L.M., Lunsford, K.V., and Mackin, A.J. (2011). Cyclosporine A affects the in vitro expression of T cell activation-related molecules and cytokines in dogs. Vet Immunol Immunopathol 140, 175\u2013180.","journal-title":"Vet Immunol Immunopathol"},{"key":"2473_CR21","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1038\/s41586-020-2886-4","volume":"587","author":"Z Fitzpatrick","year":"2020","unstructured":"Fitzpatrick, Z., Frazer, G., Ferro, A., Clare, S., Bouladoux, N., Ferdinand, J., Tuong, Z. K., Negro-Demontel, M.L., Kumar, N., Suchanek, O., et al. (2020). Gut-educated IgA plasma cells defend the meningeal venous sinuses. Nature 587, 472\u2013476.","journal-title":"Nature"},{"key":"2473_CR22","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1172\/JCI76012","volume":"125","author":"VA Gerriets","year":"2015","unstructured":"Gerriets, V.A., Kishton, R.J., Nichols, A.G., Macintyre, A.N., Inoue, M., Ilkayeva, O., Winter, P.S., Liu, X., Priyadharshini, B., Slawinska, M.E., et al. (2015). Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. J Clin Invest 125, 194\u2013207.","journal-title":"J Clin Invest"},{"key":"2473_CR23","doi-asserted-by":"publisher","first-page":"726421","DOI":"10.3389\/fimmu.2021.726421","volume":"12","author":"EN Goddery","year":"2021","unstructured":"Goddery, E.N., Fain, C.E., Lipovsky, C.G., Ayasoufi, K., Yokanovich, L.T., Malo, C.S., Khadka, R.H., Tritz, Z.P., Jin, F., Hansen, M.J., et al. (2021). Microglia and perivascular macrophages act as antigen presenting cells to promote CD8 T cell infiltration of the brain. Front Immunol 12, 726421.","journal-title":"Front Immunol"},{"key":"2473_CR24","doi-asserted-by":"publisher","first-page":"559555","DOI":"10.3389\/fimmu.2020.559555","volume":"11","author":"NC Guslund","year":"2020","unstructured":"Guslund, N.C., Solbakken, M.H., Brieuc, M.S.O., Jentoft, S., Jakobsen, K.S., and Qiao, S. W. (2020). Single-cell transcriptome profiling of immune cell repertoire of the Atlantic cod which naturally lacks the major histocompatibility class II system. Front Immunol 11, 559555.","journal-title":"Front Immunol"},{"key":"2473_CR25","doi-asserted-by":"publisher","first-page":"737332","DOI":"10.3389\/fimmu.2021.737332","volume":"12","author":"L Huang","year":"2021","unstructured":"Huang, L., Qiao, Y., Xu, W., Gong, L., He, R., Qi, W., Gao, Q., Cai, H., Grossart, H.P., and Yan, Q. (2021). Full-length transcriptome: a reliable alternative for single-cell RNA-seq analysis in the spleen of teleost without reference genome. Front Immunol 12, 737332.","journal-title":"Front Immunol"},{"key":"2473_CR26","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1128\/JVI.78.3.1256-1262.2004","volume":"78","author":"T Iwamoto","year":"2004","unstructured":"Iwamoto, T., Okinaka, Y., Mise, K., Mori, K.I., Arimoto, M., Okuno, T., and Nakai, T. (2004). Identification of host-specificity determinants in betanodaviruses by using reassortants between striped Jack nervous necrosis virus and sevenband grouper nervous necrosis virus. J Virol 78, 1256\u20131262.","journal-title":"J Virol"},{"key":"2473_CR27","doi-asserted-by":"publisher","first-page":"4476","DOI":"10.4049\/jimmunol.180.7.4476","volume":"180","author":"SR Jacobs","year":"2008","unstructured":"Jacobs, S.R., Herman, C.E., MacIver, N.J., Wofford, J.A., Wieman, H.L., Hammen, J.J., and Rathmell, J.C. (2008). Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways. J Immunol 180, 4476\u20134486.","journal-title":"J Immunol"},{"key":"2473_CR28","doi-asserted-by":"publisher","first-page":"743421","DOI":"10.3389\/fcell.2021.743421","volume":"9","author":"M Jiang","year":"2021","unstructured":"Jiang, M., Xiao, Y., E, W., Ma, L., Wang, J., Chen, H., Gao, C., Liao, Y., Guo, Q., Peng, J., et al. (2021). Characterization of the zebrafish cell landscape at single-cell resolution. Front Cell Dev Biol 9, 743421.","journal-title":"Front Cell Dev Biol"},{"key":"2473_CR29","doi-asserted-by":"publisher","first-page":"2805","DOI":"10.3389\/fimmu.2019.02805","volume":"10","author":"Y Jin","year":"2019","unstructured":"Jin, Y., Jia, K., Zhang, W., Xiang, Y., Jia, P., Liu, W., and Yi, M. (2019). Zebrafish TRIM25 promotes innate immune response to RGNNV infection by targeting 2CARD and RD regions of RIG-I for K63-linked ubiquitination. Front Immunol 10, 2805.","journal-title":"Front Immunol"},{"key":"2473_CR30","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1146\/annurev-cellbio-092910-154008","volume":"27","author":"U Koch","year":"2011","unstructured":"Koch, U., and Radtke, F. (2011). Mechanisms of T cell development and transformation. Annu Rev Cell Dev Biol 27, 539\u2013562.","journal-title":"Annu Rev Cell Dev Biol"},{"key":"2473_CR31","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1111\/j.1469-7580.2010.01305.x","volume":"217","author":"EO Koppang","year":"2010","unstructured":"Koppang, E.O., Fischer, U., Moore, L., Tranulis, M.A., Dijkstra, J.M., K\u00f6llner, B., Aune, L., Jirillo, E., and Hordvik, I. (2010). Salmonid T cells assemble in the thymus, spleen and in novel interbranchial lymphoid tissue. J Anatomy 217, 728\u2013739.","journal-title":"J Anatomy"},{"key":"2473_CR32","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1016\/j.dci.2011.03.004","volume":"35","author":"KJ Laing","year":"2011","unstructured":"Laing, K.J., and Hansen, J.D. (2011). Fish T cells: Recent advances through genomics. Dev Comp Immunol 35, 1282\u20131295.","journal-title":"Dev Comp Immunol"},{"key":"2473_CR33","doi-asserted-by":"publisher","first-page":"863096","DOI":"10.3389\/fimmu.2022.863096","volume":"13","author":"R Lama","year":"2022","unstructured":"Lama, R., Pereiro, P., Figueras, A., and Novoa, B. (2022). Zebrafish as a vertebrate model for studying nodavirus infections. Front Immunol 13, 863096.","journal-title":"Front Immunol"},{"key":"2473_CR34","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1093\/intimm\/dxh112","volume":"16","author":"MS Lee","year":"2004","unstructured":"Lee, M.S., Hanspers, K., Barker, C.S., Korn, A.P., and McCune, J.M. (2004). Gene expression profiles during human CD4+ T cell differentiation. Int Immunol 16, 1109\u20131124.","journal-title":"Int Immunol"},{"key":"2473_CR35","doi-asserted-by":"publisher","first-page":"eaau6085","DOI":"10.1126\/sciimmunol.aau6085","volume":"4","author":"SM Lewis","year":"2019","unstructured":"Lewis, S.M., Williams, A., and Eisenbarth, S.C. (2019). Structure and function of the immune system in the spleen. Sci Immunol 4, eaau6085.","journal-title":"Sci Immunol"},{"key":"2473_CR36","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.fsi.2020.04.021","volume":"102","author":"C Li","year":"2020","unstructured":"Li, C., Wei, J., Zhang, X., Sun, M., Wu, S., and Qin, Q. (2020). Fish TRAF2 promotes innate immune response to RGNNV infection. Fish Shellfish Immunol 102, 108\u2013116.","journal-title":"Fish Shellfish Immunol"},{"key":"2473_CR37","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1007\/s11427-020-1712-4","volume":"64","author":"Y Li","year":"2021","unstructured":"Li, Y., Xiao, T., and Zou, J. (2021). Fish TNF and TNF receptors. Sci China Life Sci 64, 196\u2013220.","journal-title":"Sci China Life Sci"},{"key":"2473_CR38","doi-asserted-by":"publisher","first-page":"7610","DOI":"10.1038\/s41467-022-35338-7","volume":"13","author":"Y Liu","year":"2022","unstructured":"Liu, Y., Qu, M., Jiang, H., Schneider, R., Qin, G., Luo, W., Yu, H., Zhang, B., Wang, X., Zhang, Y., et al. (2022). Immunogenetic losses co-occurred with seahorse male pregnancy and mutation in tlx1 accompanied functional asplenia. Nat Commun 13, 7610.","journal-title":"Nat Commun"},{"key":"2473_CR39","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak, K.J., and Schmittgen, T.D. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method. Methods 25, 402\u2013408.","journal-title":"Methods"},{"key":"2473_CR40","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1016\/j.molimm.2007.07.018","volume":"45","author":"MW Lu","year":"2008","unstructured":"Lu, M.W., Chao, Y.M., Guo, T.C., Santi, N., Evensen, \u00d8., Kasani, S.K., Hong, J.R., and Wu, J.L. (2008). The interferon response is involved in nervous necrosis virus acute and persistent infection in zebrafish infection model. Mol Immunol 45, 1146\u20131152.","journal-title":"Mol Immunol"},{"key":"2473_CR41","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s13059-019-1662-y","volume":"20","author":"ATL Lun","year":"2019","unstructured":"Lun, A.T.L., Riesenfeld, S., Andrews, T., Dao, T.P., Gomes, T., and Marioni, J.C. (2019). EmptyDrops: distinguishing cells from empty droplets in droplet-based single-cell RNA sequencing data. Genome Biol 20, 63.","journal-title":"Genome Biol"},{"key":"2473_CR42","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.cels.2019.03.003","volume":"8","author":"CS McGinnis","year":"2019","unstructured":"McGinnis, C.S., Murrow, L.M., and Gartner, Z.J. (2019). DoubletFinder: doublet detection in single-cell RNA sequencing data using artificial nearest neighbors. Cell Syst 8, 329\u2013337.e4.","journal-title":"Cell Syst"},{"key":"2473_CR43","doi-asserted-by":"publisher","first-page":"640","DOI":"10.3390\/biology4040640","volume":"4","author":"T Nakanishi","year":"2015","unstructured":"Nakanishi, T., Shibasaki, Y., and Matsuura, Y. (2015). T Cells in Fish. Biology 4, 640\u2013663.","journal-title":"Biology"},{"key":"2473_CR44","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.3389\/fimmu.2020.01977","volume":"11","author":"L Nazerai","year":"2020","unstructured":"Nazerai, L., Sch\u00f8ller, A.S., Bassi, M.R., Buus, S., Stryhn, A., Christensen, J.P., and Thomsen, A.R. (2020). Effector CD8 T cell-dependent Zika virus control in the CNS: a matter of time and numbers. Front Immunol 11, 1977.","journal-title":"Front Immunol"},{"key":"2473_CR45","doi-asserted-by":"publisher","first-page":"5170","DOI":"10.1016\/j.ygeno.2020.09.031","volume":"112","author":"J Niu","year":"2020","unstructured":"Niu, J., Huang, Y., Liu, X., Zhang, Z., Tang, J., Wang, B., Lu, Y., Cai, J., and Jian, J. (2020). Single-cell RNA-seq reveals different subsets of non-specific cytotoxic cells in teleost. Genomics 112, 5170\u20135179.","journal-title":"Genomics"},{"key":"2473_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jneuroim.2018.05.007","volume":"321","author":"BT Noble","year":"2018","unstructured":"Noble, B.T., Brennan, F.H., and Popovich, P.G. (2018). The spleen as a neuroimmune interface after spinal cord injury. J Neuroimmunol 321, 1\u201311.","journal-title":"J Neuroimmunol"},{"key":"2473_CR47","doi-asserted-by":"publisher","first-page":"2339","DOI":"10.1111\/febs.12786","volume":"281","author":"N Nosrati","year":"2014","unstructured":"Nosrati, N., Kapoor, N.R., and Kumar, V. (2014). Combinatorial action of transcription factors orchestrates cell cycle-dependent expression of the ribosomal protein genes and ribosome biogenesis. FEBS J 281, 2339\u20132352.","journal-title":"FEBS J"},{"key":"2473_CR48","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.molimm.2007.04.016","volume":"45","author":"L Poisa-Beiro","year":"2008","unstructured":"Poisa-Beiro, L., Dios, S., Montes, A., Aranguren, R., Figueras, A., and Novoa, B. (2008). Nodavirus increases the expression of Mx and inflammatory cytokines in fish brain. Mol Immunol 45, 218\u2013225.","journal-title":"Mol Immunol"},{"key":"2473_CR49","doi-asserted-by":"publisher","first-page":"3387","DOI":"10.1158\/0008-5472.CAN-15-2698","volume":"76","author":"S Rao","year":"2016","unstructured":"Rao, S., Cai, K.Q., Stadanlick, J.E., Greenberg-Kushnir, N., Solanki-Patel, N., Lee, S.Y., Fahl, S.P., Testa, J.R., and Wiest, D.L. (2016). Ribosomal protein Rpl22 controls the dissemination of T-cell lymphoma. Cancer Res 76, 3387\u20133396.","journal-title":"Cancer Res"},{"key":"2473_CR50","doi-asserted-by":"publisher","first-page":"2.3","DOI":"10.1145\/1963190.1970376","volume":"16","author":"R Rotta","year":"2011","unstructured":"Rotta, R., and Noack, A. (2011). Multilevel local search algorithms for modularity clustering. ACM J Exp Algorithm 16, 2.3.","journal-title":"ACM J Exp Algorithm"},{"key":"2473_CR51","doi-asserted-by":"publisher","first-page":"e202201663","DOI":"10.26508\/lsa.202201663","volume":"5","author":"N Saini","year":"2022","unstructured":"Saini, N., Naaz, A., Metur, S.P., Gahlot, P., Walvekar, A., Dutta, A., Davathamizhan, U., Sarin, A., and Laxman, S. (2022). Methionine uptake via the SLC43A2 transporter is essential for regulatory T-cell survival. Life Sci Alliance 5, e202201663.","journal-title":"Life Sci Alliance"},{"key":"2473_CR52","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/nature16939","volume":"530","author":"C Schl\u00e4ger","year":"2016","unstructured":"Schl\u00e4ger, C., K\u00f6rner, H., Krueger, M., Vidoli, S., Haberl, M., Mielke, D., Brylla, E., Issekutz, T., Caba\u00f1as, C., Nelson, P.J., et al. (2016). Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid. Nature 530, 349\u2013353.","journal-title":"Nature"},{"key":"2473_CR53","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1124\/pr.118.015735","volume":"72","author":"T Schumann","year":"2020","unstructured":"Schumann, T., K\u00f6nig, J., Henke, C., Willmes, D., Bornstein, S., Jordan, J., Fromm, M., and Birkenfeld, A. (2020). Solute carrier transporters as potential targets for the treatment of metabolic disease. Pharmacol Rev 72, 343\u2013379.","journal-title":"Pharmacol Rev"},{"key":"2473_CR54","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.1016\/j.immuni.2021.06.002","volume":"54","author":"M Schwabenland","year":"2021","unstructured":"Schwabenland, M., Sali\u00e9, H., Tanevski, J., Killmer, S., Lago, M.S., Schlaak, A.E., Mayer, L., Matschke, J., P\u00fcschel, K., Fitzek, A., et al. (2021). Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions. Immunity 54, 1594\u20131610.e11.","journal-title":"Immunity"},{"key":"2473_CR55","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1038\/ni.2556","volume":"14","author":"LV Sinclair","year":"2013","unstructured":"Sinclair, L.V., Rolf, J., Emslie, E., Shi, Y.B., Taylor, P.M., and Cantrell, D.A. (2013). Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation. Nat Immunol 14, 500\u2013508.","journal-title":"Nat Immunol"},{"key":"2473_CR56","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.dci.2013.07.014","volume":"43","author":"T Somamoto","year":"2014","unstructured":"Somamoto, T., Koppang, E.O., and Fischer, U. (2014). Antiviral functions of CD8+ cytotoxic T cells in teleost fish. Dev Comp Immunol 43, 197\u2013204.","journal-title":"Dev Comp Immunol"},{"key":"2473_CR57","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/j.bbrc.2014.03.086","volume":"446","author":"H Wang","year":"2014","unstructured":"Wang, H., Yu, J., Zhang, L., Xiong, Y., Chen, S., Xing, H., Tian, Z., Tang, K., Wei, H., Rao, Q., et al. (2014). RPS27a promotes proliferation, regulates cell cycle progression and inhibits apoptosis of leukemia cells. Biochem Biophys Res Commun 446, 1204\u20131210.","journal-title":"Biochem Biophys Res Commun"},{"key":"2473_CR58","doi-asserted-by":"publisher","first-page":"e1009665","DOI":"10.1371\/journal.ppat.1009665","volume":"17","author":"Q Wang","year":"2021","unstructured":"Wang, Q., Peng, C., Yang, M., Huang, F., Duan, X., Wang, S., Cheng, H., Yang, H., Zhao, H., and Qin, Q. (2021a). Single-cell RNA-seq landscape midbrain cell responses to red spotted grouper nervous necrosis virus infection. PLoS Pathog 17, e1009665.","journal-title":"PLoS Pathog"},{"key":"2473_CR59","doi-asserted-by":"publisher","first-page":"2784","DOI":"10.1016\/j.immuni.2021.09.016","volume":"54","author":"Y Wang","year":"2021","unstructured":"Wang, Y., Chen, D., Xu, D., Huang, C., Xing, R., He, D., and Xu, H. (2021b). Early developing B cells undergo negative selection by central nervous system-specific antigens in the meninges. Immunity 54, 2784\u20132794.e6.","journal-title":"Immunity"},{"key":"2473_CR60","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.brainresbull.2022.02.008","volume":"182","author":"Y Wei","year":"2022","unstructured":"Wei, Y., Wang, T., Liao, L., Fan, X., Chang, L., and Hashimoto, K. (2022). Brain-spleen axis in health and diseases: A review and future perspective. Brain Res Bull 182, 130\u2013140.","journal-title":"Brain Res Bull"},{"key":"2473_CR61","doi-asserted-by":"publisher","first-page":"2629","DOI":"10.1007\/s11427-022-2312-1","volume":"66","author":"B Wu","year":"2023","unstructured":"Wu, B., Gao, X., Hu, M., Hu, J., Lan, T., Xue, T., Xu, W., Zhu, C., Yuan, Y., Zheng, J., et al. (2023). Distinct and shared endothermic strategies in the heat producing tissues of tuna and other teleosts. Sci China Life Sci 66, 2629\u20132645.","journal-title":"Sci China Life Sci"},{"key":"2473_CR62","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.molimm.2017.02.015","volume":"85","author":"J Xing","year":"2017","unstructured":"Xing, J., Ma, J., Tang, X., Sheng, X., and Zhan, W. (2017). Characterizations of CD4-1, CD4-2 and CD8\u03b2 T cell subpopulations in peripheral blood leucocytes, spleen and head kidney of Japanese flounder (Paralichthys olivaceus). Mol Immunol 85, 155\u2013165.","journal-title":"Mol Immunol"},{"key":"2473_CR63","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1016\/j.immuni.2013.09.015","volume":"39","author":"K Yang","year":"2013","unstructured":"Yang, K., Shrestha, S., Zeng, H., Karmaus, P.W.F., Neale, G., Vogel, P., Guertin, D.A., Lamb, R.F., and Chi, H. (2013). T cell exit from quiescence and differentiation into Th2 cells depend on raptor-mTORC1-mediated metabolic reprogramming. Immunity 39, 1043\u20131056.","journal-title":"Immunity"},{"key":"2473_CR64","doi-asserted-by":"publisher","first-page":"e1008668","DOI":"10.1371\/journal.ppat.1008668","volume":"16","author":"W Zhang","year":"2020","unstructured":"Zhang, W., Jia, K., Jia, P., Xiang, Y., Lu, X., Liu, W., and Yi, M. (2020). Marine medaka heat shock protein 90ab1 is a receptor for red-spotted grouper nervous necrosis virus and promotes virus internalization through clathrin-mediated endocytosis. PLoS Pathog 16, e1008668.","journal-title":"PLoS Pathog"},{"key":"2473_CR65","doi-asserted-by":"publisher","first-page":"660","DOI":"10.3389\/fmicb.2020.00660","volume":"11","author":"L Zhou","year":"2020","unstructured":"Zhou, L., Wang, S., Yu, Q., Wei, S., Liu, M., Wei, J., Huang, Y., Huang, X., Li, P., and Qin, Q. (2020). Characterization of novel aptamers specifically directed to red-spotted grouper nervous necrosis virus (RGNNV)-infected cells for mediating targeted siRNA delivery. Front Microbiol 11, 660.","journal-title":"Front Microbiol"},{"key":"2473_CR66","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.dci.2012.04.001","volume":"39","author":"L Zhu","year":"2013","unstructured":"Zhu, L., Nie, L., Zhu, G., Xiang, L., and Shao, J. (2013). Advances in research of fish immune-relevant genes: A comparative overview of innate and adaptive immunity in teleosts. Dev Comp Immunol 39, 39\u201362.","journal-title":"Dev Comp Immunol"}],"container-title":["Science China Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-023-2473-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11427-023-2473-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-023-2473-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T11:15:58Z","timestamp":1712315758000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11427-023-2473-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,21]]},"references-count":66,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["2473"],"URL":"https:\/\/doi.org\/10.1007\/s11427-023-2473-x","relation":{},"ISSN":["1674-7305","1869-1889"],"issn-type":[{"value":"1674-7305","type":"print"},{"value":"1869-1889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,21]]},"assertion":[{"value":"30 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The author(s) declare that they have no conflict of interest. All animal experiments were carried out in strict accordance with the guidelines and regulations of the Animal Research and Ethics Committees of South China Agriculture University.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance and ethics"}}]}}