{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:43:47Z","timestamp":1789580627359,"version":"build-2803163510"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci. China Life Sci."],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1007\/s11427-023-2527-5","type":"journal-article","created":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T08:01:57Z","timestamp":1716019317000},"page":"1601-1619","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["LncRNA CCRR maintains Ca2+ homeostasis against myocardial infarction through the FTO-SERCA2a pathway"],"prefix":"10.1007","volume":"67","author":[{"given":"Hua","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Xuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huishan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomeng","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijia","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieru","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwei","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiufang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feihan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baofeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,16]]},"reference":[{"key":"2527_CR1","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1002\/ejhf.1672","volume":"22","author":"T Berulava","year":"2020","unstructured":"Berulava, T., Buchholz, E., Elerdashvili, V., Pena, T., Islam, M.R., Lbik, D., Mohamed, B.A., Renner, A., von Lewinski, D., Sacherer, M., et al. (2020). Changes in m6A RNA methylation contribute to heart failure progression by modulating translation. Eur J Heart Fail 22, 54\u201366.","journal-title":"Eur J Heart Fail"},{"key":"2527_CR2","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1161\/01.RES.0000077045.84609.9F","volume":"92","author":"PB Bushdid","year":"2003","unstructured":"Bushdid, P.B., Osinska, H., Waclaw, R.R., Molkentin, J.D., and Yutzey, K.E. (2003). NFATc3 and NFATc4 are required for cardiac development and mitochondrial function. Circ Res 92, 1305\u20131313.","journal-title":"Circ Res"},{"key":"2527_CR3","doi-asserted-by":"publisher","first-page":"e95499","DOI":"10.1371\/journal.pone.0095499","volume":"9","author":"L Carnevali","year":"2014","unstructured":"Carnevali, L., Graiani, G., Rossi, S., Al Banchaabouchi, M., Macchi, E., Quaini, F., Rosenthal, N., and Sgoifo, A. (2014). Signs of cardiac autonomic imbalance and proarrhythmic remodeling in FTO deficient mice. PLoS ONE 9, e95499.","journal-title":"PLoS ONE"},{"key":"2527_CR4","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1038\/ni.3771","volume":"18","author":"YG Chen","year":"2017","unstructured":"Chen, Y.G., Satpathy, A.T., and Chang, H.Y. (2017). Gene regulation in the immune system by long noncoding RNAs. Nat Immunol 18, 962\u2013972.","journal-title":"Nat Immunol"},{"key":"2527_CR5","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1038\/ng.713","volume":"42","author":"C Church","year":"2010","unstructured":"Church, C., Moir, L., McMurray, F., Girard, C., Banks, G.T., Teboul, L., Wells, S., Br\u00fcning, J.C., Nolan, P.M., Ashcroft, F.M., et al. (2010). Overexpression of Fto leads to increased food intake and results in obesity. Nat Genet 42, 1086\u20131092.","journal-title":"Nat Genet"},{"key":"2527_CR6","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.1161\/CIRCULATIONAHA.111.071480","volume":"126","author":"MJ Cutler","year":"2012","unstructured":"Cutler, M.J., Wan, X., Plummer, B.N., Liu, H., Deschenes, I., Laurita, K.R., Hajjar, R.J., and Rosenbaum, D.S. (2012). Targeted sarcoplasmic reticulum Ca2+ ATPase 2a gene delivery to restore electrical stability in the failing heart. Circulation 126, 2095\u20132104.","journal-title":"Circulation"},{"key":"2527_CR7","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1093\/cvr\/cvab044","volume":"118","author":"C de Lucia","year":"2022","unstructured":"de Lucia, C., Grisanti, L.A., Borghetti, G., Piedepalumbo, M., Ibetti, J., Lucchese, A.M., Barr, E.W., Roy, R., Okyere, A.D., Murphy, H.C., et al. (2022). G protein-coupled receptor kinase 5 (GRK5) contributes to impaired cardiac function and immune cell recruitment in post-ischemic heart failure. Cardiovasc Res 118, 169\u2013183.","journal-title":"Cardiovasc Res"},{"key":"2527_CR8","doi-asserted-by":"publisher","first-page":"2423","DOI":"10.1113\/EP089901","volume":"106","author":"W Deng","year":"2021","unstructured":"Deng, W., Jin, Q., and Li, L. (2021). Protective mechanism of demethylase fat mass and obesity-associated protein in energy metabolism disorder of hypoxia-reoxygenation-induced cardiomyocytes. Exp Physiol 106, 2423\u20132433.","journal-title":"Exp Physiol"},{"key":"2527_CR9","doi-asserted-by":"publisher","first-page":"640","DOI":"10.3390\/biomedicines10030640","volume":"10","author":"L Fassina","year":"2022","unstructured":"Fassina, L., Assenza, M.R., Miragoli, M., Isidori, A.M., Naro, F., and Barbagallo, F. (2022). Cell shortening and calcium homeostasis analysis in adult cardiomyocytes via a new software tool. Biomedicines 10, 640.","journal-title":"Biomedicines"},{"key":"2527_CR10","doi-asserted-by":"publisher","first-page":"10731","DOI":"10.1074\/jbc.RA117.001298","volume":"293","author":"KJ Faulds","year":"2018","unstructured":"Faulds, K.J., Egelston, J.N., Sedivy, L.J., Mitchell, M.K., Garimella, S., Kozlowski, H., D\u2019Alessandro, A., Hansen, K.C., Balsbaugh, J.L., and Phiel, C.J. (2018). Glycogen synthase kinase-3 (GSK-3) activity regulates mRNA methylation in mouse embryonic stem cells. J Biol Chem 293, 10731\u201310743.","journal-title":"J Biol Chem"},{"key":"2527_CR11","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.hlc.2020.09.938","volume":"30","author":"H Fu","year":"2021","unstructured":"Fu, H., Shuai, W., Kong, B., Jiang, X., and Huang, H. (2021). MD1 depletion predisposes to ventricular arrhythmias in the setting of myocardial infarction. Heart Lung Circ 30, 869\u2013881.","journal-title":"Heart Lung Circ"},{"key":"2527_CR12","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1126\/science.1141634","volume":"316","author":"TM Frayling","year":"2007","unstructured":"Frayling, T.M., Timpson, N.J., Weedon, M.N., Zeggini, E., Freathy, R.M., Lindgren, C. M., Perry, J.R.B., Elliott, K.S., Lango, H., Rayner, N.W., et al. (2007). A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316, 889\u2013894.","journal-title":"Science"},{"key":"2527_CR13","doi-asserted-by":"publisher","first-page":"e74235","DOI":"10.1371\/journal.pone.0074235","volume":"8","author":"XT Gan","year":"2013","unstructured":"Gan, X.T., Zhao, G., Huang, C.X., Rowe, A.C., Purdham, D.M., and Karmazyn, M. (2013). Identification of fat mass and obesity associated (FTO) protein expression in cardiomyocytes: regulation by leptin and its contribution to leptin-induced hypertrophy. PLoS ONE 8, e74235.","journal-title":"PLoS ONE"},{"key":"2527_CR14","doi-asserted-by":"publisher","first-page":"101563","DOI":"10.1016\/j.jbc.2022.101563","volume":"298","author":"M Gao","year":"2022","unstructured":"Gao, M., Qi, Z., Feng, W., Huang, H., Xu, Z., Dong, Z., Xu, M., Han, J., Kloeber, J.A., Huang, J., et al. (2022). m6A demethylation of cytidine deaminase APOBEC3B mRNA orchestrates arsenic-induced mutagenesis. J Biol Chem 298, 101563.","journal-title":"J Biol Chem"},{"key":"2527_CR15","doi-asserted-by":"publisher","first-page":"e14005","DOI":"10.1371\/journal.pone.0014005","volume":"5","author":"X Gao","year":"2010","unstructured":"Gao, X., Shin, Y.H., Li, M., Wang, F., Tong, Q., and Zhang, P. (2010). The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice. PLoS ONE 5, e14005.","journal-title":"PLoS ONE"},{"key":"2527_CR16","doi-asserted-by":"publisher","first-page":"e63","DOI":"10.1161\/CIRCRESAHA.118.313865","volume":"124","author":"PA Gorski","year":"2019","unstructured":"Gorski, P.A., Jang, S.P., Jeong, D., Lee, A., Lee, P., Oh, J.G., Chepurko, V., Yang, D.K., Kwak, T.H., Eom, S.H., et al. (2019). Role of SIRT1 in modulating acetylation of the sarco-endoplasmic reticulum Ca2+-ATPase in heart failure. Circ Res 124, e63.","journal-title":"Circ Res"},{"key":"2527_CR17","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1007\/s00395-020-00818-8","volume":"115","author":"A Grogan","year":"2020","unstructured":"Grogan, A., Coleman, A., Joca, H., Granzier, H., Russel, M.W., Ward, C.W., and Kontrogianni-Konstantopoulos, A. (2020). Deletion of obscurin immunoglobulin domains Ig58\/59 leads to age-dependent cardiac remodeling and arrhythmia. Basic Res Cardiol 115, 60.","journal-title":"Basic Res Cardiol"},{"key":"2527_CR18","doi-asserted-by":"publisher","first-page":"98","DOI":"10.3389\/fnins.2020.00098","volume":"14","author":"M Han","year":"2020","unstructured":"Han, M., Liu, Z., Xu, Y., Liu, X., Wang, D., Li, F., Wang, Y., and Bi, J. (2020). Abnormality of m6A mRNA methylation is involved in Alzheimer\u2019s disease. Front Neurosci 14, 98.","journal-title":"Front Neurosci"},{"key":"2527_CR19","doi-asserted-by":"publisher","first-page":"7282","DOI":"10.7150\/thno.33920","volume":"9","author":"K Hao","year":"2019","unstructured":"Hao, K., Lei, W., Wu, H., Wu, J., Yang, Z., Yan, S., Lu, X.A., Li, J., Xia, X., Han, X., et al. (2019). LncRNA-Safe contributes to cardiac fibrosis through Safe-Sfrp2-HuR complex in mouse myocardial infarction. Theranostics 9, 7282\u20137297.","journal-title":"Theranostics"},{"key":"2527_CR20","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1038\/nchembio.687","volume":"7","author":"G Jia","year":"2011","unstructured":"Jia, G., Fu, Y., Zhao, X., Dai, Q., Zheng, G., Yang, Y., Yi, C., Lindahl, T., Pan, T., Yang, Y.G., et al. (2011). N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat Chem Biol 7, 885\u2013887.","journal-title":"Nat Chem Biol"},{"key":"2527_CR21","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/s41392-020-00450-x","volume":"6","author":"X Jiang","year":"2021","unstructured":"Jiang, X., Liu, B., Nie, Z., Duan, L., Xiong, Q., Jin, Z., Yang, C., and Chen, Y. (2021). The role of m6A modification in the biological functions and diseases. Sig Transduct Target Ther 6, 74.","journal-title":"Sig Transduct Target Ther"},{"key":"2527_CR22","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1002\/cbf.3538","volume":"38","author":"S Jiang","year":"2020","unstructured":"Jiang, S., Jiao, G., Chen, Y., Han, M., Wang, X., and Liu, W. (2020). Astragaloside IV attenuates chronic intermittent hypoxia-induced myocardial injury by modulating Ca2+ homeostasis. Cell Biochem Funct 38, 710\u2013720.","journal-title":"Cell Biochem Funct"},{"key":"2527_CR23","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1002\/cbin.11153","volume":"43","author":"B Johari","year":"2019","unstructured":"Johari, B., Asadi, Z., Rismani, E., Maghsood, F., Sheikh Rezaei, Z., Farahani, S., Madanchi, H., and Kadivar, M. (2019). Inhibition of transcription factor T-cell factor 3 (TCF3) using the oligodeoxynucleotide strategy increases embryonic stem cell stemness: possible application in regenerative medicine. Cell Biol Int 43, 852\u2013862.","journal-title":"Cell Biol Int"},{"key":"2527_CR24","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.biopsych.2021.08.013","volume":"91","author":"EJ Kyzar","year":"2022","unstructured":"Kyzar, E.J., Bohnsack, J.P., and Pandey, S.C. (2022). Current and future perspectives of noncoding RNAs in brain function and neuropsychiatry disease. Biol Psychiatry 91, 183\u2013193.","journal-title":"Biol Psychiatry"},{"key":"2527_CR25","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.ccell.2016.11.017","volume":"31","author":"Z Li","year":"2017","unstructured":"Li, Z., Weng, H., Su, R., Weng, X., Zuo, Z., Li, C., Huang, H., Nachtergaele, S., Dong, L., Hu, C., et al. (2017a). FTO plays an oncogenic role in acute myeloid leukemia as a N6-methyladenosine RNA demethylase. Cancer Cell 31, 127\u2013141.","journal-title":"Cancer Cell"},{"key":"2527_CR26","doi-asserted-by":"publisher","first-page":"2398","DOI":"10.1093\/hmg\/ddx128","volume":"26","author":"L Li","year":"2017","unstructured":"Li, L., Zang, L., Zhang, F., Chen, J., Shen, H., Shu, L., Liang, F., Feng, C., Chen, D., Tao, H., et al. (2017b). Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis. Hum Mol Genet 26, 2398\u20132411.","journal-title":"Hum Mol Genet"},{"key":"2527_CR27","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.bbrc.2018.02.201","volume":"498","author":"H Li","year":"2018","unstructured":"Li, H., Ren, Y., Mao, K., Hua, F., Yang, Y., Wei, N., Yue, C., Li, D., and Zhang, H. (2018). FTO is involved in Alzheimer\u2019s disease by targeting TSC1-mTOR-Tau signaling. Biochem Biophys Res Commun 498, 234\u2013239.","journal-title":"Biochem Biophys Res Commun"},{"key":"2527_CR28","doi-asserted-by":"publisher","first-page":"4826","DOI":"10.1111\/jcmm.16455","volume":"25","author":"D Li","year":"2021","unstructured":"Li, D., Li, L., Chen, X., Zhou, C., Hao, B., and Cao, Y. (2021). Dysregulation of lncRNA-CCRR contributes to brain metastasis of breast cancer by intercellular coupling via regulating connexin 43 expression. J Cell Mol Medi 25, 4826\u20134834.","journal-title":"J Cell Mol Medi"},{"key":"2527_CR29","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1080\/21655979.2019.1704535","volume":"11","author":"K Liu","year":"2020","unstructured":"Liu, K., Zhao, D., and Wang, D. (2020a). LINC00528 regulates myocardial infarction by targeting the miR-143-3p\/COX-2 axis. Bioengineered 11, 11\u201318.","journal-title":"Bioengineered"},{"key":"2527_CR30","doi-asserted-by":"publisher","first-page":"2535","DOI":"10.3390\/ijms21072535","volume":"21","author":"B Liu","year":"2020","unstructured":"Liu, B., Lou, Q., Smith, H., Velez-Cortes, F., Dillmann, W.H., Knollmann, B.C., Armoundas, A.A., and Gy\u00f6rke, S. (2020b). Conditional up-regulation of SERCA2a exacerbates RyR2-dependent ventricular and atrial arrhythmias. Int J Mol Sci 21, 2535.","journal-title":"Int J Mol Sci"},{"key":"2527_CR31","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1038\/s41568-021-00353-1","volume":"21","author":"SJ Liu","year":"2021","unstructured":"Liu, S.J., Dang, H.X., Lim, D.A., Feng, F.Y., and Maher, C.A. (2021). Long noncoding RNAs in cancer metastasis. Nat Rev Cancer 21, 446\u2013460.","journal-title":"Nat Rev Cancer"},{"key":"2527_CR32","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1002\/hep.31222","volume":"72","author":"X Liu","year":"2020","unstructured":"Liu, X., Liu, J., Xiao, W., Zeng, Q., Bo, H., Zhu, Y., Gong, L., He, D., Xing, X., Li, R., et al. (2020c). SIRT1 regulates N6-methyladenosine RNA modification in hepatocarcinogenesis by inducing RANBP2-dependent FTO SUMOylation. Hepatology 72, 2029\u20132050.","journal-title":"Hepatology"},{"key":"2527_CR33","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1038\/nrneph.2016.51","volume":"12","author":"JM Lorenzen","year":"2016","unstructured":"Lorenzen, J.M., and Thum, T. (2016). Long noncoding RNAs in kidney and cardiovascular diseases. Nat Rev Nephrol 12, 360\u2013373.","journal-title":"Nat Rev Nephrol"},{"key":"2527_CR34","doi-asserted-by":"publisher","first-page":"3262","DOI":"10.1111\/febs.14188","volume":"284","author":"Y Ma","year":"2017","unstructured":"Ma, Y., Yu, L., Pan, S., Gao, S., Chen, W., Zhang, X., Dong, W., Li, J., Zhou, R., Huang, L., et al. (2017). CRISPR\/Cas9-mediated targeting of the Rosa26 locus produces Cre reporter rat strains for monitoring Cre-ioxP-mediated lineage tracing. FEBS J 284, 3262\u20133277.","journal-title":"FEBS J"},{"key":"2527_CR35","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1161\/CIRCULATIONAHA.118.033794","volume":"139","author":"P Mathiyalagan","year":"2019","unstructured":"Mathiyalagan, P., Adamiak, M., Mayourian, J., Sassi, Y., Liang, Y., Agarwal, N., Jha, D., Zhang, S., Kohlbrenner, E., Chepurko, E., et al. (2019). FTO-dependent N6-methyladenosine regulates cardiac function during remodeling and repair. Circulation 139, 518\u2013532.","journal-title":"Circulation"},{"key":"2527_CR36","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1038\/s42255-020-00296-1","volume":"2","author":"KS McCommis","year":"2020","unstructured":"McCommis, K.S., Kovacs, A., Weinheimer, C.J., Shew, T.M., Koves, T.R., Ilkayeva, O. R., Kamm, D.R., Pyles, K.D., King, M.T., Veech, R.L., et al. (2020). Nutritional modulation of heart failure in mitochondrial pyruvate carrier-deficient mice. Nat Metab 2, 1232\u20131247.","journal-title":"Nat Metab"},{"key":"2527_CR37","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1038\/nature01266","volume":"420","author":"Y Okazaki","year":"2002","unstructured":"Okazaki, Y., Furuno, M., Kasukawa, T., Adachi, J., Bono, H., Kondo, S., Nikaido, I., Osato, N., Saito, R., Suzuki, H., et al. (2002). Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature, 420, 563\u2013573.","journal-title":"Nature"},{"key":"2527_CR38","doi-asserted-by":"publisher","first-page":"H1525","DOI":"10.1152\/ajpheart.00890.2014","volume":"308","author":"RE Pachon","year":"2015","unstructured":"Pachon, R.E., Scharf, B.A., Vatner, D.E., and Vatner, S.F. (2015). Best anesthetics for assessing left ventricular systolic function by echocardiography in mice. Am J Physiol Heart Circul Physiol 308, H1525\u2013H1529.","journal-title":"Am J Physiol Heart Circul Physiol"},{"key":"2527_CR39","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1042\/BST20190229","volume":"48","author":"T Pallien","year":"2020","unstructured":"Pallien, T., and Klussmann, E. (2020). New aspects in cardiac L-type Ca2+ channel regulation. Biochem Soc Trans 48, 39\u201349.","journal-title":"Biochem Soc Trans"},{"key":"2527_CR40","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1159\/000363013","volume":"34","author":"AR Penitente","year":"2014","unstructured":"Penitente, A.R., Novaes, R.D., Silva, M.E., Silva, M.F., Quint\u00e3o-J\u00fanior, J.F., Guatimosim, S., Cruz, J.S., Chianca-Jr, D.A., Natali, A.J., and Neves, C.A. (2014). Basal and \u03b2-adrenergic cardiomyocytes contractility dysfunction induced by dietary protein restriction is associated with downregulation of SERCA2a expression and disturbance of endoplasmic reticulum Ca2+ regulation in rats. Cell Physiol Biochem 34, 443\u2013454.","journal-title":"Cell Physiol Biochem"},{"key":"2527_CR41","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.ejheart.2004.10.007","volume":"7","author":"F Prunier","year":"2005","unstructured":"Prunier, F., Chen, Y., Gellen, B., Heimburger, M., Choqueux, C., Escoubet, B., Michel, J., and Mercadier, J. (2005). Left ventricular SERCA2a gene down-regulation does not parallel ANP gene up-regulation during post-MI remodelling in rats. Eur J Heart Fail 7, 739\u2013747.","journal-title":"Eur J Heart Fail"},{"key":"2527_CR42","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0140-6736(16)30677-8","volume":"389","author":"GW Reed","year":"2017","unstructured":"Reed, G.W., Rossi, J.E., and Cannon, C.P. (2017). Acute myocardial infarction. Lancet 389, 197\u2013210.","journal-title":"Lancet"},{"key":"2527_CR43","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1080\/13880209.2020.1748662","volume":"58","author":"P Ren","year":"2020","unstructured":"Ren, P., Zhang, Z., Wang, P., Zhu, H., and Li, Z. (2020). Yangxinkang tablet protects against cardiac dysfunction and remodelling after myocardial infarction in rats through inhibition of AMPK\/mTOR-mediated autophagy. Pharm Biol 58, 321\u2013327.","journal-title":"Pharm Biol"},{"key":"2527_CR44","doi-asserted-by":"publisher","first-page":"H2001","DOI":"10.1152\/ajpheart.01072.2009","volume":"298","author":"A Rinne","year":"2010","unstructured":"Rinne, A., Kapur, N., Molkentin, J.D., Pogwizd, S.M., Bers, D.M., Banach, K., and Blatter, L.A. (2010). Isoform- and tissue-specific regulation of the Ca2+-sensitive transcription factor NFAT in cardiac myocytes and heart failure. Am J Physiol Heart Circul Physiol 298, H2001\u2013H2009.","journal-title":"Am J Physiol Heart Circul Physiol"},{"key":"2527_CR45","first-page":"1021","volume":"116","author":"A Roczkowsky","year":"2020","unstructured":"Roczkowsky, A., Chan, B.Y.H., Lee, T.Y.T., Mahmud, Z., Hartley, B., Julien, O., Armanious, G., Young, H.S., and Schulz, R. (2020). Myocardial MMP-2 contributes to SERCA2a proteolysis during cardiac ischaemia-reperfusion injury. Cardiovasc Res 116, 1021\u20131031.","journal-title":"Cardiovasc Res"},{"key":"2527_CR46","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1126\/science.1142382","volume":"316","author":"LJ Scott","year":"2007","unstructured":"Scott, L.J., Mohlke, K.L., Bonnycastle, L.L., Willer, C.J., Li, Y., Duren, W.L., Erdos, M. R., Stringham, H.M., Chines, P.S., Jackson, A.U., et al. (2007). A genome-wide association study of type 2 diabetes in finns detects multiple susceptibility variants. Science 316, 1341\u20131345.","journal-title":"Science"},{"key":"2527_CR47","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/s41580-020-00315-9","volume":"22","author":"L Statello","year":"2021","unstructured":"Statello, L., Guo, C.J., Chen, L.L., and Huarte, M. (2021). Gene regulation by long non-coding RNAs and its biological functions. Nat Rev Mol Cell Biol 22, 96\u2013118.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2527_CR48","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.ijcard.2014.09.032","volume":"177","author":"L Sun","year":"2014","unstructured":"Sun, L., Zhang, Y., Zhang, Y., Gu, Y., Xuan, L., Liu, S., Zhao, X., Wang, N., Huang, L., Huang, Y., et al. (2014). Expression profile of long non-coding RNAs in a mouse model of cardiac hypertrophy. Int J Cardiol 177, 73\u201375.","journal-title":"Int J Cardiol"},{"key":"2527_CR49","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/nrcardio.2017.161","volume":"15","author":"S Toldo","year":"2018","unstructured":"Toldo, S., and Abbate, A. (2018). The NLRP3 inflammasome in acute myocardial infarction. Nat Rev Cardiol 15, 203\u2013214.","journal-title":"Nat Rev Cardiol"},{"key":"2527_CR50","doi-asserted-by":"publisher","first-page":"6947","DOI":"10.3390\/ijms23136947","volume":"23","author":"E Vafiadaki","year":"2022","unstructured":"Vafiadaki, E., Haghighi, K., Arvanitis, D.A., Kranias, E.G., and Sanoudou, D. (2022). Aberrant PLN-R14del protein interactions intensify SERCA2a inhibition, driving impaired Ca2+ handling and arrhythmogenesis. Int J Mol Sci 23, 6947.","journal-title":"Int J Mol Sci"},{"key":"2527_CR51","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1093\/cvr\/cvy213","volume":"115","author":"CA Valverde","year":"2019","unstructured":"Valverde, C.A., Mazzocchi, G., Di Carlo, M.N., Ciocci Pardo, A., Salas, N., Ragone, M.I., Felice, J.I., Cely-Ortiz, A., Consolini, A.E., Portiansky, E., et al. (2019). Ablation of phospholamban rescues reperfusion arrhythmias but exacerbates myocardium infarction in hearts with Ca2+\/calmodulin kinase II constitutive phosphorylation of ryanodine receptors. Cardiovasc Res 115, 556\u2013569.","journal-title":"Cardiovasc Res"},{"key":"2527_CR52","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1161\/CIRCULATIONAHA.121.055841","volume":"145","author":"P Wang","year":"2022","unstructured":"Wang, P., Xu, S., Xu, J., Xin, Y., Lu, Y., Zhang, H., Zhou, B., Xu, H., Sheu, S.S., Tian, R., et al. (2022a). Elevated MCU expression by CaMKIBB limits pathological cardiac remodeling. Circulation 145, 1067\u20131083.","journal-title":"Circulation"},{"key":"2527_CR53","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1007\/s12012-021-09717-3","volume":"22","author":"B Wang","year":"2022","unstructured":"Wang, B., Ma, L., and Wang, J. (2022b). LncRNA HOTTIP knockdown attenuates acute myocardial infarction via regulating miR-92a-2\/c-Met axis. Cardiovasc Toxicol 22, 352\u2013364.","journal-title":"Cardiovasc Toxicol"},{"key":"2527_CR54","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/nrgastro.2017.169","volume":"15","author":"CM Wong","year":"2018","unstructured":"Wong, C.M., Tsang, F.H.C., and Ng, I.O.L. (2018). Non-coding RNAs in hepatocellular carcinoma: molecular functions and pathological implications. Nat Rev Gastroenterol Hepatol 15, 137\u2013151.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2527_CR55","doi-asserted-by":"publisher","first-page":"3100","DOI":"10.1529\/biophysj.108.130955","volume":"95","author":"LH Xie","year":"2008","unstructured":"Xie, L.H., Sato, D., Garfinkel, A., Qu, Z., and Weiss, J.N. (2008). Intracellular Ca alternans: coordinated regulation by sarcoplasmic reticulum release, uptake, and leak. Biophys J 95, 3100\u20133110.","journal-title":"Biophys J"},{"key":"2527_CR56","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1038\/s41401-020-00580-6","volume":"42","author":"G Xue","year":"2021","unstructured":"Xue, G., Li, D., Wang, Z., Liu, Y., Yang, J., Li, C., Li, X., Ma, J., Zhang, M., Lu, Y., et al. (2021). Interleukin-17 upregulation participates in the pathogenesis of heart failure in mice via NF-\u03baB-dependent suppression of SERCA2a and Cav1.2 expression. Acta Pharmacol Sin 42, 1780\u20131789.","journal-title":"Acta Pharmacol Sin"},{"key":"2527_CR57","doi-asserted-by":"publisher","first-page":"12943","DOI":"10.1093\/nar\/gkaa1151","volume":"48","author":"JH Yang","year":"2020","unstructured":"Yang, J.H., Chang, M.W., Pandey, P.R., Tsitsipatis, D., Yang, X., Martindale, J.L., Munk, R., De, S., Abdelmohsen, K., and Gorospe, M. (2020). Interaction of OIP5-AS1 with MEF2C mRNA promotes myogenic gene expression. Nucleic Acids Res 48, 12943\u201312956.","journal-title":"Nucleic Acids Res"},{"key":"2527_CR58","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1161\/CIRCULATIONAHA.113.003863","volume":"129","author":"KC Yang","year":"2014","unstructured":"Yang, K.C., Yamada, K.A., Patel, A.Y., Topkara, V.K., George, I., Cheema, F.H., Ewald, G.A., Mann, D.L., and Nerbonne, J.M. (2014). Deep RNA sequencing reveals dynamic regulation of myocardial noncoding RNAs in failing human heart and remodeling with mechanical circulatory support. Circulation 129, 1009\u20131021.","journal-title":"Circulation"},{"key":"2527_CR59","doi-asserted-by":"publisher","first-page":"2786","DOI":"10.1007\/s11427-022-2351-1","volume":"66","author":"S Yu","year":"2023","unstructured":"Yu, S., Sun, Z.Y., Wang, X., Ju, T., Wang, C., Liu, Y., Qu, Z., Liu, K.W., Mei, Z., Li, N., et al. (2023). Mettl13 protects against cardiac contractile dysfunction by negatively regulating C-Cbl-mediated ubiquitination of SERCA2a in ischemic heart failure. Sci China Life Sci 66, 2786\u20132804.","journal-title":"Sci China Life Sci"},{"key":"2527_CR60","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1161\/CIRCRESAHA.117.312117","volume":"122","author":"Y Zhang","year":"2018","unstructured":"Zhang, Y., Jiao, L., Sun, L., Li, Y., Gao, Y., Xu, C., Shao, Y., Li, M., Li, C., Lu, Y., et al. (2018a). LncRNA ZFAS1 as a SERCA2a inhibitor to cause intracellular Ca2+ overload and contractile dysfunction in a mouse model of myocardial infarction. Circ Res 122, 1354\u20131368.","journal-title":"Circ Res"},{"key":"2527_CR61","doi-asserted-by":"publisher","first-page":"4176","DOI":"10.1038\/s41467-018-06637-9","volume":"9","author":"Y Zhang","year":"2018","unstructured":"Zhang, Y., Sun, L., Xuan, L., Pan, Z., Hu, X., Liu, H., Bai, Y., Jiao, L., Li, Z., Cui, L., et al. (2018b). Long non-coding RNA CCRR controls cardiac conduction via regulating intercellular coupling. Nat Commun 9, 4176.","journal-title":"Nat Commun"},{"key":"2527_CR62","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1038\/cr.2014.151","volume":"24","author":"X Zhao","year":"2014","unstructured":"Zhao, X., Yang, Y., Sun, B.F., Shi, Y., Yang, X., Xiao, W., Hao, Y.J., Ping, X.L., Chen, Y.S., Wang, W.J., et al. (2014). FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis. Cell Res 24, 1403\u20131419.","journal-title":"Cell Res"}],"container-title":["Science China Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-023-2527-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11427-023-2527-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-023-2527-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T01:17:02Z","timestamp":1722993422000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11427-023-2527-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,16]]},"references-count":62,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["2527"],"URL":"https:\/\/doi.org\/10.1007\/s11427-023-2527-5","relation":{},"ISSN":["1674-7305","1869-1889"],"issn-type":[{"value":"1674-7305","type":"print"},{"value":"1869-1889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,16]]},"assertion":[{"value":"8 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The author(s) declare that they have no conflict of Interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance and ethics"}}]}}