{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:29:37Z","timestamp":1789424977656,"version":"build-2803163510"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T00:00:00Z","timestamp":1728691200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T00:00:00Z","timestamp":1728691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci. China Life Sci."],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1007\/s11427-023-2675-2","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T02:02:00Z","timestamp":1729476120000},"page":"502-514","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Human iPSC-derived mesenchymal stem cells relieve high blood pressure in spontaneously hypertensive rats via splenic nerve activated choline acetyltransferase-positive cells"],"prefix":"10.1007","volume":"68","author":[{"given":"Zhen","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoran","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhecun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manting","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingbing","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy Peng","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuling","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,12]]},"reference":[{"key":"2675_CR1","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1093\/cvr\/cvw054","volume":"110","author":"JM Aliotta","year":"2016","unstructured":"Aliotta, J.M., Pereira, M., Wen, S., Dooner, M.S., Del Tatto, M., Papa, E., Goldberg, L. R., Baird, G.L., Ventetuolo, C.E., Quesenberry, P.J., et al. (2016). Exosomes induce and reverse monocrotaline-induced pulmonary hypertension in mice. Cardiovasc Res 110, 319\u2013330.","journal-title":"Cardiovasc Res"},{"key":"2675_CR2","doi-asserted-by":"publisher","first-page":"13035","DOI":"10.1038\/ncomms13035","volume":"7","author":"D Carnevale","year":"2016","unstructured":"Carnevale, D., Perrotta, M., Pallante, F., Fardella, V., Iacobucci, R., Fardella, S., Carnevale, L., Carnevale, R., De Lucia, M., Cifelli, G., et al. (2016). A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication. Nat Commun 7, 13035.","journal-title":"Nat Commun"},{"key":"2675_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0301-0082(00)00067-8","volume":"65","author":"NC Danbolt","year":"2001","unstructured":"Danbolt, N.C. (2001). Glutamate uptake. Prog Neurobiol 65, 1\u2013105.","journal-title":"Prog Neurobiol"},{"key":"2675_CR4","doi-asserted-by":"publisher","first-page":"655","DOI":"10.3727\/096368910X536473","volume":"20","author":"T Deuse","year":"2011","unstructured":"Deuse, T., Stubbendorff, M., Tang-Quan, K., Phillips, N., Kay, M.A., Eiermann, T., Phan, T.T., Volk, H.D., Reichenspurner, H., Robbins, R.C., et al. (2011). Immunogenicity and immunomodulatory properties of umbilical cord lining mesenchymal stem cells. Cell Transplant 20, 655\u2013667.","journal-title":"Cell Transplant"},{"key":"2675_CR5","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1080\/14653240600855905","volume":"8","author":"M Dominici","year":"2006","unstructured":"Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F.C., Krause, D. S., Deans, R.J., Keating, A., Prockop, D.J., and Horwitz, E.M. (2006). Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8, 315\u2013317.","journal-title":"Cytotherapy"},{"key":"2675_CR6","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.trsl.2016.02.009","volume":"188","author":"D D\u2019Avola","year":"2017","unstructured":"D\u2019Avola, D., Fern\u00e1ndez-Ruiz, V., Carmona-Torre, F., M\u00e9ndez, M., P\u00e9rez-Calvo, J., Pr\u00f3sper, F., Andreu, E., Herrero, J.I., I\u00f1arrairaegui, M., Fuertes, C., et al. (2017). Phase 1\u20132 pilot clinical trial in patients with decompensated liver cirrhosis treated with bone marrow-derived endothelial progenitor cells. Transl Res 188, 80\u201391.e2.","journal-title":"Transl Res"},{"key":"2675_CR7","doi-asserted-by":"publisher","first-page":"758.10","DOI":"10.1096\/fasebj.2019.33.1_supplement.758.10","volume":"33","author":"EE Gillis","year":"2019","unstructured":"Gillis, E.E., and Sullivan, J.C. (2019). Splenectomy increases blood pressure and alters the renal T cell profile in a sex-specific manner in spontaneously hypertensive rats. FASEB J 33, 758.10.","journal-title":"FASEB J"},{"key":"2675_CR8","doi-asserted-by":"publisher","first-page":"9850","DOI":"10.1038\/s41598-020-66619-0","volume":"10","author":"D Hu","year":"2020","unstructured":"Hu, D., Al-Shalan, H.A.M., Shi, Z., Wang, P., Wu, Y., Nicholls, P.K., Greene, W.K., and Ma, B. (2020). Distribution of nerve fibers and nerve-immune cell association in mouse spleen revealed by immunofluorescent staining. Sci Rep 10, 9850.","journal-title":"Sci Rep"},{"key":"2675_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1620\/tjem.233.1","volume":"233","author":"H Junichiro","year":"2014","unstructured":"Junichiro, H. (2014). Central hemodynamics and target organ damage in hypertension. Tohoku J Exp Med 233, 1\u20138.","journal-title":"Tohoku J Exp Med"},{"key":"2675_CR10","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.molmed.2021.06.004","volume":"27","author":"LO Lerman","year":"2021","unstructured":"Lerman, L.O. (2021). Cell-based regenerative medicine for renovascular disease. Trends Mol Med 27, 882\u2013894.","journal-title":"Trends Mol Med"},{"key":"2675_CR11","doi-asserted-by":"publisher","first-page":"112256","DOI":"10.1016\/j.biopha.2021.112256","volume":"144","author":"Y Li","year":"2021","unstructured":"Li, Y., Chakraborty, A., Broughton, B.R.S., Ferens, D., Widdop, R.E., Ricardo, S.D., and Samuel, C.S. (2021). Comparing the renoprotective effects of BM-MSCs versus BM-MSC-exosomes, when combined with an anti-fibrotic drug, in hypertensive mice. Biomed Pharmacother 144, 112256.","journal-title":"Biomed Pharmacother"},{"key":"2675_CR12","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/s13287-018-0888-z","volume":"9","author":"M Lim","year":"2018","unstructured":"Lim, M., Wang, W., Liang, L., Han, Z., Li, Z., Geng, J., Zhao, M., Jia, H., Feng, J., Wei, Z., et al. (2018). Intravenous injection of allogeneic umbilical cord-derived multipotent mesenchymal stromal cells reduces the infarct area and ameliorates cardiac function in a porcine model of acute myocardial infarction. Stem Cell Res Ther 9, 129.","journal-title":"Stem Cell Res Ther"},{"key":"2675_CR13","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1038\/nbt.3663","volume":"34","author":"PS Olofsson","year":"2016","unstructured":"Olofsson, P.S., Steinberg, B.E., Sobbi, R., Cox, M.A., Ahmed, M.N., Oswald, M., Szekeres, F., Hanes, W.M., Introini, A., Liu, S.F., et al. (2016). Blood pressure regulation by CD4+ lymphocytes expressing choline acetyltransferase. Nat Biotechnol 34, 1066\u20131071.","journal-title":"Nat Biotechnol"},{"key":"2675_CR14","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.brainres.2008.06.123","volume":"1233","author":"N Pavlichenko","year":"2008","unstructured":"Pavlichenko, N., Sokolova, I., Vijde, S., Shvedova, E., Alexandrov, G., Krouglyakov, P., Fedotova, O., Gilerovich, E.G., Polyntsev, D.G., and Otellin, V.A. (2008). Mesenchymal stem cells transplantation could be beneficial for treatment of experimental ischemic stroke in rats. Brain Res 1233, 203\u2013213.","journal-title":"Brain Res"},{"key":"2675_CR15","doi-asserted-by":"publisher","first-page":"2806","DOI":"10.1002\/jcb.24166","volume":"113","author":"DG Phinney","year":"2012","unstructured":"Phinney, D.G. (2012). Functional heterogeneity of mesenchymal stem cells: implications for cell therapy. J Cell Biochem 113, 2806\u20132812.","journal-title":"J Cell Biochem"},{"key":"2675_CR16","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1073\/pnas.1221655110","volume":"110","author":"C Reardon","year":"2013","unstructured":"Reardon, C., Duncan, G.S., Br\u00fcstle, A., Brenner, D., Tusche, M.W., Olofsson, P.S., Rosas-Ballina, M., Tracey, K.J., and Mak, T.W. (2013). Lymphocyte-derived ACh regulates local innate but not adaptive immunity. Proc Natl Acad Sci USA 110, 1410\u20131415.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2675_CR17","first-page":"183","volume":"5","author":"FD Reilly","year":"1991","unstructured":"Reilly, F.D. (1991). Innervation and vascular pharmacodynamics of the mouse spleen. Scanning Microsc 5, 183\u2013188.","journal-title":"Scanning Microsc"},{"key":"2675_CR18","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/nature10761","volume":"481","author":"DA Robinton","year":"2012","unstructured":"Robinton, D.A., and Daley, G.Q. (2012). The promise of induced pluripotent stem cells in research and therapy. Nature 481, 295\u2013305.","journal-title":"Nature"},{"key":"2675_CR19","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.1093\/eurheartj\/ehq455","volume":"32","author":"J Roncalli","year":"2011","unstructured":"Roncalli, J., Mouquet, F., Piot, C., Trochu, J.N., Le Corvoisier, P., Neuder, Y., Le Tourneau, T., Agostini, D., Gaxotte, V., Sportouch, C., et al. (2011). Intracoronary autologous mononucleated bone marrow cell infusion for acute myocardial infarction: results of the randomized multicenter BONAMI trial. Eur Heart J 32, 1748\u20131757.","journal-title":"Eur Heart J"},{"key":"2675_CR20","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1186\/s10020-021-00380-6","volume":"27","author":"A Stiegler","year":"2021","unstructured":"Stiegler, A., Li, J.H., Shah, V., Tsaava, T., Tynan, A., Yang, H., Tamari, Y., Brines, M., Tracey, K.J., and Chavan, S.S. (2021). Systemic administration of choline acetyltransferase decreases blood pressure in murine hypertension. Mol Med 27, 133.","journal-title":"Mol Med"},{"key":"2675_CR21","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.stem.2015.06.007","volume":"17","author":"A Trounson","year":"2015","unstructured":"Trounson, A., and McDonald, C. (2015). Stem cell therapies in clinical trials: progress and challenges. Cell Stem Cell 17, 11\u201322.","journal-title":"Cell Stem Cell"},{"key":"2675_CR22","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.bbi.2018.12.009","volume":"77","author":"TJM Verlinden","year":"2019","unstructured":"Verlinden, T.J.M., van Dijk, P., Hikspoors, J., Herrler, A., Lamers, W.H., and K\u00f6hler, S. E. (2019). Innervation of the human spleen: a complete hilum-embedding approach. Brain Behav Immun 77, 92\u2013100.","journal-title":"Brain Behav Immun"},{"key":"2675_CR23","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.7150\/thno.30487","volume":"9","author":"H Wang","year":"2019","unstructured":"Wang, H., Li, D., Zhai, Z., Zhang, X., Huang, W., Chen, X., Huang, L., Liu, H., Sun, J., Zou, Z., et al. (2019). Characterization and therapeutic application of mesenchymal stem cells with neuromesodermal origin from human pluripotent stem cells. Theranostics 9, 1683\u20131697.","journal-title":"Theranostics"},{"key":"2675_CR24","doi-asserted-by":"publisher","first-page":"717772","DOI":"10.3389\/fcell.2021.717772","volume":"9","author":"W Wruck","year":"2021","unstructured":"Wruck, W., Graffmann, N., Spitzhorn, L.S., and Adjaye, J. (2021). Human induced pluripotent stem cell-derived mesenchymal stem cells acquire rejuvenation and reduced heterogeneity. Front Cell Dev Biol 9, 717772.","journal-title":"Front Cell Dev Biol"},{"key":"2675_CR25","first-page":"1780","volume":"42","author":"M Zhang","year":"2021","unstructured":"Zhang, M., Wu, J., Zhang, X., Hu, C.H., Zhao, Z.P., Li, C., Huang, Z.J., Zhou, M.G., and Wang, L.M. (2021). Prevalence and control of hypertension in adults in China, 2018 (in Chinese). Chin J Epidemiol 42, 1780\u20131789.","journal-title":"Chin J Epidemiol"},{"key":"2675_CR26","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/s41392-022-01124-6","volume":"7","author":"X Zhang","year":"2022","unstructured":"Zhang, X., Wei, X., Deng, Y., Yuan, X., Shi, J., Huang, W., Huang, J., Chen, X., Zheng, S., Chen, J., et al. (2022). Mesenchymal stromal cells alleviate acute respiratory distress syndrome through the cholinergic anti-inflammatory pathway. Sig Transduct Target Ther 7, 307.","journal-title":"Sig Transduct Target Ther"},{"key":"2675_CR27","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s11427-023-2403-7","volume":"67","author":"H Zhu","year":"2024","unstructured":"Zhu, H., Li, T., Xu, P., Ding, L., Zhu, X., Wang, B., Tang, X., Li, J., Zhu, P., Wang, H., et al. (2024). Effect of autologous bone marrow stem cells-scaffold transplantation on the ongoing pregnancy rate in intrauterine adhesion women: a randomized, controlled trial. Sci China Life Sci 67, 113\u2013121.","journal-title":"Sci China Life Sci"}],"container-title":["Science China Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-023-2675-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11427-023-2675-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-023-2675-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T13:05:59Z","timestamp":1737637559000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11427-023-2675-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,12]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["2675"],"URL":"https:\/\/doi.org\/10.1007\/s11427-023-2675-2","relation":{},"ISSN":["1674-7305","1869-1889"],"issn-type":[{"value":"1674-7305","type":"print"},{"value":"1869-1889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,12]]},"assertion":[{"value":"8 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest. The authors conformed with the Helsinki Declaration of 1975 (as revised in 2008) concerning human and animal rights and the policy concerning informed consent, as shown on .","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance and ethics"}}]}}