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At the time of recruitment, each patient enrolled provided informed consent. The study was carried out in strict accordance with the Declaration of Helsinki principles for research on humans and was approved by the Ethic Committee of Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (approval number: S-551). The clinical trial identification number was ChiCTR-OPN-16008964. All applicable institutional and\/or national guidelines for the care and use of animals were followed.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance and ethics"}}]}}