{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:46:57Z","timestamp":1792802817853,"version":"4.5.0"},"reference-count":513,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci. China Life Sci."],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1007\/s11427-024-2661-3","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T02:01:50Z","timestamp":1721613710000},"page":"1792-1832","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Biomolecular condensates and disease pathogenesis"],"prefix":"10.1007","volume":"67","author":[{"given":"Ke","family":"Ruan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanshan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingguo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boxun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Songyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuguo","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,17]]},"reference":[{"key":"2661_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41439-023-00229-w","volume":"10","author":"Z Abbasi","year":"2023","unstructured":"Abbasi, Z., Jafari Khamirani, H., Tabei, S.M.B., Manoochehri, J., Dianatpour, M., and Dastgheib, S.A. (2023). EPS8 variant causes deafness, autosomal recessive 102 (DFNB102) and literature review. Hum Genome Var 10, 1.","journal-title":"Hum Genome Var"},{"key":"2661_CR2","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/S0896-6273(00)80886-7","volume":"25","author":"A Abeliovich","year":"2000","unstructured":"Abeliovich, A., Schmitz, Y., Fari\u00f1as, I., Choi-Lundberg, D., Ho, W.H., Castillo, P.E., Shinsky, N., Verdugo, J.M.G., Armanini, M., Ryan, A., et al. (2000). Mice lacking \u03b1-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 25, 239\u2013252.","journal-title":"Neuron"},{"key":"2661_CR3","doi-asserted-by":"publisher","first-page":"eaat8657","DOI":"10.1126\/science.aat8657","volume":"363","author":"A Ablasser","year":"2019","unstructured":"Ablasser, A., and Chen, Z.J. (2019). cGAS in action: Expanding roles in immunity and inflammation. Science 363, eaat8657.","journal-title":"Science"},{"key":"2661_CR4","doi-asserted-by":"publisher","first-page":"5760","DOI":"10.1039\/D1SC07151C","volume":"13","author":"G Ado","year":"2022","unstructured":"Ado, G., Noda, N., Vu, H.T., Perron, A., Mahapatra, A.D., Arista, K.P., Yoshimura, H., Packwood, D.M., Ishidate, F., Sato, S., et al. (2022). Discovery of a phase-separating small molecule that selectively sequesters tubulin in cells. Chem Sci 13, 5760\u20135766.","journal-title":"Chem Sci"},{"key":"2661_CR5","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1038\/s41467-022-28797-5","volume":"13","author":"A Agarwal","year":"2022","unstructured":"Agarwal, A., Arora, L., Rai, S.K., Avni, A., and Mukhopadhyay, S. (2022). Spatiotemporal modulations in heterotypic condensates of prion and \u03b1-synuclein control phase transitions and amyloid conversion. Nat Commun 13, 1154.","journal-title":"Nat Commun"},{"key":"2661_CR6","doi-asserted-by":"crossref","unstructured":"Agarwal, A., Raza, F., Hilcenko, C., Stott, K., Morone, N., Warren, A.J., and Lautenschl\u00e4ger, J. (2023). VAMP2 regulates phase separation of alpha-synuclein. bioRxiv, 2023.2006.2016.545277.","DOI":"10.1101\/2023.06.16.545277"},{"key":"2661_CR7","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1038\/s41586-020-2992-3","volume":"591","author":"J Agudo-Canalejo","year":"2021","unstructured":"Agudo-Canalejo, J., Schultz, S.W., Chino, H., Migliano, S.M., Saito, C., Koyama-Honda, I., Stenmark, H., Brech, A., May, A.I., Mizushima, N., et al. (2021). Wetting regulates autophagy of phase-separated compartments and the cytosol. Nature 591, 142\u2013146.","journal-title":"Nature"},{"key":"2661_CR8","doi-asserted-by":"publisher","first-page":"e201900489","DOI":"10.26508\/lsa.201900489","volume":"2","author":"F Aktar","year":"2019","unstructured":"Aktar, F., Burudpakdee, C., Polanco, M., Pei, S., Swayne, T.C., Lipke, P.N., and Emtage, L. (2019). The huntingtin inclusion is a dynamic phase-separated compartment. Life Sci Alliance 2, e201900489.","journal-title":"Life Sci Alliance"},{"key":"2661_CR9","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1038\/s41580-020-00326-6","volume":"22","author":"S Alberti","year":"2021","unstructured":"Alberti, S., and Hyman, A.A. (2021). Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing. Nat Rev Mol Cell Biol 22, 196\u2013213.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2661_CR10","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.cell.2018.12.035","volume":"176","author":"S Alberti","year":"2019","unstructured":"Alberti, S., Gladfelter, A., and Mittag, T. (2019). Considerations and challenges in studying liquid-liquid phase separation and biomolecular condensates. Cell 176, 419\u2013434.","journal-title":"Cell"},{"key":"2661_CR11","doi-asserted-by":"publisher","first-page":"3605","DOI":"10.1073\/pnas.0409889102","volume":"102","author":"E Allemand","year":"2005","unstructured":"Allemand, E., Guil, S., Myers, M., Moscat, J., C\u00e1ceres, J.F., and Krainer, A.R. (2005). Regulation of heterogenous nuclear ribonucleoprotein A1 transport by phosphorylation in cells stressed by osmotic shock. Proc Natl Acad Sci USA 102, 3605\u20133610.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2661_CR12","doi-asserted-by":"publisher","first-page":"8088","DOI":"10.1038\/ncomms9088","volume":"6","author":"M Altmeyer","year":"2015","unstructured":"Altmeyer, M., Neelsen, K.J., Teloni, F., Pozdnyakova, I., Pellegrino, S., Gr\u00f8fte, M., Rask, M.B.D., Streicher, W., Jungmichel, S., Nielsen, M.L., et al. (2015). Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose). Nat Commun 6, 8088.","journal-title":"Nat Commun"},{"key":"2661_CR13","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/s41467-017-00480-0","volume":"8","author":"S Ambadipudi","year":"2017","unstructured":"Ambadipudi, S., Biernat, J., Riedel, D., Mandelkow, E., and Zweckstetter, M. (2017). Liquid\u2013liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau. Nat Commun 8, 275.","journal-title":"Nat Commun"},{"key":"2661_CR14","doi-asserted-by":"publisher","first-page":"e201800113","DOI":"10.26508\/lsa.201800113","volume":"1","author":"M Anders","year":"2018","unstructured":"Anders, M., Chelysheva, I., Goebel, I., Trenkner, T., Zhou, J., Mao, Y., Verzini, S., Qian, S.B., and Ignatova, Z. (2018). Dynamic m6 A methylation facilitates mRNA triaging to stress granules. Life Sci Alliance 1, e201800113.","journal-title":"Life Sci Alliance"},{"key":"2661_CR15","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/290457a0","volume":"290","author":"S Anderson","year":"1981","unstructured":"Anderson, S., Bankier, A.T., Barrell, B.G., de Bruijn, M.H.L., Coulson, A.R., Drouin, J., Eperon, I.C., Nierlich, D.P., Roe, B.A., Sanger, F., et al. (1981). Sequence and organization of the human mitochondrial genome. Nature 290, 457\u2013465.","journal-title":"Nature"},{"key":"2661_CR16","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.neuron.2019.07.004","volume":"104","author":"MG Andrusiak","year":"2019","unstructured":"Andrusiak, M.G., Sharifnia, P., Lyu, X., Wang, Z., Dickey, A.M., Wu, Z., Chisholm, A. D., and Jin, Y. (2019). Inhibition of axon regeneration by liquid-like TIAR-2 granules. Neuron 104, 290\u2013304.e8.","journal-title":"Neuron"},{"key":"2661_CR17","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s00018-022-04276-4","volume":"79","author":"IA Antifeeva","year":"2022","unstructured":"Antifeeva, I.A., Fonin, A.V., Fefilova, A.S., Stepanenko, O.V., Povarova, O.I., Silonov, S.A., Kuznetsova, I.M., Uversky, V.N., and Turoverov, K.K. (2022). Liquid\u2013liquid phase separation as an organizing principle of intracellular space: overview of the evolution of the cell compartmentalization concept. Cell Mol Life Sci 79, 251.","journal-title":"Cell Mol Life Sci"},{"key":"2661_CR18","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/j.celrep.2015.01.030","volume":"10","author":"H Antonicka","year":"2015","unstructured":"Antonicka, H., and Shoubridge, E.A. (2015). Mitochondrial RNA granules are centers for posttranscriptional rna processing and ribosome biogenesis. Cell Rep 10, 920\u2013932.","journal-title":"Cell Rep"},{"key":"2661_CR19","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1093\/brain\/awx024","volume":"140","author":"Y Aoki","year":"2017","unstructured":"Aoki, Y., Manzano, R., Lee, Y., Dafinca, R., Aoki, M., Douglas, A.G.L., Varela, M.A., Sathyaprakash, C., Scaber, J., Barbagallo, P., et al. (2017). C9orf72 and RAB7L1 regulate vesicle trafficking in amyotrophic lateral sclerosis and frontotemporal dementia. Brain 140, 887\u2013897.","journal-title":"Brain"},{"key":"2661_CR20","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/s41593-017-0022-z","volume":"21","author":"DJ Apicco","year":"2018","unstructured":"Apicco, D.J., Ash, P.E.A., Maziuk, B., LeBlang, C., Medalla, M., Al Abdullatif, A., Ferragud, A., Botelho, E., Ballance, H.I., Dhawan, U., et al. (2018). Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo. Nat Neurosci 21, 72\u201380.","journal-title":"Nat Neurosci"},{"key":"2661_CR21","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.cell.2020.01.027","volume":"180","author":"T Arakhamia","year":"2020","unstructured":"Arakhamia, T., Lee, C.E., Carlomagno, Y., Kumar, M., Duong, D.M., Wesseling, H., Kundinger, S.R., Wang, K., Williams, D., DeTure, M., et al. (2020). Posttranslational modifications mediate the structural diversity of tauopathy strains. Cell 180, 633\u2013644.e12.","journal-title":"Cell"},{"key":"2661_CR22","doi-asserted-by":"publisher","first-page":"2684","DOI":"10.1093\/hmg\/ddaa159","volume":"29","author":"A Arenas","year":"2020","unstructured":"Arenas, A., Chen, J., Kuang, L., Barnett, K.R., Kasarskis, E.J., Gal, J., and Zhu, H. (2020). Lysine acetylation regulates the RNA binding, subcellular localization and inclusion formation of FUS. Hum Mol Genet 29, 2684\u20132697.","journal-title":"Hum Mol Genet"},{"key":"2661_CR23","doi-asserted-by":"publisher","first-page":"e2014188118","DOI":"10.1073\/pnas.2014188118","volume":"118","author":"PEA Ash","year":"2021","unstructured":"Ash, P.E.A., Lei, S., Shattuck, J., Boudeau, S., Carlomagno, Y., Medalla, M., Mashimo, B.L., Socorro, G., Al-Mohanna, L.F.A., Jiang, L., Ozturk, M.M., Knobel, M., Ivanov, P., Petrucelli, L., Wegmann, S., Kanaan, N.M., and Wolozin, B. (2021). TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau. Proc Natl Acad Sci USA 118, e2014188118.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2661_CR24","doi-asserted-by":"publisher","first-page":"5574","DOI":"10.1038\/s41467-020-19211-z","volume":"11","author":"WM Babinchak","year":"2020","unstructured":"Babinchak, W.M., Dumm, B.K., Venus, S., Boyko, S., Putnam, A.A., Jankowsky, E., and Surewicz, W.K. (2020). Small molecules as potent biphasic modulators of protein liquid-liquid phase separation. Nat Commun 11, 5574.","journal-title":"Nat Commun"},{"key":"2661_CR25","doi-asserted-by":"publisher","first-page":"6306","DOI":"10.1074\/jbc.RA118.007222","volume":"294","author":"WM Babinchak","year":"2019","unstructured":"Babinchak, W.M., Haider, R., Dumm, B.K., Sarkar, P., Surewicz, K., Choi, J.K., and Surewicz, W.K. (2019). The role of liquid\u2013liquid phase separation in aggregation of the TDP-43 low-complexity domain. J Biol Chem 294, 6306\u20136317.","journal-title":"J Biol Chem"},{"key":"2661_CR26","doi-asserted-by":"publisher","first-page":"25806","DOI":"10.1038\/srep25806","volume":"6","author":"B Bailly","year":"2016","unstructured":"Bailly, B., Richard, C.A., Sharma, G., Wang, L., Johansen, L., Cao, J., Pendharkar, V., Sharma, D.C., Galloux, M., Wang, Y., et al. (2016). Targeting human respiratory syncytial virus transcription anti-termination factor M2-1 to inhibit in vivo viral replication. Sci Rep 6, 25806.","journal-title":"Sci Rep"},{"key":"2661_CR27","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/nrm.2017.7","volume":"18","author":"SF Banani","year":"2017","unstructured":"Banani, S.F., Lee, H.O., Hyman, A.A., and Rosen, M.K. (2017). Biomolecular condensates: organizers of cellular biochemistry. Nat Rev Mol Cell Biol 18, 285\u2013298.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2661_CR28","doi-asserted-by":"publisher","first-page":"104639","DOI":"10.1016\/j.nbd.2019.104639","volume":"134","author":"Y Baradaran-Heravi","year":"2020","unstructured":"Baradaran-Heravi, Y., Van Broeckhoven, C., and van der Zee, J. (2020). Stress granule mediated protein aggregation and underlying gene defects in the FTD-ALS spectrum. Neurobiol Dis 134, 104639.","journal-title":"Neurobiol Dis"},{"key":"2661_CR29","doi-asserted-by":"publisher","first-page":"2727","DOI":"10.1091\/mbc.E14-04-0940","volume":"26","author":"PG Barr-Gillespie","year":"2015","unstructured":"Barr-Gillespie, P.G., and Bement, W. (2015). Assembly of hair bundles, an amazing problem for cell biology. Mol Biol Cell 26, 2727\u20132732.","journal-title":"Mol Biol Cell"},{"key":"2661_CR30","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.molcel.2014.08.027","volume":"56","author":"R Batra","year":"2014","unstructured":"Batra, R., Charizanis, K., Manchanda, M., Mohan, A., Li, M., Finn, D.J., Goodwin, M., Zhang, C., Sobczak, K., Thornton, C.A., et al. (2014). Loss of MBNL leads to disruption of developmentally regulated alternative polyadenylation in RNA-mediated disease. Mol Cell 56, 311\u2013322.","journal-title":"Mol Cell"},{"key":"2661_CR31","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1016\/j.cell.2016.11.022","volume":"167","author":"JL Benci","year":"2016","unstructured":"Benci, J.L., Xu, B., Qiu, Y., Wu, T.J., Dada, H., Twyman-Saint Victor, C., Cucolo, L., Lee, D.S.M., Pauken, K.E., Huang, A.C., et al. (2016). Tumor interferon signaling regulates a multigenic resistance program to immune checkpoint blockade. Cell 167, 1540\u20131554.e12.","journal-title":"Cell"},{"key":"2661_CR32","doi-asserted-by":"publisher","first-page":"102364","DOI":"10.1016\/j.jbc.2022.102364","volume":"298","author":"K Bhattarai","year":"2022","unstructured":"Bhattarai, K., Richard, T., Fatica, T., Frangione, B., Willmore, W.G., and Holcik, M. (2022). AMPK-related protein kinase ARK5 regulates subcellular localization of RNA-binding protein hnRNP A1 during hypertonic stress. J Biol Chem 298, 102364.","journal-title":"J Biol Chem"},{"key":"2661_CR33","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1093\/hmg\/ddq007","volume":"19","author":"E Blackwell","year":"2010","unstructured":"Blackwell, E., Zhang, X., and Ceman, S. (2010). Arginines of the RGG box regulate FMRP association with polyribosomes and mRNA. Hum Mol Genet 19, 1314\u20131323.","journal-title":"Hum Mol Genet"},{"key":"2661_CR34","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1002\/pro.4029","volume":"30","author":"AS Bock","year":"2021","unstructured":"Bock, A.S., Murthy, A.C., Tang, W.S., Jovic, N., Shewmaker, F., Mittal, J., and Fawzi, N.L. (2021). N-terminal acetylation modestly enhances phase separation and reduces aggregation of the low-complexity domain of RNA-binding protein fused in sarcoma. Protein Sci 30, 1337\u20131349.","journal-title":"Protein Sci"},{"key":"2661_CR35","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.tcb.2018.02.004","volume":"28","author":"S Boeynaems","year":"2018","unstructured":"Boeynaems, S., Alberti, S., Fawzi, N.L., Mittag, T., Polymenidou, M., Rousseau, F., Schymkowitz, J., Shorter, J., Wolozin, B., Van Den Bosch, L., et al. (2018). Protein phase separation: a new phase in cell biology. Trends Cell Biol 28, 420\u2013435.","journal-title":"Trends Cell Biol"},{"key":"2661_CR36","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1016\/j.molcel.2017.02.013","volume":"65","author":"S Boeynaems","year":"2017","unstructured":"Boeynaems, S., Bogaert, E., Kovacs, D., Konijnenberg, A., Timmerman, E., Volkov, A., Guharoy, M., De Decker, M., Jaspers, T., Ryan, V.H., et al. (2017). Phase separation of C9orf72 dipeptide repeats perturbs stress granule dynamics. Mol Cell 65, 1044\u20131055.e5.","journal-title":"Mol Cell"},{"key":"2661_CR37","doi-asserted-by":"publisher","first-page":"2020","DOI":"10.1016\/j.molcel.2023.05.025","volume":"83","author":"S Boeynaems","year":"2023","unstructured":"Boeynaems, S., Dorone, Y., Zhuang, Y., Shabardina, V., Huang, G., Marian, A., Kim, G., Sanyal, A., \u015een, N.E., Griffith, D., et al. (2023). Poly(A)-binding protein is an ataxin-2 chaperone that regulates biomolecular condensates. Mol Cell 83, 2020\u20132034.e6.","journal-title":"Mol Cell"},{"key":"2661_CR38","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.molcel.2018.08.027","volume":"72","author":"JJ Bouchard","year":"2018","unstructured":"Bouchard, J.J., Otero, J.H., Scott, D.C., Szulc, E., Martin, E.W., Sabri, N., Granata, D., Marzahn, M.R., Lindorff-Larsen, K., Salvatella, X., et al. (2018). Cancer mutations of the tumor suppressor SPOP disrupt the formation of active, phase-separated compartments. Mol Cell 72, 19\u201336.e8.","journal-title":"Mol Cell"},{"key":"2661_CR39","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.cell.2017.07.036","volume":"171","author":"G Boulay","year":"2017","unstructured":"Boulay, G., Sandoval, G.J., Riggi, N., Iyer, S., Buisson, R., Naigles, B., Awad, M.E., Rengarajan, S., Volorio, A., McBride, M.J., et al. (2017). Cancer-specific retargeting of BAF complexes by a prion-like domain. Cell 171, 163\u2013178.e19.","journal-title":"Cell"},{"key":"2661_CR40","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.molcel.2010.09.024","volume":"40","author":"S Boulon","year":"2010","unstructured":"Boulon, S., Westman, B.J., Hutten, S., Boisvert, F.M., and Lamond, A.I. (2010). The nucleolus under stress. Mol Cell 40, 216\u2013227.","journal-title":"Mol Cell"},{"key":"2661_CR41","doi-asserted-by":"publisher","first-page":"8678","DOI":"10.1093\/nar\/gku582","volume":"42","author":"O Bounedjah","year":"2014","unstructured":"Bounedjah, O., Desforges, B., Wu, T.D., Pioche-Durieu, C., Marco, S., Hamon, L., Curmi, P.A., Guerquin-Kern, J.L., Pi\u00e9trement, O., and Pastr\u00e9, D. (2014). Free mRNA in excess upon polysome dissociation is a scaffold for protein multi-merization to form stress granules. Nucleic Acids Res 42, 8678\u20138691.","journal-title":"Nucleic Acids Res"},{"key":"2661_CR42","doi-asserted-by":"publisher","first-page":"11054","DOI":"10.1074\/jbc.AC119.009198","volume":"294","author":"S Boyko","year":"2019","unstructured":"Boyko, S., Qi, X., Chen, T.H., Surewicz, K., and Surewicz, W.K. (2019). Liquid-liquid phase separation of tau protein: the crucial role of electrostatic interactions. J Biol Chem 294, 11054\u201311059.","journal-title":"J Biol Chem"},{"key":"2661_CR43","doi-asserted-by":"publisher","first-page":"31882","DOI":"10.1073\/pnas.2012460117","volume":"117","author":"S Boyko","year":"2020","unstructured":"Boyko, S., Surewicz, K., and Surewicz, W.K. (2020). Regulatory mechanisms of tau protein fibrillation under the conditions of liquid\u2013liquid phase separation. Proc Natl Acad Sci USA 117, 31882\u201331890.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2661_CR44","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1016\/j.cell.2018.10.048","volume":"175","author":"D Bracha","year":"2018","unstructured":"Bracha, D., Walls, M.T., Wei, M.T., Zhu, L., Kurian, M., Avalos, J.L., Toettcher, J.E., and Brangwynne, C.P. (2018). Mapping local and global liquid phase behavior in living cells using photo-oligomerizable seeds. Cell 175, 1467\u20131480.e13.","journal-title":"Cell"},{"key":"2661_CR45","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1111\/j.1471-4159.2010.07098.x","volume":"116","author":"OA Brady","year":"2011","unstructured":"Brady, O.A., Meng, P., Zheng, Y., Mao, Y., and Hu, F. (2011). Regulation of TDP-43 aggregation by phosphorylation andp62\/SQSTM1. J Neurochem 116, 248\u2013259.","journal-title":"J Neurochem"},{"key":"2661_CR46","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1126\/science.1172046","volume":"324","author":"CP Brangwynne","year":"2009","unstructured":"Brangwynne, C.P., Eckmann, C.R., Courson, D.S., Rybarska, A., Hoege, C., Gharakhani, J., J\u00fclicher, F., and Hyman, A.A. (2009). Germline P granules are liquid droplets that localize by controlled dissolution\/condensation. Science 324, 1729\u20131732.","journal-title":"Science"},{"key":"2661_CR47","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/s41587-019-0355-0","volume":"38","author":"TC Branon","year":"2020","unstructured":"Branon, T.C., Bosch, J.A., Sanchez, A.D., Udeshi, N.D., Svinkina, T., Carr, S.A., Feldman, J.L., Perrimon, N., and Ting, A.Y. (2020). Author Correction: efficient proximity labeling in living cells and organisms with TurboID. Nat Biotechnol 38, 108.","journal-title":"Nat Biotechnol"},{"key":"2661_CR48","doi-asserted-by":"publisher","first-page":"4225","DOI":"10.1039\/D0LC00613K","volume":"20","author":"A Bremer","year":"2020","unstructured":"Bremer, A., Mittag, T., and Heymann, M. (2020). Microfluidic characterization of macromolecular liquid\u2013liquid phase separation. Lab Chip 20, 4225\u20134234.","journal-title":"Lab Chip"},{"key":"2661_CR49","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1016\/j.cell.2013.05.037","volume":"153","author":"JR Buchan","year":"2013","unstructured":"Buchan, J.R., Kolaitis, R.M., Taylor, J.P., and Parker, R. (2013). Eukaryotic stress granules are cleared by autophagy and Cdc48\/VCP Function. Cell 153, 1461\u20131474.","journal-title":"Cell"},{"key":"2661_CR50","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/S0076-6879(10)70025-2","volume":"470","author":"JR Buchan","year":"2010","unstructured":"Buchan, J.R., Nissan, T., and Parker, R. (2010). Analyzing P-bodies and stress granules in Saccharomyces cerevisiae. Methods Enzymol 470, 619\u2013640.","journal-title":"Methods Enzymol"},{"key":"2661_CR51","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.molcel.2015.09.006","volume":"60","author":"KA Burke","year":"2015","unstructured":"Burke, K.A., Janke, A.M., Rhine, C.L., and Fawzi, N.L. (2015). Residue-by-residue view of in vitro FUS granules that bind the C-terminal domain of RNA polymerase II. Mol Cell 60, 231\u2013241.","journal-title":"Mol Cell"},{"key":"2661_CR52","doi-asserted-by":"publisher","first-page":"E4274","DOI":"10.1073\/pnas.1416598111","volume":"111","author":"J Burr\u00e9","year":"2014","unstructured":"Burr\u00e9, J., Sharma, M., and S\u00fcdhof, T.C. (2014). \u03b1-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation. Proc Natl Acad Sci USA 111, E4274\u20134283.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2661_CR53","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1126\/science.1195227","volume":"329","author":"J Burr\u00e9","year":"2010","unstructured":"Burr\u00e9, J., Sharma, M., Tsetsenis, T., Buchman, V., Etherton, M.R., and S\u00fcdhof, T.C. (2010). \u03b1-synuclein promotes SNARE-complex assembly in vivo and in vitro. Science 329, 1663\u20131667.","journal-title":"Science"},{"key":"2661_CR54","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1038\/s41586-023-06726-w","volume":"623","author":"C Bussi","year":"2023","unstructured":"Bussi, C., Mangiarotti, A., Vanhille-Campos, C., Aylan, B., Pellegrino, E., Athanasiadi, N., Fearns, A., Rodgers, A., Franzmann, T.M., \u0160ari\u0107, A., et al. (2023). Stress granules plug and stabilize damaged endolysosomal membranes. Nature 623, 1062\u20131069.","journal-title":"Nature"},{"key":"2661_CR55","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/s41422-020-00439-9","volume":"31","author":"Q Cai","year":"2021","unstructured":"Cai, Q., Zeng, M., Wu, X., Wu, H., Zhan, Y., Tian, R., and Zhang, M. (2021). CaMKII\u03b1-driven, phosphatase-checked postsynaptic plasticity via phase separation. Cell Res 31, 37\u201351.","journal-title":"Cell Res"},{"key":"2661_CR56","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.devcel.2022.02.022","volume":"57","author":"SJ Cha","year":"2022","unstructured":"Cha, S.J., Lee, S., Choi, H.J., Han, Y.J., Jeon, Y.M., Jo, M., Lee, S., Nahm, M., Lim, S.M., Kim, S.H., et al. (2022). Therapeutic modulation of GSTO activity rescues FUS-associated neurotoxicity via deglutathionylation in ALS disease models. Dev Cell 57, 783\u2013798.e8.","journal-title":"Dev Cell"},{"key":"2661_CR57","doi-asserted-by":"publisher","first-page":"2147","DOI":"10.3390\/ijms20092147","volume":"20","author":"R Chakrabarti","year":"2019","unstructured":"Chakrabarti, R., and Wichmann, C. (2019). Nanomachinery organizing release at neuronal and ribbon synapses. Int J Mol Sci 20, 2147.","journal-title":"Int J Mol Sci"},{"key":"2661_CR58","doi-asserted-by":"publisher","first-page":"35186","DOI":"10.1074\/jbc.M804857200","volume":"283","author":"K Chalupn\u00edkov\u00e1","year":"2008","unstructured":"Chalupn\u00edkov\u00e1, K., Lattmann, S., Selak, N., Iwamoto, F., Fujiki, Y., and Nagamine, Y. (2008). Recruitment of the RNA Helicase RHAU to Stress Granules via a Unique RNA-binding Domain. J Biol Chem 283, 35186\u201335198.","journal-title":"J Biol Chem"},{"key":"2661_CR59","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1146\/annurev-pathmechdis-012419-032711","volume":"15","author":"DC Chan","year":"2020","unstructured":"Chan, D.C. (2020). Mitochondrial dynamics and its involvement in disease. Annu Rev Pathol Mech Dis 15, 235\u2013259.","journal-title":"Annu Rev Pathol Mech Dis"},{"key":"2661_CR60","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1158\/2159-8290.CD-21-0674","volume":"12","author":"B Chandra","year":"2022","unstructured":"Chandra, B., Michmerhuizen, N.L., Shirnekhi, H.K., Tripathi, S., Pioso, B.J., Baggett, D.W., Mitrea, D.M., Iacobucci, I., White, M.R., Chen, J., et al. (2022). Phase separation mediates NUP98 fusion oncoprotein leukemic transformation. Canc Discov 12, 1152\u20131169.","journal-title":"Canc Discov"},{"key":"2661_CR61","doi-asserted-by":"publisher","first-page":"847865","DOI":"10.1002\/jcp.30980","volume":"238","author":"X Che","year":"2023","unstructured":"Che, X., Wu, J., Liu, H., Su, J., and Chen, X. (2023). Cellular liquid\u2013liquid phase separation: concept, functions, regulations, and detections. J Cell Physiol 238, 847865.","journal-title":"J Cell Physiol"},{"key":"2661_CR62","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1038\/s41556-023-01165-1","volume":"25","author":"B Chen","year":"2023","unstructured":"Chen, B., Ge, T., Jian, M., Chen, L., Fang, Z., He, Z., Huang, C., An, Y., Yin, S., Xiong, Y., et al. (2023). Transmembrane nuclease NUMEN\/ENDOD1 regulates DNA repair pathway choice at the nuclear periphery. Nat Cell Biol 25, 1004\u20131016.","journal-title":"Nat Cell Biol"},{"key":"2661_CR63","doi-asserted-by":"publisher","first-page":"e202103160","DOI":"10.1083\/jcb.202103160","volume":"220","author":"C Chen","year":"2021","unstructured":"Chen, C., Yamanaka, Y., Ueda, K., Li, P., Miyagi, T., Harada, Y., Tezuka, S., Narumi, S., Sugimoto, M., Kuroda, M., et al. (2021). Phase separation and toxicity of C9orf72 poly(PR) depends on alternate distribution of arginine. J Cell Biol 220, e202103160.","journal-title":"J Cell Biol"},{"key":"2661_CR64","doi-asserted-by":"publisher","first-page":"e2115369119","DOI":"10.1073\/pnas.2115369119","volume":"119","author":"Z Chen","year":"2022","unstructured":"Chen, Z., Hou, C., Wang, L., Yu, C., Chen, T., Shen, B., Hou, Y., Li, P., and Li, T. (2022). Screening membraneless organelle participants with machine-learning models that integrate multimodal features. Proc Natl Acad Sci USA 119, e2115369119.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2661_CR65","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1038\/cr.2013.122","volume":"23","author":"AW Cheng","year":"2013","unstructured":"Cheng, A.W., Wang, H., Yang, H., Shi, L., Katz, Y., Theunissen, T.W., Rangarajan, S., Shivalila, C.S., Dadon, D.B., and Jaenisch, R. (2013). Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system. Cell Res 23, 1163\u20131171.","journal-title":"Cell Res"},{"key":"2661_CR66","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1016\/j.ccell.2021.04.017","volume":"39","author":"Y Cheng","year":"2021","unstructured":"Cheng, Y., Xie, W., Pickering, B.F., Chu, K.L., Savino, A.M., Yang, X., Luo, H., Nguyen, D.T., Mo, S., Barin, E., et al. (2021). N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation. Canc Cell 39, 958\u2013972.e8.","journal-title":"Canc Cell"},{"key":"2661_CR67","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1001\/archneurol.2011.53","volume":"68","author":"AS Chen-Plotkin","year":"2011","unstructured":"Chen-Plotkin, A.S., Martinez-Lage, M., Sleiman, P.M.A., Hu, W., Greene, R., Wood, E. M.C., Bing, S., Grossman, M., Schellenberg, G.D., Hatanpaa, K.J., et al. (2011). Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration. Arch Neurol 68, 488\u2013497.","journal-title":"Arch Neurol"},{"key":"2661_CR68","doi-asserted-by":"publisher","first-page":"2794","DOI":"10.1038\/s41467-018-05273-7","volume":"9","author":"M Chitiprolu","year":"2018","unstructured":"Chitiprolu, M., Jagow, C., Tremblay, V., Bondy-Chorney, E., Paris, G., Savard, A., Palidwor, G., Barry, F.A., Zinman, L., Keith, J., et al. (2018). A complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy. Nat Commun 9, 2794.","journal-title":"Nat Commun"},{"key":"2661_CR69","doi-asserted-by":"publisher","first-page":"eaar2555","DOI":"10.1126\/science.aar2555","volume":"361","author":"S Chong","year":"2018","unstructured":"Chong, S., Dugast-Darzacq, C., Liu, Z., Dong, P., Dailey, G.M., Cattoglio, C., Heckert, A., Banala, S., Lavis, L., Darzacq, X., et al. (2018). Imaging dynamic and selective low-complexity domain interactions that control gene transcription. Science 361, eaar2555.","journal-title":"Science"},{"key":"2661_CR70","doi-asserted-by":"publisher","first-page":"2084","DOI":"10.1016\/j.molcel.2022.04.007","volume":"82","author":"S Chong","year":"2022","unstructured":"Chong, S., Graham, T.G.W., Dugast-Darzacq, C., Dailey, G.M., Darzacq, X., and Tjian, R. (2022). Tuning levels of low-complexity domain interactions to modulate endogenous oncogenic transcription. Mol Cell 82, 2084\u20132097.e5.","journal-title":"Mol Cell"},{"key":"2661_CR71","doi-asserted-by":"publisher","first-page":"e3001425","DOI":"10.1371\/journal.pbio.3001425","volume":"19","author":"A Jack","year":"2021","unstructured":"Jack, A., Ferro, L.S., Trnka, M.J., Wehri, E., Nadgir, A., Nguyenla, X., Fox, D., Costa, K., Stanley, S., Schaletzky, J., et al. (2021). SARS-CoV-2 nucleocapsid protein forms condensates with viral genomic RNA. PLoS Biol 19, e3001425.","journal-title":"PLoS Biol"},{"key":"2661_CR72","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.gde.2017.03.006","volume":"44","author":"JD Cleary","year":"2017","unstructured":"Cleary, J.D., and Ranum, L.P. (2017). New developments in RAN translation: insights from multiple diseases. Curr Opin Genet Dev 44, 125\u2013134.","journal-title":"Curr Opin Genet Dev"},{"key":"2661_CR73","doi-asserted-by":"publisher","first-page":"5845","DOI":"10.1038\/ncomms6845","volume":"6","author":"TJ Cohen","year":"2015","unstructured":"Cohen, T.J., Hwang, A.W., Restrepo, C.R., Yuan, C.X., Trojanowski, J.Q., and Lee, V. M.Y. (2015). An acetylation switch controls TDP-43 function and aggregation propensity. Nat Commun 6, 5845.","journal-title":"Nat Commun"},{"key":"2661_CR74","doi-asserted-by":"publisher","first-page":"e17820","DOI":"10.7554\/eLife.17820","volume":"5","author":"EG Conlon","year":"2016","unstructured":"Conlon, E.G., Lu, L., Sharma, A., Yamazaki, T., Tang, T., Shneider, N.A., and Manley, J.L. (2016). The C9ORF72 GGGGCC expansion forms RNA G-quadruplex inclusions and sequesters hnRNP H to disrupt splicing in ALS brains. eLife 5, e17820.","journal-title":"eLife"},{"key":"2661_CR75","doi-asserted-by":"publisher","first-page":"6005","DOI":"10.1038\/s41467-022-33434-2","volume":"13","author":"E Courchaine","year":"2022","unstructured":"Courchaine, E., Gelles-Watnick, S., Machyna, M., Straube, K., Sauyet, S., Enright, J., and Neugebauer, K.M. (2022). The coilin N-terminus mediates multivalent interactions between coilin and Nopp140 to form and maintain Cajal bodies. Nat Commun 13, 6005.","journal-title":"Nat Commun"},{"key":"2661_CR76","doi-asserted-by":"publisher","first-page":"3612","DOI":"10.1016\/j.cell.2021.05.008","volume":"184","author":"EM Courchaine","year":"2021","unstructured":"Courchaine, E.M., Barentine, A.E.S., Straube, K., Lee, D.R., Bewersdorf, J., and Neugebauer, K.M. (2021). DMA-tudor interaction modules control the specificity of in vivo condensates. Cell 184, 3612\u20133625.e17.","journal-title":"Cell"},{"key":"2661_CR77","doi-asserted-by":"publisher","first-page":"101222","DOI":"10.1016\/j.jbc.2021.101222","volume":"297","author":"B Dai","year":"2021","unstructured":"Dai, B., Zhong, T., Chen, Z.X., Chen, W., Zhang, N., Liu, X.L., Wang, L.Q., Chen, J., and Liang, Y. (2021). Myricetin slows liquid\u2013liquid phase separation of Tau and activates ATG5-dependent autophagy to suppress Tau toxicity. J Biol Chem 297, 101222.","journal-title":"J Biol Chem"},{"key":"2661_CR78","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1038\/s41594-023-00988-8","volume":"30","author":"T Dai","year":"2023","unstructured":"Dai, T., Zhang, L., Ran, Y., Zhang, M., Yang, B., Lu, H., Lin, S., Zhang, L., and Zhou, F. (2023). MAVS deSUMOylation by SENP1 inhibits its aggregation and antagonizes IRF3 activation. Nat Struct Mol Biol 30, 785\u2013799.","journal-title":"Nat Struct Mol Biol"},{"key":"2661_CR79","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/s42003-023-04480-3","volume":"6","author":"M Dang","year":"2023","unstructured":"Dang, M., Li, T., and Song, J. (2023). ATP and nucleic acids competitively modulate LLPS of the SARS-CoV2 nucleocapsid protein. Commun Biol 6, 80.","journal-title":"Commun Biol"},{"key":"2661_CR80","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1038\/s42003-022-04293-w","volume":"5","author":"M Dang","year":"2022","unstructured":"Dang, M., Li, T., Zhou, S., and Song, J. (2022). Arg\/Lys-containing IDRs are cryptic binding domains for ATP and nucleic acids that interplay to modulate LLPS. Commun Biol 5, 1315.","journal-title":"Commun Biol"},{"key":"2661_CR81","doi-asserted-by":"publisher","first-page":"e01014","DOI":"10.1128\/JVI.01014-19","volume":"93","author":"D Davis","year":"2019","unstructured":"Davis, D., Yuan, H., Liang, F.X., Yang, Y.M., Westley, J., Petzold, C., Dancel-Manning, K., Deng, Y., Sall, J., Sehgal, P.B., et al. (2019). Human antiviral protein MxA forms novel metastable membraneless cytoplasmic condensates exhibiting rapid reversible tonicity-driven phase transitions. J Virol 93, e01014\u201319.","journal-title":"J Virol"},{"key":"2661_CR82","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1021\/acschembio.6b00182","volume":"11","author":"E De Mol","year":"2016","unstructured":"De Mol, E., Fenwick, R.B., Phang, C.T.W., Buz\u00f3n, V., Szulc, E., de la Fuente, A., Escobedo, A., Garc\u00eda, J., Bertoncini, C.W., Est\u00e9banez-Perpi\u00f1\u00e1, E., et al. (2016). EPI-001, a compound active against castration-resistant prostate cancer, targets transactivation unit 5 of the androgen receptor. ACS Chem Biol 11, 2499\u20132505.","journal-title":"ACS Chem Biol"},{"key":"2661_CR83","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1007\/s00439-022-02448-7","volume":"141","author":"S Delmaghani","year":"2022","unstructured":"Delmaghani, S., and El-Amraoui, A. (2022). The genetic and phenotypic landscapes of Usher syndrome: from disease mechanisms to a new classification. Hum Genet 141, 709\u2013735.","journal-title":"Hum Genet"},{"key":"2661_CR84","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1038\/s42003-023-05608-1","volume":"6","author":"S Dhakal","year":"2023","unstructured":"Dhakal, S., Mondal, M., Mirzazadeh, A., Banerjee, S., Ghosh, A., and Rangachari, V. (2023). \u03b1-Synuclein emulsifies TDP-43 prion-like domain\u2014RNA liquid droplets to promote heterotypic amyloid fibrils. Commun Biol 6, 1227.","journal-title":"Commun Biol"},{"key":"2661_CR85","doi-asserted-by":"publisher","first-page":"166953","DOI":"10.1016\/j.jmb.2021.166953","volume":"433","author":"S Dhakal","year":"2021","unstructured":"Dhakal, S., Wyant, C.E., George, H.E., Morgan, S.E., and Rangachari, V. (2021). Prion-like C-terminal domain of TDP-43 and \u03b1-synuclein interact synergistically to generate neurotoxic hybrid fibrils. J Mol Biol 433, 166953.","journal-title":"J Mol Biol"},{"key":"2661_CR86","doi-asserted-by":"publisher","first-page":"e00592","DOI":"10.7554\/eLife.00592","volume":"2","author":"J Diao","year":"2013","unstructured":"Diao, J., Burr\u00e9, J., Vivona, S., Cipriano, D.J., Sharma, M., Kyoung, M., S\u00fcdhof, T.C., and Brunger, A.T. (2013). Native \u03b1-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2\/VAMP2. eLife 2, e00592.","journal-title":"eLife"},{"key":"2661_CR87","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/S0006-291X(02)03008-5","volume":"301","author":"MM Dinardo","year":"2003","unstructured":"Dinardo, M.M., Musicco, C., Fracasso, F., Milella, F., Gadaleta, M.N., Gadaleta, G., and Cantatore, P. (2003). Acetylation and level of mitochondrial transcription factor A in several organs of young and old rats. Biochem Biophys Res Commun 301, 187\u2013191.","journal-title":"Biochem Biophys Res Commun"},{"key":"2661_CR88","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1016\/j.ajhg.2012.04.008","volume":"90","author":"D Doherty","year":"2012","unstructured":"Doherty, D., Chudley, A.E., Coghlan, G., Ishak, G.E., Innes, A.M., Lemire, E.G., Rogers, R.C., Mhanni, A.A., Phelps, I.G., Jones, S.J.M., et al. (2012). GPSM2 mutations cause the brain malformations and hearing loss in chudley-mccullough syndrome. Am J Hum Genet 90, 1088\u20131093.","journal-title":"Am J Hum Genet"},{"key":"2661_CR89","doi-asserted-by":"publisher","first-page":"4022","DOI":"10.1039\/c2lc40174f","volume":"12","author":"ME Dolega","year":"2012","unstructured":"Dolega, M.E., Jakiela, S., Razew, M., Rakszewska, A., Cybulski, O., and Garstecki, P. (2012). Iterative operations on microdroplets and continuous monitoring of processes within them.determination of solubility diagrams of proteins. Lab Chip 12, 4022\u20134025.","journal-title":"Lab Chip"},{"key":"2661_CR90","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1038\/d41586-018-03070-2","volume":"555","author":"E Dolgin","year":"2018","unstructured":"Dolgin, E. (2018). What lava lamps and vinaigrette can teach us about cell biology. Nature 555, 300\u2013302.","journal-title":"Nature"},{"key":"2661_CR91","doi-asserted-by":"publisher","first-page":"4258","DOI":"10.1038\/emboj.2012.261","volume":"31","author":"D Dormann","year":"2012","unstructured":"Dormann, D., Madl, T., Valori, C.F., Bentmann, E., Tahirovic, S., Abou-Ajram, C., Kremmer, E., Ansorge, O., Mackenzie, I.R.A., Neumann, M., et al. (2012). Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS. EMBO J 31, 4258\u20134275.","journal-title":"EMBO J"},{"key":"2661_CR92","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1126\/science.aat1022","volume":"361","author":"M Du","year":"2018","unstructured":"Du, M., and Chen, Z.J. (2018). DNA-induced liquid phase condensation of cGAS activates innate immune signaling. Science 361, 704\u2013709.","journal-title":"Science"},{"key":"2661_CR93","doi-asserted-by":"publisher","first-page":"2415","DOI":"10.1016\/j.molcel.2022.03.037","volume":"82","author":"M Du","year":"2022","unstructured":"Du, M., Ea, C.K., Fang, Y., and Chen, Z.J. (2022). Liquid phase separation of NEMO induced by polyubiquitin chains activates NF-\u03baB. Mol Cell 82, 2415\u20132426.e5.","journal-title":"Mol Cell"},{"key":"2661_CR94","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/s41422-019-0141-z","volume":"29","author":"Y Duan","year":"2019","unstructured":"Duan, Y., Du, A., Gu, J., Duan, G., Wang, C., Gui, X., Ma, Z., Qian, B., Deng, X., Zhang, K., et al. (2019). PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins. Cell Res 29, 233\u2013247.","journal-title":"Cell Res"},{"key":"2661_CR95","doi-asserted-by":"publisher","first-page":"3382","DOI":"10.1172\/JCI94351","volume":"128","author":"D Dulon","year":"2018","unstructured":"Dulon, D., Papal, S., Patni, P., Cortese, M., Vincent, P.F.Y., Tertrais, M., Emptoz, A., Tlili, A., Bouleau, Y., Michel, V., et al. (2018). Clarin-1 gene transfer rescues auditory synaptopathy in model of Usher syndrome. J Clin Invest 128, 3382\u20133401.","journal-title":"J Clin Invest"},{"key":"2661_CR96","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1083\/jcb.200311121","volume":"164","author":"M Dundr","year":"2004","unstructured":"Dundr, M., Hebert, M.D., Karpova, T.S., Stanek, D., Xu, H., Shpargel, K.B., Meier, U.T., Neugebauer, K.M., Matera, A.G., and Misteli, T. (2004). In vivo kinetics of Cajal body components. J Cell Biol 164, 831\u2013842.","journal-title":"J Cell Biol"},{"key":"2661_CR97","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1172\/JCI39715","volume":"120","author":"I Ebermann","year":"2010","unstructured":"Ebermann, I., Phillips, J.B., Liebau, M.C., Koenekoop, R.K., Schermer, B., Lopez, I., Sch\u00e4fer, E., Roux, A.F., Dafinger, C., Bernd, A., et al. (2010). PDZD7 is a modifier of retinal disease and a contributor to digenic Usher syndrome. J Clin Invest 120, 1812\u20131823.","journal-title":"J Clin Invest"},{"key":"2661_CR98","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s00439-006-0304-0","volume":"121","author":"I Ebermann","year":"2007","unstructured":"Ebermann, I., Scholl, H.P.N., Charbel Issa, P., Becirovic, E., Lamprecht, J., Jurklies, B., Mill\u00e1n, J.M., Aller, E., Mitter, D., and Bolz, H. (2007). A novel gene for Usher syndrome type 2: mutations in the long isoform of whirlin are associated with retinitis pigmentosa and sensorineural hearing loss. Hum Genet 121, 203\u2013211.","journal-title":"Hum Genet"},{"key":"2661_CR99","doi-asserted-by":"publisher","first-page":"4593","DOI":"10.1242\/jcs.02636","volume":"118","author":"A El-Amraoui","year":"2005","unstructured":"El-Amraoui, A., and Petit, C. (2005). Usher I syndrome: unravelling the mechanisms that underlie the cohesion of the growing hair bundle in inner ear sensory cells. J Cell Sci 118, 4593\u20134603.","journal-title":"J Cell Sci"},{"key":"2661_CR100","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1038\/s41589-021-00752-3","volume":"17","author":"L Emmanouilidis","year":"2021","unstructured":"Emmanouilidis, L., Esteban-Hofer, L., Damberger, F.F., de Vries, T., Nguyen, C.K.X., Ib\u00e1\u00f1ez, L.F., Mergenthal, S., Klotzsch, E., Yulikov, M., Jeschke, G., et al. (2021). NMR and EPR reveal a compaction of the RNA-binding protein FUS upon droplet formation. Nat Chem Biol 17, 608\u2013614.","journal-title":"Nat Chem Biol"},{"key":"2661_CR101","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1126\/science.280.5370.1753","volume":"280","author":"JD Eudy","year":"1998","unstructured":"Eudy, J.D., Weston, M.D., Yao, S.F., Hoover, D.M., Rehm, H.L., Ma-Edmonds, M., Yan, D., Ahmad, I., Cheng, J.J., Ayuso, C., et al. (1998). Mutation of a gene encoding a protein with extracellular matrix motifs in usher syndrome type IIa. Science 280, 1753\u20131757.","journal-title":"Science"},{"key":"2661_CR102","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.semcdb.2023.05.006","volume":"156","author":"H Fakim","year":"2024","unstructured":"Fakim, H., and Vande Velde, C. (2024). The implications of physiological biomolecular condensates in amyotrophic lateral sclerosis. Semin Cell Dev Biol 156, 176\u2013189.","journal-title":"Semin Cell Dev Biol"},{"key":"2661_CR103","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1039\/D3CC04654K","volume":"60","author":"WW Fan","year":"2024","unstructured":"Fan, W.W., Xu, T., Gao, J., Zhang, H.Y., Li, Y., Hu, D.D., Gao, S., Zhang, J.H., Liu, X., Liu, D., et al. (2024). A bivalent inhibitor against TDRD3 to suppress phase separation of methylated G3BP1. Chem Commun 60, 762\u2013765.","journal-title":"Chem Commun"},{"key":"2661_CR104","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1016\/j.neuron.2019.05.048","volume":"103","author":"MY Fang","year":"2019","unstructured":"Fang, M.Y., Markmiller, S., Vu, A.Q., Javaherian, A., Dowdle, W.E., Jolivet, P., Bushway, P.J., Castello, N.A., Baral, A., Chan, M.Y., et al. (2019). Small-molecule modulation of TDP-43 recruitment to stress granules prevents persistent TDP-43 accumulation in ALS\/FTD. Neuron 103, 802\u2013819.e11.","journal-title":"Neuron"},{"key":"2661_CR105","doi-asserted-by":"publisher","first-page":"7722","DOI":"10.1038\/s41467-022-35370-7","volume":"13","author":"M Farag","year":"2022","unstructured":"Farag, M., Cohen, S.R., Borcherds, W.M., Bremer, A., Mittag, T., and Pappu, R.V. (2022). Condensates formed by prion-like low-complexity domains have small-world network structures and interfaces defined by expanded conformations. Nat Commun 13, 7722.","journal-title":"Nat Commun"},{"key":"2661_CR106","doi-asserted-by":"publisher","first-page":"5527","DOI":"10.1038\/s41467-023-41274-x","volume":"14","author":"M Farag","year":"2023","unstructured":"Farag, M., Borcherds, W.M., Bremer, A., Mittag, T., and Pappu, R.V. (2023). Phase separation of protein mixtures is driven by the interplay of homotypic and heterotypic interactions. Nat Commun 14, 5527.","journal-title":"Nat Commun"},{"key":"2661_CR107","first-page":"841","volume":"23","author":"M Farjami","year":"2020","unstructured":"Farjami, M., Assadi, R., Afzal Javan, F., Alimardani, M., Eslami, S., Mansoori Derakhshan, S., Eslahi, A., and Mojarrad, M. (2020). The worldwide frequency of MYO15A gene mutations in patients with non-syndromic hearing loss: a meta-analysis. Iran J Basic Med Sci 23, 841\u2013848.","journal-title":"Iran J Basic Med Sci"},{"key":"2661_CR108","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1021\/sb400081r","volume":"2","author":"F Farzadfard","year":"2013","unstructured":"Farzadfard, F., Perli, S.D., and Lu, T.K. (2013). Tunable and multifunctional eukaryotic transcription factors based on CRISPR\/Cas. ACS Synth Biol 2, 604\u2013613.","journal-title":"ACS Synth Biol"},{"key":"2661_CR109","doi-asserted-by":"publisher","first-page":"3573","DOI":"10.1016\/j.celrep.2017.11.093","volume":"21","author":"MM Fay","year":"2017","unstructured":"Fay, M.M., Anderson, P.J., and Ivanov, P. (2017). ALS\/FTD-associated C9ORF72 repeat RNA promotes phase transitions in vitro and in cells. Cell Rep 21, 3573\u20133584.","journal-title":"Cell Rep"},{"key":"2661_CR110","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1016\/S0140-6736(22)01272-7","volume":"400","author":"EL Feldman","year":"2022","unstructured":"Feldman, E.L., Goutman, S.A., Petri, S., Mazzini, L., Savelieff, M.G., Shaw, P.J., and Sobue, G. (2022). Amyotrophic lateral sclerosis. Lancet 400, 1363\u20131380.","journal-title":"Lancet"},{"key":"2661_CR111","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/s41422-024-00938-z","volume":"34","author":"R Feng","year":"2024","unstructured":"Feng, R., Liu, F., Li, R., Zhou, Z., Lin, Z., Lin, S., Deng, S., Li, Y., Nong, B., Xia, Y., et al. (2024). The rapid proximity labeling system PhastID identifies ATP6AP1 as an unconventional GEF for Rheb. Cell Res 34, 355\u2013369.","journal-title":"Cell Res"},{"key":"2661_CR112","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.tibs.2018.03.002","volume":"43","author":"X Feng","year":"2018","unstructured":"Feng, X., Luo, S., and Lu, B. (2018). Conformation polymorphism of polyglutamine proteins. Trends Biochem Sci 43, 424\u2013435.","journal-title":"Trends Biochem Sci"},{"key":"2661_CR113","doi-asserted-by":"publisher","first-page":"108622","DOI":"10.1016\/j.neuropharm.2021.108622","volume":"193","author":"Z Feng","year":"2021","unstructured":"Feng, Z., Wu, X., and Zhang, M. (2021). Presynaptic bouton compartmentalization and postsynaptic density-mediated glutamate receptor clustering via phase separation. Neuropharmacology 193, 108622.","journal-title":"Neuropharmacology"},{"key":"2661_CR114","doi-asserted-by":"publisher","first-page":"e107165","DOI":"10.15252\/embj.2020107165","volume":"40","author":"M Feric","year":"2021","unstructured":"Feric, M., Demarest, T.G., Tian, J., Croteau, D.L., Bohr, V.A., and Misteli, T. (2021). Self-assembly of multi-component mitochondrial nucleoids via phase separation. EMBO J 40, e107165.","journal-title":"EMBO J"},{"key":"2661_CR115","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1016\/j.cell.2016.04.047","volume":"165","author":"M Feric","year":"2016","unstructured":"Feric, M., Vaidya, N., Harmon, T.S., Mitrea, D.M., Zhu, L., Richardson, T.M., Kriwacki, R.W., Pappu, R.V., and Brangwynne, C.P. (2016). Coexisting liquid phases underlie nucleolar subcompartments. Cell 165, 1686\u20131697.","journal-title":"Cell"},{"key":"2661_CR116","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.3390\/ijms19051360","volume":"19","author":"JC Ferreon","year":"2018","unstructured":"Ferreon, J.C., Jain, A., Choi, K.J., Tsoi, P.S., MacKenzie, K.R., Jung, S.Y., and Ferreon, A.C. (2018). Acetylation Disfavors Tau Phase Separation. Int J Mol Sci 19, 1360.","journal-title":"Int J Mol Sci"},{"key":"2661_CR117","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1002\/cphy.c160049","volume":"7","author":"R Fettiplace","year":"2017","unstructured":"Fettiplace, R. (2017). Hair cell transduction, tuning, and synaptic transmission in the mammalian cochlea. Compr Physiol 7, 1197\u20131227.","journal-title":"Compr Physiol"},{"key":"2661_CR118","doi-asserted-by":"publisher","first-page":"7354","DOI":"10.1002\/anie.201402885","volume":"53","author":"SA Fromm","year":"2014","unstructured":"Fromm, S.A., Kamenz, J., N\u00f6ldeke, E.R., Neu, A., Zocher, G., and Sprangers, R. (2014). In vitro reconstitution of a cellular phase-transition process that involves the mRNA decapping machinery. Angew Chem Int Ed 53, 7354\u20137359.","journal-title":"Angew Chem Int Ed"},{"key":"2661_CR119","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1038\/s41589-020-0524-y","volume":"16","author":"Y Fu","year":"2020","unstructured":"Fu, Y., and Zhuang, X. (2020). m6A-binding YTHDF proteins promote stress granule formation. Nat Chem Biol 16, 955\u2013963.","journal-title":"Nat Chem Biol"},{"key":"2661_CR120","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1002\/pro.4010","volume":"30","author":"JC Fuentes-Monteverde","year":"2020","unstructured":"Fuentes-Monteverde, J.C., Becker, S., and Rezaei-Ghaleh, N. (2020). Biomolecular phase separation through the lens of sodium-23 NMR. Protein Science 30, 1315\u20131325.","journal-title":"Protein Science"},{"key":"2661_CR121","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1007\/s11064-015-1758-z","volume":"41","author":"S Fujii","year":"2016","unstructured":"Fujii, S., Takanashi, K., Kitajo, K., and Yamaguchi, A. (2016). Treatment with a global methyltransferase inhibitor induces the intranuclear aggregation of ALS-linked FUS mutant in vitro. Neurochem Res 41, 826\u2013835.","journal-title":"Neurochem Res"},{"key":"2661_CR122","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1016\/j.cub.2023.04.012","volume":"33","author":"D Fujikawa","year":"2023","unstructured":"Fujikawa, D., Nakamura, T., Yoshioka, D., Li, Z., Moriizumi, H., Taguchi, M., Tokai-Nishizumi, N., Kozuka-Hata, H., Oyama, M., and Takekawa, M. (2023). Stress granule formation inhibits stress-induced apoptosis by selectively sequestering executioner caspases. Curr Biol 33, 1967\u20131981.e8.","journal-title":"Curr Biol"},{"key":"2661_CR123","doi-asserted-by":"publisher","first-page":"8099","DOI":"10.1093\/nar\/gks566","volume":"40","author":"K Fujimura","year":"2012","unstructured":"Fujimura, K., Sasaki, A.T., and Anderson, P. (2012). Selenite targets eIF4E-binding protein-1 to inhibit translation initiation and induce the assembly of non-canonical stress granules. Nucleic Acids Res 40, 8099\u20138110.","journal-title":"Nucleic Acids Res"},{"key":"2661_CR124","doi-asserted-by":"publisher","first-page":"e00052","DOI":"10.1128\/MCB.00052-19","volume":"39","author":"J Gal","year":"2019","unstructured":"Gal, J., Chen, J., Na, D.Y., Tichacek, L., Barnett, K.R., and Zhu, H. (2019). The acetylation of lysine-376 of G3BP1 regulates RNA binding and stress granule dynamics. Mol Cell Biol 39, e00052\u201319.","journal-title":"Mol Cell Biol"},{"key":"2661_CR125","doi-asserted-by":"publisher","first-page":"111086","DOI":"10.1016\/j.celrep.2022.111086","volume":"40","author":"C Gao","year":"2022","unstructured":"Gao, C., Gu, J., Zhang, H., Jiang, K., Tang, L., Liu, R., Zhang, L., Zhang, P., Liu, C., Dai, B., et al. (2022a). Hyperosmotic-stress-induced liquid-liquid phase separation of ALS-related proteins in the nucleus. Cell Rep 40, 111086.","journal-title":"Cell Rep"},{"key":"2661_CR126","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1080\/15548627.2022.2062873","volume":"18","author":"K Gao","year":"2022","unstructured":"Gao, K., Shi, Q., Liu, Y., and Wang, C. (2022b). Enhanced autophagy and NFE2L2\/NRF2 pathway activation in SPOP mutation-driven prostate cancer. Autophagy 18, 2013\u20132015.","journal-title":"Autophagy"},{"key":"2661_CR127","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1016\/j.cell.2013.04.046","volume":"153","author":"P Gao","year":"2013","unstructured":"Gao, P., Ascano, M., Wu, Y., Barchet, W., Gaffney, B.L., Zillinger, T., Serganov, A.A., Liu, Y., Jones, R.A., Hartmann, G., et al. (2013). Cyclic [G(2\u2032,5\u2032)pA(3\u2032,5\u2032)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell 153, 1094\u20131107.","journal-title":"Cell"},{"key":"2661_CR128","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1038\/s41467-022-28822-7","volume":"13","author":"J Garcia Morato","year":"2022","unstructured":"Garcia Morato, J., Hans, F., von Zweydorf, F., Feederle, R., Els\u00e4sser, S.J., Skodras, A.A., Gloeckner, C.J., Buratti, E., Neumann, M., and Kahle, P.J. (2022). Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43. Nat Commun 13, 1223.","journal-title":"Nat Commun"},{"key":"2661_CR129","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.ajhg.2008.08.009","volume":"83","author":"D Ghezzi","year":"2008","unstructured":"Ghezzi, D., Saada, A., D\u2019Adamo, P., Fernandez-Vizarra, E., Gasparini, P., Tiranti, V., Elpeleg, O., and Zeviani, M. (2008). FASTKD2 nonsense mutation in an infantile mitochondrial encephalomyopathy associated with cytochrome c oxidase deficiency. Am J Hum Genet 83, 415\u2013423.","journal-title":"Am J Hum Genet"},{"key":"2661_CR130","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.cell.2014.09.029","volume":"159","author":"LA Gilbert","year":"2014","unstructured":"Gilbert, L.A., Horlbeck, M.A., Adamson, B., Villalta, J.E., Chen, Y., Whitehead, E.H., Guimaraes, C., Panning, B., Ploegh, H.L., Bassik, M.C., et al. (2014). Genome-dcale CRISPR-mediated control of gene repression and activation. Cell 159, 647\u2013661.","journal-title":"Cell"},{"key":"2661_CR131","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.cell.2013.06.044","volume":"154","author":"LA Gilbert","year":"2013","unstructured":"Gilbert, L.A., Larson, M.H., Morsut, L., Liu, Z., Brar, G.A., Torres, S.E., Stern-Ginossar, N., Brandman, O., Whitehead, E.H., Doudna, J.A., et al. (2013). CRISPR-mediated modularRNA-guided regulation of transcription in eukaryotes. Cell 154, 442\u2013451.","journal-title":"Cell"},{"key":"2661_CR132","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.cbpa.2018.10.017","volume":"48","author":"AC Gingras","year":"2019","unstructured":"Gingras, A.C., Abe, K.T., and Raught, B. (2019). Getting to know the neighborhood: using proximity-dependent biotinylation to characterize protein complexes and map organelles. Curr Opin Chem Biol 48, 44\u201354.","journal-title":"Curr Opin Chem Biol"},{"key":"2661_CR133","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.ijbiomac.2020.01.032","volume":"147","author":"A Girdhar","year":"2020","unstructured":"Girdhar, A., Bharathi, V., Tiwari, V.R., Abhishek, S., Deeksha, W., Mahawar, U.S., Raju, G., Singh, S.K., Prabusankar, G., Rajakumara, E., et al. (2020). Computational insights into mechanism of AIM4-mediated inhibition of aggregation of TDP-43 protein implicated in ALS and evidence for in vitro inhibition of liquid-liquid phase separation (LLPS) of TDP-432C-A315T by AIM4. Int J Biol Macromol 147, 117\u2013130.","journal-title":"Int J Biol Macromol"},{"key":"2661_CR134","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1126\/science.1132814","volume":"314","author":"M Goedert","year":"2006","unstructured":"Goedert, M., and Spillantini, M.G. (2006). A century of Alzheimer\u2019s disease. Science 314, 777\u2013781.","journal-title":"Science"},{"key":"2661_CR135","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/nrneurol.2012.242","volume":"9","author":"M Goedert","year":"2013","unstructured":"Goedert, M., Spillantini, M.G., Del Tredici, K., and Braak, H. (2013). 100 years of Lewy pathology. Nat Rev Neurol 9, 13\u201324.","journal-title":"Nat Rev Neurol"},{"key":"2661_CR136","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1002\/cne.20513","volume":"485","author":"RJ Goodyear","year":"2005","unstructured":"Goodyear, R.J., Marcotti, W., Kros, C.J., and Richardson, G.P. (2005). Development and properties of stereociliary link types in hair cells of the mouse cochlea. J Comp Neurol 485, 75\u201385.","journal-title":"J Comp Neurol"},{"key":"2661_CR137","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1042\/bj0890585","volume":"89","author":"NM Green","year":"1963","unstructured":"Green, N.M. (1963). Avidin. 1. the use of [14c]biotin for kinetic studies and for assay. Biochem J 89, 585\u2013591.","journal-title":"Biochem J"},{"key":"2661_CR138","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1038\/s41572-023-00447-0","volume":"9","author":"M Grossman","year":"2023","unstructured":"Grossman, M., Seeley, W.W., Boxer, A.L., Hillis, A.E., Knopman, D.S., Ljubenov, P.A., Miller, B., Piguet, O., Rademakers, R., Whitwell, J.L., et al. (2023). Frontotemporal lobar degeneration. Nat Rev Dis Primers 9, 40.","journal-title":"Nat Rev Dis Primers"},{"key":"2661_CR139","doi-asserted-by":"publisher","first-page":"e108443","DOI":"10.15252\/embj.2021108443","volume":"41","author":"LA Gruijs da Silva","year":"2022","unstructured":"Gruijs da Silva, L.A., Simonetti, F., Hutten, S., Riemenschneider, H., Sternburg, E.L., Pietrek, L.M., Gebel, J., D\u00f6tsch, V., Edbauer, D., Hummer, G., et al. (2022). Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation. EMBO J 41, e108443.","journal-title":"EMBO J"},{"key":"2661_CR140","doi-asserted-by":"publisher","first-page":"31123","DOI":"10.1073\/pnas.2002437117","volume":"117","author":"J Gu","year":"2020","unstructured":"Gu, J., Liu, Z., Zhang, S., Li, Y., Xia, W., Wang, C., Xiang, H., Liu, Z., Tan, L., Fang, Y., et al. (2020). Hsp40 proteins phase separate to chaperone the assembly and maintenance of membraneless organelles. Proc Natl Acad Sci USA 117, 31123\u201331133.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2661_CR141","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1038\/s41422-021-00526-5","volume":"31","author":"J Gu","year":"2021","unstructured":"Gu, J., Wang, C., Hu, R., Li, Y., Zhang, S., Sun, Y., Wang, Q., Li, D., Fang, Y., and Liu, C. (2021). Hsp70 chaperones TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation. Cell Res 31, 1024\u20131027.","journal-title":"Cell Res"},{"key":"2661_CR142","doi-asserted-by":"publisher","first-page":"102926","DOI":"10.1016\/j.jbc.2023.102926","volume":"299","author":"X Gui","year":"2023","unstructured":"Gui, X., Feng, S., Li, Z., Li, Y., Reif, B., Shi, B., and Niu, Z. (2023). Liquid-liquid phase separation of amyloid-\u03b2 oligomers modulates amyloid fibrils formation. J Biol Chem 299, 102926.","journal-title":"J Biol Chem"},{"key":"2661_CR143","doi-asserted-by":"publisher","first-page":"5744","DOI":"10.1128\/MCB.00224-06","volume":"26","author":"S Guil","year":"2006","unstructured":"Guil, S., Long, J.C., and C\u00e1ceres, J.F. (2006). hnRNP A1 relocalization to the stress granules reflects a role in the stress response. Mol Cell Biol 26, 5744\u20135758.","journal-title":"Mol Cell Biol"},{"key":"2661_CR144","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.molcel.2020.06.034","volume":"79","author":"B Guilhas","year":"2020","unstructured":"Guilhas, B., Walter, J.C., Rech, J., David, G., Walliser, N.O., Palmeri, J., Mathieu-Demaziere, C., Parmeggiani, A., Bouet, J.Y., Le Gall, A., et al. (2020). ATP-driven separation of liquid phase condensates in bacteria. Mol Cell 79, 293\u2013303.e4.","journal-title":"Mol Cell"},{"key":"2661_CR145","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.cell.2020.03.049","volume":"181","author":"J Guill\u00e9n-Boixet","year":"2020","unstructured":"Guill\u00e9n-Boixet, J., Kopach, A., Holehouse, A.S., Wittmann, S., Jahnel, M., Schl\u00fc\u00dfler, R., Kim, K., Trussina, I.R.E.A., Wang, J., Mateju, D., et al. (2020). RNA-induced conformational switching and clustering of G3BP drive stress granule assembly by condensation. Cell 181, 346\u2013361.e17.","journal-title":"Cell"},{"key":"2661_CR146","doi-asserted-by":"publisher","first-page":"eaay4858","DOI":"10.1126\/sciadv.aay4858","volume":"6","author":"C Guo","year":"2020","unstructured":"Guo, C., Che, Z., Yue, J., Xie, P., Hao, S., Xie, W., Luo, Z., and Lin, C. (2020). ENL initiates multivalent phase separation of the super elongation complex (SEC) in controlling rapid transcriptional activation. Sci Adv 6, eaay4858.","journal-title":"Sci Adv"},{"key":"2661_CR147","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.cell.2018.03.002","volume":"173","author":"L Guo","year":"2018","unstructured":"Guo, L., Kim, H.J., Wang, H., Monaghan, J., Freyermuth, F., Sung, J.C., O\u2019Donovan, K., Fare, C.M., Diaz, Z., Singh, N., et al. (2018). Nuclear-import receptors reverse aberrant phase transitions of RNA-binding proteins with prion-like domains. Cell 173, 677\u2013692.e20.","journal-title":"Cell"},{"key":"2661_CR148","doi-asserted-by":"publisher","first-page":"eabf6548","DOI":"10.1126\/science.abf6548","volume":"372","author":"Y Gwon","year":"2021","unstructured":"Gwon, Y., Maxwell, B.A., Kolaitis, R.M., Zhang, P., Kim, H.J., and Taylor, J.P. (2021). Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner. Science 372, eabf6548.","journal-title":"Science"},{"key":"2661_CR149","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1016\/j.cell.2012.04.016","volume":"149","author":"TW Han","year":"2012","unstructured":"Han, T.W., Kato, M., Xie, S., Wu, L.C., Mirzaei, H., Pei, J., Chen, M., Xie, Y., Allen, J., Xiao, G., and McKnight, S.L. (2012). Cell-free formation of RNA granules: bound RNAs identify features and components of cellular assemblies. Cell 149, 768\u2013779.","journal-title":"Cell"},{"key":"2661_CR150","doi-asserted-by":"publisher","first-page":"19164","DOI":"10.1074\/jbc.M114.561704","volume":"289","author":"F Hans","year":"2014","unstructured":"Hans, F., Fiesel, F.C., Strong, J.C., Jackel, S., Rasse, T.M., Geisler, S., Springer, W., Schulz, J.B., Voigt, A., and Kahle, P.J. (2014). UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase Y regulate TDP-43 protein ubiquitination. J Biol Chem 289, 19164\u201319179.","journal-title":"J Biol Chem"},{"key":"2661_CR151","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/S0021-9258(17)49926-1","volume":"295","author":"F Hans","year":"2020","unstructured":"Hans, F., Glasebach, H., and Kahle, P.J. (2020). Multiple distinct pathways lead to hyperubiquitylated insoluble TDP-43 protein independent of its translocation into stress granules. J Biol Chem 295, 673\u2013689.","journal-title":"J Biol Chem"},{"key":"2661_CR152","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/1471-2121-8-28","volume":"8","author":"L Hao","year":"2007","unstructured":"Hao, L., Fuller, H.R., Lam, L.T., Le, T.T., Burghes, A.H., and Morris, G.E. (2007). Absence of gemin5 from SMN complexes in nuclear Cajal bodies. BMC Cell Biol 8, 28.","journal-title":"BMC Cell Biol"},{"key":"2661_CR153","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/s41577-022-00682-8","volume":"22","author":"CR Harapas","year":"2022","unstructured":"Harapas, C.R., Idiiatullina, E., Al-Azab, M., Hrovat-Schaale, K., Reygaerts, T., Steiner, A., Laohamonthonkul, P., Davidson, S., Yu, C.H., Booty, L., et al. (2022). Organellar homeostasis and innate immune sensing. Nat Rev Immunol 22, 535\u2013549.","journal-title":"Nat Rev Immunol"},{"key":"2661_CR154","first-page":"282","volume":"13","author":"MC Hardenberg","year":"2021","unstructured":"Hardenberg, M.C., Sinnige, T., Casford, S., Dada, S.T., Poudel, C., Robinson, E.A., Fuxreiter, M., Kaminksi, C.F., Kaminski Schierle, G.S., Nollen, E.A.A., Dobson, C.M., and Vendruscolo, M. (2021). Observation of an alpha-synuclein liquid droplet state and its maturation into Lewy body-like assemblies. J Mol Cell Biol 13, 282\u2013294.","journal-title":"J Mol Cell Biol"},{"key":"2661_CR155","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1126\/science.1072994","volume":"297","author":"J Hardy","year":"2002","unstructured":"Hardy, J., and Selkoe, D.J. (2002). The amyloid hypothesis of Alzheimer\u2019s disease: progress and problems on the road to therapeutics. Science 297, 353\u2013356.","journal-title":"Science"},{"key":"2661_CR156","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1002\/ana.21425","volume":"64","author":"M Hasegawa","year":"2008","unstructured":"Hasegawa, M., Arai, T., Nonaka, T., Kametani, F., Yoshida, M., Hashizume, Y., Beach, T.G., Buratti, E., Baralle, F., Morita, M., et al. (2008). Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Ann Neurol 64, 60\u201370.","journal-title":"Ann Neurol"},{"key":"2661_CR157","doi-asserted-by":"publisher","unstructured":"Haubrich, K., Augsten, S., \u00c1lvarez, L., Huppertz, I., Simon, B., Perez, K., Masiewicz, P., Lethier, M., Rittinger, K., Gabel, F., Hentze, M.W., Cusack, S., and Hennig, J. (2020). Mechanistic insights into RNA binding and RNA-regulated RIG-I ubiquitination by TRIM25. bioRxiv doi: https:\/\/doi.org\/10.1101\/2020.05.04.070177.","DOI":"10.1101\/2020.05.04.070177"},{"key":"2661_CR158","doi-asserted-by":"publisher","first-page":"2746","DOI":"10.1016\/j.cell.2024.03.023","volume":"187","author":"J He","year":"2024","unstructured":"He, J., Huo, X., Pei, G., Jia, Z., Yan, Y., Yu, J., Qu, H., Xie, Y., Yuan, J., Zheng, Y., et al. (2024). Dual-role transcription factors stabilize intermediate expression levels. Cell 187, 2746\u20132766.e25.","journal-title":"Cell"},{"key":"2661_CR159","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1016\/j.celrep.2019.09.027","volume":"29","author":"Y He","year":"2019","unstructured":"He, Y., Li, J., and Zhang, M. (2019). Myosin VII, USH1C, and ANKS4B or USH1G together form condensed molecular assembly via liquid-liquid phase separation. Cell Rep 29, 974\u2013986.e4.","journal-title":"Cell Rep"},{"key":"2661_CR160","doi-asserted-by":"publisher","first-page":"4103","DOI":"10.1074\/jbc.M112.419945","volume":"288","author":"ML Hebron","year":"2013","unstructured":"Hebron, M.L., Lonskaya, I., Sharpe, K., Weerasinghe, P.P.K., Algarzae, N.K., Shekoyan, A.R., and Moussa, C.E.H. (2013). Parkin ubiquitinates Tar-DNAbinding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6). J Biol Chem 288, 4103\u20134115.","journal-title":"J Biol Chem"},{"key":"2661_CR161","doi-asserted-by":"publisher","first-page":"2304","DOI":"10.1016\/j.celrep.2017.08.042","volume":"20","author":"A Hern\u00e1ndez-Vega","year":"2017","unstructured":"Hern\u00e1ndez-Vega, A., Braun, M., Scharrel, L., Jahnel, M., Wegmann, S., Hyman, B.T., Alberti, S., Diez, S., and Hyman, A.A. (2017). Local nucleation of microtubule bundles through tubulin concentration into a condensed Tau phase. Cell Rep 20, 2304\u20132312.","journal-title":"Cell Rep"},{"key":"2661_CR162","doi-asserted-by":"publisher","first-page":"9644","DOI":"10.1038\/s41598-020-66482-z","volume":"10","author":"H Heydarian","year":"2020","unstructured":"Heydarian, H., Yazdanfar, P., Zarif, A., and Rashidian, B. (2020). Near field differential interference contrast microscopy. Sci Rep 10, 9644.","journal-title":"Sci Rep"},{"key":"2661_CR163","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1038\/s41594-018-0122-9","volume":"25","author":"HS Hillen","year":"2018","unstructured":"Hillen, H.S., Temiakov, D., and Cramer, P. (2018). Structural basis of mitochondrial transcription. Nat Struct Mol Biol 25, 754\u2013765.","journal-title":"Nat Struct Mol Biol"},{"key":"2661_CR164","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1038\/s41580-022-00558-8","volume":"24","author":"T Hirose","year":"2022","unstructured":"Hirose, T., Ninomiya, K., Nakagawa, S., and Yamazaki, T. (2022). A guide to membraneless organelles and their various roles in gene regulation. Nat Rev Mol Cell Biol 24, 288\u2013304.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2661_CR165","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/nbt1278","volume":"25","author":"RA Hoebe","year":"2007","unstructured":"Hoebe, R.A., Van Oven, C.H., GadellaJr, T.W.J., Dhonukshe, P.B., Van Noorden, C.J.F., and Manders, E.M.M. (2007). Controlled light-exposure microscopy reduces photobleaching and phototoxicity in fluorescence live-cell imaging. Nat Biotechnol 25, 249\u2013253.","journal-title":"Nat Biotechnol"},{"key":"2661_CR166","doi-asserted-by":"publisher","first-page":"166961","DOI":"10.1016\/j.jmb.2021.166961","volume":"433","author":"C Hoffmann","year":"2021","unstructured":"Hoffmann, C., Sansevrino, R., Morabito, G., Logan, C., Vabulas, R.M., Ulusoy, A., Ganzella, M., and Milovanovic, D. (2021). Synapsin condensates recruit alpha-synuclein. J Mol Biol 433, 166961.","journal-title":"J Mol Biol"},{"key":"2661_CR167","doi-asserted-by":"publisher","first-page":"118876","DOI":"10.1016\/j.bbamcr.2020.118876","volume":"1868","author":"S Hofmann","year":"2021","unstructured":"Hofmann, S., Kedersha, N., Anderson, P., and Ivanov, P. (2021). Molecular mechanisms of stress granule assembly and disassembly. Biochim Biophys Acta 1868, 118876.","journal-title":"Biochim Biophys Acta"},{"key":"2661_CR168","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1016\/j.cell.2018.03.004","volume":"173","author":"M Hofweber","year":"2018","unstructured":"Hofweber, M., Hutten, S., Bourgeois, B., Spreitzer, E., Niedner-Boblenz, A., Schifferer, M., Ruepp, M.D., Simons, M., Niessing, D., Madl, T., et al. (2018). Phase separation of FUS is suppressed by its nuclear import receptor and arginine methylation. Cell 173, 706\u2013719.e13.","journal-title":"Cell"},{"key":"2661_CR169","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1038\/s41586-019-1502-y","volume":"573","author":"M Hondele","year":"2019","unstructured":"Hondele, M., Sachdev, R., Heinrich, S., Wang, J., Vallotton, P., Fontoura, B.M.A., and Weis, K. (2019). DEAD-box ATPases are global regulators of phase-separated organelles. Nature 573, 144\u2013148.","journal-title":"Nature"},{"key":"2661_CR170","doi-asserted-by":"publisher","first-page":"D460","DOI":"10.1093\/nar\/gkac783","volume":"51","author":"C Hou","year":"2023","unstructured":"Hou, C., Wang, X., Xie, H., Chen, T., Zhu, P., Xu, X., You, K., and Li, T. (2023). PhaSepDB in 2022: annotating phase separation-related proteins with droplet states, co-phase separation partners and other experimental information. Nucleic Acids Res 51, D460\u2013D465.","journal-title":"Nucleic Acids Res"},{"key":"2661_CR171","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/2716870","volume":"2019","author":"CA Houghton","year":"2019","unstructured":"Houghton, C.A. (2019). Sulforaphane: its \u201ccoming of age\u201d as a clinically relevant nutraceutical in the prevention and treatment of chronic disease. Oxid Med Cell Longev 2019, 1\u201327.","journal-title":"Oxid Med Cell Longev"},{"key":"2661_CR172","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1038\/nature05528","volume":"445","author":"YC Hsu","year":"2007","unstructured":"Hsu, Y.C., Chern, J.J., Cai, Y., Liu, M., and Choi, K.W. (2007). Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase. Nature 445, 785\u2013788.","journal-title":"Nature"},{"key":"2661_CR173","doi-asserted-by":"publisher","first-page":"14565","DOI":"10.3390\/ijms232314565","volume":"23","author":"R Hu","year":"2022","unstructured":"Hu, R., Qian, B., Li, A., and Fang, Y. (2022). Role of proteostasis regulation in the turnover of stress granules. Int J Mol Sci 23, 14565.","journal-title":"Int J Mol Sci"},{"key":"2661_CR174","first-page":"323","volume":"25","author":"X Hu","year":"2023","unstructured":"Hu, X., Wu, X., Berry, K., Zhao, C., Xin, D., Ogurek, S., Liu, X., Zhang, L., Luo, Z., Sakabe, M., Trubicka, J., \u0141astowska, M., Szulzewsky, F., Holland, E.C., Lee, L., Hu, M., Xin, M., and Lu, Q.R. (2023). Nuclear condensates of YAP fusion proteins alter transcription to drive ependymoma tumourigenesis. Nat Cell Biol 25, 323\u2013336.","journal-title":"Nat Cell Biol"},{"key":"2661_CR175","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1042\/BJ20080281","volume":"412","author":"J Huang","year":"2008","unstructured":"Huang, J., and Manning, B.D. (2008). The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochem J 412, 179\u2013190.","journal-title":"Biochem J"},{"key":"2661_CR176","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1002\/1873-3468.14361","volume":"596","author":"S Huang","year":"2022","unstructured":"Huang, S., Mo, X., Wang, J., Ye, X., Yu, H., and Liu, Y. (2022a). \u03b1-Synuclein phase separation and amyloid aggregation are modulated by C-terminal truncations. FEBS Lett 596, 1388\u20131400.","journal-title":"FEBS Lett"},{"key":"2661_CR177","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.bbrc.2022.02.097","volume":"603","author":"S Huang","year":"2022","unstructured":"Huang, S., Xu, B., and Liu, Y. (2022b). Calcium promotes \u03b1-synuclein liquid-liquid phase separation to accelerate amyloid aggregation. Biochem Biophys Res Commun 603, 13\u201320.","journal-title":"Biochem Biophys Res Commun"},{"key":"2661_CR178","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.molcel.2017.09.003","volume":"68","author":"A Hubstenberger","year":"2017","unstructured":"Hubstenberger, A., Courel, M., B\u00e9nard, M., Souquere, S., Ernoult-Lange, M., Chouaib, R., Yi, Z., Morlot, J.B., Munier, A., Fradet, M., et al. (2017). P-body purification reveals the condensation of repressed mRNA regulons. Mol Cell 68, 144\u2013157.e5.","journal-title":"Mol Cell"},{"key":"2661_CR179","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1038\/s41580-018-0060-8","volume":"19","author":"MG Iadanza","year":"2018","unstructured":"Iadanza, M.G., Jackson, M.P., Hewitt, E.W., Ranson, N.A., and Radford, S.E. (2018). A new era for understanding amyloid structures and disease. Nat Rev Mol Cell Biol 19, 755\u2013773.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2661_CR180","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/S1471-4914(02)02440-1","volume":"8","author":"EM Ingram","year":"2002","unstructured":"Ingram, E.M., and Spillantini, M.G. (2002). Tau gene mutations: dissecting the pathogenesis of FTDP-17. Trends Mol Med 8, 555\u2013562.","journal-title":"Trends Mol Med"},{"key":"2661_CR181","first-page":"4555","volume":"125","author":"M Isabelle","year":"2012","unstructured":"Isabelle M, Gagne JP, Gallouzi IE, Poirier GG. (2012). Quantitative proteomics and dynamic imaging reveal that G3BP-mediated stress granule assembly is poly(ADP-ribose)-dependent following exposure to MNNG-induced DNA alkylation. J Cell Sci 125, 4555\u20134566.","journal-title":"J Cell Sci"},{"key":"2661_CR182","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.1073\/pnas.0437660100","volume":"100","author":"S Iuchi","year":"2003","unstructured":"Iuchi, S., Hoffner, G., Verbeke, P., Djian, P., and Green, H. (2003). Oligomeric and polymeric aggregates formed by proteins containing expanded polyglutamine. Proc Natl Acad Sci USA 100, 2409\u20132414.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2661_CR183","doi-asserted-by":"publisher","first-page":"a032813","DOI":"10.1101\/cshperspect.a032813","volume":"11","author":"P Ivanov","year":"2019","unstructured":"Ivanov, P., Kedersha, N., and Anderson, P. (2019). Stress granules and processing bodies in translational control. Cold Spring Harb Perspect Biol 11, a032813.","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2661_CR184","doi-asserted-by":"publisher","first-page":"308a","DOI":"10.1016\/j.bpj.2021.11.1219","volume":"121","author":"A Jack","year":"2022","unstructured":"Jack, A., Kim, Y., Strom, A.R., Lee, D.S., Williams, B., Schaub, J.M., Kellogg, E.H., Finkelstein, I.J., Ferro, L., Yildiz, A., et al. (2022). Compartmentalization of telomeres through DNA-scaffolded phase separation. Biophys J 121, 308a.","journal-title":"Biophys J"},{"key":"2661_CR185","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/j.bpj.2020.07.005","volume":"119","author":"H Jafarinia","year":"2020","unstructured":"Jafarinia, H., van der Giessen, E., and Onck, P.R. (2020). Phase separation of toxic dipeptide repeat proteins related to C9orf72 ALS\/FTD. Biophys J 119, 843\u2013851.","journal-title":"Biophys J"},{"key":"2661_CR186","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/nature22386","volume":"546","author":"A Jain","year":"2017","unstructured":"Jain, A., and Vale, R.D. (2017). RNA phase transitions in repeat expansion disorders. Nature 546, 243\u2013247.","journal-title":"Nature"},{"key":"2661_CR187","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.cell.2015.12.038","volume":"164","author":"S Jain","year":"2016","unstructured":"Jain, S., Wheeler, J.R., Walters, R.W., Agrawal, A., Barsic, A., and Parker, R. (2016). ATPase-modulated stress granules contain a diverse proteome and substructure. Cell 164, 487\u2013498.","journal-title":"Cell"},{"key":"2661_CR188","doi-asserted-by":"publisher","first-page":"e2021719118","DOI":"10.1073\/pnas.2021719118","volume":"118","author":"AK Jayabalan","year":"2021","unstructured":"Jayabalan, A.K., Adivarahan, S., Koppula, A., Abraham, R., Batish, M., Zenklusen, D., Griffin, D.E., and Leung, A.K.L. (2021). Stress granule formation, disassembly, and composition are regulated by alphavirus ADP-ribosylhydrolase activity. Proc Natl Acad Sci USA 118, e2021719118.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2661_CR189","doi-asserted-by":"publisher","first-page":"4209","DOI":"10.1016\/j.molcel.2021.07.038","volume":"81","author":"L Jiang","year":"2021","unstructured":"Jiang, L., Lin, W., Zhang, C., Ash, P.E.A., Verma, M., Kwan, J., van Vliet, E., Yang, Z., Cruz, A.L., Boudeau, S., et al. (2021). Interaction of Tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy. Mol Cell 81, 4209\u20134227.e12.","journal-title":"Mol Cell"},{"key":"2661_CR190","doi-asserted-by":"publisher","first-page":"eabh2929","DOI":"10.1126\/sciadv.abh2929","volume":"7","author":"X Jin","year":"2021","unstructured":"Jin, X., Lee, J.E., Schaefer, C., Luo, X., Wollman, A.J.M., Payne-Dwyer, A.L., Tian, T., Zhang, X., Chen, X., Li, Y., et al. (2021). Membraneless organelles formed by liquidliquid phase separation increase bacterial fitness. Sci Adv 7, eabh2929.","journal-title":"Sci Adv"},{"key":"2661_CR191","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1038\/s41596-020-0313-9","volume":"15","author":"J Jonkman","year":"2020","unstructured":"Jonkman, J., Brown, C.M., Wright, G.D., Anderson, K.I., and North, A.J. (2020). Tutorial: guidance for quantitative confocal microscopy. Nat Protoc 15, 1585\u20131611.","journal-title":"Nat Protoc"},{"key":"2661_CR192","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.cmet.2013.02.005","volume":"17","author":"AA Jourdain","year":"2013","unstructured":"Jourdain, A.A., Koppen, M., Wydro, M., Rodley, C.D., Lightowlers, R.N., Chrzanowska-Lightowlers, Z.M., and Martinou, J.C. (2013). GRSF1 regulates RNA processing in mitochondrial RNA granules. Cell Metab 17, 399\u2013410.","journal-title":"Cell Metab"},{"key":"2661_CR193","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1038\/nri3757","volume":"14","author":"JC Kagan","year":"2014","unstructured":"Kagan, J.C., Magupalli, V.G., and Wu, H. (2014). SMOCs: supramolecular organizing centres that control innate immunity. Nat Rev Immunol 14, 821\u2013826.","journal-title":"Nat Rev Immunol"},{"key":"2661_CR194","doi-asserted-by":"publisher","first-page":"2809","DOI":"10.1038\/s41467-020-16580-3","volume":"11","author":"NM Kanaan","year":"2020","unstructured":"Kanaan, N.M., Hamel, C., Grabinski, T., and Combs, B. (2020). Liquid-liquid phase separation induces pathogenic tau conformations in vitro. Nat Commun 11, 2809.","journal-title":"Nat Commun"},{"key":"2661_CR195","doi-asserted-by":"publisher","first-page":"11748","DOI":"10.1073\/pnas.0604970103","volume":"103","author":"RN Kanadia","year":"2006","unstructured":"Kanadia, R.N., Shin, J., Yuan, Y., Beattie, S.G., Wheeler, T.M., Thornton, C.A., and Swanson, M.S. (2006). Reversal of RNA missplicing and myotonia after muscleblind overexpression in a mouse poly(CUG) model for myotonic dystrophy. Proc Natl Acad Sci USA 103, 11748\u201311753.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2661_CR196","doi-asserted-by":"publisher","first-page":"e3000327","DOI":"10.1371\/journal.pbio.3000327","volume":"17","author":"J Kang","year":"2019","unstructured":"Kang, J., Lim, L., Lu, Y., Song, J., and Bates, G.P. (2019). A unified mechanism for LLPS of ALS\/FTLD-causing FUS as well as its modulation by ATP and oligonucleic acids. PLoS Biol 17, e3000327.","journal-title":"PLoS Biol"},{"key":"2661_CR197","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.cell.2012.04.017","volume":"149","author":"M Kato","year":"2012","unstructured":"Kato, M., Han, T.W., Xie, S., Shi, K., Du, X., Wu, L.C., Mirzaei, H., Goldsmith, E.J., Longgood, J., Pei, J., et al. (2012). Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels. Cell 149, 753\u2013767.","journal-title":"Cell"},{"key":"2661_CR198","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s00018-023-04739-2","volume":"80","author":"SS Keating","year":"2023","unstructured":"Keating, S.S., Bademosi, A.T., San Gil, R., and Walker, A.K. (2023). Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43. Cell Mol Life Sci 80, 95.","journal-title":"Cell Mol Life Sci"},{"key":"2661_CR199","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1083\/jcb.200502088","volume":"169","author":"N Kedersha","year":"2005","unstructured":"Kedersha, N., Stoecklin, G., Ayodele, M., Yacono, P., Lykke-Andersen, J., Fritzler, M.J., Scheuner, D., Kaufman, R.J., Golan, D.E., and Anderson, P. (2005). Stress granules and processing bodies are dynamically linked sites of mRNP remodeling. J Cell Biol 169, 871\u2013884.","journal-title":"J Cell Biol"},{"key":"2661_CR200","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.molcel.2020.05.017","volume":"79","author":"J Keiten-Schmitz","year":"2020","unstructured":"Keiten-Schmitz, J., Wagner, K., Piller, T., Kaulich, M., Alberti, S., and M\u00fcller, S. (2020). The nuclear SUMO-targeted ubiquitin quality control network regulates the dynamics of cytoplasmic stress granules. Mol Cell 79, 54\u201367.e7.","journal-title":"Mol Cell"},{"key":"2661_CR201","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1038\/s41589-022-01046-y","volume":"18","author":"HR Kilgore","year":"2022","unstructured":"Kilgore, H.R., and Young, R.A. (2022). Learning the chemical grammar of biomolecular condensates. Nat Chem Biol 18, 1298\u20131306.","journal-title":"Nat Chem Biol"},{"key":"2661_CR202","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/s41589-023-01432-0","volume":"20","author":"HR Kilgore","year":"2024","unstructured":"Kilgore, H.R., Mikhael, P.G., Overholt, K.J., Boija, A., Hannett, N.M., Van Dongen, C., Lee, T.I., Chang, Y.T., Barzilay, R., and Young, R.A. (2024). Distinct chemical environments in biomolecular condensates. Nat Chem Biol 20, 291\u2013301.","journal-title":"Nat Chem Biol"},{"key":"2661_CR203","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1091\/mbc.E15-12-0844","volume":"27","author":"DI Kim","year":"2016","unstructured":"Kim, D.I., Jensen, S.C., Noble, K.A., Kc, B., Roux, K.H., Motamedchaboki, K., Roux, K. J., and Zheng, Y. (2016a). An improved smaller biotin ligase for BioID proximity labeling. Mol Biol Cell 27, 1188\u20131196.","journal-title":"Mol Biol Cell"},{"key":"2661_CR204","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.neuron.2017.07.029","volume":"96","author":"HJ Kim","year":"2017","unstructured":"Kim, H.J., and Taylor, J.P. (2017). Lost in transportation: nucleocytoplasmic transport defects in ALS and other neurodegenerative diseases. Neuron 96, 285\u2013297.","journal-title":"Neuron"},{"key":"2661_CR205","doi-asserted-by":"crossref","first-page":"E847","DOI":"10.1073\/pnas.1502545112","volume":"113","author":"S Kim","year":"2016","unstructured":"Kim, S., Huang, J., Lee, Y., Dutta, S., Yoo, H.Y., Jung, Y.M., Jho, Y., Zeng, H., and Hwang, D.S. (2016b). Complexation and coacervation of like-charged polyelectrolytes inspired by mussels. Proc Natl Acad Sci USA 113, E847\u2013E853.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2661_CR206","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/j.molcel.2016.07.022","volume":"63","author":"YE Kim","year":"2016","unstructured":"Kim, Y.E., Hosp, F., Frottin, F., Ge, H., Mann, M., Hayer-Hartl, M., and Hartl, F.U. (2016c). Soluble oligomers of polyq-expanded huntingtin target a multiplicity of key cellular factors. Mol Cell 63, 951\u2013964.","journal-title":"Mol Cell"},{"key":"2661_CR207","doi-asserted-by":"publisher","first-page":"3633","DOI":"10.1093\/nar\/gky204","volume":"46","author":"GA King","year":"2018","unstructured":"King, G.A., Hashemi Shabestari, M., Taris, K.K.H., Pandey, A.K., Venkatesh, S., Thilagavathi, J., Singh, K., Krishna Koppisetti, R., Temiakov, D., Roos, W.H., et al. (2018). Acetylation and phosphorylation of human TFAM regulate TFAM\u2013DNA interactions via contrasting mechanisms. Nucleic Acids Res 46, 3633\u20133642.","journal-title":"Nucleic Acids Res"},{"key":"2661_CR208","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1126\/science.aaz4427","volume":"368","author":"IA Klein","year":"2020","unstructured":"Klein, I.A., Boija, A., Afeyan, L.K., Hawken, S.W., Fan, M., Dall\u2019Agnese, A., Oksuz, O., Henninger, J.E., Shrinivas, K., Sabari, B.R., et al. (2020). Partitioning of cancer therapeutics in nuclear condensates. Science 368, 1386\u20131392.","journal-title":"Science"},{"key":"2661_CR209","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s41572-021-00269-y","volume":"7","author":"DS Knopman","year":"2021","unstructured":"Knopman, D.S., Amieva, H., Petersen, R.C., Ch\u00e9telat, G., Holtzman, D.M., Hyman, B. T., Nixon, R.A., and Jones, D.T. (2021). Alzheimer disease. Nat Rev Dis Primers 7, 33.","journal-title":"Nat Rev Dis Primers"},{"key":"2661_CR210","doi-asserted-by":"publisher","first-page":"818655","DOI":"10.3389\/fnins.2022.818655","volume":"16","author":"LC Koehler","year":"2022","unstructured":"Koehler, L.C., Grese, Z.R., Bastos, A.C.S., Mamede, L.D., Heyduk, T., and Ayala, Y.M. (2022). TDP-43 oligomerization and phase separation properties are necessary for autoregulation. Front Neurosci 16, 818655.","journal-title":"Front Neurosci"},{"key":"2661_CR211","doi-asserted-by":"publisher","first-page":"30420","DOI":"10.1038\/srep30420","volume":"6","author":"K Koos","year":"2016","unstructured":"Koos, K., Moln\u00e1r, J., Kelemen, L., Tam\u00e1s, G., and Horvath, P. (2016). DIC image reconstruction using an energy minimization framework to visualize optical path length distribution. Sci Rep 6, 30420.","journal-title":"Sci Rep"},{"key":"2661_CR212","doi-asserted-by":"publisher","unstructured":"Kroschwald, S., Maharana, S., and Simon, A. (2017). Hexanediol: a chemical probe to investigate the material properties of membrane-less compartments. Matters doi: https:\/\/doi.org\/10.19185\/MATTERS.201702000010.","DOI":"10.19185\/MATTERS.201702000010"},{"key":"2661_CR213","doi-asserted-by":"publisher","first-page":"3327","DOI":"10.1016\/j.celrep.2018.05.041","volume":"23","author":"S Kroschwald","year":"2018","unstructured":"Kroschwald, S., Munder, M.C., Maharana, S., Franzmann, T.M., Richter, D., Ruer, M., Hyman, A.A., and Alberti, S. (2018). Different material states of Pub1 condensates define distinct modes of stress adaptation and recovery. Cell Rep 23, 3327\u20133339.","journal-title":"Cell Rep"},{"key":"2661_CR214","doi-asserted-by":"publisher","first-page":"11288","DOI":"10.1073\/pnas.1512131112","volume":"112","author":"C Kukat","year":"2015","unstructured":"Kukat, C., Davies, K.M., Wurm, C.A., Sp\u00e5hr, H., Bonekamp, N.A., K\u00fchl, I., Joos, F., Polosa, P.L., Park, C.B., Posse, V., et al. (2015). Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid. Proc Natl Acad Sci USA 112, 11288\u201311293.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2661_CR215","doi-asserted-by":"publisher","first-page":"18540","DOI":"10.1073\/pnas.2005019117","volume":"117","author":"AM Ladouceur","year":"2020","unstructured":"Ladouceur, A.M., Parmar, B.S., Biedzinski, S., Wall, J., Tope, S.G., Cohn, D., Kim, A., Soubry, N., Reyes-Lamothe, R., and Weber, S.C. (2020). Clusters of bacterial RNA polymerase are biomolecular condensates that assemble through liquid\u2013liquid phase separation. Proc Natl Acad Sci USA 117, 18540\u201318549.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2661_CR216","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1038\/s41580-020-0272-6","volume":"22","author":"DLJ Lafontaine","year":"2021","unstructured":"Lafontaine, D.L.J., Riback, J.A., Bascetin, R., and Brangwynne, C.P. (2021). The nucleolus as a multiphase liquid condensate. Nat Rev Mol Cell Biol 22, 165\u2013182.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2661_CR217","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/nrn3406","volume":"14","author":"HA Lashuel","year":"2013","unstructured":"Lashuel, H.A., Overk, C.R., Oueslati, A., and Masliah, E. (2013). The many faces of \u03b1-synuclein: from structure and toxicity to therapeutic target. Nat Rev Neurosci 14, 38\u201348.","journal-title":"Nat Rev Neurosci"},{"key":"2661_CR218","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1111\/dgd.12794","volume":"64","author":"ED Lavering","year":"2022","unstructured":"Lavering, E.D., Petros, I.N., and Weeks, D.L. (2022). Component analysis of nucleolar protein compartments using Xenopus laevis oocytes. Dev Growth Differ 64, 306\u2013317.","journal-title":"Dev Growth Differ"},{"key":"2661_CR219","doi-asserted-by":"publisher","first-page":"7202","DOI":"10.1021\/jacs.9b03083","volume":"141","author":"H Le Ferrand","year":"2019","unstructured":"Le Ferrand, H., Duchamp, M., Gabryelczyk, B., Cai, H., and Miserez, A. (2019). Time-resolved observations of liquid\u2013liquid phase separation at the nanoscale using in situ liquid transmission electron microscopy. J Am Chem Soc 141, 7202\u20137210.","journal-title":"J Am Chem Soc"},{"key":"2661_CR220","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1093\/nar\/gkab1242","volume":"50","author":"R Lee","year":"2022","unstructured":"Lee, R., Kang, M.K., Kim, Y.J., Yang, B., Shim, H., Kim, S., Kim, K., Yang, C.M., Min, B., Jung, W.J., et al. (2022). CTCF-mediated chromatin looping provides a topological framework for the formation of phase-separated transcriptional condensates. Nucleic Acids Res 50, 207\u2013226.","journal-title":"Nucleic Acids Res"},{"key":"2661_CR221","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1016\/j.celrep.2013.10.049","volume":"5","author":"YB Lee","year":"2013","unstructured":"Lee, Y.B., Chen, H.J., Peres, J.N., Gomez-Deza, J., Attig, J., \u0160talekar, M., Troakes, C., Nishimura, A.L., Scotter, E.L., Vance, C., et al. (2013). Hexanucleotide repeats in ALS\/FTD form length-dependent RNA foci, sequester RNA binding proteins, and are neurotoxic. Cell Rep 5, 1178\u20131186.","journal-title":"Cell Rep"},{"key":"2661_CR222","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/0092-8674(95)90460-3","volume":"80","author":"S Lefebvre","year":"1995","unstructured":"Lefebvre, S., B\u00fcrglen, L., Reboullet, S., Clermont, O., Burlet, P., Viollet, L., Benichou, B., Cruaud, C., Millasseau, P., Zeviani, M., et al. (1995). Identification and characterization of a spinal muscular atrophy-determining gene. Cell 80, 155\u2013165.","journal-title":"Cell"},{"key":"2661_CR223","doi-asserted-by":"publisher","first-page":"14777","DOI":"10.1074\/jbc.M109.093708","volume":"285","author":"J Legleiter","year":"2010","unstructured":"Legleiter, J., Mitchell, E., Lotz, G.P., Sapp, E., Ng, C., DiFiglia, M., Thompson, L.M., and Muchowski, P.J. (2010). Mutant huntingtin fragments form oligomers in a polyglutamine length-dependent manner in vitro and in vivo. J Biol Chem 285, 14777\u201314790.","journal-title":"J Biol Chem"},{"key":"2661_CR224","doi-asserted-by":"publisher","first-page":"5223","DOI":"10.3748\/wjg.v26.i35.5223","volume":"26","author":"N Legrand","year":"2020","unstructured":"Legrand, N., Dixon, D.A., and Sobolewski, C. (2020). Stress granules in colorectal cancer: current knowledge and potential therapeutic applications. World J Gastroenterol 26, 5223\u20135247.","journal-title":"World J Gastroenterol"},{"key":"2661_CR225","doi-asserted-by":"publisher","first-page":"101517","DOI":"10.1016\/j.isci.2020.101517","volume":"23","author":"C Lemos","year":"2020","unstructured":"Lemos, C., Schulze, L., Weiske, J., Meyer, H., Braeuer, N., Barak, N., Ebersp\u00e4cher, U., Werbeck, N., Stresemann, C., Lange, M., et al. (2020). Identification of small molecules that modulate mutant p53 condensation. iScience 23, 101517.","journal-title":"iScience"},{"key":"2661_CR226","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.molcel.2011.04.015","volume":"42","author":"AKL Leung","year":"2011","unstructured":"Leung, A.K.L., Vyas, S., Rood, J.E., Bhutkar, A., Sharp, P.A., and Chang, P. (2011). Poly(ADP-ribose) regulates stress responses and microRNA activity in the cytoplasm. Mol Cell 42, 489\u2013499.","journal-title":"Mol Cell"},{"key":"2661_CR227","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/s41583-022-00603-7","volume":"23","author":"D Li","year":"2022","unstructured":"Li, D., and Liu, C. (2022). Conformational strains of pathogenic amyloid proteins in neurodegenerative diseases. Nat Rev Neurosci 23, 523\u2013534.","journal-title":"Nat Rev Neurosci"},{"key":"2661_CR228","doi-asserted-by":"publisher","first-page":"e23075","DOI":"10.1371\/journal.pone.0023075","volume":"6","author":"HY Li","year":"2011","unstructured":"Li, H.Y., Yeh, P.A., Chiu, H.C., Tang, C.Y., Tu, B.P., and Ginsberg, S.D. (2011). Hyperphosphorylation as a defense mechanism to reduce TDP-43 aggregation. PLoS One 6, e23075.","journal-title":"PLoS One"},{"key":"2661_CR229","first-page":"E3776","volume":"114","author":"J Li","year":"2017","unstructured":"Li, J., He, Y., Weck, M.L., Lu, Q., Tyska, M.J., and Zhang, M. (2017). Structure of Myo7b\/USH1C complex suggests a general PDZ domain binding mode by MyTH4-FERM myosins. Proc Natl Acad Sci USA 114, E3776\u2013E3785.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2661_CR230","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s43556-022-00075-2","volume":"3","author":"J Li","year":"2022","unstructured":"Li, J., Zhang, M., Ma, W., Yang, B., Lu, H., Zhou, F., and Zhang, L. (2022a). Post-translational modifications in liquid-liquid phase separation: a comprehensive review. Mol Biomed 3, 13.","journal-title":"Mol Biomed"},{"key":"2661_CR231","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1038\/nature10879","volume":"483","author":"P Li","year":"2012","unstructured":"Li, P., Banjade, S., Cheng, H.C., Kim, S., Chen, B., Guo, L., Llaguno, M., Hollingsworth, J.V., King, D.S., Banani, S.F., et al. (2012). Phase transitions in the assembly of multivalent signalling proteins. Nature 483, 336\u2013340.","journal-title":"Nature"},{"key":"2661_CR232","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1007\/s11684-023-1026-6","volume":"17","author":"Q Li","year":"2023","unstructured":"Li, Q., and Gao, P. (2023). Phase separation in cGAS-STING signaling. Front Med 17, 855\u2013866.","journal-title":"Front Med"},{"key":"2661_CR233","doi-asserted-by":"publisher","first-page":"6796","DOI":"10.3390\/ijms21186796","volume":"21","author":"Q Li","year":"2020","unstructured":"Li, Q., Wang, X., Dou, Z., Yang, W., Huang, B., Lou, J., and Zhang, Z. (2020). Protein databases related to liquid-liquid phase separation. Int J Mol Sci 21, 6796.","journal-title":"Int J Mol Sci"},{"key":"2661_CR234","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1038\/s41422-021-00530-9","volume":"31","author":"RH Li","year":"2021","unstructured":"Li, R.H., Tian, T., Ge, Q.W., He, X.Y., Shi, C.Y., Li, J.H., Zhang, Z., Liu, F.Z., Sang, L.J., Yang, Z.Z., et al. (2021). A phosphatidic acid-binding lncRNA SNHG9 facilitates LATS1 liquid\u2013liquid phase separation to promote oncogenic YAP signaling. Cell Res 31, 1088\u20131105.","journal-title":"Cell Res"},{"key":"2661_CR235","first-page":"843","volume":"2","author":"X Li","year":"2022","unstructured":"Li, X., Lu, S.Y., Lu, B.X., and Sun, X.L. (2022b). Optogenetic control of GGGGCC repeat-containing RNA phase transition. Fund Res-China 2, 843\u2013850.","journal-title":"Fund Res-China"},{"key":"2661_CR236","doi-asserted-by":"publisher","first-page":"e2300215120","DOI":"10.1073\/pnas.2300215120","volume":"120","author":"CM Lim","year":"2023","unstructured":"Lim, C.M., Gonz\u00e1lez D\u00edaz, A., Fuxreiter, M., Pun, F.W., Zhavoronkov, A., and Vendruscolo, M. (2023). Multiomic prediction of therapeutic targets for human diseases associated with protein phase separation. Proc Natl Acad Sci USA 120, e2300215120.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2661_CR237","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.tcb.2023.09.002","volume":"34","author":"CC Lin","year":"2023","unstructured":"Lin, C.C., Suen, K.M., Lidster, J., and Ladbury, J.E. (2023). The emerging role of receptor tyrosine kinase phase separation in cancer. Trends Cell Biol 34, 371\u2013379.","journal-title":"Trends Cell Biol"},{"key":"2661_CR238","doi-asserted-by":"publisher","first-page":"108770","DOI":"10.1016\/j.celrep.2021.108770","volume":"34","author":"L Lin","year":"2021","unstructured":"Lin, L., Shi, Y., Wang, M., Wang, C., Lu, Q., Zhu, J., and Zhang, R. (2021). Phase separation-mediated condensation of Whirlin-Myo15-Eps8 stereocilia tip complex. Cell Rep 34, 108770.","journal-title":"Cell Rep"},{"key":"2661_CR239","doi-asserted-by":"publisher","first-page":"e42571","DOI":"10.7554\/eLife.42571","volume":"8","author":"Y Lin","year":"2019","unstructured":"Lin, Y., McCarty, J., Rauch, J.N., Delaney, K.T., Kosik, K.S., Fredrickson, G.H., Shea, J. E., and Han, S. (2019). Narrow equilibrium window for complex coacervation of tau and RNA under cellular conditions. Elife 8, e42571.","journal-title":"Elife"},{"key":"2661_CR240","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.molcel.2015.08.018","volume":"60","author":"Y Lin","year":"2015","unstructured":"Lin, Y., Protter, D.S.W., Rosen, M.K., and Parker, R. (2015). Formation and maturation of phase-separated liquid droplets by RNA-binding proteins. Mol Cell 60, 208\u2013219.","journal-title":"Mol Cell"},{"key":"2661_CR241","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.neuron.2013.07.033","volume":"79","author":"SC Ling","year":"2013","unstructured":"Ling, S.C., Polymenidou, M., and Cleveland, D.W. (2013). Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis. Neuron 79, 416\u2013438.","journal-title":"Neuron"},{"key":"2661_CR242","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1038\/s41557-023-01289-9","volume":"15","author":"M Linsenmeier","year":"2023","unstructured":"Linsenmeier, M., Faltova, L., Morelli, C., Capasso Palmiero, U., Seiffert, C., K\u00fcffner, A. M., Pinotsi, D., Zhou, J., Mezzenga, R., and Arosio, P. (2023). The interface of condensates of the hnRNPA1 low-complexity domain promotes formation of amyloid fibrils. Nat Chem 15, 1340\u20131349.","journal-title":"Nat Chem"},{"key":"2661_CR243","doi-asserted-by":"publisher","first-page":"eabq6495","DOI":"10.1126\/sciadv.abq6495","volume":"8","author":"WP Lipi\u0144ski","year":"2022","unstructured":"Lipi\u0144ski, W.P., Visser, B.S., Robu, I., Fakhree, M.A.A., Lindhoud, S., Claessens, M.M.A.E., and Spruijt, E. (2022). Biomolecular condensates can both accelerate and suppress aggregation of \u03b1-synuclein. Sci Adv 8, eabq6495.","journal-title":"Sci Adv"},{"key":"2661_CR244","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1093\/procel\/pwad013","volume":"14","author":"J Liu","year":"2023","unstructured":"Liu, J., Chen, Y., Nong, B., Luo, X., Cui, K., Li, Z., Zhang, P., Tan, W., Yang, Y., Ma, W., et al. (2023). CRISPR-assisted transcription activation by phase-separation proteins. Protein Cell 14, 874\u2013887.","journal-title":"Protein Cell"},{"key":"2661_CR245","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1038\/s41467-021-21386-y","volume":"12","author":"J Liu","year":"2021","unstructured":"Liu, J., Xie, Y., Guo, J., Li, X., Wang, J., Jiang, H., Peng, Z., Wang, J., Wang, S., Li, Q., et al. (2021a). Targeting NSD2-mediated SRC-3 liquid\u2013liquid phase separation sensitizes bortezomib treatment in multiple myeloma. Nat Commun 12, 1022.","journal-title":"Nat Commun"},{"key":"2661_CR246","doi-asserted-by":"publisher","first-page":"6051","DOI":"10.1093\/nar\/gkx141","volume":"45","author":"N Liu","year":"2017","unstructured":"Liu, N., Zhou, K.I., Parisien, M., Dai, Q., Diatchenko, L., and Pan, T. (2017). N 6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein. Nucleic Acids Res 45, 6051\u20136063.","journal-title":"Nucleic Acids Res"},{"key":"2661_CR247","doi-asserted-by":"publisher","first-page":"5559","DOI":"10.1016\/j.cell.2021.10.001","volume":"184","author":"Q Liu","year":"2021","unstructured":"Liu, Q., Li, J., Zhang, W., Xiao, C., Zhang, S., Nian, C., Li, J., Su, D., Chen, L., Zhao, Q., et al. (2021b). Glycogen accumulation and phase separation drives liver tumor initiation. Cell 184, 5559\u20135576.e19.","journal-title":"Cell"},{"key":"2661_CR248","doi-asserted-by":"publisher","first-page":"5083","DOI":"10.1007\/s00018-021-03840-8","volume":"78","author":"S Liu","year":"2021","unstructured":"Liu, S., Wang, S., Zou, L., and Xiong, W. (2021c). Mechanisms in cochlear hair cell mechano-electrical transduction for acquisition of sound frequency and intensity. Cell Mol Life Sci 78, 5083\u20135094.","journal-title":"Cell Mol Life Sci"},{"key":"2661_CR249","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/s41594-020-0399-3","volume":"27","author":"Z Liu","year":"2020","unstructured":"Liu, Z., Zhang, S., Gu, J., Tong, Y., Li, Y., Gui, X., Long, H., Wang, C., Zhao, C., Lu, J., et al. (2020). Hsp27 chaperones FUS phase separation under the modulation of stress-induced phosphorylation. Nat Struct Mol Biol 27, 363\u2013372.","journal-title":"Nat Struct Mol Biol"},{"key":"2661_CR250","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.gene.2018.12.046","volume":"692","author":"GP Livi","year":"2019","unstructured":"Livi, G.P. (2019). Halcyon days of TOR: reflections on the multiple independent discovery of the yeast and mammalian TOR proteins. Gene 692, 145\u2013155.","journal-title":"Gene"},{"key":"2661_CR251","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.cell.2019.09.001","volume":"179","author":"JM Long","year":"2019","unstructured":"Long, J.M., and Holtzman, D.M. (2019). Alzheimer disease: an update on pathobiology and treatment strategies. Cell 179, 312\u2013339.","journal-title":"Cell"},{"key":"2661_CR252","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1038\/s41594-021-00671-w","volume":"28","author":"Q Long","year":"2021","unstructured":"Long, Q., Zhou, Y., Wu, H., Du, S., Hu, M., Qi, J., Li, W., Guo, J., Wu, Y., Yang, L., et al. (2021). Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation. Nat Struct Mol Biol 28, 900\u2013908.","journal-title":"Nat Struct Mol Biol"},{"key":"2661_CR253","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1038\/s41580-023-00647-2","volume":"24","author":"N Louros","year":"2023","unstructured":"Louros, N., Schymkowitz, J., and Rousseau, F. (2023). Mechanisms and pathology of protein misfolding and aggregation. Nat Rev Mol Cell Biol 24, 912\u2013933.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2661_CR254","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.molcel.2012.10.023","volume":"49","author":"B Lu","year":"2013","unstructured":"Lu, B., Lee, J., Nie, X., Li, M., Morozov, Y.I., Venkatesh, S., Bogenhagen, D.F., Temiakov, D., and Suzuki, C.K. (2013). Phosphorylation of human TFAM in mitochondria impairs DNA binding and promotes degradation by the AAA+ lon protease. Mol Cell 49, 121\u2013132.","journal-title":"Mol Cell"},{"key":"2661_CR255","doi-asserted-by":"publisher","first-page":"e2101895","DOI":"10.1002\/advs.202101895","volume":"8","author":"B Lu","year":"2021","unstructured":"Lu, B., Zou, C., Yang, M., He, Y., He, J., Zhang, C., Chen, S., Yu, J., Liu, K.Y., Cao, Q., et al. (2021). Pharmacological inhibition of core regulatory circuitry liquid\u2013liquid phase separation suppresses metastasis and chemoresistance in osteosarcoma. Adv Sci 8, e2101895.","journal-title":"Adv Sci"},{"key":"2661_CR256","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.chembiol.2015.05.009","volume":"22","author":"J Lu","year":"2015","unstructured":"Lu, J., Qian, Y., Altieri, M., Dong, H., Wang, J., Raina, K., Hines, J., Winkler, J.D., Crew, A.P., Coleman, K., et al. (2015). Hijacking the E3 ubiquitin ligase cereblon to efficiently target BRD4. Chem Biol 22, 755\u2013763.","journal-title":"Chem Biol"},{"key":"2661_CR257","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1038\/s41556-022-00988-8","volume":"24","author":"S Lu","year":"2022","unstructured":"Lu, S., Hu, J., Arogundade, O.A., Goginashvili, A., Vazquez-Sanchez, S., Diedrich, J.K., Gu, J., Blum, J., Oung, S., Ye, Q., et al. (2022). Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition. Nat Cell Biol 24, 1378\u20131393.","journal-title":"Nat Cell Biol"},{"key":"2661_CR258","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1038\/s41467-020-20768-y","volume":"12","author":"S Lu","year":"2021","unstructured":"Lu, S., Ye, Q., Singh, D., Cao, Y., Diedrich, J.K., Yates III, J.R., Villa, E., Cleveland, D.W., and Corbett, K.D. (2021). The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein. Nat Commun 12, 502.","journal-title":"Nat Commun"},{"key":"2661_CR259","doi-asserted-by":"publisher","first-page":"eaba3613","DOI":"10.1126\/scitranslmed.aba3613","volume":"12","author":"Y Lu","year":"2020","unstructured":"Lu, Y., Sun, Y., Liu, Z., Lu, Y., Zhu, X., Lan, B., Mi, Z., Dang, L., Li, N., Zhan, W., et al. (2020). Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease. Sci Transl Med 12, eaba3613.","journal-title":"Sci Transl Med"},{"key":"2661_CR260","doi-asserted-by":"publisher","first-page":"5271","DOI":"10.1093\/nar\/gkad301","volume":"51","author":"S Ma","year":"2023","unstructured":"Ma, S., Liao, K., Li, M., Wang, X., Lv, J., Zhang, X., Huang, H., Li, L., Huang, T., Guo, X., et al. (2023). Phase-separated DropCRISPRa platform for efficient gene activation in mammalian cells and mice. Nucleic Acids Res 51, 5271\u20135284.","journal-title":"Nucleic Acids Res"},{"key":"2661_CR261","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1016\/j.cell.2018.10.007","volume":"175","author":"W Ma","year":"2018","unstructured":"Ma, W., and Mayr, C. (2018). A membraneless organelle associated with the endoplasmic reticulum enables 3\u2032UTR-mediated protein-protein interactions. Cell 175, 1492\u20131506.e19.","journal-title":"Cell"},{"key":"2661_CR262","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1002\/wrna.1139","volume":"4","author":"M Machyna","year":"2013","unstructured":"Machyna, M., Heyn, P., and Neugebauer, K.M. (2013). Cajal bodies: where form meets function. WIREs RNA 4, 17\u201334.","journal-title":"WIREs RNA"},{"key":"2661_CR263","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1016\/S1474-4422(10)70195-2","volume":"9","author":"IR Mackenzie","year":"2010","unstructured":"Mackenzie, I.R., Rademakers, R., and Neumann, M. (2010). TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia. Lancet Neurol 9, 995\u20131007.","journal-title":"Lancet Neurol"},{"key":"2661_CR264","first-page":"268551926","volume":"33","author":"A Mahapatra","year":"2023","unstructured":"Mahapatra, A., and Newberry, R.W. (2023). Liquid-liquid phase separation of alpha-synuclein is highly sensitive to sequence complexity. bioRxiv 33, 268551926.","journal-title":"bioRxiv"},{"key":"2661_CR265","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1126\/science.aar7366","volume":"360","author":"S Maharana","year":"2018","unstructured":"Maharana, S., Wang, J., Papadopoulos, D.K., Richter, D., Pozniakovsky, A., Poser, I., Bickle, M., Rizk, S. J., Franzmann, T.M., et al. (2018). RNA buffers the phase separation behavior of prion-like RNA binding proteins. Science 360, 918\u2013921.","journal-title":"Science"},{"key":"2661_CR266","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/978-1-0716-2597-2_27","volume":"2551","author":"J Mahato","year":"2023","unstructured":"Mahato, J., Ray, S., Maji, S.K., and Chowdhury, A. (2023). Spectrally resolved FRET microscopy of alpha-synuclein phase-separated liquid droplets. Methods Mol Biol 2551, 425\u2013447.","journal-title":"Methods Mol Biol"},{"key":"2661_CR267","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/s41580-021-00382-6","volume":"22","author":"I Malik","year":"2021","unstructured":"Malik, I., Kelley, C.P., Wang, E.T., and Todd, P.K. (2021). Molecular mechanisms underlying nucleotide repeat expansion disorders. Nat Rev Mol Cell Biol 22, 589\u2013607.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2661_CR268","doi-asserted-by":"publisher","first-page":"2663","DOI":"10.1016\/j.neuron.2021.06.023","volume":"109","author":"JR Mann","year":"2021","unstructured":"Mann, J.R., and Donnelly, C.J. (2021). RNA modulates physiological and neuro-pathological protein phase transitions. Neuron 109, 2663\u20132681.","journal-title":"Neuron"},{"key":"2661_CR269","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.neuron.2019.01.048","volume":"102","author":"JR Mann","year":"2019","unstructured":"Mann, J.R., Gleixner, A.M., Mauna, J.C., Gomes, E., DeChellis-Marks, M.R., Needham, P.G., Copley, K.E., Hurtle, B., Portz, B., Pyles, N.J., et al. (2019). RNA binding antagonizes neurotoxic phase transitions of TDP-43. Neuron 102, 321\u2013338.e8.","journal-title":"Neuron"},{"key":"2661_CR270","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.cub.2010.12.046","volume":"21","author":"U Manor","year":"2011","unstructured":"Manor, U., Disanza, A., Grati, M.H., Andrade, L., Lin, H., Di Fiore, P.P., Scita, G., and Kachar, B. (2011). Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8. Curr Biol 21, 167\u2013172.","journal-title":"Curr Biol"},{"key":"2661_CR271","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.cell.2017.12.032","volume":"172","author":"S Markmiller","year":"2018","unstructured":"Markmiller, S., Soltanieh, S., Server, K.L., Mak, R., Jin, W., Fang, M.Y., Luo, E.C., Krach, F., Yang, D., Sen, A., et al. (2018). Context-dependent and disease-specific diversity in protein interactions within stress granules. Cell 172, 590\u2013604e13.","journal-title":"Cell"},{"key":"2661_CR272","doi-asserted-by":"publisher","first-page":"102385","DOI":"10.1016\/j.pbi.2023.102385","volume":"74","author":"I Maruri-Lopez","year":"2023","unstructured":"Maruri-Lopez, I., and Chodasiewicz, M. (2023). Involvement of small molecules and metabolites in regulation of biomolecular condensate properties. Curr Opin Plant Biol 74, 102385.","journal-title":"Curr Opin Plant Biol"},{"key":"2661_CR273","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1016\/j.cell.2020.11.010","volume":"183","author":"D Mateju","year":"2020","unstructured":"Mateju, D., Eichenberger, B., Voigt, F., Eglinger, J., Roth, G., and Chao, J.A. (2020). Single-molecule imaging reveals translation of mRNAs localized to stress granules. Cell 183, 1801\u20131812.e13.","journal-title":"Cell"},{"key":"2661_CR274","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1126\/science.abb8032","volume":"370","author":"C Mathieu","year":"2020","unstructured":"Mathieu, C., Pappu, R.V., and Taylor, J.P. (2020). Beyond aggregation: pathological phase transitions in neurodegenerative disease. Science 370, 56\u201360.","journal-title":"Science"},{"key":"2661_CR275","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.jns.2019.02.030","volume":"399","author":"S Mathis","year":"2019","unstructured":"Mathis, S., Goizet, C., Soulages, A., Vallat, J.M., and Masson, G.L. (2019). Genetics of amyotrophic lateral sclerosis: a review. J Neurol Sci 399, 217\u2013226.","journal-title":"J Neurol Sci"},{"key":"2661_CR276","doi-asserted-by":"publisher","first-page":"14907","DOI":"10.1038\/ncomms14907","volume":"8","author":"SA Mauriac","year":"2017","unstructured":"Mauriac, S.A., Hien, Y.E., Bird, J.E., Carvalho, S.D.S., Peyroutou, R., Lee, S.C., Moreau, M.M., Blanc, J.M., Gezer, A., Medina, C., et al. (2017). Defective Gpsm2\/G\u03b1i3 signalling disrupts stereocilia development and growth cone actin dynamics in Chudley-McCullough syndrome. Nat Commun 8, 14907.","journal-title":"Nat Commun"},{"key":"2661_CR277","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1093\/hmg\/ddr021","volume":"20","author":"KK McDonald","year":"2011","unstructured":"McDonald, K.K., Aulas, A., Destroismaisons, L., Pickles, S., Beleac, E., Camu, W., Rouleau, G.A., and Vande Velde, C. (2011). TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1. Hum Mol Genet 20, 1400\u20131410.","journal-title":"Hum Mol Genet"},{"key":"2661_CR278","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.molcel.2018.07.002","volume":"71","author":"L McGurk","year":"2018","unstructured":"McGurk, L., Gomes, E., Guo, L., Mojsilovic-Petrovic, J., Tran, V., Kalb, R.G., Shorter, J., and Bonini, N.M. (2018a). Poly(ADP-Ribose) prevents pathological phase separation of TDP-43 by promoting liquid demixing and stress granule localization. Mol Cell 71, 703\u2013717.e9.","journal-title":"Mol Cell"},{"key":"2661_CR279","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/s40478-018-0586-1","volume":"6","author":"L McGurk","year":"2018","unstructured":"McGurk, L., Mojsilovic-Petrovic, J., Van Deerlin, V.M., Shorter, J., Kalb, R.G., Lee, V. M., Trojanowski, J.Q., Lee, E.B., and Bonini, N.M. (2018b). Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis. acta neuropathol commun 6, 84.","journal-title":"acta neuropathol commun"},{"key":"2661_CR280","doi-asserted-by":"publisher","first-page":"e47098","DOI":"10.7554\/eLife.47098","volume":"8","author":"DT McSwiggen","year":"2019","unstructured":"McSwiggen, D.T., Hansen, A.S., Teves, S.S., Marie-Nelly, H., Hao, Y., Heckert, A.B., Umemoto, K.K., Dugast-Darzacq, C., Tjian, R., and Darzacq, X. (2019a). Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation. Elife 8, e47098.","journal-title":"Elife"},{"key":"2661_CR281","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1101\/gad.331520.119","volume":"33","author":"DT McSwiggen","year":"2019","unstructured":"McSwiggen, D.T., Mir, M., Darzacq, X., and Tjian, R. (2019b). Evaluating phase separation in live cells: diagnosis, caveats, and functional consequences. Genes Dev 33, 1619\u20131634.","journal-title":"Genes Dev"},{"key":"2661_CR282","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/s41568-022-00444-7","volume":"22","author":"S Mehta","year":"2022","unstructured":"Mehta, S., and Zhang, J. (2022). Liquid\u2013liquid phase separation drives cellular function and dysfunction in cancer. Nat Rev Canc 22, 239\u2013252.","journal-title":"Nat Rev Canc"},{"key":"2661_CR283","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/S0962-8924(02)02371-1","volume":"12","author":"G Meister","year":"2002","unstructured":"Meister, G. (2002). SMN-mediated assembly of RNPs: a complex story. Trends Cell Biol 12, 472\u2013478.","journal-title":"Trends Cell Biol"},{"key":"2661_CR284","doi-asserted-by":"publisher","first-page":"4147","DOI":"10.1016\/j.molcel.2021.07.040","volume":"81","author":"F Meng","year":"2021","unstructured":"Meng, F., Yu, Z., Zhang, D., Chen, S., Guan, H., Zhou, R., Wu, Q., Zhang, Q., Liu, S., Venkat Ramani, M.K., et al. (2021). Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity. Mol Cell 81, 4147\u20134164.e7.","journal-title":"Mol Cell"},{"key":"2661_CR285","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/s42254-023-00598-9","volume":"5","author":"TCT Michaels","year":"2023","unstructured":"Michaels, T.C.T., Qian, D., \u0160ari\u0107, A., Vendruscolo, M., Linse, S., and Knowles, T.P.J. (2023). Amyloid formation as a protein phase transition. Nat Rev Phys 5, 379\u2013397.","journal-title":"Nat Rev Phys"},{"key":"2661_CR286","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1146\/annurev-neuro-070918-050428","volume":"42","author":"N Michalski","year":"2019","unstructured":"Michalski, N., and Petit, C. (2019). Genes involved in the development and physiology of both the peripheral and central auditory systems. Annu Rev Neurosci 42, 67\u201386.","journal-title":"Annu Rev Neurosci"},{"key":"2661_CR287","doi-asserted-by":"publisher","first-page":"4439","DOI":"10.1093\/emboj\/19.17.4439","volume":"19","author":"JW Miller","year":"2000","unstructured":"Miller, J.W. (2000). Recruitment of human muscleblind proteins to (CUG)n expansions associated with myotonic dystrophy. EMBO J 19, 4439\u20134448.","journal-title":"EMBO J"},{"key":"2661_CR288","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1126\/science.aat5671","volume":"361","author":"D Milovanovic","year":"2018","unstructured":"Milovanovic, D., Wu, Y., Bian, X., and De Camilli, P. (2018). A liquid phase of synapsin and lipid vesicles. Science 361, 604\u2013607.","journal-title":"Science"},{"key":"2661_CR289","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1038\/s41573-022-00505-4","volume":"21","author":"DM Mitrea","year":"2022","unstructured":"Mitrea, D.M., Mittasch, M., Gomes, B.F., Klein, I.A., and Murcko, M.A. (2022). Modulating biomolecular condensates: a novel approach to drug discovery. Nat Rev Drug Discov 21, 841\u2013862.","journal-title":"Nat Rev Drug Discov"},{"key":"2661_CR290","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.cell.2015.09.015","volume":"163","author":"A Molliex","year":"2015","unstructured":"Molliex, A., Temirov, J., Lee, J., Coughlin, M., Kanagaraj, A.P., Kim, H.J., Mittag, T., and Taylor, J.P. (2015). Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization. Cell 163, 123\u2013133.","journal-title":"Cell"},{"key":"2661_CR291","doi-asserted-by":"publisher","first-page":"2951","DOI":"10.15252\/embj.201696394","volume":"36","author":"Z Monahan","year":"2017","unstructured":"Monahan, Z., Ryan, V.H., Janke, A.M., Burke, K.A., Rhoads, S.N., Zerze, G.H., O\u2019Meally, R., Dignon, G.L., Conicella, A.E., Zheng, W., et al. (2017). Phosphorylation of the FUS low-complexity domain disrupts phase separation, aggregation, and toxicity. EMBO J 36, 2951\u20132967.","journal-title":"EMBO J"},{"key":"2661_CR292","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.cell.2017.08.048","volume":"171","author":"DT Murray","year":"2017","unstructured":"Murray, D.T., Kato, M., Lin, Y., Thurber, K.R., Hung, I., McKnight, S.L., and Tycko, R. (2017). Structure of FUS protein fibrils and its relevance to self-assembly and phase separation of low-complexity domains. Cell 171, 615\u2013627.e16.","journal-title":"Cell"},{"key":"2661_CR293","doi-asserted-by":"publisher","first-page":"7787","DOI":"10.1038\/s41467-022-35430-y","volume":"13","author":"F Muzzopappa","year":"2022","unstructured":"Muzzopappa, F., Hummert, J., Anfossi, M., Tashev, S.A., Herten, D.-P., and Erdel, F. (2022). Detecting and quantifying liquid\u2013liquid phase separation in living cells by model-free calibrated half-bleaching. Nat Commun 13, 7787.","journal-title":"Nat Commun"},{"key":"2661_CR294","doi-asserted-by":"publisher","first-page":"eaax3993","DOI":"10.1126\/scitranslmed.aax3993","volume":"12","author":"M Nahm","year":"2020","unstructured":"Nahm, M., Lim, S.M., Kim, Y.E., Park, J., Noh, M.Y., Lee, S., Roh, J.E., Hwang, S.M., Park, C.K., Kim, Y.H., et al. (2020). ANXA11 mutations in ALS cause dysregulation of calcium homeostasis and stress granule dynamics. Sci Transl Med 12, eaax3993.","journal-title":"Sci Transl Med"},{"key":"2661_CR295","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1002\/pro.4101","volume":"30","author":"S Najafi","year":"2021","unstructured":"Najafi, S., Lin, Y., Longhini, A.P., Zhang, X., Delaney, K.T., Kosik, K.S., Fredrickson, G. H., Shea, J.-., and Han, S. (2021). Liquid\u2013liquid phase separation of Tau by self and complex coacervation. Protein Sci 30, 1393\u20131407.","journal-title":"Protein Sci"},{"key":"2661_CR296","doi-asserted-by":"publisher","first-page":"1242925","DOI":"10.3389\/fnmol.2023.1242925","volume":"16","author":"A Naskar","year":"2023","unstructured":"Naskar, A., Nayak, A., Salaikumaran, M.R., Vishal, S.S., and Gopal, P.P. (2023). Phase separation and pathologic transitions of RNP condensates in neurons: implications for amyotrophic lateral sclerosis, frontotemporal dementia and other neurodegenerative disorders. Front Mol Neurosci 16, 1242925.","journal-title":"Front Mol Neurosci"},{"key":"2661_CR297","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1038\/s41582-019-0157-5","volume":"15","author":"NB Nedelsky","year":"2019","unstructured":"Nedelsky, N.B., and Taylor, J.P. (2019). Bridging biophysics and neurology: aberrant phase transitions in neurodegenerative disease. Nat Rev Neurol 15, 272\u2013286.","journal-title":"Nat Rev Neurol"},{"key":"2661_CR298","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/nan.12526","volume":"45","author":"M Neumann","year":"2019","unstructured":"Neumann, M., and Mackenzie, I.R.A. (2019). Review: neuropathology of non-tau frontotemporal lobar degeneration. NeuroPathol Appl Neurobiol 45, 19\u201340.","journal-title":"NeuroPathol Appl Neurobiol"},{"key":"2661_CR299","doi-asserted-by":"publisher","first-page":"D288","DOI":"10.1093\/nar\/gkz1027","volume":"48","author":"W Ning","year":"2020","unstructured":"Ning, W., Guo, Y., Lin, S., Mei, B., Wu, Y., Jiang, P., Tan, X., Zhang, W., Chen, G., Peng, D., et al. (2020). DrLLPS: a data resource of liquid\u2013liquid phase separation in eukaryotes. Nucleic Acids Res 48, D288\u2013D295.","journal-title":"Nucleic Acids Res"},{"key":"2661_CR300","doi-asserted-by":"publisher","first-page":"5473","DOI":"10.1074\/jbc.M115.695379","volume":"291","author":"T Nonaka","year":"2016","unstructured":"Nonaka, T., Suzuki, G., Tanaka, Y., Kametani, F., Hirai, S., Okado, H., Miyashita, T., Saitoe, M., Akiyama, H., Masai, H., et al. (2016). Phosphorylation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Truncated Casein Kinase 1\u03b4 Triggers Mislocalization and Accumulation of TDP-43. J Biol Chem 291, 5473\u20135483.","journal-title":"J Biol Chem"},{"key":"2661_CR301","doi-asserted-by":"publisher","first-page":"D508","DOI":"10.1093\/nar\/gks1226","volume":"41","author":"ME Oates","year":"2012","unstructured":"Oates, M.E., Romero, P., Ishida, T., Ghalwash, M., Mizianty, M.J., Xue, B., Doszt\u00e1nyi, Z., Uversky, V.N., Obradovic, Z., Kurgan, L., et al. (2012). D2P2: database of disordered protein predictions. Nucleic Acids Res 41, D508\u2013D516.","journal-title":"Nucleic Acids Res"},{"key":"2661_CR302","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1083\/jcb.201404016","volume":"207","author":"O Ogun","year":"2014","unstructured":"Ogun, O., and Zallocchi, M. (2014). Clarin-1 acts as a modulator of mechan-otransduction activity and presynaptic ribbon assembly. J Cell Biol 207, 375\u2013391.","journal-title":"J Cell Biol"},{"key":"2661_CR303","doi-asserted-by":"publisher","first-page":"11845","DOI":"10.1002\/chem.202101592","volume":"27","author":"R Oliva","year":"2021","unstructured":"Oliva, R., Mukherjee, S.K., Ostermeier, L., Pazurek, L.A., Kriegler, S., Bader, V., Prumbaum, D., Raunser, S., Winklhofer, K.F., Tatzelt, J., et al. (2021). Remodeling of the fibrillation pathway of \u03b1-synuclein by interaction with antimicrobial peptide LL-III. Chem Eur J 27, 11845\u201311851.","journal-title":"Chem Eur J"},{"key":"2661_CR304","doi-asserted-by":"publisher","first-page":"21807","DOI":"10.1074\/jbc.M109.084434","volume":"285","author":"MA Olshina","year":"2010","unstructured":"Olshina, M.A., Angley, L.M., Ramdzan, Y.M., Tang, J., Bailey, M.F., Hill, A.F., and Hatters, D.M. (2010). Tracking mutant huntingtin aggregation kinetics in cells reveals three major populations that include an invariant oligomer pool. J Biol Chem 285, 21807\u201321816.","journal-title":"J Biol Chem"},{"key":"2661_CR305","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.molcel.2016.05.042","volume":"63","author":"CW Pak","year":"2016","unstructured":"Pak, C.W., Kosno, M., Holehouse, A.S., Padrick, S.B., Mittal, A., Ali, R., Yunus, A.A., Liu, D.R., Pappu, R.V., and Rosen, M.K. (2016). Sequence determinants of intracellular phase separation by complex coacervation of a disordered protein. Mol Cell 63, 72\u201385.","journal-title":"Mol Cell"},{"key":"2661_CR306","first-page":"25","volume":"27","author":"L Pan","year":"2012","unstructured":"Pan, L., and Zhang, M. (2012). Structures of usher syndrome 1 proteins and their complexes. Physiology (Bethesda) 27, 25\u201342.","journal-title":"Physiology (Bethesda)"},{"key":"2661_CR307","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1038\/s41589-023-01384-5","volume":"19","author":"Y Pan","year":"2023","unstructured":"Pan, Y., Lu, J., Feng, X., Lu, S., Yang, Y., Yang, G., Tan, S., Wang, L., Li, P., Luo, S., et al. (2023). Gelation of cytoplasmic expanded CAG RNA repeats suppresses global protein synthesis. Nat Chem Biol 19, 1372\u20131383.","journal-title":"Nat Chem Biol"},{"key":"2661_CR308","doi-asserted-by":"publisher","first-page":"5360","DOI":"10.3390\/ijms21155360","volume":"21","author":"YJ Park","year":"2020","unstructured":"Park, Y.J., Choi, D.W., Cho, S.W., Han, J., Yang, S., and Choi, C.Y. (2020). Stress granule formation attenuates RACK1-mediated apoptotic cell death induced by morusin. Int J Mol Sci 21, 5360.","journal-title":"Int J Mol Sci"},{"key":"2661_CR309","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1016\/j.cell.2015.07.047","volume":"162","author":"A Patel","year":"2015","unstructured":"Patel, A., Lee, H.O., Jawerth, L., Maharana, S., Jahnel, M., Hein, M.Y., Stoynov, S., Mahamid, J., Saha, S., Franzmann, T.M., et al. (2015). A liquid-to-solid phase transition of the ALS protein FUS accelerated by disease mutation. Cell 162, 1066\u20131077.","journal-title":"Cell"},{"key":"2661_CR310","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1016\/S0960-9822(01)00316-5","volume":"11","author":"L Pellizzoni","year":"2001","unstructured":"Pellizzoni, L., Baccon, J., Charroux, B., and Dreyfuss, G. (2001). The survival of motor neurons (SMN) protein interacts with the snoRNP proteins fibrillarin and GAR1. Curr Biol 11, 1079\u20131088.","journal-title":"Curr Biol"},{"key":"2661_CR311","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.molcel.2018.04.007","volume":"70","author":"TR Peskett","year":"2018","unstructured":"Peskett, T.R., Rau, F., O\u2019Driscoll, J., Patani, R., Lowe, A.R., and Saibil, H.R. (2018). A liquid to solid phase transition underlying pathological huntingtin Exon1 aggregation. Mol Cell 70, 588\u2013601.e6.","journal-title":"Mol Cell"},{"key":"2661_CR312","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1016\/j.neuron.2015.11.018","volume":"88","author":"OM Peters","year":"2015","unstructured":"Peters, O.M., Cabrera, G.T., Tran, H., Gendron, T.F., McKeon, J.E., Metterville, J., Weiss, A., Wightman, N., Salameh, J., Kim, J., et al. (2015). Human C9ORF72 hexanucleotide expansion reproduces RNA foci and dipeptide repeat proteins but not neurodegeneration in BAC transgenic mice. Neuron 88, 902\u2013909.","journal-title":"Neuron"},{"key":"2661_CR313","doi-asserted-by":"publisher","first-page":"974","DOI":"10.3390\/biom12070974","volume":"12","author":"C Pintado-Grima","year":"2022","unstructured":"Pintado-Grima, C., B\u00e1rcenas, O., and Ventura, S. (2022). In-silico analysis of pH-dependent liquid-liquid phase separation in intrinsically disordered proteins. Biomolecules 12, 974.","journal-title":"Biomolecules"},{"key":"2661_CR314","doi-asserted-by":"publisher","first-page":"D471","DOI":"10.1093\/nar\/gkx1071","volume":"46","author":"D Piovesan","year":"2018","unstructured":"Piovesan, D., Tabaro, F., Paladin, L., Necci, M., Mi\u010deti\u0107, I., Camilloni, C., Davey, N., Doszt\u00e1nyi, Z., M\u00e9sz\u00e1ros, B., Monzon, A.M., et al. (2018). MobiDB 3.0: more annotations for intrinsic disorder, conformational diversity and interactions in proteins. Nucleic Acids Res 46, D471\u2013D476.","journal-title":"Nucleic Acids Res"},{"key":"2661_CR315","doi-asserted-by":"publisher","first-page":"17013","DOI":"10.1038\/nrdp.2017.13","volume":"3","author":"W Poewe","year":"2017","unstructured":"Poewe, W., Seppi, K., Tanner, C.M., Halliday, G.M., Brundin, P., Volkmann, J., Schrag, A.E., and Lang, A.E. (2017). Parkinson disease. Nat Rev Dis Primers 3, 17013.","journal-title":"Nat Rev Dis Primers"},{"key":"2661_CR316","doi-asserted-by":"publisher","first-page":"41032","DOI":"10.1074\/jbc.M205809200","volume":"277","author":"MA Poirier","year":"2002","unstructured":"Poirier, M.A., Li, H., Macosko, J., Cai, S., Amzel, M., and Ross, C.A. (2002). Huntingtin spheroids and protofibrils as precursors in polyglutamine fibrilization. J Biol Chem 277, 41032\u201341037.","journal-title":"J Biol Chem"},{"key":"2661_CR317","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/nchembio.1753","volume":"11","author":"LR Polstein","year":"2015","unstructured":"Polstein, L.R., and Gersbach, C.A. (2015). A light-inducible CRISPR-Cas9 system for control of endogenous gene activation. Nat Chem Biol 11, 198\u2013200.","journal-title":"Nat Chem Biol"},{"key":"2661_CR318","doi-asserted-by":"publisher","first-page":"e4787","DOI":"10.1002\/pro.4787","volume":"32","author":"AE Posey","year":"2023","unstructured":"Posey, A.E., Ross, K.A., Bagheri, M., Lanum, E.N., Khan, M.A., Jennings, C.E., Harwig, M.C., Kennedy, N.W., Hilser, V.J., Harden, J.L., and Hill, R.B. (2023). The variable domain from dynamin-related protein 1 promotes liquid\u2013liquid phase separation that enhances its interaction with cardiolipin-containing membranes. Protein Sci 32, e4787.","journal-title":"Protein Sci"},{"key":"2661_CR319","doi-asserted-by":"publisher","first-page":"3734","DOI":"10.1074\/jbc.RA117.000357","volume":"293","author":"AE Posey","year":"2018","unstructured":"Posey, A.E., Ruff, K.M., Harmon, T.S., Crick, S.L., Li, A., Diamond, M.I., and Pappu, R. V. (2018). Profilin reduces aggregation and phase separation of huntingtin N-terminal fragments by preferentially binding to soluble monomers and oligomers. J Biol Chem 293, 3734\u20133746.","journal-title":"J Biol Chem"},{"key":"2661_CR320","doi-asserted-by":"publisher","first-page":"39490","DOI":"10.1038\/srep39490","volume":"6","author":"A Prasad","year":"2016","unstructured":"Prasad, A., Raju, G., Sivalingam, V., Girdhar, A., Verma, M., Vats, A., Taneja, V., Prabusankar, G., and Patel, B.K. (2016). An acridine derivative, [4,5-bis{(N-carboxy methyl imidazolium)methyl}acridine] dibromide, shows anti-TDP-43 aggregation effect in ALS disease models. Sci Rep 6, 39490.","journal-title":"Sci Rep"},{"key":"2661_CR321","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.biochi.2018.05.003","volume":"150","author":"A Prasad","year":"2018","unstructured":"Prasad, A., Sivalingam, V., Bharathi, V., Girdhar, A., and Patel, B.K. (2018). The amyloidogenicity of a C-terminal region of TDP-43 implicated in amyotrophic lateral sclerosis can be affected by anions, acetylation and homodimerization. Biochimie 150, 76\u201387.","journal-title":"Biochimie"},{"key":"2661_CR322","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.tcb.2016.05.004","volume":"26","author":"DSW Protter","year":"2016","unstructured":"Protter, D.S.W., and Parker, R. (2016). Principles and properties of stress granules. Trends Cell Biol 26, 668\u2013679.","journal-title":"Trends Cell Biol"},{"key":"2661_CR323","doi-asserted-by":"publisher","first-page":"326","DOI":"10.3389\/fnins.2018.00326","volume":"12","author":"MD Purice","year":"2018","unstructured":"Purice, M.D., and Taylor, J.P. (2018). Linking hnRNP function to ALS and FTD pathology. Front Neurosci 12, 326.","journal-title":"Front Neurosci"},{"key":"2661_CR324","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/j.cell.2018.03.056","volume":"173","author":"S Qamar","year":"2018","unstructured":"Qamar, S., Wang, G.Z., Randle, S.J., Ruggeri, F.S., Varela, J.A., Lin, J.Q., Phillips, E.C., Miyashita, A., Williams, D., Str\u00f6hl, F., et al. (2018). FUS phase separation is modulated by a molecular chaperone and methylation of arginine cation-\u03c0 interactions. Cell 173, 720\u2013734.e15.","journal-title":"Cell"},{"key":"2661_CR325","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1016\/j.cell.2013.02.022","volume":"152","author":"LS Qi","year":"2013","unstructured":"Qi, L.S., Larson, M.H., Gilbert, L.A., Doudna, J.A., Weissman, J.S., Arkin, A.P., and Lim, W.A. (2013). Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell 152, 1173\u20131183.","journal-title":"Cell"},{"key":"2661_CR326","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1038\/s41590-022-01269-0","volume":"23","author":"Z Qin","year":"2022","unstructured":"Qin, Z., Fang, X., Sun, W., Ma, Z., Dai, T., Wang, S., Zong, Z., Huang, H., Ru, H., Lu, H., et al. (2022). Deactylation by SIRT1 enables liquid\u2013liquid phase separation of IRF3\/IRF7 in innate antiviral immunity. Nat Immunol 23, 1193\u20131207.","journal-title":"Nat Immunol"},{"key":"2661_CR327","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s41421-021-00270-5","volume":"7","author":"Z Qin","year":"2021","unstructured":"Qin, Z., Sun, H., Yue, M., Pan, X., Chen, L., Feng, X., Yan, X., Zhu, X., and Ji, H. (2021). Phase separation of EML4\u2013ALK in firing downstream signaling and promoting lung tumorigenesis. Cell Discov 7, 33.","journal-title":"Cell Discov"},{"key":"2661_CR328","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/j.molcel.2023.02.012","volume":"83","author":"R Quintana-Cabrera","year":"2023","unstructured":"Quintana-Cabrera, R., and Scorrano, L. (2023). Determinants and outcomes of mitochondrial dynamics. Mol Cell 83, 857\u2013876.","journal-title":"Mol Cell"},{"key":"2661_CR329","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1038\/nmeth0518-394b","volume":"15","author":"M Ramanathan","year":"2018","unstructured":"Ramanathan, M., Majzoub, K., Rao, D.S., Neela, P.H., Zarnegar, B.J., Mondal, S., Roth, J.G., Gai, H., Kovalski, J.R., Siprashvili, Z., et al. (2018). Erratum: Corrigendum: RNA\u2013protein interaction detection in living cells. Nat Methods 15, 394.","journal-title":"Nat Methods"},{"key":"2661_CR330","doi-asserted-by":"publisher","first-page":"e3465","DOI":"10.1002\/psc.3465","volume":"29","author":"M Ramesh","year":"2022","unstructured":"Ramesh, M., Balachandra, C., Baruah, P., and Govindaraju, T. (2022). Cyclic dipeptide-based small molecules modulate zinc-mediated liquid\u2013liquid phase separation of tau. J Peptide Sci 29, e3465.","journal-title":"J Peptide Sci"},{"key":"2661_CR331","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/jnc.13625","volume":"138","author":"A Ratti","year":"2016","unstructured":"Ratti, A., and Buratti, E. (2016). Physiological functions and pathobiology of TDP-43 and FUS\/TLS proteins. J Neurochem 138, 95\u2013111.","journal-title":"J Neurochem"},{"key":"2661_CR332","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1038\/s41557-020-0465-9","volume":"12","author":"S Ray","year":"2020","unstructured":"Ray, S., Singh, N., Kumar, R., Patel, K., Pandey, S., Datta, D., Mahato, J., Panigrahi, R., Navalkar, A., Mehra, S., et al. (2020). \u03b1-Synuclein aggregation nucleates through liquid\u2013liquid phase separation. Nat Chem 12, 705\u2013716.","journal-title":"Nat Chem"},{"key":"2661_CR333","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1002\/humu.23042","volume":"37","author":"AU Rehman","year":"2016","unstructured":"Rehman, A.U., Bird, J.E., Faridi, R., Shahzad, M., Shah, S., Lee, K., Khan, S.N., Imtiaz, A., Ahmed, Z.M., Riazuddin, S., et al. (2016). Mutational spectrum of MYO15A and the molecular mechanisms of DFNB3 human deafness. Hum Mutat 37, 991\u20131003.","journal-title":"Hum Mutat"},{"key":"2661_CR334","doi-asserted-by":"publisher","first-page":"3005","DOI":"10.1016\/j.febslet.2008.07.057","volume":"582","author":"H Rehmann","year":"2008","unstructured":"Rehmann, H., Br\u00fcning, M., Berghaus, C., Schwarten, M., K\u00f6hler, K., Stocker, H., Stoll, R., Zwartkruis, F.J., and Wittinghofer, A. (2008). Biochemical characterisation of TCTP questions its function as a guanine nucleotide exchange factor for Rheb. FEBS Lett 582, 3005\u20133010.","journal-title":"FEBS Lett"},{"key":"2661_CR335","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1038\/s41577-020-0288-3","volume":"20","author":"J Rehwinkel","year":"2020","unstructured":"Rehwinkel, J., and Gack, M.U. (2020). RIG-I-like receptors: their regulation and roles in RNA sensing. Nat Rev Immunol 20, 537\u2013551.","journal-title":"Nat Rev Immunol"},{"key":"2661_CR336","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/nn.3584","volume":"17","author":"AE Renton","year":"2014","unstructured":"Renton, A.E., Chi\u00f2, A., and Traynor, B.J. (2014). State of play in amyotrophic lateral sclerosis genetics. Nat Neurosci 17, 17\u201323.","journal-title":"Nat Neurosci"},{"key":"2661_CR337","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1002\/cyto.a.22295","volume":"83","author":"M Renz","year":"2013","unstructured":"Renz, M. (2013). Fluorescence microscopy\u2014a historical and technical perspective. Cytometry Pt A 83, 767\u2013779.","journal-title":"Cytometry Pt A"},{"key":"2661_CR338","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1038\/s41556-020-00584-8","volume":"22","author":"T Rey","year":"2020","unstructured":"Rey, T., Zaganelli, S., Cuillery, E., Vartholomaiou, E., Croisier, M., Martinou, J.C., and Manley, S. (2020). Mitochondrial RNA granules are fluid condensates positioned by membrane dynamics. Nat Cell Biol 22, 1180\u20131186.","journal-title":"Nat Cell Biol"},{"key":"2661_CR339","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1016\/j.molcel.2022.01.018","volume":"82","author":"K Rhine","year":"2022","unstructured":"Rhine, K., Dasovich, M., Yoniles, J., Badiee, M., Skanchy, S., Ganser, L.R., Ge, Y., Fare, C.M., Shorter, J., Leung, A.K.L., et al. (2022). Poly(ADP-ribose) drives condensation of FUS via a transient interaction. Mol Cell 82, 969\u2013985.e11.","journal-title":"Mol Cell"},{"key":"2661_CR340","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1091\/mbc.E17-12-0735","volume":"29","author":"SN Rhoads","year":"2018","unstructured":"Rhoads, S.N., Monahan, Z.T., Yee, D.S., Leung, A.Y., Newcombe, C.G., O\u2019Meally, R.N., Cole, R.N., Shewmaker, F.P., and Cohen-Fix, O. (2018). The prionlike domain of FUS is multiphosphorylated following DNA damage without altering nuclear localization. Mol Biol Cell 29, 1786\u20131797.","journal-title":"Mol Biol Cell"},{"key":"2661_CR341","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/s41586-019-1374-1","volume":"571","author":"RJ Ries","year":"2019","unstructured":"Ries, R.J., Zaccara, S., Klein, P., Olarerin-George, A., Namkoong, S., Pickering, B.F., Patil, D.P., Kwak, H., Lee, J.H., and Jaffrey, S.R. (2019). m6A enhances the phase separation potential of mRNA. Nature 571, 424\u2013428.","journal-title":"Nature"},{"key":"2661_CR342","doi-asserted-by":"publisher","first-page":"4737","DOI":"10.1016\/j.cell.2023.09.006","volume":"186","author":"N Ripin","year":"2023","unstructured":"Ripin, N., and Parker, R. (2023). Formation, function, and pathology of RNP granules. Cell 186, 4737\u20134756.","journal-title":"Cell"},{"key":"2661_CR343","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1038\/s41586-021-03703-z","volume":"595","author":"J Risso-Ballester","year":"2021","unstructured":"Risso-Ballester, J., Galloux, M., Cao, J., Le Goffic, R., Hontonnou, F., Jobart-Malfait, A., Desquesnes, A., Sake, S.M., Haid, S., Du, M., et al. (2021). A condensate-hardening drug blocks RSV replication in vivo. Nature 595, 596\u2013599.","journal-title":"Nature"},{"key":"2661_CR344","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1083\/jcb.201112098","volume":"196","author":"KJ Roux","year":"2012","unstructured":"Roux, K.J., Kim, D.I., Raida, M., and Burke, B. (2012). A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. J Cell Biol 196, 801\u2013810.","journal-title":"J Cell Biol"},{"key":"2661_CR345","doi-asserted-by":"publisher","first-page":"2077","DOI":"10.1038\/s41467-022-29715-5","volume":"13","author":"R Roy","year":"2022","unstructured":"Roy, R., Das, G., Kuttanda, I.A., Bhatter, N., and Rajyaguru, P.I. (2022). Low complexity RGG-motif sequence is required for processing body (P-body) disassembly. Nat Commun 13, 2077.","journal-title":"Nat Commun"},{"key":"2661_CR346","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1093\/nar\/gkt835","volume":"42","author":"SL Rulten","year":"2014","unstructured":"Rulten, S.L., Rotheray, A., Green, R.L., Grundy, G.J., Moore, D.A.Q., G\u00f3mez-Herreros, F., Hafezparast, M., and Caldecott, K.W. (2014). PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS\/TLS to sites of oxidative DNA damage. Nucleic Acids Res 42, 307\u2013314.","journal-title":"Nucleic Acids Res"},{"key":"2661_CR347","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.molcel.2017.12.022","volume":"69","author":"VH Ryan","year":"2018","unstructured":"Ryan, V.H., Dignon, G.L., Zerze, G.H., Chabata, C.V., Silva, R., Conicella, A.E., Amaya, J., Burke, K.A., Mittal, J., and Fawzi, N.L. (2018). Mechanistic view of hnRNPA2 low-complexity domain structure, interactions, and phase separation altered by mutation and arginine methylation. Mol Cell 69, 465\u2013479.e7.","journal-title":"Mol Cell"},{"key":"2661_CR348","doi-asserted-by":"publisher","first-page":"e105001","DOI":"10.15252\/embj.2020105001","volume":"40","author":"VH Ryan","year":"2021","unstructured":"Ryan, V.H., Perdikari, T.M., Naik, M.T., Saueressig, C.F., Lins, J., Dignon, G.L., Mittal, J., Hart, A.C., and Fawzi, N.L. (2021). Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning and reduces neurodegeneration. EMBO J 40, e105001.","journal-title":"EMBO J"},{"key":"2661_CR349","doi-asserted-by":"publisher","first-page":"2822","DOI":"10.1016\/j.neurobiolaging.2014.07.026","volume":"35","author":"HH Ryu","year":"2014","unstructured":"Ryu, H.H., Jun, M.H., Min, K.J., Jang, D.J., Lee, Y.S., Kim, H.K., and Lee, J.A. (2014). Autophagy regulates amyotrophic lateral sclerosis-linked fused in sarcoma-positive stress granules in neurons. Neurobiol Aging 35, 2822\u20132831.","journal-title":"Neurobiol Aging"},{"key":"2661_CR350","doi-asserted-by":"publisher","first-page":"11818","DOI":"10.1073\/pnas.1716173114","volume":"114","author":"DM Sabatini","year":"2017","unstructured":"Sabatini, D.M. (2017). Twenty-five years of mTOR: uncovering the link from nutrients to growth. Proc Natl Acad Sci USA 114, 11818\u201311825.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2661_CR351","doi-asserted-by":"publisher","first-page":"3653","DOI":"10.1038\/s41596-023-00900-0","volume":"18","author":"C Sahin","year":"2023","unstructured":"Sahin, C., Leppert, A., and Landreh, M. (2023a). Advances in mass spectrometry to unravel the structure and function of protein condensates. Nat Protoc 18, 3653\u20133661.","journal-title":"Nat Protoc"},{"key":"2661_CR352","doi-asserted-by":"publisher","first-page":"10659","DOI":"10.1021\/jacs.3c00932","volume":"145","author":"C Sahin","year":"2023","unstructured":"Sahin, C., Motso, A., Gu, X., Feyrer, H., Lama, D., Arndt, T., Rising, A., Gese, G.V., H\u00e4llberg, B.M., Marklund, E.G., et al. (2023b). Mass spectrometry of RNA-binding proteins during liquid\u2013liquid phase separation reveals distinct assembly mechanisms and droplet architectures. J Am Chem Soc 145, 10659\u201310668.","journal-title":"J Am Chem Soc"},{"key":"2661_CR353","doi-asserted-by":"publisher","first-page":"4882","DOI":"10.1016\/j.cub.2020.09.043","volume":"30","author":"PK Sahoo","year":"2020","unstructured":"Sahoo, P.K., Kar, A.N., Samra, N., Terenzio, M., Patel, P., Lee, S.J., Miller, S., Thames, E., Jones, B., Kawaguchi, R., et al. (2020). A Ca2+-dependent switch activates axonal casein kinase 2\u03b1 translation and drives G3BP1 granule disassembly for axon regeneration. Curr Biol 30, 4882\u20134895.e6.","journal-title":"Curr Biol"},{"key":"2661_CR354","doi-asserted-by":"publisher","first-page":"3358","DOI":"10.1038\/s41467-018-05647-x","volume":"9","author":"PK Sahoo","year":"2018","unstructured":"Sahoo, P.K., Lee, S.J., Jaiswal, P.B., Alber, S., Kar, A.N., Miller-Randolph, S., Taylor, E. E., Smith, T., Singh, B., Ho, T.S.Y., et al. (2018). Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration. Nat Commun 9, 3358.","journal-title":"Nat Commun"},{"key":"2661_CR355","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.tins.2023.01.001","volume":"46","author":"R Sansevrino","year":"2023","unstructured":"Sansevrino, R., Hoffmann, C., and Milovanovic, D. (2023). Condensate biology of synaptic vesicle clusters. Trends Neuroscis 46, 293\u2013306.","journal-title":"Trends Neuroscis"},{"key":"2661_CR356","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1002\/anie.202011157","volume":"60","author":"A Savastano","year":"2021","unstructured":"Savastano, A., Flores, D., Kadavath, H., Biernat, J., Mandelkow, E., and Zweckstetter, M. (2021). Disease-associated tau phosphorylation hinders tubulin assembly within tau condensates. Angew Chem Int Ed 60, 726\u2013730.","journal-title":"Angew Chem Int Ed"},{"key":"2661_CR357","doi-asserted-by":"publisher","first-page":"3676","DOI":"10.1021\/acs.biochem.1c00434","volume":"60","author":"AS Sawner","year":"2021","unstructured":"Sawner, A.S., Ray, S., Yadav, P., Mukherjee, S., Panigrahi, R., Poudyal, M., Patel, K., Ghosh, D., Kummerant, E., Kumar, A., et al. (2021). Modulating \u03b1-synuclein liquid\u2013liquid phase separation. Biochemistry 60, 3676\u20133696.","journal-title":"Biochemistry"},{"key":"2661_CR358","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/B978-0-12-803480-4.00010-7","volume-title":"Nuclear Architecture and Dynamics","author":"IA Sawyer","year":"2018","unstructured":"Sawyer, I.A., and Dundr, M. (2018). Nuclear bodies. In: Lavelle, C., and Victor, J-M., eds. Nuclear Architecture and Dynamics. Amsterdam: Elsevier 235\u2013256."},{"key":"2661_CR359","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.cell.2017.03.035","volume":"169","author":"RA Saxton","year":"2017","unstructured":"Saxton, R.A., and Sabatini, D.M. (2017). mTOR signaling in growth, metabolism, and Disease (vol 168, pg 960, 2017). Cell 169, 362\u2013362.","journal-title":"Cell"},{"key":"2661_CR360","doi-asserted-by":"publisher","first-page":"e61576","DOI":"10.1371\/journal.pone.0061576","volume":"8","author":"C Scaramuzzino","year":"2013","unstructured":"Scaramuzzino, C., Monaghan, J., Milioto, C., Lanson, N.A., Maltare, A., Aggarwal, T., Casci, I., Fackelmayer, F.O., Pennuto, M., Pandey, U.B., et al. (2013). Protein arginine methyltransferase 1 and 8 interact with FUS to modify its sub-cellular distribution and toxicity in vitro and in vivo. PLoS ONE 8, e61576.","journal-title":"PLoS ONE"},{"key":"2661_CR361","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/s41586-023-06437-2","volume":"621","author":"SHW Scheres","year":"2023","unstructured":"Scheres, S.H.W., Ryskeldi-Falcon, B., and Goedert, M. (2023). Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids. Nature 621, 701\u2013710.","journal-title":"Nature"},{"key":"2661_CR362","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1083\/jcb.201001138","volume":"190","author":"M Schwander","year":"2010","unstructured":"Schwander, M., Kachar, B., and M\u00fcller, U. (2010). The cell biology of hearing. J Cell Biol 190, 9\u201320.","journal-title":"J Cell Biol"},{"key":"2661_CR363","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/j.celrep.2013.11.017","volume":"5","author":"JC Schwartz","year":"2013","unstructured":"Schwartz, J.C., Wang, X., Podell, E.R., and Cech, T.R. (2013). RNA seeds higher-order assembly of FUS protein. Cell Rep 5, 918\u2013925.","journal-title":"Cell Rep"},{"key":"2661_CR364","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.celrep.2013.02.004","volume":"3","author":"C Sellier","year":"2013","unstructured":"Sellier, C., Freyermuth, F., Tabet, R., Tran, T., He, F., Ruffenach, F., Alunni, V., Moine, H., Thibault, C., Page, A., et al. (2013). Sequestration of DROSHA and DGCR8 by expanded CGG RNA repeats alters microRNA processing in fragile X-associated tremor\/ataxia syndrome. Cell Rep 3, 869\u2013880.","journal-title":"Cell Rep"},{"key":"2661_CR365","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/s41586-023-05767-5","volume":"615","author":"L Shan","year":"2023","unstructured":"Shan, L., Xu, G., Yao, R.W., Luan, P.F., Huang, Y., Zhang, P.H., Pan, Y.H., Zhang, L., Gao, X., Li, Y., et al. (2023). Nucleolar URB1 ensures 3\u2032 ETS rRNA removal to prevent exosome surveillance. Nature 615, 526\u2013534.","journal-title":"Nature"},{"key":"2661_CR366","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1126\/science.aaa8172","volume":"348","author":"P Sharma","year":"2015","unstructured":"Sharma, P., and Allison, J.P. (2015). The future of immune checkpoint therapy. Science 348, 56\u201361.","journal-title":"Science"},{"key":"2661_CR367","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/s41576-019-0099-1","volume":"20","author":"JW Shay","year":"2019","unstructured":"Shay, J.W., and Wright, W.E. (2019). Telomeres and telomerase: three decades of progress. Nat Rev Genet 20, 299\u2013309.","journal-title":"Nat Rev Genet"},{"key":"2661_CR368","volume-title":"GeneReviews(\u00ae)","author":"AE Shearer","year":"1993","unstructured":"Shearer, A.E., Hildebrand, M.S., Schaefer, A.M., and Smith, R.J.H. (1993). Genetic Hearing Loss Overview. In GeneReviews(\u00ae), M.P. Adam, J. Feldman, G.M. Mirzaa, R.A. Pagon, S.E. Wallace, L.J.H. Bean, K.W. Gripp, and A. Amemiya, eds. Seattle (WA): University of Washington."},{"key":"2661_CR369","doi-asserted-by":"publisher","first-page":"5759","DOI":"10.1016\/j.cell.2021.09.032","volume":"184","author":"C Shen","year":"2021","unstructured":"Shen, C., Li, R., Negro, R., Cheng, J., Vora, S.M., Fu, T.M., Wang, A., He, K., Andreeva, L., Gao, P., et al. (2021). Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome. Cell 184, 5759\u20135774.e20.","journal-title":"Cell"},{"key":"2661_CR370","doi-asserted-by":"publisher","first-page":"e2301366120","DOI":"10.1073\/pnas.2301366120","volume":"120","author":"Y Shen","year":"2023","unstructured":"Shen, Y., Chen, A., Wang, W., Shen, Y., Ruggeri, F.S., Aime, S., Wang, Z., Qamar, S., Espinosa, J.R., Garaizar, A., et al. (2023). The liquid-to-solid transition of FUS is promoted by the condensate surface. Proc Natl Acad Sci USA 120, e2301366120.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2661_CR371","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1038\/s41586-021-03903-7","volume":"597","author":"B Shi","year":"2021","unstructured":"Shi, B., Li, W., Song, Y., Wang, Z., Ju, R., Ulman, A., Hu, J., Palomba, F., Zhao, Y., Le, J.P., et al. (2021). UTX condensation underlies its tumour-suppressive activity. Nature 597, 726\u2013731.","journal-title":"Nature"},{"key":"2661_CR372","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.ceb.2020.03.002","volume":"63","author":"M Shi","year":"2020","unstructured":"Shi, M., Zhang, P., Vora, S.M., and Wu, H. (2020). Higher-order assemblies in innate immune and inflammatory signaling: a general principle in cell biology. Curr Opin Cell Biol 63, 194\u2013203.","journal-title":"Curr Opin Cell Biol"},{"key":"2661_CR373","doi-asserted-by":"publisher","first-page":"eabn4556","DOI":"10.1126\/sciadv.abn4556","volume":"8","author":"Y Shi","year":"2022","unstructured":"Shi, Y., Lin, L., Wang, C., and Zhu, J. (2022). Promotion of row 1\u2013specific tip complex condensates by Gpsm2-G\u03b1i provides insights into row identity of the tallest stereocilia. Sci Adv 8, eabn4556.","journal-title":"Sci Adv"},{"key":"2661_CR374","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/nm.4490","volume":"24","author":"Y Shi","year":"2018","unstructured":"Shi, Y., Lin, S., Staats, K.A., Li, Y., Chang, W.H., Hung, S.T., Hendricks, E., Linares, G. R., Wang, Y., Son, E.Y., et al. (2018). Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS\/FTD human induced motor neurons. Nat Med 24, 313\u2013325.","journal-title":"Nat Med"},{"key":"2661_CR375","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1042\/BJ20110739","volume":"441","author":"JW Shih","year":"2012","unstructured":"Shih, J.W., Wang, W.T., Tsai, T.Y., Kuo, C.Y., Li, H.K., and Wu Lee, Y.H. (2012). Critical roles of RNA helicase DDX3 and its interactions with eIF4E\/PABP1 in stress granule assembly and stress response. Biochem J 441, 119\u2013129.","journal-title":"Biochem J"},{"key":"2661_CR376","doi-asserted-by":"publisher","first-page":"eaaf4382","DOI":"10.1126\/science.aaf4382","volume":"357","author":"Y Shin","year":"2017","unstructured":"Shin, Y., and Brangwynne, C.P. (2017). Liquid phase condensation in cell physiology and disease. Science 357, eaaf4382.","journal-title":"Science"},{"key":"2661_CR377","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.cell.2016.11.054","volume":"168","author":"Y Shin","year":"2017","unstructured":"Shin, Y., Berry, J., Pannucci, N., Haataja, M.P., Toettcher, J.E., and Brangwynne, C.P. (2017). Spatiotemporal control of intracellular phase transitions using light-activated optoDroplets. Cell 168, 159\u2013171.e14.","journal-title":"Cell"},{"key":"2661_CR378","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1016\/j.cell.2018.10.057","volume":"175","author":"Y Shin","year":"2018","unstructured":"Shin, Y., Chang, Y.C., Lee, D.S.W., Berry, J., Sanders, D.W., Ronceray, P., Wingreen, N.S., Haataja, M., and Brangwynne, C.P. (2018). Liquid nuclear condensates mechanically sense and restructure the genome. Cell 175, 1481\u20131491.e13.","journal-title":"Cell"},{"key":"2661_CR379","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1002\/pro.4025","volume":"30","author":"A Siegert","year":"2021","unstructured":"Siegert, A., Rankovic, M., Favretto, F., Ukmar-Godec, T., Stroh\u00e4ker, T., Becker, S., and Zweckstetter, M. (2021). Interplay between tau and \u03b1-synuclein liquid\u2013liquid phase separation. Protein Sci 30, 1326\u20131336.","journal-title":"Protein Sci"},{"key":"2661_CR380","doi-asserted-by":"publisher","first-page":"22","DOI":"10.15252\/emmm.201707850","volume":"10","author":"R Simone","year":"2017","unstructured":"Simone, R., Balendra, R., Moens, T.G., Preza, E., Wilson, K.M., Heslegrave, A., Woodling, N.S., Niccoli, T., Gilbert-Jaramillo, J., Abdelkarim, S., et al. (2017). Gquadruplex-binding small molecules ameliorate C9or\/72FTD\/ALS pathology in vitro and in vivo. EMBO Mol Med 10, 22\u201331.","journal-title":"EMBO Mol Med"},{"key":"2661_CR381","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1016\/j.celrep.2019.04.031","volume":"27","author":"AS Singatulina","year":"2019","unstructured":"Singatulina, A.S., Hamon, L., Sukhanova, M.V., Desforges, B., Joshi, V., Bouhss, A., Lavrik, O.I., and Pastr\u00e9, D. (2019). PARP-1 activation directs FUS to DNA damage sites to form PARG-reversible compartments enriched in damaged DNA. Cell Rep 27, 1809\u20131821.e5.","journal-title":"Cell Rep"},{"key":"2661_CR382","doi-asserted-by":"publisher","first-page":"5850","DOI":"10.1074\/jbc.AC120.013166","volume":"295","author":"V Singh","year":"2020","unstructured":"Singh, V., Xu, L., Boyko, S., Surewicz, K., and Surewicz, W.K. (2020). Zinc promotes liquid\u2013liquid phase separation of tau protein. J Biol Chem 295, 5850\u20135856.","journal-title":"J Biol Chem"},{"key":"2661_CR383","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1146\/annurev-virology-111821-115636","volume":"10","author":"KM Slavik","year":"2023","unstructured":"Slavik, K.M., and Kranzusch, P.J. (2023). CBASS to cGAS-STING: the origins and mechanisms of nucleotide second messenger immune signaling. Annu Rev Virol 10, 423\u2013453.","journal-title":"Annu Rev Virol"},{"key":"2661_CR384","doi-asserted-by":"publisher","first-page":"8490","DOI":"10.1039\/D0TB01300E","volume":"8","author":"JW Smith","year":"2020","unstructured":"Smith, J.W., and Chen, Q. (2020). Liquid-phase electron microscopy imaging of cellular and biomolecular systems. J Mater Chem B 8, 8490\u20138506.","journal-title":"J Mater Chem B"},{"key":"2661_CR385","doi-asserted-by":"publisher","unstructured":"Song, J. (2023). Molecular mechanisms of phase separation and amyloidosis of ALS\/ FTD-linked FUS and TDP-43. Aging Dis doi: https:\/\/doi.org\/10.14336\/AD.2023.1118.","DOI":"10.14336\/AD.2023.1118"},{"key":"2661_CR386","doi-asserted-by":"publisher","first-page":"4080","DOI":"10.1016\/j.molcel.2022.09.034","volume":"82","author":"L Song","year":"2022","unstructured":"Song, L., Yao, X., Li, H., Peng, B., Boka, A.P., Liu, Y., Chen, G., Liu, Z., Mathias, K.M., Xia, L., et al. (2022). Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer. Mol Cell 82, 4080\u20134098.e12.","journal-title":"Mol Cell"},{"key":"2661_CR387","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s12943-019-1124-x","volume":"19","author":"YZ Song","year":"2020","unstructured":"Song, Y.Z., Xu, Y.H., Pan, C.Y., Yan, L.H., Wang, Z.W., and Zhu, X.Q. (2020). The emerging role of SPOP protein in tumorigenesis and cancer therapy. Mol Cancer 19, 2.","journal-title":"Mol Cancer"},{"key":"2661_CR388","doi-asserted-by":"publisher","first-page":"167685","DOI":"10.1016\/j.jmb.2022.167685","volume":"434","author":"A Soranno","year":"2022","unstructured":"Soranno, A., Incicco, J.J., De Bona, P., Tomko, E.J., Galburt, E.A., Holehouse, A.S., and Galletto, R. (2022). Shelterin Components Modulate Nucleic Acids Condensation and Phase Separation in the Context of Telomeric DNA. J Mol Biol 434, 167685.","journal-title":"J Mol Biol"},{"key":"2661_CR389","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1111\/tra.12704","volume":"20","author":"S Spannl","year":"2019","unstructured":"Spannl, S., Tereshchenko, M., Mastromarco, G.J., Ihn, S.J., and Lee, H.O. (2019). Biomolecular condensates in neurodegeneration and cancer. Traffic 20, 890\u2013911.","journal-title":"Traffic"},{"key":"2661_CR390","doi-asserted-by":"publisher","first-page":"6469","DOI":"10.1073\/pnas.95.11.6469","volume":"95","author":"MG Spillantini","year":"1998","unstructured":"Spillantini, M.G., Crowther, R.A., Jakes, R., Hasegawa, M., and Goedert, M. (1998). \u03b1-Synuclein in filamentous inclusions of Lewy bodies from Parkinson\u2019s disease and dementia with Lewy bodies. Proc Natl Acad Sci USA 95, 6469\u20136473.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2661_CR391","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1038\/42166","volume":"388","author":"MG Spillantini","year":"1997","unstructured":"Spillantini, M.G., Luise Schmidt, M., Lee, V.M.Y., Trojanowski, J.Q., Jakes, R., and Goedert, M. (1997). \u03b1-Synuclein in Lewy bodies. Nature 388, 839\u2013840.","journal-title":"Nature"},{"key":"2661_CR392","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.1016\/j.jprot.2012.01.030","volume":"75","author":"C Stadler","year":"2012","unstructured":"Stadler, C., Hjelmare, M., Neumann, B., Jonasson, K., Pepperkok, R., Uhl\u00e9n, M., and Lundberg, E. (2012). Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. J Proteomics 75, 2236\u20132251.","journal-title":"J Proteomics"},{"key":"2661_CR393","doi-asserted-by":"publisher","first-page":"7289","DOI":"10.1038\/s41467-021-27433-y","volume":"12","author":"EGP Stender","year":"2021","unstructured":"Stender, E.G.P., Ray, S., Norrild, R.K., Larsen, J.A., Petersen, D., Farzadfard, A., Galvagnion, C., Jensen, H., and Buell, A.K. (2021). Capillary flow experiments for thermodynamic and kinetic characterization of protein liquid-liquid phase separation. Nat Commun 12, 7289.","journal-title":"Nat Commun"},{"key":"2661_CR394","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1126\/science.aad9964","volume":"352","author":"X Su","year":"2016","unstructured":"Su, X., Ditlev, J.A., Hui, E., Xing, W., Banjade, S., Okrut, J., King, D.S., Taunton, J., Rosen, M.K., and Vale, R.D. (2016). Phase separation of signaling molecules promotes T cell receptor signal transduction. Science 352, 595\u2013599.","journal-title":"Science"},{"key":"2661_CR395","doi-asserted-by":"publisher","first-page":"C1561","DOI":"10.1152\/ajpcell.00076.2008","volume":"295","author":"J Suarez","year":"2008","unstructured":"Suarez, J., Hu, Y., Makino, A., Fricovsky, E., Wang, H., and Dillmann, W.H. (2008). Alterations in mitochondrial function and cytosolic calcium induced by hyperglycemia are restored by mitochondrial transcription factor A in cardiomyocytes. Am J Physiol Cell Physiol 295, C1561\u2013C1568.","journal-title":"Am J Physiol Cell Physiol"},{"key":"2661_CR396","doi-asserted-by":"publisher","first-page":"3655","DOI":"10.1021\/acschemneuro.3c00286","volume":"14","author":"S Sudhakar","year":"2023","unstructured":"Sudhakar, S., Manohar, A., and Mani, E. (2023). Liquid\u2013liquid phase separation (LLPS)-driven fibrilization of amyloid-\u03b2 protein. ACS Chem Neurosci 14, 3655\u20133664.","journal-title":"ACS Chem Neurosci"},{"key":"2661_CR397","doi-asserted-by":"publisher","first-page":"11113","DOI":"10.1073\/pnas.1903049116","volume":"116","author":"J Sun","year":"2019","unstructured":"Sun, J., Wang, L., Bao, H., Premi, S., Das, U., Chapman, E.R., and Roy, S. (2019). Functional cooperation of \u03b1-synuclein and VAMP2 in synaptic vesicle recycling. Proc Natl Acad Sci USA 116, 11113\u201311115.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2661_CR398","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1126\/science.1232458","volume":"339","author":"L Sun","year":"2013","unstructured":"Sun, L., Wu, J., Du, F., Chen, X., and Chen, Z.J. (2013). Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 339, 786\u2013791.","journal-title":"Science"},{"key":"2661_CR399","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1038\/s41586-023-06701-5","volume":"623","author":"Y Sun","year":"2023","unstructured":"Sun, Y., Dai, H., Dai, X., Yin, J., Cui, Y., Liu, X., Gonzalez, G., Yuan, J., Tang, F., Wang, N., et al. (2023). m1A in CAG repeat RNA binds to TDP-43 and induces neurodegeneration. Nature 623, 580\u2013587.","journal-title":"Nature"},{"key":"2661_CR400","doi-asserted-by":"publisher","first-page":"30307","DOI":"10.18632\/oncotarget.8728","volume":"7","author":"W Szaflarski","year":"2016","unstructured":"Szaflarski, W., Fay, M.M., Kedersha, N., Zabel, M., Anderson, P., and Ivanov, P. (2016). Vinca alkaloid drugs promote stress-induced translational repression and stress granule formation. Oncotarget 7, 30307\u201330322.","journal-title":"Oncotarget"},{"key":"2661_CR401","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1016\/j.cub.2019.01.051","volume":"29","author":"ALD Tadenev","year":"2019","unstructured":"Tadenev, A.L.D., Akturk, A., Devanney, N., Mathur, P.D., Clark, A.M., Yang, J., and Tarchini, B. (2019). GPSM2-GNAI specifies the tallest stereocilia and defines hair bundle row identity. Curr Biol 29, 921\u2013934.e4.","journal-title":"Curr Biol"},{"key":"2661_CR402","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1242\/jcs.099234","volume":"125","author":"SWG Tait","year":"2012","unstructured":"Tait, S.W.G., and Green, D.R. (2012). Mitochondria and cell signalling. J Cell Sci 125, 807\u2013815.","journal-title":"J Cell Sci"},{"key":"2661_CR403","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1038\/s41556-019-0375-5","volume":"21","author":"R Tan","year":"2019","unstructured":"Tan, R., Lam, A.J., Tan, T., Han, J., Nowakowski, D.W., Vershinin, M., Sim\u00f3, S., Ori-McKenney, K.M., and McKenney, R.J. (2019). Microtubules gate tau condensation to spatially regulate microtubule functions. Nat Cell Biol 21, 1078\u20131085.","journal-title":"Nat Cell Biol"},{"key":"2661_CR404","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.cell.2019.12.031","volume":"180","author":"D Tauber","year":"2020","unstructured":"Tauber, D., Tauber, G., Khong, A., Van Treeck, B., Pelletier, J., and Parker, R. (2020). Modulation of RNA condensation by the DEAD-box protein eIF4A. Cell 180, 411\u2013426.e16.","journal-title":"Cell"},{"key":"2661_CR405","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/nature20413","volume":"539","author":"JP Taylor","year":"2016","unstructured":"Taylor, J.P., BrownJr, R.H., and Cleveland, D.W. (2016). Decoding ALS: from genes to mechanism. Nature 539, 197\u2013206.","journal-title":"Nature"},{"key":"2661_CR406","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/s41594-020-00550-w","volume":"28","author":"S Terlecki-Zaniewicz","year":"2021","unstructured":"Terlecki-Zaniewicz, S., Humer, T., Eder, T., Schmoellerl, J., Heyes, E., Manhart, G., Kuchynka, N., Parapatics, K., Liberante, F.G., M\u00fcller, A.C., et al. (2021). Biomolecular condensation of NUP98 fusion proteins drives leukemogenic gene expression. Nat Struct Mol Biol 28, 190\u2013201.","journal-title":"Nat Struct Mol Biol"},{"key":"2661_CR407","doi-asserted-by":"publisher","first-page":"e2211832120","DOI":"10.1073\/pnas.2211832120","volume":"120","author":"T Thiyagarajan","year":"2023","unstructured":"Thiyagarajan, T., Ponnusamy, S., Hwang, D.J., He, Y., Asemota, S., Young, K.L., Johnson, D.L., Bocharova, V., Zhou, W., Jain, A.K., et al. (2023). Inhibiting androgen receptor splice variants with cysteine-selective irreversible covalent inhibitors to treat prostate cancer. Proc Natl Acad Sci USA 120, e2211832120.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2661_CR408","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1146\/annurev.cb.08.110192.001353","volume":"8","author":"LG Tilney","year":"1992","unstructured":"Tilney, L.G., Tilney, M.S., and DeRosier, D.J. (1992). Actin filaments, stereocilia, and hair cells: how cells count and measure. Annu Rev Cell Biol 8, 257\u2013274.","journal-title":"Annu Rev Cell Biol"},{"key":"2661_CR409","doi-asserted-by":"publisher","first-page":"3624","DOI":"10.3390\/ijms23073624","volume":"23","author":"N Tolay","year":"2022","unstructured":"Tolay, N., and Buchberger, A. (2022). Role of the ubiquitin system in stress granule metabolism. Int J Mol Sci 23, 3624.","journal-title":"Int J Mol Sci"},{"key":"2661_CR410","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1093\/hmg\/ddr448","volume":"21","author":"ML Tradewell","year":"2012","unstructured":"Tradewell, M.L., Yu, Z., Tibshirani, M., Boulanger, M.C., Durham, H.D., and Richard, S. (2012). Arginine methylation by PRMT1 regulates nuclear-cytoplasmic localization and toxicity of FUS\/TLS harbouring ALS-linked mutations. Hum Mol Genet 21, 136\u2013149.","journal-title":"Hum Mol Genet"},{"key":"2661_CR411","doi-asserted-by":"publisher","first-page":"F1000","DOI":"10.12688\/f1000research.16903.1","volume":"8","author":"L Trinkle-Mulcahy","year":"2019","unstructured":"Trinkle-Mulcahy, L. (2019). Recent advances in proximity-based labeling methods for interactome mapping. F1000Res 8, F1000.","journal-title":"F1000Res"},{"key":"2661_CR412","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.1016\/j.molcel.2022.04.017","volume":"82","author":"J Trojanowski","year":"2022","unstructured":"Trojanowski, J., Frank, L., Rademacher, A., M\u00fccke, N., Grigaitis, P., and Rippe, K. (2022). Transcription activation is enhanced by multivalent interactions independent of phase separation. Mol Cell 82, 1878\u20131893.e10.","journal-title":"Mol Cell"},{"key":"2661_CR413","doi-asserted-by":"publisher","first-page":"22671","DOI":"10.1074\/jbc.M116.739573","volume":"291","author":"WC Tsai","year":"2016","unstructured":"Tsai, W.C., Gayatri, S., Reineke, L.C., Sbardella, G., Bedford, M.T., and Lloyd, R.E. (2016). Arginine demethylation of G3BP1 promotes stress granule assembly. J Biol Chem 291, 22671\u201322685.","journal-title":"J Biol Chem"},{"key":"2661_CR414","doi-asserted-by":"publisher","first-page":"18886","DOI":"10.1074\/jbc.M117.800706","volume":"292","author":"WC Tsai","year":"2017","unstructured":"Tsai, W.C., Reineke, L.C., Jain, A., Jung, S.Y., and Lloyd, R.E. (2017). Histone arginine demethylase JMJD6 is linked to stress granule assembly through demethylation of the stress granule\u2013nucleating protein G3BP1. J Biol Chem 292, 18886\u201318896.","journal-title":"J Biol Chem"},{"key":"2661_CR415","doi-asserted-by":"publisher","first-page":"4218","DOI":"10.1073\/pnas.1814385116","volume":"116","author":"B Tsang","year":"2019","unstructured":"Tsang, B., Arsenault, J., Vernon, R.M., Lin, H., Sonenberg, N., Wang, L.Y., Bah, A., and Forman-Kay, J.D. (2019). Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation. Proc Natl Acad Sci USA 116, 4218\u20134227.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2661_CR416","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1016\/j.cell.2020.11.050","volume":"183","author":"B Tsang","year":"2020","unstructured":"Tsang, B., Priti\u0161anac, I., Scherer, S.W., Moses, A.M., and Forman-Kay, J.D. (2020). Phase separation as a missing mechanism for interpretation of disease mutations. Cell 183, 1742\u20131756.","journal-title":"Cell"},{"key":"2661_CR417","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1002\/pro.4108","volume":"30","author":"PS Tsoi","year":"2021","unstructured":"Tsoi, P.S., Quan, M.D., Choi, K.-., Dao, K.M., Ferreon, J.C., and Ferreon, A.C.M. (2021). Electrostatic modulation of hnRNPA1 low-complexity domain liquid\u2013liquid phase separation and aggregation. Protein Sci 30, 1408\u20131417.","journal-title":"Protein Sci"},{"key":"2661_CR418","doi-asserted-by":"publisher","first-page":"2649","DOI":"10.1016\/j.cell.2021.03.031","volume":"184","author":"A Tulpule","year":"2021","unstructured":"Tulpule, A., Guan, J., Neel, D.S., Allegakoen, H.R., Lin, Y.P., Brown, D., Chou, Y.T., Heslin, A., Chatterjee, N., Perati, S., et al. (2021). Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules. Cell 184, 2649\u20132664.e18.","journal-title":"Cell"},{"key":"2661_CR419","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1016\/j.molcel.2018.04.021","volume":"70","author":"A Turakhiya","year":"2018","unstructured":"Turakhiya, A., Meyer, S.R., Marincola, G., B\u00f6hm, S., Vanselow, J.T., Schlosser, A., Hofmann, K., and Buchberger, A. (2018). ZFAND1 ruits p97 and the 26S proteasome to promote the clearance of arsenite-induced stress granules. Mol Cell 70, 906\u2013919.e7.","journal-title":"Mol Cell"},{"key":"2661_CR420","doi-asserted-by":"publisher","first-page":"e202205726","DOI":"10.1002\/anie.202205726","volume":"61","author":"D Ubbiali","year":"2022","unstructured":"Ubbiali, D., Fratini, M., Piersimoni, L., Ihling, C.H., Kipping, M., Heilmann, I., Iacobucci, C., and Sinz, A. (2022). Direct observation of \u201celongated\u201d conformational states in \u03b1-synuclein upon liquid-liquid phase separation. Angew Chem Int Ed 61, e202205726.","journal-title":"Angew Chem Int Ed"},{"key":"2661_CR421","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1093\/hmg\/ddt408","volume":"23","author":"M Udan-Johns","year":"2014","unstructured":"Udan-Johns, M., Bengoechea, R., Bell, S., Shao, J., Diamond, M.I., True, H.L., Weihl, C. C., and Baloh, R.H. (2014). Prion-like nuclear aggregation of TDP-43 during heat shock is regulated by HSP40\/70 chaperones. Hum Mol Genet 23, 157\u2013170.","journal-title":"Hum Mol Genet"},{"key":"2661_CR422","doi-asserted-by":"publisher","first-page":"2909","DOI":"10.1038\/s41467-019-10792-y","volume":"10","author":"T Ukmar-Godec","year":"2019","unstructured":"Ukmar-Godec, T., Hutten, S., Grieshop, M.P., Rezaei-Ghaleh, N., Cima-Omori, M.S., Biernat, J., Mandelkow, E., S\u00f6ding, J., Dormann, D., and Zweckstetter, M. (2019). Lysine\/RNA-interactions drive and regulate biomolecular condensation. Nat Commun 10, 2909.","journal-title":"Nat Commun"},{"key":"2661_CR423","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1039\/C1MB05251A","volume":"8","author":"V Vacic","year":"2012","unstructured":"Vacic, V., and Iakoucheva, L.M. (2012). Disease mutations in disordered regions\u2013exception to the rule? Mol Biosyst 8, 27\u201332.","journal-title":"Mol Biosyst"},{"key":"2661_CR424","doi-asserted-by":"publisher","first-page":"2084","DOI":"10.1016\/S0140-6736(17)31287-4","volume":"390","author":"MA van Es","year":"2017","unstructured":"van Es, M.A., Hardiman, O., Chio, A., Al-Chalabi, A., Pasterkamp, R.J., Veldink, J.H., and van den Berg, L.H. (2017). Amyotrophic lateral sclerosis. Lancet 390, 2084\u20132098.","journal-title":"Lancet"},{"key":"2661_CR425","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/j.cell.2018.07.023","volume":"174","author":"B Van Treeck","year":"2018","unstructured":"Van Treeck, B., and Parker, R. (2018). Emerging roles for intermolecular RNA-RNA interactions in RNP assemblies. Cell 174, 791\u2013802.","journal-title":"Cell"},{"key":"2661_CR426","doi-asserted-by":"publisher","first-page":"2734","DOI":"10.1073\/pnas.1800038115","volume":"115","author":"B Van Treeck","year":"2018","unstructured":"Van Treeck, B., Protter, D.S.W., Matheny, T., Khong, A., Link, C.D., and Parker, R. (2018). RNA self-assembly contributes to stress granule formation and defining the stress granule transcriptome. Proc Natl Acad Sci USA 115, 2734\u20132739.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2661_CR427","doi-asserted-by":"publisher","first-page":"e100730","DOI":"10.15252\/embj.2018100730","volume":"38","author":"EM van Well","year":"2019","unstructured":"van Well, E.M., Bader, V., Patra, M., S\u00e1nchez-Vicente, A., Meschede, J., Furthmann, N., Schnack, C., Blusch, A., Longworth, J., Petrasch-Parwez, E., et al. (2019). A protein quality control pathway regulated by linear ubiquitination. EMBO J 38, e100730.","journal-title":"EMBO J"},{"key":"2661_CR428","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1016\/j.celrep.2016.04.045","volume":"15","author":"T Vanderweyde","year":"2016","unstructured":"Vanderweyde, T., Apicco, D.J., Youmans-Kidder, K., Ash, P.E.A., Cook, C., Lummertz da Rocha, E., Jansen-West, K., Frame, A.A., Citro, A., Leszyk, J.D., et al. (2016). Interaction of tau with the RNA-binding protein TIA1 regulates tau pathophysiology and toxicity. Cell Rep 15, 1455\u20131466.","journal-title":"Cell Rep"},{"key":"2661_CR429","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/0092-8674(91)90397-H","volume":"65","author":"AJMH Verkerk","year":"1991","unstructured":"Verkerk, A.J.M.H., Pieretti, M., Sutcliffe, J.S., Fu, Y.H., Kuhl, D.P.A., Pizzuti, A., Reiner, O., Richards, S., Victoria, M.F., Zhang, F., et al. (1991). Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome. Cell 65, 905\u2013914.","journal-title":"Cell"},{"key":"2661_CR430","doi-asserted-by":"publisher","first-page":"8758","DOI":"10.3390\/ijms21228758","volume":"21","author":"RA Voorn","year":"2020","unstructured":"Voorn, R.A., and Vogl, C. (2020). Molecular assembly and structural plasticity of sensory ribbon synapses-a presynaptic perspective. Int J Mol Sci 21, 8758.","journal-title":"Int J Mol Sci"},{"key":"2661_CR431","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.jmb.2016.12.011","volume":"429","author":"ML Wall","year":"2017","unstructured":"Wall, M.L., and Lewis, S.M. (2017). Methylarginines within the RGG-motif region of hnRNP A1 affect its IRES trans-acting factor activity and are required for hnRNP A1 stress granule localization and formation. J Mol Biol 429, 295\u2013307.","journal-title":"J Mol Biol"},{"key":"2661_CR432","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.ajhg.2010.05.010","volume":"87","author":"T Walsh","year":"2010","unstructured":"Walsh, T., Shahin, H., Elkan-Miller, T., Lee, M.K., Thornton, A.M., Roeb, W., Abu Rayyan, A., Loulus, S., Avraham, K.B., King, M.C., et al. (2010). Whole exome sequencing and homozygosity mapping identify mutation in the cell polarity protein GPSM2 as the cause of nonsyndromic hearing loss DFNB82. Am J Hum Genet 87, 90\u201394.","journal-title":"Am J Hum Genet"},{"key":"2661_CR433","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/s41586-018-0132-0","volume":"557","author":"G Wan","year":"2018","unstructured":"Wan, G., Fields, B.D., Spracklin, G., Shukla, A., Phillips, C.M., and Kennedy, S. (2018). Spatiotemporal regulation of liquid-like condensates in epigenetic inheritance. Nature 557, 679\u2013683.","journal-title":"Nature"},{"key":"2661_CR434","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/s41586-019-1842-7","volume":"577","author":"L Wan","year":"2020","unstructured":"Wan, L., Chong, S., Xuan, F., Liang, A., Cui, X., Gates, L., Carroll, T.S., Li, Y., Feng, L., Chen, G., et al. (2020). Impaired cell fate through gain-of-function mutations in a chromatin reader. Nature 577, 121\u2013126.","journal-title":"Nature"},{"key":"2661_CR435","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/nature21687","volume":"543","author":"L Wan","year":"2017","unstructured":"Wan, L., Wen, H., Li, Y., Lyu, J., Xi, Y., Hoshii, T., Joseph, J.K., Wang, X., Loh, Y.H.E., Erb, M.A., et al. (2017). ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia. Nature 543, 265\u2013269.","journal-title":"Nature"},{"key":"2661_CR436","doi-asserted-by":"publisher","first-page":"e97452","DOI":"10.15252\/embj.201797452","volume":"37","author":"A Wang","year":"2018","unstructured":"Wang, A., Conicella, A.E., Schmidt, H.B., Martin, E.W., Rhoads, S.N., Reeb, A.N., Nourse, A., Ramirez Montero, D., Ryan, V.H., Rohatgi, R., et al. (2018a). A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing. EMBO J 37, e97452.","journal-title":"EMBO J"},{"key":"2661_CR437","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/s41392-021-00678-1","volume":"6","author":"B Wang","year":"2021","unstructured":"Wang, B., Zhang, L., Dai, T., Qin, Z., Lu, H., Zhang, L., and Zhou, F. (2021a). Liquid\u2013liquid phase separation in human health and diseases. Sig Transduct Target Ther 6, 290.","journal-title":"Sig Transduct Target Ther"},{"key":"2661_CR438","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.molcel.2020.06.019","volume":"79","author":"C Wang","year":"2020","unstructured":"Wang, C., Duan, Y., Duan, G., Wang, Q., Zhang, K., Deng, X., Qian, B., Gu, J., Ma, Z., Zhang, S., et al. (2020). Stress induces dynamic, cytotoxicity-antagonizing TDP-43 nuclear bodies via paraspeckle LncRNA NEAT1-mediated liquid-liquid phase separation. Mol Cell 79, 443\u2013458.e7.","journal-title":"Mol Cell"},{"key":"2661_CR439","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1093\/procel\/pwad054","volume":"15","author":"C Wang","year":"2023","unstructured":"Wang, C., Huang, Y., Yang, Y., Li, R., Li, Y., Qiu, H., Wu, J., Shi, G., Ma, W., and Songyang, Z. (2023a). ILF3 safeguards telomeres from aberrant homologous recombination as a telomeric R-loop reader. Protein Cell 15, 493\u2013511.","journal-title":"Protein Cell"},{"key":"2661_CR440","doi-asserted-by":"publisher","first-page":"103719","DOI":"10.1016\/j.isci.2021.103719","volume":"25","author":"C Wang","year":"2022","unstructured":"Wang, C., Lu, H., Liu, X., Gao, X., Tian, W., Chen, H., Xue, Y., and Zhou, Q. (2022a). A natural product targets BRD4 to inhibit phase separation and gene transcription. iScience 25, 103719.","journal-title":"iScience"},{"key":"2661_CR441","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1093\/hmg\/ddy432","volume":"28","author":"ET Wang","year":"2019","unstructured":"Wang, E.T., Treacy, D., Eichinger, K., Struck, A., Estabrook, J., Olafson, H., Wang, T. T., Bhatt, K., Westbrook, T., Sedehizadeh, S., et al. (2019). Transcriptome alterations in myotonic dystrophy skeletal muscle and heart. Hum Mol Genet 28, 1312\u20131321.","journal-title":"Hum Mol Genet"},{"key":"2661_CR442","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1038\/s41467-023-37267-5","volume":"14","author":"H Wang","year":"2023","unstructured":"Wang, H., Du, H., Ren, R., Du, T., Lin, L., Feng, Z., Zhao, D., Wei, X., Zhai, X., Wang, H., et al. (2023b). Temporal and spatial assembly of inner ear hair cell ankle link condensate through phase separation. Nat Commun 14, 1657.","journal-title":"Nat Commun"},{"key":"2661_CR443","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/j.cell.2018.06.006","volume":"174","author":"J Wang","year":"2018","unstructured":"Wang, J., Choi, J.M., Holehouse, A.S., Lee, H.O., Zhang, X., Jahnel, M., Maharana, S., Lemaitre, R., Pozniakovsky, A., Drechsel, D., et al. (2018b). A molecular grammar governing the driving forces for phase separation of prion-like RNA binding proteins. Cell 174, 688\u2013699.e16.","journal-title":"Cell"},{"key":"2661_CR444","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.mito.2014.04.008","volume":"17","author":"KZQ Wang","year":"2014","unstructured":"Wang, K.Z.Q., Zhu, J., Dagda, R.K., Uechi, G., Cherra III, S.J., Gusdon, A.M., Balasubramani, M., and Chu, C.T. (2014). ERK-mediated phosphorylation of TFAM downregulates mitochondrial transcription: implications for Parkinson\u2019s disease. Mitochondrion 17, 132\u2013140.","journal-title":"Mitochondrion"},{"key":"2661_CR445","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/s41467-017-00088-4","volume":"8","author":"P Wang","year":"2017","unstructured":"Wang, P., Wander, C.M., Yuan, C.X., Bereman, M.S., and Cohen, T.J. (2017). Acetylation-induced TDP-43 pathology is suppressed by an HSF1-dependent chaperone program. Nat Commun 8, 82.","journal-title":"Nat Commun"},{"key":"2661_CR446","doi-asserted-by":"publisher","first-page":"e2205255119","DOI":"10.1073\/pnas.2205255119","volume":"119","author":"Q Wang","year":"2022","unstructured":"Wang, Q., Li, Z., Zhang, S., Li, Y., Wang, Y., Fang, Z., Ma, Y., Liu, Z., Zhang, W., Li, D., et al. (2022b). Global profiling of arginine dimethylation in regulating protein phase separation by a steric effect\u2013based chemical-enrichment method. Proc Natl Acad Sci USA 119, e2205255119.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2661_CR447","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1038\/s41556-021-00710-0","volume":"23","author":"S Wang","year":"2021","unstructured":"Wang, S., Dai, T., Qin, Z., Pan, T., Chu, F., Lou, L., Zhang, L., Yang, B., Huang, H., Lu, H., et al. (2021b). Targeting liquid\u2013liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity. Nat Cell Biol 23, 718\u2013732.","journal-title":"Nat Cell Biol"},{"key":"2661_CR448","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.1038\/s41467-023-37606-6","volume":"14","author":"X Wang","year":"2023","unstructured":"Wang, X., Wang, H., Wang, J., Liu, X., Hao, H., Tan, Y.S., Zhang, Y., Zhang, H., Ding, X., Zhao, W., et al. (2023c). Single-shot isotropic differential interference contrast microscopy. Nat Commun 14, 2063.","journal-title":"Nat Commun"},{"key":"2661_CR449","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/nrn.2015.1","volume":"17","author":"Y Wang","year":"2016","unstructured":"Wang, Y., and Mandelkow, E. (2016). Tau in physiology and pathology. Nat Rev Neurosci 17, 5\u201321.","journal-title":"Nat Rev Neurosci"},{"key":"2661_CR450","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1038\/s41589-023-01376-5","volume":"19","author":"Y Wang","year":"2023","unstructured":"Wang, Y., Yu, C., Pei, G., Jia, W., Li, T., and Li, P. (2023d). Dissolution of oncofusion transcription factor condensates for cancer therapy. Nat Chem Biol 19, 1223\u20131234.","journal-title":"Nat Chem Biol"},{"key":"2661_CR451","doi-asserted-by":"publisher","first-page":"101782","DOI":"10.1016\/j.jbc.2022.101782","volume":"298","author":"Z Wang","year":"2022","unstructured":"Wang, Z., Lou, J., and Zhang, H. (2022c). Essence determines phenomenon: assaying the material properties of biological condensates. J Biol Chem 298, 101782.","journal-title":"J Biol Chem"},{"key":"2661_CR452","doi-asserted-by":"publisher","first-page":"e202112024","DOI":"10.1083\/jcb.202112024","volume":"221","author":"Z Wang","year":"2022","unstructured":"Wang, Z., Chen, D., Guan, D., Liang, X., Xue, J., Zhao, H., Song, G., Lou, J., He, Y., and Zhang, H. (2022d). Material properties of phase-separated TFEB condensates regulate the autophagy-lysosome pathway. J Cell Biol 221, e202112024.","journal-title":"J Cell Biol"},{"key":"2661_CR453","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/j.devcel.2023.04.004","volume":"58","author":"Z Wang","year":"2023","unstructured":"Wang, Z., Yang, C., Guan, D., Li, J., and Zhang, H. (2023e). Cellular proteins act as surfactants to control the interfacial behavior and function of biological condensates. Dev Cell 58, 919\u2013932.e5.","journal-title":"Dev Cell"},{"key":"2661_CR454","doi-asserted-by":"publisher","first-page":"e98049","DOI":"10.15252\/embj.201798049","volume":"37","author":"S Wegmann","year":"2018","unstructured":"Wegmann, S., Eftekharzadeh, B., Tepper, K., Zoltowska, K.M., Bennett, R.E., Dujardin, S., Laskowski, P.R., MacKenzie, D., Kamath, T., Commins, C., et al. (2018). Tau protein liquid\u2013liquid phase separation can initiate tau aggregation. EMBO J 37, e98049.","journal-title":"EMBO J"},{"key":"2661_CR455","doi-asserted-by":"publisher","first-page":"2908","DOI":"10.1158\/0008-5472.CAN-22-4017","volume":"83","author":"M Wei","year":"2023","unstructured":"Wei, M., Huang, X., Liao, L., Tian, Y., and Zheng, X. (2023). SENP1 decreases RNF168 phase separation to promote DNA damage repair and drug resistance in colon cancer. Canc Res 83, 2908\u20132923.","journal-title":"Canc Res"},{"key":"2661_CR456","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1002\/humu.23985","volume":"41","author":"X Wei","year":"2020","unstructured":"Wei, X., Du, M., Li, D., Wen, S., Xie, J., Li, Y., Chen, A., Zhang, K., Xu, P., Jia, M., et al. (2020). Mutations in FASTKD2 are associated with mitochondrial disease with multi-OXPHOS deficiency. Hum Mutat 41, 961\u2013972.","journal-title":"Hum Mutat"},{"key":"2661_CR457","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1016\/j.cell.2020.10.029","volume":"183","author":"H Wesseling","year":"2020","unstructured":"Wesseling, H., Mair, W., Kumar, M., Schlaffner, C.N., Tang, S., Beerepoot, P., Fatou, B., Guise, A.J., Cheng, L., Takeda, S., et al. (2020). Tau PTM profiles identify patient heterogeneity and stages of Alzheimer\u2019s disease. Cell 183, 1699\u20131713.e13.","journal-title":"Cell"},{"key":"2661_CR458","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1086\/381685","volume":"74","author":"MD Weston","year":"2004","unstructured":"Weston, M.D., Luijendijk, M.W.J., Humphrey, K.D., M\u00f6ller, C., and Kimberling, W.J. (2004). Mutations in the VLGR1 gene implicate g-protein signaling in the pathogenesis of usher syndrome type II. Am J Hum Genet 74, 357\u2013366.","journal-title":"Am J Hum Genet"},{"key":"2661_CR459","doi-asserted-by":"publisher","unstructured":"Wheeler, R. J., Lee, H. O., Poser, I., Pal, A., Doeleman, T., Kishigami, S., Hyman, A. A. (2019). Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease. BioRxiv, 721001, doi:https:\/\/doi.org\/10.1101\/721001.","DOI":"10.1101\/721001"},{"key":"2661_CR460","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1146\/annurev.biochem.73.011303.073756","volume":"73","author":"FS Willard","year":"2004","unstructured":"Willard, F.S., Kimple, R.J., and Siderovski, D.P. (2004). Return of the GDI: the goloco motif in cell division. Annu Rev Biochem 73, 925\u2013951.","journal-title":"Annu Rev Biochem"},{"key":"2661_CR461","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1038\/s41467-020-14544-1","volume":"11","author":"LE Wong","year":"2020","unstructured":"Wong, L.E., Bhatt, A., Erdmann, P.S., Hou, Z., Maier, J., Pirkuliyeva, S., Engelke, M., Becker, S., Plitzko, J., Wienands, J., et al. (2020a). Tripartite phase separation of two signal effectors with vesicles priming B cell responsiveness. Nat Commun 11, 848.","journal-title":"Nat Commun"},{"key":"2661_CR462","doi-asserted-by":"publisher","first-page":"2471","DOI":"10.1021\/jacs.9b12208","volume":"142","author":"LE Wong","year":"2020","unstructured":"Wong, L.E., Kim, T.H., Muhandiram, D.R., Forman-Kay, J.D., and Kay, L.E. (2020b). NMR experiments for studies of dilute and condensed protein phases: application to the phase-separating protein CAPRIN1. J Am Chem Soc 142, 2471\u20132489.","journal-title":"J Am Chem Soc"},{"key":"2661_CR463","doi-asserted-by":"publisher","first-page":"9728","DOI":"10.3390\/ijms22189728","volume":"22","author":"C Wu","year":"2021","unstructured":"Wu, C., Zhao, J., Wu, Q., Tan, Q., Liu, Q., and Xiao, S. (2021a). Tau N-terminal inserts regulate tau liquid-liquid phase separation and condensates maturation in a neuronal cell model. Int J Mol Sci 22, 9728.","journal-title":"Int J Mol Sci"},{"key":"2661_CR464","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1016\/j.cell.2016.05.004","volume":"165","author":"H Wu","year":"2016","unstructured":"Wu, H., and Fuxreiter, M. (2016). The structure and dynamics of higher-order assemblies: amyloids, signalosomes, and granules. Cell 165, 1055\u20131066.","journal-title":"Cell"},{"key":"2661_CR465","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1126\/science.1198848","volume":"331","author":"L Wu","year":"2011","unstructured":"Wu, L., Pan, L., Wei, Z., and Zhang, M. (2011). Structure of MyTH4-FERM domains in myosin VIIa tail bound to cargo. Science 331, 757\u2013760.","journal-title":"Science"},{"key":"2661_CR466","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1126\/science.abf6582","volume":"373","author":"M Wu","year":"2021","unstructured":"Wu, M., Xu, G., Han, C., Luan, P.F., Xing, Y.H., Nan, F., Yang, L.Z., Huang, Y., Yang, Z.H., Shan, L., et al. (2021b). lncRNA SLERT controls phase separation of FC\/DFCs to facilitate Pol I transcription. Science 373, 547\u2013555.","journal-title":"Science"},{"key":"2661_CR467","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1016\/j.str.2020.04.001","volume":"28","author":"X Wu","year":"2020","unstructured":"Wu, X., Cai, Q., Chen, Y., Zhu, S., Mi, J., Wang, J., and Zhang, M. (2020). Structural basis for the high-affinity interaction between CASK and Mint1. Structure 28, 664\u2013673.e3.","journal-title":"Structure"},{"key":"2661_CR468","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/j.molcel.2018.12.007","volume":"73","author":"X Wu","year":"2019","unstructured":"Wu, X., Cai, Q., Shen, Z., Chen, X., Zeng, M., Du, S., and Zhang, M. (2019). RIM and RIM-BP form presynaptic active-zone-like condensates via phase separation. Mol Cell 73, 971\u2013984.e5.","journal-title":"Mol Cell"},{"key":"2661_CR469","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.molcel.2020.10.029","volume":"81","author":"X Wu","year":"2021","unstructured":"Wu, X., Ganzella, M., Zhou, J., Zhu, S., Jahn, R., and Zhang, M. (2021c). Vesicle tethering on the surface of phase-separated active zone condensates. Mol Cell 81, 13\u201324.e7.","journal-title":"Mol Cell"},{"key":"2661_CR470","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1038\/s43018-023-00522-1","volume":"4","author":"Y Wu","year":"2023","unstructured":"Wu, Y., Zhou, L., Zou, Y., Zhang, Y., Zhang, M., Xu, L., Zheng, L., He, W., Yu, K., Li, T., et al. (2023). Disrupting the phase separation of KAT8\u2013IRF1 diminishes PD-L1 expression and promotes antitumor immunity. Nat Canc 4, 382\u2013400.","journal-title":"Nat Canc"},{"key":"2661_CR471","doi-asserted-by":"publisher","first-page":"9502","DOI":"10.3390\/ijms22179502","volume":"22","author":"VJ Xavier","year":"2021","unstructured":"Xavier, V.J., and Martinou, J.C. (2021). RNA granules in the mitochondria and their organization under mitochondrial stresses. Int J Mol Sci 22, 9502.","journal-title":"Int J Mol Sci"},{"key":"2661_CR472","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1007\/s13238-021-00839-6","volume":"12","author":"S Xia","year":"2021","unstructured":"Xia, S., Chen, Z., Shen, C., and Fu, T.M. (2021). Higher-order assemblies in immune signaling: supramolecular complexes and phase separation. Protein Cell 12, 680\u2013694.","journal-title":"Protein Cell"},{"key":"2661_CR473","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1038\/s41577-021-00572-5","volume":"22","author":"Q Xiao","year":"2022","unstructured":"Xiao, Q., McAtee, C.K., and Su, X. (2022). Phase separation in immune signalling. Nat Rev Immunol 22, 188\u2013199.","journal-title":"Nat Rev Immunol"},{"key":"2661_CR474","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1038\/s41589-022-01151-y","volume":"18","author":"J Xie","year":"2022","unstructured":"Xie, J., He, H., Kong, W., Li, Z., Gao, Z., Xie, D., Sun, L., Fan, X., Jiang, X., Zheng, Q., et al. (2022). Targeting androgen receptor phase separation to overcome antiandrogen resistance. Nat Chem Biol 18, 1341\u20131350.","journal-title":"Nat Chem Biol"},{"key":"2661_CR475","doi-asserted-by":"publisher","first-page":"11946","DOI":"10.1073\/pnas.1905013116","volume":"116","author":"W Xie","year":"2019","unstructured":"Xie, W., Lama, L., Adura, C., Tomita, D., Glickman, J.F., Tuschl, T., and Patel, D.J. (2019). Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation. Proc Natl Acad Sci USA 116, 11946\u201311955.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2661_CR476","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1186\/gb-2008-9-9-232","volume":"9","author":"HW Xin","year":"2008","unstructured":"Xin, H.W., Liu, D., and Zhou, S.Y. (2008). The telosome\/shelterin complex and its functions. Genome Biol 9, 232.","journal-title":"Genome Biol"},{"key":"2661_CR477","doi-asserted-by":"publisher","first-page":"30281","DOI":"10.1021\/acsomega.2c03534","volume":"7","author":"B Xu","year":"2022","unstructured":"Xu, B., Chen, J., and Liu, Y. (2022a). Curcumin interacts with \u03b1-synuclein condensates to inhibit amyloid aggregation under phase separation. ACS Omega 7, 30281\u201330290.","journal-title":"ACS Omega"},{"key":"2661_CR478","doi-asserted-by":"publisher","first-page":"726","DOI":"10.3390\/biom13050726","volume":"13","author":"B Xu","year":"2023","unstructured":"Xu, B., Fan, F., Liu, Y., Liu, Y., Zhou, L., and Yu, H. (2023). Distinct effects of familial Parkinson\u2019s Disease-associated mutations on alpha-synuclein phase separation and amyloid aggregation. Biomolecules 13, 726.","journal-title":"Biomolecules"},{"key":"2661_CR479","doi-asserted-by":"publisher","first-page":"e202200216","DOI":"10.1002\/cbic.202200216","volume":"23","author":"B Xu","year":"2022","unstructured":"Xu, B., Mo, X., Chen, J., Yu, H., and Liu, Y. (2022b). Myricetin inhibits \u03b1-synuclein amyloid aggregation by delaying the liquid-to-solid phase transition. ChemBioChem 23, e202200216.","journal-title":"ChemBioChem"},{"key":"2661_CR480","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1038\/s41467-022-28765-z","volume":"13","author":"S Xue","year":"2022","unstructured":"Xue, S., Zhou, F., Zhao, T., Zhao, H., Wang, X., Chen, L., Li, J.-p., and Luo, S.-Z. (2022). Phase separation on cell surface facilitates bFGF signal transduction with heparan sulphate. Nat Commun 13, 1112.","journal-title":"Nat Commun"},{"key":"2661_CR481","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s00401-007-0287-5","volume":"115","author":"M Yamada","year":"2008","unstructured":"Yamada, M., Sato, T., Tsuji, S., and Takahashi, H. (2008). CAG repeat disorder models and human neuropathology: similarities and differences. Acta Neuropathol 115, 71\u201386.","journal-title":"Acta Neuropathol"},{"key":"2661_CR482","doi-asserted-by":"publisher","first-page":"e49267","DOI":"10.1371\/journal.pone.0049267","volume":"7","author":"A Yamaguchi","year":"2012","unstructured":"Yamaguchi, A., Kitajo, K., and Kahle, P.J. (2012). The effect of PRMT1-mediated arginine methylation on the subcellular localization, stress granules, and detergent-insoluble aggregates of FUS\/TLS. PLoS One 7, e49267.","journal-title":"PLoS One"},{"key":"2661_CR483","doi-asserted-by":"publisher","first-page":"4040","DOI":"10.1073\/pnas.0911385107","volume":"107","author":"J Yan","year":"2010","unstructured":"Yan, J., Pan, L., Chen, X., Wu, L., and Zhang, M. (2010). The structure of the harmonin\/sans complex reveals an unexpected interaction mode of the two Usher syndrome proteins. Proc Natl Acad Sci USA 107, 4040\u20134045.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2661_CR484","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1080\/15548627.2022.2164427","volume":"19","author":"C Yang","year":"2023","unstructured":"Yang, C., Wang, Z., Kang, Y., Yi, Q., Wang, T., Bai, Y., and Liu, Y. (2023). Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules. Autophagy 19, 1934\u20131951.","journal-title":"Autophagy"},{"key":"2661_CR485","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.cell.2020.03.046","volume":"181","author":"P Yang","year":"2020","unstructured":"Yang, P., Mathieu, C., Kolaitis, R.M., Zhang, P., Messing, J., Yurtsever, U., Yang, Z., Wu, J., Li, Y., Pan, Q., et al. (2020). G3BP1 is a tunable switch that triggers phase separation to assemble stress granules. Cell 181, 325\u2013345.e28.","journal-title":"Cell"},{"key":"2661_CR486","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1038\/s41589-023-01477-1","volume":"20","author":"S Ye","year":"2023","unstructured":"Ye, S., Latham, A.P., Tang, Y., Hsiung, C.H., Chen, J., Luo, F., Liu, Y., Zhang, B., and Zhang, X. (2023). Micropolarity governs the structural organization of biomolecular condensates. Nat Chem Biol 20, 443\u2013451.","journal-title":"Nat Chem Biol"},{"key":"2661_CR487","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.mito.2017.05.005","volume":"35","author":"DH Yoo","year":"2017","unstructured":"Yoo, D.H., Choi, Y.C., Nam, D.E., Choi, S.S., Kim, J.W., Choi, B.O., and Chung, K.W. (2017). Identification of FASTKD2 compound heterozygous mutations as the underlying cause of autosomal recessive MELAS-like syndrome. Mitochondrion 35, 54\u201358.","journal-title":"Mitochondrion"},{"key":"2661_CR488","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/j.molcel.2022.01.005","volume":"82","author":"H Yoo","year":"2022","unstructured":"Yoo, H., Bard, J.A.M., Pilipenko, E.V., and Drummond, D.A. (2022). Chaperones directly and efficiently disperse stress-triggered biomolecular condensates. Mol Cell 82, 741\u2013755.e11.","journal-title":"Mol Cell"},{"key":"2661_CR489","doi-asserted-by":"publisher","first-page":"eabb4309","DOI":"10.1126\/science.abb4309","volume":"371","author":"H Yu","year":"2021","unstructured":"Yu, H., Lu, S., Gasior, K., Singh, D., Vazquez-Sanchez, S., Tapia, O., Toprani, D., Beccari, M.S., YatesIII, J.R., Da Cruz, S., et al. (2021a). HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells. Science 371, eabb4309.","journal-title":"Science"},{"key":"2661_CR490","doi-asserted-by":"publisher","first-page":"15864","DOI":"10.1038\/ncomms15864","volume":"8","author":"IM Yu","year":"2017","unstructured":"Yu, I.M., Planelles-Herrero, V.J., Sourigues, Y., Moussaoui, D., Sirkia, H., Kikuti, C., Stroebel, D., Titus, M.A., and Houdusse, A. (2017). Myosin 7 and its adaptors link cadherins to actin. Nat Commun 8, 15864.","journal-title":"Nat Commun"},{"key":"2661_CR491","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1016\/j.molcel.2021.01.010","volume":"81","author":"M Yu","year":"2021","unstructured":"Yu, M., Peng, Z., Qin, M., Liu, Y., Wang, J., Zhang, C., Lin, J., Dong, T., Wang, L., Li, S., et al. (2021b). Interferon-\u03b3 induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation. Mol Cell 81, 1216\u20131230.e9.","journal-title":"Mol Cell"},{"key":"2661_CR492","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/s41556-021-00659-0","volume":"23","author":"X Yu","year":"2021","unstructured":"Yu, X., Zhang, L., Shen, J., Zhai, Y., Jiang, Q., Yi, M., Deng, X., Ruan, Z., Fang, R., Chen, Z., et al. (2021c). The STING phase-separator suppresses innate immune signalling. Nat Cell Biol 23, 330\u2013340.","journal-title":"Nat Cell Biol"},{"key":"2661_CR493","doi-asserted-by":"publisher","first-page":"e1001048","DOI":"10.1371\/journal.pbio.1001048","volume":"9","author":"V Zampini","year":"2011","unstructured":"Zampini, V., R\u00fcttiger, L., Johnson, S.L., Franz, C., Furness, D.N., Waldhaus, J., Xiong, H., Hackney, C.M., Holley, M.C., Offenhauser, N., et al. (2011). Eps8 regulates hair bundle length and functional maturation of mammalian auditory hair cells. PLoS Biol 9, e1001048.","journal-title":"PLoS Biol"},{"key":"2661_CR494","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1016\/j.cell.2018.06.047","volume":"174","author":"M Zeng","year":"2018","unstructured":"Zeng, M., Chen, X., Guan, D., Xu, J., Wu, H., Tong, P., and Zhang, M. (2018). Reconstituted postsynaptic density as a molecular platform for understanding synapse formation and plasticity. Cell 174, 1172\u20131187.e16.","journal-title":"Cell"},{"key":"2661_CR495","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1038\/nbt.3149","volume":"33","author":"B Zetsche","year":"2015","unstructured":"Zetsche, B., Volz, S.E., and Zhang, F. (2015). A split-Cas9 architecture for inducible genome editing and transcription modulation. Nat Biotechnol 33, 139\u2013142.","journal-title":"Nat Biotechnol"},{"key":"2661_CR496","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1016\/j.cell.2020.07.043","volume":"182","author":"JZ Zhang","year":"2020","unstructured":"Zhang, J.Z., Lu, T.W., Stolerman, L.M., Tenner, B., Yang, J.R., Zhang, J.F., Falcke, M., Rangamani, P., Taylor, S.S., Mehta, S., et al. (2020a). Phase separation of a PKA regulatory subunit controls camp compartmentation and oncogenic signaling. Cell 182, 1531\u20131544.e15.","journal-title":"Cell"},{"key":"2661_CR497","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/nature14973","volume":"525","author":"K Zhang","year":"2015","unstructured":"Zhang, K., Donnelly, C.J., Haeusler, A.R., Grima, J.C., Machamer, J.B., Steinwald, P., Daley, E.L., Miller, S.J., Cunningham, K.M., Vidensky, S., et al. (2015). The C9orf72 repeat expansion disrupts nucleocytoplasmic transport. Nature 525, 56\u201361.","journal-title":"Nature"},{"key":"2661_CR498","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1038\/s41467-022-28019-y","volume":"13","author":"L Zhang","year":"2022","unstructured":"Zhang, L., Geng, X., Wang, F., Tang, J., Ichida, Y., Sharma, A., Jin, S., Chen, M., Tang, M., Pozo, F.M., et al. (2022). 53BP1 regulates heterochromatin through liquid phase separation. Nat Commun 13, 360.","journal-title":"Nat Commun"},{"key":"2661_CR499","doi-asserted-by":"publisher","first-page":"e39578","DOI":"10.7554\/eLife.39578","volume":"8","author":"P Zhang","year":"2019","unstructured":"Zhang, P., Fan, B., Yang, P., Temirov, J., Messing, J., Kim, H.J., and Taylor, J.P. (2019). Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology. eLife 8, e39578.","journal-title":"eLife"},{"key":"2661_CR500","doi-asserted-by":"publisher","first-page":"e2002183","DOI":"10.1371\/journal.pbio.2002183","volume":"15","author":"X Zhang","year":"2017","unstructured":"Zhang, X., Lin, Y., Eschmann, N.A., Zhou, H., Rauch, J.N., Hernandez, I., Guzman, E., Kosik, K.S., Han, S., and Bates, G. (2017). RNA stores tau reversibly in complex coacervates. PLoS Biol 15, e2002183.","journal-title":"PLoS Biol"},{"key":"2661_CR501","doi-asserted-by":"publisher","first-page":"e202006054","DOI":"10.1083\/jcb.202006054","volume":"219","author":"X Zhang","year":"2020","unstructured":"Zhang, X., Vigers, M., McCarty, J., Rauch, J.N., Fredrickson, G.H., Wilson, M.Z., Shea, J.E., Han, S., and Kosik, K.S. (2020b). The proline-rich domain promotes Tau liquid-liquid phase separation in cells. J Cell Biol 219, e202006054.","journal-title":"J Cell Biol"},{"key":"2661_CR502","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1007\/s13238-021-00832-z","volume":"12","author":"D Zhao","year":"2021","unstructured":"Zhao, D., Xu, W., Zhang, X., Wang, X., Ge, Y., Yuan, E., Xiong, Y., Wu, S., Li, S., Wu, N., Tian, T., Feng, X., Shu, H., Lang, P., Li, J., Zhu, F., Shen, X., Li, H., Li, P., and Zeng, J. (2021a). Understanding the phase separation characteristics of nucleocapsid protein provides a new therapeutic opportunity against SARS-CoV-2. Protein Cell 12, 734\u2013740.","journal-title":"Protein Cell"},{"key":"2661_CR503","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1038\/s41467-021-22297-8","volume":"12","author":"M Zhao","year":"2021","unstructured":"Zhao, M., Yu, Y., Sun, L.M., Xing, J.Q., Li, T., Zhu, Y., Wang, M., Yu, Y., Xue, W., Xia, T., et al. (2021b). GCG inhibits SARS-CoV-2 replication by disrupting the liquid phase condensation of its nucleocapsid protein. Nat Commun 12, 2114.","journal-title":"Nat Commun"},{"key":"2661_CR504","doi-asserted-by":"publisher","first-page":"3208","DOI":"10.1016\/j.cell.2023.05.047","volume":"186","author":"Z Zhao","year":"2023","unstructured":"Zhao, Z., Qing, Y., Dong, L., Han, L., Wu, D., Li, Y., Li, W., Xue, J., Zhou, K., Sun, M., et al. (2023). QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism. Cell 186, 3208\u20133226.e27.","journal-title":"Cell"},{"key":"2661_CR505","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.molcel.2021.01.024","volume":"81","author":"W Zhou","year":"2021","unstructured":"Zhou, W., Mohr, L., Maciejowski, J., and Kranzusch, P.J. (2021). cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing. Mol Cell 81, 739\u2013755.e7.","journal-title":"Mol Cell"},{"key":"2661_CR506","doi-asserted-by":"publisher","first-page":"4277","DOI":"10.1038\/s41467-022-32055-z","volume":"13","author":"W Zhou","year":"2022","unstructured":"Zhou, W., Richmond-Buccola, D., Wang, Q., and Kranzusch, P.J. (2022). Structural basis of human TREX1 DNA degradation and autoimmune disease. Nat Commun 13, 4277.","journal-title":"Nat Commun"},{"key":"2661_CR507","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.cell.2018.06.026","volume":"174","author":"W Zhou","year":"2018","unstructured":"Zhou, W., Whiteley, A.T., de Oliveira Mann, C.C., Morehouse, B.R., Nowak, R.P., Fischer, E.S., Gray, N.S., Mekalanos, J.J., and Kranzusch, P.J. (2018). Structure of the human cGAS\u2013DNA complex reveals enhanced control of immune surveillance. Cell 174, 300\u2013311.e11.","journal-title":"Cell"},{"key":"2661_CR508","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1038\/s41422-021-00504-x","volume":"31","author":"G Zhu","year":"2021","unstructured":"Zhu, G., Xie, J., Fu, Z., Wang, M., Zhang, Q., He, H., Chen, Z., Guo, X., and Zhu, J. (2021). Pharmacological inhibition of SRC-1 phase separation suppresses YAP oncogenic transcription activity. Cell Res 31, 1028\u20131031.","journal-title":"Cell Res"},{"key":"2661_CR509","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.cell.2020.09.002","volume":"183","author":"G Zhu","year":"2020","unstructured":"Zhu, G., Xie, J., Kong, W., Xie, J., Li, Y., Du, L., Zheng, Q., Sun, L., Guan, M., Li, H., et al. (2020a). Phase separation of disease-associated SHP2 mutants underlies MAPK hyperactivation. Cell 183, 490\u2013502.e18.","journal-title":"Cell"},{"key":"2661_CR510","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.molcel.2011.07.011","volume":"43","author":"J Zhu","year":"2011","unstructured":"Zhu, J., Wen, W., Zheng, Z., Shang, Y., Wei, Z., Xiao, Z., Pan, Z., Du, Q., Wang, W., and Zhang, M. (2011). LGN\/mInsc and LGN\/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3\/mInsc\/LGN and G\u03b1i\/LGN\/NuMA pathways. Mol Cell 43, 418\u2013431.","journal-title":"Mol Cell"},{"key":"2661_CR511","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1038\/s41593-020-0619-5","volume":"23","author":"Q Zhu","year":"2020","unstructured":"Zhu, Q., Jiang, J., Gendron, T.F., McAlonis-Downes, M., Jiang, L., Taylor, A., Diaz Garcia, S., Ghosh Dastidar, S., Rodriguez, M.J., King, P., et al. (2020b). Reduced C9ORF72 function exacerbates gain of toxicity from ALS\/FTD-causing repeat expansion in C9orf72. Nat Neurosci 23, 615\u2013624.","journal-title":"Nat Neurosci"},{"key":"2661_CR512","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1002\/cbf.3369","volume":"37","author":"Y Zou","year":"2019","unstructured":"Zou, Y., Ma, D., and Wang, Y. (2019). The PROTAC technology in drug development. Cell Biochem Function 37, 21\u201330.","journal-title":"Cell Biochem Function"},{"key":"2661_CR513","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1038\/s41467-021-21690-7","volume":"12","author":"L Zuo","year":"2021","unstructured":"Zuo, L., Zhang, G., Massett, M., Cheng, J., Guo, Z., Wang, L., Gao, Y., Li, R., Huang, X., Li, P., et al. (2021). Loci-specific phase separation of FET fusion oncoproteins promotes gene transcription. Nat Commun 12, 1491.","journal-title":"Nat Commun"}],"container-title":["Science China Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-024-2661-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11427-024-2661-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-024-2661-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T17:07:53Z","timestamp":1724778473000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11427-024-2661-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,17]]},"references-count":513,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["2661"],"URL":"https:\/\/doi.org\/10.1007\/s11427-024-2661-3","relation":{},"ISSN":["1674-7305","1869-1889"],"issn-type":[{"value":"1674-7305","type":"print"},{"value":"1869-1889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,17]]},"assertion":[{"value":"1 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of Interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance and ethics"}}]}}