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China Life Sci."],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>To compare and characterize hypertriglyceridemia-induced acute pancreatitis (HTG-AP) across the geographical regions, we conducted a systematic review and a multi-center cohort study. We conducted a systematic review and random effects meta-analysis of studies reporting HTG-AP. Also, we separately characterized HTG-AP in a multi-center retrospective cohort study involving eight centers in China. The key outcomes of interest included the pooled proportion of HTG-AP and its severity parameters after adjusting for the effect of confounding factors through logistic regression. Our systematic review identified 110 studies from 15 countries accounting for 3,057,428 participants (35% female, median age 50 years). The pooled proportion of HTG-AP was 11.6% globally while the Eastern and Western countries reported the proportions as 16.3% and 5.4%, respectively (<jats:italic>P<\/jats:italic>&lt;0.01). The pooled mortality rate was remarkably higher in Eastern countries (4.1%) than in Western countries (1.0%) (<jats:italic>P<\/jats:italic>&lt;0.01). 3,224 participants (37% female, median age 48 years) were included in our multi-center cohort study, and the proportion of HTG-AP was much higher at 35.9% with a nearly three-fold higher mortality rate compared with acute pancreatitis (AP) due to other etiologies (odds ratio (OR): 2.77, 95% confidence interval (CI): 1.60 to 4.81). The proportion of patients with HTG-AP is remarkably higher in Eastern countries, particularly China, than in Western countries. Furthermore, compared with other causes of AP, HTG-AP has a poorer prognosis and may warrant aggressive management.<\/jats:p>","DOI":"10.1007\/s11427-024-2900-6","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T22:58:00Z","timestamp":1750719480000},"page":"3010-3020","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Global burden and characterization of hypertriglyceridemia-induced acute pancreatitis: results from a systematic review and a multi-center cohort study"],"prefix":"10.1007","volume":"68","author":[{"given":"Zhengyang","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuelun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyin","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanna","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naishi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkata Sandeep","family":"Akshintala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"key":"2900_CR1","first-page":"40","volume":"98","author":"ME Afari","year":"2015","unstructured":"Afari, M.E., Shafqat, H., Shafi, M., Marmoush, F.Y., Roberts, M.B., and Minami, T. 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The protocol for the cohort study was approved by the Ethics committee at Peking Union Medical College Hospital (reference number: K5349). Protocol of the systematic review has been registered in the PROSPERO (Registration number: CRD42024519810). Reporting of the manuscript follows the PRISMA and STROBE statements (Liberati et al., 2009; von Elm et al., 2007). All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance and ethics"}}]}}